外推法

评估外推法预测谷浓度以指导口服抗癌药物的治疗药物监测

Methods: Plasma concentrations of abiraterone, dabrafenib, im- atinib, and pazopanib at a random time (C t,sim ) and at the end of the dosing interval (C min,sim ) were simulated from population pharma- cokinetic models including 1000 patients, and the values were con- verted into simulated observed concentrations (C t,sim,obs and C min,sim,obs ) by adding a residual error.，以C T，SIM，SIM，OBS和典型的种群浓度的比率（方法1）与C Min，SIM，SIM 2）的典型种群值（方法2）和log-linearearearearexextral（方法3）相乘。通过比较c min进行比较，评估了目标的目标，即与拟议的相关靶标与效率相关和计算阳性预测和负预测值有关。