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CRISPR 革命：基因组编辑的新时代
Dr. Pratibha Tiwari DOI: https://doi.org/10.33545/26174693.2024.v8.i1Sg.382 Abstract This article provides an in-depth exploration of CRISPR-Cas9, a ground breaking genome editing technology that has revolutionized the field of genetic research. It begins with a historical overview of CRISPR, tracing its origins from a natural defense mechanism in bacteria to its development into a powerful tool for precise genetic manipulation. The mechanism of action of CRISPR-Cas9 is then elucidated, highlighting its role as a molecular scissor guided by RNA to target specific DNA sequences for editing. The transformative impact of this technology on genetic research is discussed, emphasizing its contributions to various scientific domains, including medicine, agriculture, and bioengineering. Furthermore, the article addresses the ethical considerations and debates surrounding genome editing, particularly the implications of germline modifications and the potential for misuse. Potential applications and future directions of CRISPR-Cas9 are explored, revealing its vast possibilities in treating genetic disorders, enhancing crop resilience, and more. This comprehensive review underscores the significance of CRISPR-Cas9 in advancing genetic research while acknowledging the need for responsible and ethical application in this rapidly evolving field. Keywords: CRISPR-Cas9, DNA, RNA, genetic research, genes etc. Introduction In the annals of scientific discovery, few innovations have sparked a revolution quite like the advent of CRISPR-Cas9 genome editing technology. This ground breaking tool has not only reshaped our understanding of the genetic blueprint of life but has also opened up a realm of possibilities that were once relegated to the realm of science fiction. Genome editing, a concept that involves the precise alteration of DNA within a living organism, has transitioned from a complex and costly endeavor to a more accessible and accurate technique, thanks to CRISPR-Cas9 [1, 5] . The story of CRISPR-Cas9 is one of serendipity and ingenuity, rooted in a quest that began decades ago. It's a narrative that winds its way from the discovery of restriction enzymes in the 1970s to the intricate mechanisms of bacterial immune and is crucial, as it lays the foundation for understanding how CRISPR-Cas9 evolved from a natural phenomenon into a formidable tool in genetic engineering [6, 12] . Today, CRISPR-Cas9 stands at the forefront of modern biology, heralding a new era of genetic exploration and manipulation. Its significance cannot be overstated; it is not merely a tool for editing genes but a gateway to potential cures for genetic diseases, advancements in agricultural resilience, and solutions to ongoing environmental challenges and it sets the stage for an in-depth exploration of CRISPR-Cas9, delving into its development, mechanism, and the profound impact it has on our approach to biology and medicine [13] . CRISPR-Cas9: Mechanism and Development The CRISPR-Cas9 system, a revolutionary tool in the field of genetic engineering, represents a significant leap forward in our ability to modify DNA with precision and efficiency. This section of the article delves into both the intricate mechanism of CRISPR-Cas9 and its developmental journey from a bacterial defense strategy to a cutting-edge tool in genome editing [14] . Mechanism of CRISPR-Cas9 The CRISPR-Cas9 system originates from a natural process used by bacteria to protect themselves against invading viruses.
CS8082 - 机器学习技术
，结果回来了。该测试在实际存在该疾病的病例中只有98％的情况下回来了正确的阳性结果，并且仅在不存在该疾病的病例中，正确的阴性结果是正确的。此外，整个人群中有0.008患有这种癌症。
线激光金属 3D 打印机 AZ600
摘要 增材制造（AM，3D打印）在制造业中得到越来越广泛的应用。三菱电机开发了线激光金属3D打印机“AZ600”，这是日本*1首次采用金属线和激光的组合作为材料和热源。AZ600配备了AM过程控制功能，可使用各种传感器检测打印状态并协调加工条件和轴速度，实现稳定的打印和高精度。此外，通过使用三菱电机独特的点形成，可以抑制热变形和氧化。如果将AZ600应用于AM，可以减少加工时间、制造成本和材料浪费，从而有助于实现碳中和。此外，我们可以期待依赖于个人的工作质量更加稳定，并更好地响应自动化和省力化的需求。
Kyowa Kirin首席执行官Miyamoto的新年消息：加速我们的改革，决心为患者提供改变生活的价值
在2024年，我们建立了“ 2030年愿景的故事”。这是我们通过克服内部和外部面临的强烈变化，同时最大程度地发挥我们的优势，这是我们将要实现2030愿景的途径。In line with this Story, we have indeed made investments to maximize our strengths, such as the acquisition of Orchard Therapeutics which has hematopoietic stem cell gene therapy technology platform, the construction of the HB7 Building, a new biopharmaceutical active pharmaceutical ingredients (API) manufacturing building at the Takasaki Plant, and the start of construction of a biologics API manufacturing plant in North Carolina, USA.此外，我们可以保持全球战略产品的稳定增长。此外，Kyowa Kirin在重组我们的Apac地区业务和研发结构方面做出了一些重要的管理决定。我们仍然致力于以坚定的决心前进，以确保切实的结果。
Julearn：一个易于使用的库，用于无泄漏评估和检查ML模型
防止域专家可用的常见错误。Julearn的创建是易于使用的，可用于具有不同背景的研究人员，并创造可重现的结果。此外，我们设计了Julearn，因此很容易扩展和维护，以便跟上神经科学和药物等不断发展的领域。Julearn的可访问性和可用性方面决定是核心，因为我们旨在帮助研究人员应用ML。我们通过仔细设计应用程序编程接口（API）来实现这一目标，仅包括一些简单的密钥功能和类来创建和评估复杂的ML管道。此外，我们添加了几个公用事业，使研究人员可以详细了解所得管道。为了使Julearn保持最新状态，我们在Scikit-Learn [3，4]的顶部构建了它，并遵循软件工程的共同最佳实践，例如单元测试和连续集成。
