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Exploring the antiangiogenic effects of Phospholipases A2 from Bothrops diporus venom
探索来自Bothrops Diporus venomabstractangiogenesogenesecenation磷脂酶A2的抗血管生成作用,是由现有的脉管系统形成的新血管,是包括癌症在内的生理和病理环境中的至关重要的过程。在蛇毒中发现的酶A2(PLA2S)A2(PLA2S)由于潜在的抗血管生成特性而引起了人们的注意。在这项研究中,我们探索了使用体内和离体模型的组合从Botorops Diporus毒液中分离出的PLA2同工型的抗血管生成作用。绒毛膜斜膜(CAM)测定法显示,PLA2S治疗后血管密度和分支显着降低,组织学分析确认了血管回归,包括血管壁稀疏和腔内塌陷。此外,PLA2S诱导内皮