aGVHD acute graft-versus-host disease ADA antidrug antibodies AE adverse event BLA biologics license application CBER Center for Biologics Evaluation and Research CD Crohn's disease CIBMTR Center for International Blood and Marrow Transplant Research CMC Chemistry, Manufacturing, and Controls CNI calcineurin inhibitor CR complete response DOR duration of response DP drug product EAP expanded access protocol ETF ectopic tissue formation FAS full analysis set FDA Food and Drug Administration GI gastrointestinal GVHD graft-versus-host disease HLA human leukocyte antigen HLA-DR human leukocyte antigen DR HSCT hematopoietic stem cell transplantation IL-2Rα interleukin-2 receptor alpha IR information request IV intravenous LSM least squares mean MAGIC Mount Sinai急性GVHD国际联盟MBS山急性GVHD国际联盟生物标志物评分MP甲基丙酮甲醇酮MSC MSC中质基质细胞nr nr无响应响应ORR总体生存率OS总体生存PD药态动力学PK PR PP PP PP PP PR PROMPIAL SAPIAL SAPIAL SAPIAL SAP SAP SAP SAPS SAP SAP SAP SAPS SAP SAP SAP SAPS SAP SAP SAPS SAP SAP SAP SAPS SAP SAP SAP SAP SAP SAP SAP SAP SAP SAP SAP SAP SAP SAPS SAP SAPS SAP SAP SAPS SAP SAP肿瘤发生2 SR-AGVHD类固醇难治性急性急性移植 - 抗宿主病TNFR1肿瘤坏死因子受体1 TP治疗的种群
阿片类药物泛滥夺走了更多生命,让这场日益严重的公共卫生危机笼罩在绝望和绝望的氛围中。但是,从纳洛酮药物的配方到鼻喷雾剂的开发,再到广泛的纳洛酮获取法,以及无数个人为研究这一流行病、努力减少耻辱感和争取提高各种治疗可及性而做出的巨大努力,每一步都让我们看到了希望。这是增加纳洛酮获取的最新历史性进步,即非处方纳洛酮鼻喷雾剂的批准,这是这场斗争中的又一步、又一次胜利和又一线希望,它在这条黑暗隧道的尽头点燃了一丝曙光,代表着无数生命将在这一过程中得到拯救。