WT1-树突状细胞疫苗治疗从第155天开始,共注射8剂,直至第280天。通过测量迟发型超敏反应(DTH)的大小来确定对WT1抗原的细胞免疫反应强度。为了测量DTH,将0.1毫升WT1抗原皮内注射到前臂掌侧中心。该注射与WT1-DC腹股沟注射同一天进行。计算皮肤红斑长径和短径的平均值。第四次至第八次注射的DTH平均直径为74.3毫米。DTH的平均直径直到第三次注射才达到60毫米,但从第四次注射开始,它就超过了60毫米,第四次至第八次注射后的平均DTH为74.3毫米。
Figure 7.Chest CT scan 16 months after surgery: (A) Lung window shows multiple small nodular lesions in both lungs, with a high possibility of bilateral lung metastases, changes compared to previous scan not significant.(B) Bone window shows bone destruction at the posterior edge of the T8 vertebral body and its attachments, indicating a high possibility of bone me- tastasis; (C) and (D) are upper abdominal MR scans 16 months after surgery, showing a nodular abnormal signal shadow with a long diameter of approximately 33mm in the left adrenal area, with slight uneven enhancement.The nodular abnormal signal shadow in the left adrenal area has significantly increased compared to before, indicating a high possibility of metastatic tumor 图 7.术后 16 个月胸部 CT , (A) 肺窗示双肺多发小结节灶,考虑双肺转移瘤可能性大,较前变化不明显, (B) 骨窗 示约 T8 椎体后缘及附件骨质破坏,骨转移可能性大; (C) (D) 术后 16 个月上腹 MR ,左侧肾上腺区可见长径约 33 mm 的结节状异常信号影,不均匀轻度强化,左侧肾上腺区结节状异常信号影,较前明显增大,考虑转移瘤可能性大