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披露:Camidge 博士报告担任 AbbVie、Apollomics、AstraZeneca、Daiichi Sankyo、Elevation、Kestrel、Nuvalent、Seattle Genetics、Takeda、Turning Point、Amgen、Anchiano、Bio-Thera、Bristol-Myers Squibb、Eisai、EMD Serono、Eli Lilly、GlaxoSmithKline、Helsinn、Janssen、OnKure、 Mersana、辉瑞、齐鲁、罗氏、赛诺菲、CBT Pharmaceuticals、G1 Therapeutics、Blueprint、Achilles、BeyondSpring、Archer、美敦力和 Ribon;接受 Inivata 的研究资助;并参加由 AbbVie、AstraZeneca、Dizal、Inhibrx、Karyopharm、P fi zer、Phosplatin、PsiOxus、Rain、Roche/Genentech、Seattle Genetics、Takeda 和 Turning Point 等公司赞助的试验(机构)。Barlesi 博士自述担任 Roche/Genentech、P fi zer、Novartis、Pierre Fabre、Bristol-Myers Squibb、AstraZeneca/MedImmune、Boehringer Ingelheim、Eli Lilly、Merck Serono、Merck Sharp & Dohme Oncology 和 Takeda 的顾问或顾问角色;从 Roche/Genentech、Bristol-Myers Squibb 和 AstraZeneca/MedImmune 获得差旅、住宿和费用资助;获得罗氏/基因泰克、辉瑞、诺华、皮埃尔法伯、百时美施贵宝、阿斯利康/MedImmune、勃林格殷格翰、礼来、默克雪兰诺、默克夏普和多姆肿瘤学以及武田的酬金;以及罗氏/基因泰克、阿斯利康/MedImmune、百时美施贵宝和皮埃尔法伯提供的研究资金。Angevin 博士自述担任默克夏普和多姆、葛兰素史克、新基和 MedImmune 的顾问或顾问角色并开展研究;并从 AbbVie、罗氏、赛诺菲、辉瑞和 MedImmune 获得差旅、住宿和费用资助。Bauer 博士自述担任 Guardant Health、Ignyta、Loxo 和辉瑞的顾问;并获得 AbbVie、Aileron Therapeutics、Amgen、Astellas Pharma、AstraZeneca、Boehringer Ingelheim、Bristol-Myers Squibb、Calithera Biosciences、Daiichi Sankyo、Deciphera、Genentech/Roche、GlaxoSmithKline、Ignyta、Immunocore、ImmunoGen、Incyte、Kolltan Pharmaceuticals、Leap Therapeutics、Eli Lilly、MabVax、MedImmune、MedPacto Inc.、Merck、Merrimack、Millennium、Mirati Therapeutics、Moderna Therapeutics、Novartis、Peloton、P fi zer、Principia Biopharma、Roche、Sano fi 和 Stemline Therapeutics 的研究资助。 Delmonte 博士自述担任 Bristol-Myers Squibb、AstraZeneca、Roche 和 Takeda 的顾问或顾问委员会成员,并担任 AbbVie 部分临床试验的主要研究员。Dunbar 博士、Motwani 博士、Parikh 博士、Noon 博士、Wu 博士和 Blot 博士均为 AbbVie 的员工,可能持有其股份。Goldman 博士自述获得 AbbVie 和 Genentech/Roche 的研究经费;获得 Genentech 的咨询费;以及获得 AbbVie、Bristol-Myers Squibb 和 Genentech 的研究经费和咨询费。Heist 博士自述获得 Boehringer Ingelheim、Tarveda 和 Novartis 的顾问酬金;担任 Apollomics、Daichii Sankyo、和 EMD Serono;并获得机构研究经费(而非个人)
图4.30。Global conservation status overview of species recorded within project study area ........................................................................................................................................... 82 Figure 4.31.Location of species of local and global conservation value vis-à-vis habitat types ........................................................................................................................................... 82 Figure 4.32.保护受计划的井眼作品影响的重要植物群................................................................................................................................................... 98图4.33。Conservation significant flora affected by planned borehole, manhole and trench works ................................................................................................................................ 101 Figure 5.1.新加坡的集水区(公共事业委员会,2019年).................................................................................................................................................................................................................................................................................................在2011 - 2021年期间在荣获西风站的年度降雨量..... 111图5.3。自然流在项目研究区域的位置............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 112图5.4。照片显示了项目研究区域内的各种流..................................... 113图5.5。流动特征调查点的位置.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................项目研究区域中地表水质采样点的位置........... 127图5.7。Surface water sampling activities .................................................................... 127 Figure 5.8.Project boundary, including original footprint (magenta) and revised footprint (cyan) ......................................................................................................................................... 137 Figure 6.1.基线噪声监测设备的设置................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 150图6.2。项目研究区域内基线噪声监测站的位置......... 151图6.3。基线LEQ在一个星期内在N1站进行5分钟监测结果... 152图6.4。基线LEQ在一周内在N2站进行5分钟监测结果... 153图6.5。基线LEQ在一个星期内在N3站进行5分钟监测结果... 154图6.6。基线LEQ在一个星期内在N4站进行5分钟监测结果... 155图6.7。基线LEQ在一周内在N5站进行5分钟监测结果... 156图6.8。Predicted daytime noise level from Area 1 & 2 activities without mitigation measures .......................................................................................................................... 161 Figure 6.9.Predicted night-time noise level from Area 1 activities without mitigation measures ......................................................................................................................................... 162 Figure 6.10.Predicted daytime noise level from Area 3 activities without mitigation measures ......................................................................................................................................... 163 Figure 6.11.Predicted night-time noise level from Area 3 activities without mitigation measures ......................................................................................................................................... 163 Figure 6.12.通过缓解措施预测区域1和2的白天噪声水平……165图6.13。通过缓解措施预测区域1处的夜间噪声水平................................................................................................................................................................................................................................................... 165图6.14。Predicted day-time noise level at Area 3 with mitigation measures ................ 166 Figure 6.15.通过缓解措施预测区域3的夜间噪声水平............................................................................................................................................................................... 167图7.1。基线环境空气质量监测设备的设置........................................................................................................................................................................................................................................... 175图7.2。基线环境质量监测站的位置在项目区域内................................................................................................................................................................................................................................................................................. 175图8.1。基线接地振动监控设备的设置....................................................................................................................................................................................................................................................................................................................................................................... 189项目区域内的环境振动监控站的位置............................................................................................................................................. 189。在夜间调查期间观察到的CCKWW设施的人造光196图9.2。Artificial lighting observed along Dunbar Walk ................................................. 197 Figure 9.3.Example of light shielding ................................................................................ 199 Figure 9.4.Example of hedge planting using Murraya paniculata ..................................... 201 Figure 13.1.环境发生率报告流程图............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 237图13.2。Directional Clearance 1 ................................................................................. 243 Figure 13.3.Directional Clearance 2 ................................................................................. 244 Figure 13.4.Directional Clearance 3 ................................................................................. 245
围产期中风是一种局部血管性脑损伤,导致数百万人终身残疾( Nelson ,2007; Dunbar 和 Kirton ,2019)。作为偏瘫性脑瘫的主要原因,且无法预防,当前的研究主要致力于了解和改善运动康复。偏瘫的严重程度在不同个体之间差异很大,有些儿童患肢和手的使用极其有限。因此,这些儿童除了参加适合其年龄的娱乐活动外,还可能在梳洗、洗澡和喂食等日常生活活动中遇到困难。遗憾的是,目前的治疗选择有限,但随着对生命初期单侧损伤后大脑发育方式的了解不断加深,治疗选择将越来越丰富。大量的临床前和人脑映射研究正在确定围产期中风后发生的发育可塑性(Kirton,2013b;Hilderley 等人,2019;Craig 等人,2021;Kirton 等人,2021)。在运动系统中,出生时等比例存在的双侧皮质脊髓束通常会在生命最初几年从同侧撤出(Eyre,2007)。然而,早期单侧损伤可能会损害对侧脊髓神经支配,导致同侧连接异常持续存在以及未受损半球对受影响肢体的运动控制异常(Staudt,2007;Kirton,2013a;Kirton 等人,2015)。不同的中风亚型代表了早期脑损伤后发育可塑性的人类模型(Kirton 和 DeVeber,2013 年)。人们对此类模型与现有的康复疗法之间的关系理解得越来越深刻。强制性运动疗法 (CIMT) 和双手疗法对某些人可能有效,但需要高剂量且效果不大(Novak 等人,2013 年)。模型还定义了非侵入性神经调节的目标,即未受损的初级运动皮层,对照临床试验表明该区域具有额外的疗效(Kirton 等人,2015 年;Hilderley 等人,2019 年)。目前尚无明确的围产期中风儿童神经可塑性模型,因为它与皮质运动意象和运动计划的重组有关。由于缺乏对早期受伤后幼小大脑如何重组的理解,在尝试将心理意象和意图作为康复模式的一部分时,带来了独特的挑战。功能性电刺激 (FES) 是一种新兴的康复选择,在偏瘫儿童中尚未得到充分研究。FES 是一种神经肌肉电刺激 (NMES),它将患者的运动尝试与通过低强度电流刺激目标肌肉相结合,以促进受损功能性运动的重复。患者的自愿努力是 FES 的重要组成部分,其中感觉运动区域的皮质激活与功能改善有关(Eraifej 等人,2017 年;Musselman 等人,2020 年)。成人 FES 已证明中风后偏瘫的上肢功能改善和神经可塑性变化,包括日常生活活动 (ADL) 的改善,并被当前最佳中风康复实践指南推荐(Eraifej 等人,2017 年;Musselman 等人,2020 年)。对偏瘫性 CP 儿童进行的小规模研究表明,将 FES 与治疗相结合可改善手部功能,并伴随皮质神经生理学的变化(Wright 和 Granat,2000 年;
