利用分子农业的潜力

通过Brush Up Summaries掌握最新的最新科学。

什么是分子种植？

Molecular farming is a technique that uses plants as factories to produce recombinant protein products such as antibodies and vaccines for pharmaceutical purposes.1 “Molecular farming is the art and science of making proteins of pharmaceutical interest in plants, as an alternative production system to the more conventional mammalian cells, yeast, and bacteria,” explained Edward Rybicki, a biotechnologist and former director of the开普敦大学的生物军械研究部门。

分子种植 ¹ Edward Rybicki

科学家使用分子农业技术来开发植物中重要的生物学化合物。

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分子种植比传统系统的优势

In the 1980s, scientists synthesized the first recombinant human insulin in the bacterium Escherichia coli.2 Over the years since, researchers have explored many alternative expression systems to synthesize similar value-added biological compounds, such as insects, bacterial species other than E. coli, fungi, yeast, plant cells in culture, and transgenic plants and animals.3

重组人胰岛素 大肠杆菌2 ² 替代表达系统 大肠杆菌 ³ 动物蛋白 ⁴ 翻译后修改 ⁵

最后，尽管转基因动物和哺乳动物细胞培养系统促进了由于正确的蛋白质修饰而促进了最佳表达，但它们很昂贵，这会阻碍有效的大规模生产。与常规的多细胞平台相比，植物为生物制药生产提供了较高的速度，更高的安全性和可伸缩性。

分子农业技术

策略 ⁶

分子耕作工作流程使用植物表达感兴趣的克隆基因，从而产生可收获的重组蛋白产物，例如抗体和疫苗，以实现药物目的。

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