日本东京,2023 年 8 月 31 日——三井不动产住宅株式会社和藤泽 SST 委员会(牵头组织者:松下集团)在神奈川县藤泽市藤泽可持续智能城(藤泽 SST)内新设立了未来共创 FINECOURT Ⅲ,这是经过认证的生命周期碳减排 (LCCM) 住宅*2,其理念是“只要住在里面就能产生能量的房屋”。视察之旅将于 2023 年 9 月 1 日星期五开始。该样板房的开发旨在解决可持续发展目标,并提出由于新冠疫情后在家办公人数增加而产生的新生活方式,以及解决进一步促进碳中和等社会问题。该住宅安装了基于建筑环境可持续发展目标清单的技术和设备,并提出了一种实现身心健康的生活方式*3。此外,该住宅还将通过利用钙钛矿太阳能电池和其他可再生能源发电,并采用车到家 (V2H) 电力存储和空调系统,为实现脱碳社会做出贡献。三井不动产住宅有限公司和藤泽 SST 委员会将继续创造和发展新的服务和解决方案,并致力于创建一个在未来 100 年不断发展的智能城镇。
摘要 背景 错配修复缺陷 (dMMR) 是免疫检查点阻断 (ICB) 反应的一个公认的生物标志物。将 MMR 熟练 (pMMR) 转化为 dMMR 表型以使肿瘤对 ICB 敏感的策略受到高度追捧。含溴结构域 4 (BRD4) 抑制和 ICB 的结合提供了有希望的抗肿瘤作用。然而,其潜在机制仍然未知。在这里,我们发现 BRD4 抑制会在癌症中诱导持续的 dMMR 表型。方法我们通过对癌症基因组图谱和临床蛋白质组肿瘤分析联盟数据进行生物信息学分析以及对卵巢癌标本的免疫组织化学 (IHC) 评分进行统计分析,证实了 BRD4 与错配修复 (MMR) 之间的相关性。通过定量逆转录 PCR、蛋白质印迹和 IHC 测量 MMR 基因 (MLH1、MSH2、MSH6、PMS2)。通过全外显子组测序、RNA 测序、MMR 检测和次黄嘌呤-鸟嘌呤磷酸核糖转移酶基因突变检测确认 MMR 状态。在体内和体外诱导 BRD4i AZD5153 耐药模型。通过细胞系之间的染色质免疫沉淀和来自 Cistrome 数据浏览器的数据研究了 BRD4 对 MMR 基因转录的影响。在体内证明了对 ICB 的治疗反应。通过流式细胞术测量了肿瘤免疫微环境标志物,例如 CD4、CD8、TIM-3、FOXP3。结果我们在转录和翻译方面确定了 BRD4 和 MMR 基因之间的正相关性。此外,BRD4 转录抑制会降低 MMR 基因表达,导致 dMMR 状态和突变负荷升高。此外,长期暴露于 AZD5153 可在体内和体外促进持久的 dMMR 特征,增强肿瘤的免疫原性,并且尽管获得了耐药性,但仍增加了对 α - 程序性死亡配体-1 疗法的敏感性。
Block 1: Understanding Grifols We address the needs of thousands of patients..................................................... 12 Joining forces with Biotest.................................................................................... 13 Our global footprint.............................................................................................. 14 Our business model creates value......................................................................... 16 Sustainability and human rights.............................................................................18 Grifols' value chain............................................................................................... 36 Donors and patients............................................................................................. 52 Innovation at Grifols............................................................................................. 72
NY CREATES 正在与纽约、全国乃至世界各地的合作伙伴共同加速未来几十年在经济发展中发挥重要作用的领域的技术发展:集成光子学、神经形态计算/人工智能、量子技术、用于电力和射频的宽带隙电子学、纳米生物设备
• Determines granular process inefficiencies • Finds, monitors, and sets up tasks for automation with bots or scripts • Extrapolates information from occurrences on a workstation or recorded from screens, creates process documentation, and automates simulation model generation • Restores or expands a model and provides process recommendations based on previous data
● Completion: Increase basic needs security ● Pathways and Partnerships: Community engagement, experiential learning, bridge to SDSU (and graduate studies) ● Community: An inclusive space that creates a sense of belonging ● Stewardship: Alignment with Climate Action Plan, reducing carbon footprint, and increasing climate literacy ● Scholarship: Undergraduate research and work experience opportunities
Access to affordable health care raises labor supply and supports workers' performance .......................................... 39 Improving educational access and attainment, including in fundamental skills like literacy, creates a larger and more skilled workforce ................................................................. 39 Well-designed job and career training programs can match those currently out of the labor force with promising career opportunities ............................................... workforce while punishing those in need with unnecessary bureaucracy ................................................................................................ 42
dsDNA 或 ssODN 作为模板进行精确修复 , 而非同源末端连接 (NHEJ) 介导的随机修复可造成插入 、 缺失或突变 . ssODN: 单链寡核苷酸 ; dsDNA: 双链 DNA Figure 3 Two CRISPR/Cas9 gene editing strategies. Cas9 creates DNA double strand break at three bases upstream of the PAM sequence. Homologous recombination repair (HDR) mediates precise repair using dsDNA or ssODN as a template, while non-homologous end joining (NHEJ) -mediated repair can cause insertion, deletion or mutation. ssODN: Single-strand oligodeoxynucleotide; dsDNA: Double strand DNA
ReEnergy Holdings – 太阳能系统经济分析,以确定拟议太阳能电池阵列的经济和战略可行性。NY CREATES – SUNY RF 通过品牌重塑和数字化转型开发新网站并领导管理和营销团队。SUNY Poly 先进制造绩效中心 (AMP) 建立了技术进步平台 (TAP) 和职业进步平台 (CAP) SUNY Polytechnic 和纳米科学与工程学院 (CNSE) 选择 ReWire 协助测量和验证 (M&V) 战略和规划服务,用于评估和优化零能耗纳米技术大楼 (ZEN) 的性能,ZEN 是美国最大的零能耗混合用途设施。
• Capable of testing the quasi-normal and abnormal systems of mobile networks, which is difficult to achieve with real networks • Easily creates complex test environments with wireless power fluctuations in driving environments • Mobile network environments from around the world can be built in the lab for operational verification • Easy-to-use GUI that requires no knowledge of mobile protocols • PSAP* simulator for evaluation of eCall certification tests for each country's laws and regulations and type批准