披露T.A.Y是德克萨斯大学医学博士Anderson癌症中心的雇员,也是应用癌症研究所的医学主任,该研究所对DDR和其他抑制作用具有商业兴趣; has received fund funding paid to their institution from Acrivon, Artios, AstraZeneca, Bayere, Blueprint, Bristol Myrs Squbibb, Clovis, Constellation, Cyteir, Eli Lilly, Emd Serono, Forbis, F-star, Glaxosmithkline, Genentech, Haihe, IONSENSOR, iOnis, iPsen, Karyopharm, KSQ, Kyowa,默克,Mirati,Novarti,Pfizer,Ribion Therapeutics,Repare,Repare,Repare,Rubus,Sanfi,Scholock,Scholar Rock,Seattle Genetics,Tesro,Vivace和Zenith;已经获得了Abbvie,Astrazeneca,Acrivo,Acrivo,Acrivo,Acrivo,Acrivo,Almac,Aduphista,Aduphista,Artios,Artios,Artios,Avoro,Avoro,Avoro,Avoro,Avoro,Avoro,Avoro,Avoro,Axiom,Baptist Health Systems,Bayere,Bayere,Bayere,Bayere,Begene,Boxer,Boxer,Brisol Miyers Squire,cy cy cy cy cy cy a cy can cy cy cal, Emd sero, F-star, Genmab, GLG, GLG, Globe Life Sciences, Glaxosmithkline, Guidepoint, Ignyta, Ignyta, I-mab, Immunesensor, Institute, gustave Roussy, intellisphere, Jansen, Kyn, mei pharma, mereo, mereo, mereo, merck, natira, nexys, nocure, ohsu, online Pharma,Pegascy,Per,Pfizer,Piper-Sandler,Progynx,Reparo,Restorbio,Rothe,Roche,Schrodinger,Theragnostics,Varian,Verian,Versation,Vibliome,vibliome,Xinhera,Zai Labs和Zelbio;并且是本季节的股东。I.M.S.,A.J,J.D.S,C.M,D.U,V.R和MK是Reparetics的雇员,可以持有股票和/或股票期权。 M.Z是Repare Therapeutics的前Empiloyee,可以持有股票和/或股票期权。I.M.S.,A.J,J.D.S,C.M,D.U,V.R和MK是Reparetics的雇员,可以持有股票和/或股票期权。M.Z是Repare Therapeutics的前Empiloyee,可以持有股票和/或股票期权。缩写2W/1W,休假2周; 3D/4D,3天/4天休假; alt,端粒的替代延长; APB,与Alt相关的PML体; ATRI,共济失调的毛细血管扩张和RAD3相关抑制剂; BNHL,B细胞非霍奇金淋巴瘤; CA-125,癌症抗原125; Cam,Camonsertib; CHRC,铬虫肾细胞癌; ctDNA,循环肿瘤DNA; CTF,循环肿瘤部分; EAC,食管腺癌; ECOG PS,东方合作肿瘤学组绩效状况;上皮; GBM,胶质母细胞瘤多形;吉西他他滨妇科癌综合宝石; HCC,肝细胞癌;人力资源,同源重组; IPI,ipilimumab; LGG,低级神经胶质瘤; LMS,平滑肌肉瘤; LPS,脂肪肉瘤; MVAF,平均变体等位基因频率; Nivo,Nivolumab;奥拉(Ola),奥拉帕里布(Olaparib); OS,骨肉瘤; PAAD,胰腺腺癌; PARPI,聚ADP-核糖聚合酶抑制剂; PCAWG,整个基因组的泛伴奏分析; PNET,胰腺神经内分泌肿瘤; PR,部分反应; PSA,前列腺特异性抗原; QD,每天一次; RCC,肾细胞癌;恢复,实体瘤的反应评估标准; RP2D,建议的2期剂量; SNIPDX,用于精确诊断的合成致命相互作用; ssDNA,单链DNA; ST,软组织; TF,肿瘤分数; TVR,端粒变体重复; W,周; WGS,整个基因组测序;是的,多年。
提示 lenabasum 20 mg vs PBO 可改善 ΔFVC%(名义 P = 0.0386)和 ΔFVC mL(名义 P = 0.0481)。在基线时患有 ILD 的既往 IST 受试者中也观察到 FVC 改善,lenabasum 20 mg vs PBO • mACR CRISS 评分显示天花板效应,与 ΔmRSS(r = -0.739)相关性最高,与 MDGA(-0.432)、HAQ-DI(-0.362)、FVC%(0.366)和 PtGA(-0.288)相关性中等 结论:本研究中使用 Lenabasum 是安全的。背景 IST,尤其是 MMF 的意外高改善此前尚未有报道。未达到主要终点。事后分析表明,与接受 PBO 治疗的受试者相比,接受 lenabasum 治疗且未接受背景性 IST 的受试者和接受已建立 IST 的受试者(包括患有 ILD 的受试者)的病情改善更为显著。利益披露:Robert Spiera 为以下公司的顾问:Abbvie、Roche-Genetech、GSK、CSL Behring、Sanofi、Janssen、Chemocentryx、Formation Biologics、Mit- subishi Tanabe,获得以下公司的资助 / 研究支持:Roche-Genetech、GSK、Boehringer Ingelheim、Chemocentryx、Corbus、Formation Biologics、Sanofi、Inflarx、Astra Zeneca、Kadmon、Masataka Kuwana 演讲局:Boehringer-Ingelheim、Chugai、Janssen,为以下公司的顾问:Boehringer-Ingelheim、Chugai、Corbus,获得以下公司的资助 / 研究支持:Boehringer-Ingelheim、Chugai、MBL、Ono Pharmaceu- ticals、Tanabe-Mitsubishi、Dinesh Khanna 为以下公司的股东:Eicos Sciences, Inc(少于 5%)。领导 / 股权职位 – 首席医疗官,CiviBioP- harma/Eicos Sciences, Inc,以下公司的顾问:Acceleron、Actelion、Abbvie、Amgen、Bayer、Boehringer Ingelheim、CSL Behring、Corbus、Gilead、Galapagos、Genentech/Roche、GSK、Horizon、Merck、Mitsubishi Tanabe Pharma、Sanofi-Aventis 和 United Therapeutics,资助 / 研究支持来自:NIH、Immune Tolerance Network、Bayer、BMS、Horizon、Pfizer、Laura Hummers 以下公司的顾问:CSL Behring、Boehringer Ingelheim,资助 / 研究支持来自:Corbus Pharmaceuticals 赞助的研究的研究员。 Corbus、Boehringer Ingelheim、Medpace、Kadmon、Cumberland、CSL Behring、Tracy Frech 资助/研究支持来自:由 Corbus Pharmaceuticals 赞助的研究的研究人员、Wendy Stevens 资助/研究支持来自:由 Corbus Pharmaceuticals 赞助的研究的研究人员、Jessica Gordon 资助/研究支持来自:由 Corbus Pharmaceuticals 赞助的研究的研究人员。 EICOS Pharmaceuticals 和 Cumberland Pharmaceuticals 的研究资金。, Suzanne Kafaja 资助/研究支持来自: Corbus Pharmaceu- ticals 资助的研究研究人员, Marco Matucci-Cerinic 以下公司的顾问: Actelion、Janssen、Inventiva、Bayer、Biogen、Boehringer、CSL Behring、Corbus、Galapagos、Mitsubishi、Samsung、Regeneron、Acceleron、MSD、Chemomab、Lilly、Pfizer、Roche、 资助/研究支持来自: Corbus Pharmaceuticals 资助的研究研究人员,Oli- ver Distler 以下公司的顾问:与以下公司在系统性硬化症及其并发症的潜在治疗领域建立了咨询关系和/或获得了研究资助(过去三年):Abbvie、Acceleron Pharma、Amgen、AnaMar、Arxx Therapeutics、Baecon Discovery、Blade Therapeutics、Bayer、Boehringer Ingelheim、ChemomAb、Corbus Pharmaceuticals、CSL Behring、Galapagos NV、Glenmark Pharmaceuticals、GSK、Horizon (Curzion) Pharmaceuticals、Inventiva、iQvia、Italfarmaco、iQone、Kymera Therapeutics、Lilly、Medac、Medscape、Mitsub- ishi Tanabe Pharma、MSD、Novartis、Pfizer、Roche、Sanofi、Serodapharm、Topadur、Target Bioscience 和 UCB。Eun Bong Lee 资助/研究支持来自:Corbus Pharmaceuticals 资助的研究研究员、Yair Levy 资助/研究支持来自:Corbus Pharmaceu- ticals 资助的研究研究员 Jae-Bum Jun 顾问:Boehringer Ingelheim Korea、Jeil Pharma、Dae Woong Pharma、Kwangdong Pharma 和 Sama Pharma 的顾问 资助 / 研究支持来自:Corbus Pharmaceuticals 资助的研究研究员 Scott Constantine 员工:Corbus Pharmaceu- ticals 员工 Nancy Dgetluck 员工:Corbus Pharmaceuticals 员工 Barbara White 员工:Corbus Pharmaceu- ticals 员工和股东 Daniel Furst 顾问:Corbus、Galapagos、Pfizer、CSL Behring、Mitsubishi Tanabi、Actelion、Amgen、Novartis、Roche/Genentech、Gilead、Talaris 和 Boehringer Ingelheim 资助 资助 / 研究支持来自:Corbus 的资助
我们感谢参加TRESR和/或ATTACC的患者的无私和愿意参加临床研究。我们感谢整个Camonsertib研究团队对TRESR RP-3500-01和ATTACC RP-3500-03的贡献。我们还要感谢我们的合作伙伴实验室,《守护者》(Guardant Health)为这项研究提供的技术帮助和数据生成。我们感谢全球主要公司Onyx在排版和准备海报方面的支持。E.R是一名研究研究者。 J.S.R-F是一名研究研究员;并收到了高盛,Paige.ai,Repare Therapeutics和Persantis的咨询费;是Volition RX,Paige.ai,Repare Therapeutics,Personis和Bain Capital的科学咨询委员会的成员;是Grupo Oncoclinicas董事会成员;并且是Roche Tissue Diagnostics,Ventana Medical Systems,Astrazeneca,Daiichi Sankyo和Merck Sharp&Dohme的科学咨询委员会的临时成员。 B.A.C已通过阿斯利康,Abbvie,Actaute Therapeutics,Astellas,Bayer,Draginfly Therapeutics,Pfizer和Repare and then the Pepepeutics获得了Astrazeneca,Actaute Therapeutics,Actaute Therapeutics,Actaute Therapeutics,Actautics Therapeutics,并获得了研究资金。 s.l已从默克,阿斯利康,雷金伦,罗氏,雷神治疗,葛兰素史克林和西根获得了其机构的赠款或合同; Novocure,Merck,Astrazeneca,Glaxosmithkline,Eisai和Shattuck Labs获得的咨询费;付款或荣誉奖,以进行讲座,演讲,发言人的局,手稿写作或来自阿斯利康,葛兰素史克林和Eisai/Merck的教育活动;并参与Astrazeneca的数据安全监控委员会或顾问委员会。 A.Y. ,E.L。 ,M.CA.E.R是一名研究研究者。J.S.R-F是一名研究研究员;并收到了高盛,Paige.ai,Repare Therapeutics和Persantis的咨询费;是Volition RX,Paige.ai,Repare Therapeutics,Personis和Bain Capital的科学咨询委员会的成员;是Grupo Oncoclinicas董事会成员;并且是Roche Tissue Diagnostics,Ventana Medical Systems,Astrazeneca,Daiichi Sankyo和Merck Sharp&Dohme的科学咨询委员会的临时成员。B.A.C已通过阿斯利康,Abbvie,Actaute Therapeutics,Astellas,Bayer,Draginfly Therapeutics,Pfizer和Repare and then the Pepepeutics获得了Astrazeneca,Actaute Therapeutics,Actaute Therapeutics,Actaute Therapeutics,Actautics Therapeutics,并获得了研究资金。s.l已从默克,阿斯利康,雷金伦,罗氏,雷神治疗,葛兰素史克林和西根获得了其机构的赠款或合同; Novocure,Merck,Astrazeneca,Glaxosmithkline,Eisai和Shattuck Labs获得的咨询费;付款或荣誉奖,以进行讲座,演讲,发言人的局,手稿写作或来自阿斯利康,葛兰素史克林和Eisai/Merck的教育活动;并参与Astrazeneca的数据安全监控委员会或顾问委员会。A.Y. ,E.L。 ,M.CA.A.Y.,E.L。 ,M.CA.,E.L。 ,M.CA.M.CE已获得国家癌症研究所(NCI)指导的临床科学家研究职业发展奖;拜耳制药,DAVA肿瘤学,Taiho Pharmaceuticals,Seattle Genetics,Macrogenics和Daiichi Sankyo的个人费用;并持有Parthenon Therapeutics的股票期权。B.H已从Eisai获得酬金;曾在Amgen担任咨询或咨询角色;并从:Repare Therapeutics(Inst),Ideaya Biosciences(Inst),Amgen(Inst),Revolution Medicines(Inst),Astellas Pharma(Inst)获得研究资金。和S.Z.是监护人的雇员。D.U. ,I.K。 ,I.M.S。 ,J.D.S,J.Y,K.F,M.K,P.N,S.S,V.R和Y.X是Repare的员工,可能会持有股票和/或股票期权。 联系人:Ian Silverman(Isilverman@reparerx.com)缩写D.U.,I.K。 ,I.M.S。 ,J.D.S,J.Y,K.F,M.K,P.N,S.S,V.R和Y.X是Repare的员工,可能会持有股票和/或股票期权。 联系人:Ian Silverman(Isilverman@reparerx.com)缩写,I.K。,I.M.S。 ,J.D.S,J.Y,K.F,M.K,P.N,S.S,V.R和Y.X是Repare的员工,可能会持有股票和/或股票期权。 联系人:Ian Silverman(Isilverman@reparerx.com)缩写,I.M.S。 ,J.D.S,J.Y,K.F,M.K,P.N,S.S,V.R和Y.X是Repare的员工,可能会持有股票和/或股票期权。联系人:Ian Silverman(Isilverman@reparerx.com)缩写
利益冲突:K.P。收到了三菱Tanabe Pharma的讲座费。N.V.C. 获得了R-Biopharm,Takeda和UCB的研究赠款和个人费用;以及Alimentiv,Inc。(以前是Robarts Clinical Trials,Inc。)的个人费用,Celltrion和Prometheus。 A.S.C:收到了Abbvie,Janssen,Takeda,Bacainn,Arena Pharmaceuticals,Grifols,Prometheus,Samsung,Bristol Myers Squibb和Pfizer和Pfizer以及Inform诊断的研究支持。 s.v. 获得了Abbvie,J&J,Pfizer和Takeda的赠款;并已收到Abbvie,Arena Pharmaceuticals,Avaxia,Boehringer Ingelheim,Celgene,Celgene,Falk Pharma博士,Falk Pharma,Ferring,Galapagos,Galapagos,Gelentech-Roche,Gilead,Gilead,Hospira,Hospira,Hospira,Hospira,Janssen,Janssen,Janssen,Mundipharma,Msdipharma,Progigest,Promise,Promise,Promise,Promise,promister,promigen,promigen,promigen,promigen,promigen,promigen,基因组,郡,武田,Theravance和Tilots Pharma ag。 N.A. 从辉瑞(Pfizer)获得了赠款,并从辉瑞(Pfizer)和武田(Takeda)获得了詹森(Janssen)的演讲费。 T.K. 报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。 p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.N.V.C.获得了R-Biopharm,Takeda和UCB的研究赠款和个人费用;以及Alimentiv,Inc。(以前是Robarts Clinical Trials,Inc。)的个人费用,Celltrion和Prometheus。A.S.C:收到了Abbvie,Janssen,Takeda,Bacainn,Arena Pharmaceuticals,Grifols,Prometheus,Samsung,Bristol Myers Squibb和Pfizer和Pfizer以及Inform诊断的研究支持。s.v.获得了Abbvie,J&J,Pfizer和Takeda的赠款;并已收到Abbvie,Arena Pharmaceuticals,Avaxia,Boehringer Ingelheim,Celgene,Celgene,Falk Pharma博士,Falk Pharma,Ferring,Galapagos,Galapagos,Gelentech-Roche,Gilead,Gilead,Hospira,Hospira,Hospira,Hospira,Janssen,Janssen,Janssen,Mundipharma,Msdipharma,Progigest,Promise,Promise,Promise,Promise,promister,promigen,promigen,promigen,promigen,promigen,promigen,基因组,郡,武田,Theravance和Tilots Pharma ag。N.A.从辉瑞(Pfizer)获得了赠款,并从辉瑞(Pfizer)和武田(Takeda)获得了詹森(Janssen)的演讲费。T.K. 报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。 p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.T.K.报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.p.m.i.M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.M.F.P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.P.G.K.N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.N.K.已从Janssen获得发言人费用。W.A.A.J.Y.A.J.Y.W. J. S. reports: research grants from Abbvie, Abivax, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene, Genentech, Gilead Sciences, Glaxo Smith Kline, Janssen, Lilly, Pfizer, Prometheus Biosciences, Seres Therapeutics, Shire, Takeda, Theravance Biopharma; consulting fees from Abbvie, Abivax, Admirx, Alfasigma, Alimentiv (previously Robarts Clinical Trials, owned by Alimentiv Health Trust), Alivio Therapeutics, Allakos, Amgen, Applied Molecular Transport, Arena Pharmaceuticals, Bausch Health (Salix), Beigene, Bellatrix Pharmaceuticals, Boehringer Ingelheim, Boston药物,Bristol Meyers Squibb,Celgene,细胞训练,细胞,Cosmo Pharmaceuticals,Escalier Biosciences,Equillium,Equillium,Forbion,Genentech/Roche,Gilead Sciences,Glenmark Sciences,Glenmark Pharmaceuticals,Gossamer Bio,Gossamer Bio,Gossamer Bio,Immunic(Immunic Pharmace) Kyverna Therapeutics, Landos Biopharma, Lilly, Oppilan Pharma, Otsuka, Pandion Therapeutics, Pfizer, Progenity, Prometheus Biosciences, Prometheus Laboratories, Protagonists Therapeutics, Provention Bio, Reistone Biopharma, Seres Therapeutics, Shanghai Pharma Biotherapeutics, Shire, Shoreline Biosciences, Sublimity治疗剂,苏格达,武术,Theravance Biopharma,Thetis Pharmaceuticals,Tillotts Pharma,UCB,Vendata Biosciences,Ventyx Biosciences,Vimalan Biosciences,Vimalan Biosciences,Vivelix Pharmaceuticals,Vivreon Biosciences,Vivreon Biosciences,Zealand Pharma;以及来自Allakos,Beigene,Gossamer Bio,Oppilan Pharma,Prometheus Biosciences,Prometheus Laboratories Gropenity,Shoreline Biosciences,Ventyx Biosciences,Vimalan Biosciences,Vimalan Biosciences,Vivreon Biosciences的股票或股票期权。从Abvie,Janssen,Pfizer,Takeda,Ferring,Novartis,Novartis和Takeda和Pfizer的科学赠款中获得了咨询和演讲费。配偶:Iveric Bio-顾问,股票期权;后代 - 股票; Oppilan Pharma-顾问,股票期权; Prometheus Biosciences-员工,股票,股票期权;普罗米修斯实验室 - 股票,股票期权,顾问; Ventyx Biosciences - 股票,股票期权; Vimalan Biosciences - 股票,股票期权。报告了Abbvie,BMS,Celgene,Falk Pharma,Ferring,Gilead,MSD,Janssen,Janssen,Janssen,Pfizer,Takeda,Takeda,Theotts,Sapphire Medical,Sandoz,Shire,Warner Chilcott,Warner Chilcott,MSD,Pfizer,Takeeda和AbbBBBBBBBBBBBBBBB,GILA,GILE,GILE,GILE,GILA,GILE,GILE,sanire,sandoz,sandoz,sandoz,sandoz,sandoz,sandoz,sandoz医学, Janssen,Lilly,MSD,Pfizer,Pharmacosmos,Procise,Prometheus,Roche,Sandoz,Samsung Bioepis,Takeda,Topivert,Topivert,VH2,Vifor Pharma,Warner Chilcott。reports financial support for research from Abbvie, Amgen, Biogen, Janssen, Pfizer, and Takeda, consultancy fees from Abbvie, Boehringer-Ingelheim, Celltrion, Janssen, Lilly, Medtronic, MSD, Pfizer, Sandoz, Takeda and Thermo Fisher and speakers fees from Abbvie, Amgen, Biogen, Boehringer-ingelheim,Falk,Ferring,Janssen,Lamepro,MSD,Mylan,Pfizer,Sandoz,Takeda和Truvion Healthcare。D. D.曾担任MSD,Abbvie,Takeda,Pfizer,Janssen,Amgen,Biogen和Krka的发言人,顾问和顾问委员会成员。J.L received unrestricted grants from AbbVie, Almirall, Celgene, Eli Lilly, Janssen-Cilag, LEO Pharma, Novartis, UCB, speaker fees for AbbVie, Almirall, BMS, Janssen-Cilag, Pfizer, UCB and consultant fees for AbbVie, BMS, Celgene, Eli Lilly, Janssen-Cilag, LEO Pharma,Novartis和UCB。从Abbvie,Amgen,Arena Pharmaceuticals,Dynacare,Janssen,Merck,Novartis,Novartis,Pfizer,Sandoz,Takeda获得了咨询费。S.D.S.D.已从Prometheus Labs,Takeda,Arena Pharmaceuticals和Bristol Myers Squibb获得顾问/顾问委员会费用。曾担任Schering-plow,Abbvie,MSD,UCB Pharma,Ferring,Ferring,Cellerix,Cellerix,Takeda,Nycomed,Pharmacosmos,Actelion,Actelion,Actelion,Actelion,Actelion,Actelerman,Alphawasserman,Genentech,Genentech,Grunenthal,Pfizer,Pfizer,Pfizer and vocm andocm andocm andocm andocm and vocm,约翰逊(Johnson),尼克索(Nikkiso)欧洲Gmbh,Theravance。M.C.D. 从Janssen,Abbvie,Pfizer,Takeda,UCB,Celgene,BMS,Prometheus Biosciences,Arena,Lilly,Lilly和Abbvie,Abbvie,Pfizer,Janssen获得了顾问费。 L.P-B: grant support from AbbVie, MSD, Takeda, consulting fees from AbbVie, Janssen, Genentech, Ferring, Tillots, Pharmacosmos, Celltrion, Takeda, Boerhinger Ingelheim, Pfizer, Index Pharmaceuticals, Sandoz, Celgene, Biogen, Samsung Bioepis, Alma, Sterna, Nestle, Enterome, Allergan,MSD,Roche,Arena,Gilead,Hikma,Amga,Amgr,BMS,Vifor,Norgine; Mylan,Lilly,Fresenius,Oppilan Pharma,Sublimity Therapeutics,应用分子运输,OSE免疫治疗药,Enthera以及CTMA的股票或股票期权。 其余的作者没有什么可披露的。M.C.D.从Janssen,Abbvie,Pfizer,Takeda,UCB,Celgene,BMS,Prometheus Biosciences,Arena,Lilly,Lilly和Abbvie,Abbvie,Pfizer,Janssen获得了顾问费。L.P-B: grant support from AbbVie, MSD, Takeda, consulting fees from AbbVie, Janssen, Genentech, Ferring, Tillots, Pharmacosmos, Celltrion, Takeda, Boerhinger Ingelheim, Pfizer, Index Pharmaceuticals, Sandoz, Celgene, Biogen, Samsung Bioepis, Alma, Sterna, Nestle, Enterome, Allergan,MSD,Roche,Arena,Gilead,Hikma,Amga,Amgr,BMS,Vifor,Norgine; Mylan,Lilly,Fresenius,Oppilan Pharma,Sublimity Therapeutics,应用分子运输,OSE免疫治疗药,Enthera以及CTMA的股票或股票期权。其余的作者没有什么可披露的。
通讯作者:Luc Friboulet博士,Inserm 981,Gustave Roussy Cancer Campus。114 Rue Edouard Vaillant,法国Villejuif 94800。电话 + 33(01)4211-6510:luc.friboulet@gustaveroussy.fr。利益冲突陈述:L.M.咨询,咨询角色:Roche Diagnostics。讲座和教育活动:Bristol-Myers Squibb,Tecnofarma,Roche,Astrazeneca。旅行,住宿,费用:chugai。D.P. 咨询,咨询角色或演讲:阿斯利康,布里斯托尔美犬,Boehringer Ingelheim,Celgene,Daiichi Sankyo,Eli Sankyo,Eli Lilly,Lilly,Merck,Medimmune,Novimmune,Novartis,Pfizer,Pfizer,Prime Oncology,Prime Oncology,Peer Cme,Roche,Roche。 Honoraria:阿斯利康,布里斯托尔 - 美犬squibb,Boehringer Ingelheim,Celgene,Eli Lilly,Merck,Novartis,Novartis,Pfizer,Prime Oncology,Pele CME,Roche,Roche。 Clinical trials research as principal or co-investigator (Institutional financial interests): AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Pfizer, Roche, Medimmun, Sanofi-Aventis, Taiho Pharma, Novocure, Daiichi Sanky. 旅行,住宿,费用:阿斯利康,罗氏,诺华,主要肿瘤学,辉瑞A.G. 收到了旅行住宿,国会注册费用来自Boehringer Ingelheim,Novartis,Pfizer,Roche。 从Astrazeneca,BMS,Boehringer Ingelheim,Janssen Cilag,Merck,Novartis,Novartis,Pfizer,Roche,Roche,Sanofi获得的研究赠款。 来自阿斯利康,拜耳,BMS,Boringher Ingelheim,Johnson&Johnson,Lilly,Medimmune,Medimmune,Merck,NH Theraguix,Pfizer,Roche K.H. 是Inivata的雇员和股东。 O.D. P.L.D.P.咨询,咨询角色或演讲:阿斯利康,布里斯托尔美犬,Boehringer Ingelheim,Celgene,Daiichi Sankyo,Eli Sankyo,Eli Lilly,Lilly,Merck,Medimmune,Novimmune,Novartis,Pfizer,Pfizer,Prime Oncology,Prime Oncology,Peer Cme,Roche,Roche。Honoraria:阿斯利康,布里斯托尔 - 美犬squibb,Boehringer Ingelheim,Celgene,Eli Lilly,Merck,Novartis,Novartis,Pfizer,Prime Oncology,Pele CME,Roche,Roche。Clinical trials research as principal or co-investigator (Institutional financial interests): AstraZeneca, Bristol-Myers Squibb, Boehringer Ingelheim, Eli Lilly, Merck, Novartis, Pfizer, Roche, Medimmun, Sanofi-Aventis, Taiho Pharma, Novocure, Daiichi Sanky.旅行,住宿,费用:阿斯利康,罗氏,诺华,主要肿瘤学,辉瑞A.G.收到了旅行住宿,国会注册费用来自Boehringer Ingelheim,Novartis,Pfizer,Roche。从Astrazeneca,BMS,Boehringer Ingelheim,Janssen Cilag,Merck,Novartis,Novartis,Pfizer,Roche,Roche,Sanofi获得的研究赠款。来自阿斯利康,拜耳,BMS,Boringher Ingelheim,Johnson&Johnson,Lilly,Medimmune,Medimmune,Merck,NH Theraguix,Pfizer,Roche K.H.是Inivata的雇员和股东。O.D. P.L.O.D.P.L.P.L.Novartis的顾问/专家角色。 Blueprint药物,Boehringer Ingelheim,Bristol Myers Squibb,CA,Celgene Corporation,Chugai Pharmaceutical Co.,Clovis肿瘤学,Daiichi Sankyo,Daiichi Sankyo,Debiopharmarm S.A. Pharmaceuticals,H3 Biomedicine,Inc,Hoffmann La Roche AG,Incyte Corporation,Insate Pharma,Iris Servier,Janssen,Janssen,Kura肿瘤学,Kyowa Kirin Pharm,Lilly,Lilly,Loxo肿瘤学 Pharmaceuticals, Merus, Millennium Pharmaceuticals, Nanobiotix, Nektar Therapeutics, Novartis Pharma, Octimet Oncology Nv, Oncoethix, Oncomed, Oncopeptides, Onyx Therapeutics, Orion Pharma, Oryzon Genomics, Pfizer, Pharma Mar, Pierre Fabre, Rigontec Gmbh, Roche, Sanofi Aventis, Sierra肿瘤学,Taiho Pharma,Tesaro,Inc,Tioma Therapeutics,Inc。,Xencor。是Xentech的员工。旅行住宿:Astellas-Pharma,Astra Zeneca,Ipsen,Janssen Oncology A.H. A.H. Amgen,Amgen,Spectrum Pharmaceuticals,Lilly的顾问/咨询角色。邀请了Servier,Amgen,Lilly课程,拜耳的培训的邀请。 CookMédical的Proctor,发言人和GE Healthcare E.A.的专家 咨询或咨询角色:Merck Sharp&Dohme,GlaxoSmithkline,Celgene Research,Medimmune。 旅行,住宿,费用:Abbvie,Roche,Sanofi,Pfizer,Medimmune。 A.E.邀请了Servier,Amgen,Lilly课程,拜耳的培训的邀请。CookMédical的Proctor,发言人和GE Healthcare E.A.的专家咨询或咨询角色:Merck Sharp&Dohme,GlaxoSmithkline,Celgene Research,Medimmune。旅行,住宿,费用:Abbvie,Roche,Sanofi,Pfizer,Medimmune。A.E.Abbvie,Agios Pharmaceuticals,Amgen,Argan-X BVBA,Arno Therapeutics,Astex Pharmaceuticals,Astra Zeneca,Ave,AVE,AVE,AVE,AVE,AVE,AVE,AVE,AVE,AVE,AVE,ASTEX Pharmaceuticals,AMGAN-X BVBA的临床试验主/子注视剂 Blueprint药物,Boehringer Ingelheim,Bristol Myrs Squibb,Celgen Corporation,Chugai Pharmaceutical Co.,Clovis肿瘤学,Daichi Sankyo,Devis,Choharms.a. Inc.,GlaxoSmithkline,H3 Biomedicine,Inc,Hoffmann La Roche AG,Inte Pharma,Irris Servier,Jansen Cilag,Kyowa Kiin Pharm。 临床试验的主/子注视器(Inst。) for ABBVIE, Aduro, Agios, Amgen, Argan-X, AstraZeneca, Ave Pharmaceuuticals, Bayer, Beigen, Bluepring, BMS, Boeringer Ingelheim, Celgen, Chugai, Clovis, Daichi Sankyo, Deteram, Eisai, EoS, exelixis,格式,gamabs,Genentech,Gotec,GSK,H3 Biomedecine,事件,先天性药物,Jansen,Kura Oncology,Kyowa,Lilly,Lilly,Lylill,Loxy,Lysarc,Lysarc,Lytix Biopharma,Medimmuni,Medimmuni,Medimmuni,Merus,Merus,Merus,Merus,MSD,MSD,MSD,MSD,MSD,网络,网络Therapeutics,Novartis,Octimet,Oncoethx,Choress AB,Orion,Pfizer,Pharmamar,Pierre Fabre,Roche,Sannofi,Sannofi,Sannofi,Servier,Servier,Sierra Oncology,Taiho,Taiho,Takeda,Takeda,Takeda,Tesaro,Tesaro,Tesaro,Xencord。 自2017年9月以来的Medimmun的全职员工。 阿斯利康和格里特酮的股份。 B.B.Blueprint药物,Boehringer Ingelheim,Bristol Myrs Squibb,Celgen Corporation,Chugai Pharmaceutical Co.,Clovis肿瘤学,Daichi Sankyo,Devis,Choharms.a. Inc.,GlaxoSmithkline,H3 Biomedicine,Inc,Hoffmann La Roche AG,Inte Pharma,Irris Servier,Jansen Cilag,Kyowa Kiin Pharm。临床试验的主/子注视器(Inst。) for ABBVIE, Aduro, Agios, Amgen, Argan-X, AstraZeneca, Ave Pharmaceuuticals, Bayer, Beigen, Bluepring, BMS, Boeringer Ingelheim, Celgen, Chugai, Clovis, Daichi Sankyo, Deteram, Eisai, EoS, exelixis,格式,gamabs,Genentech,Gotec,GSK,H3 Biomedecine,事件,先天性药物,Jansen,Kura Oncology,Kyowa,Lilly,Lilly,Lylill,Loxy,Lysarc,Lysarc,Lytix Biopharma,Medimmuni,Medimmuni,Medimmuni,Merus,Merus,Merus,Merus,MSD,MSD,MSD,MSD,MSD,网络,网络Therapeutics,Novartis,Octimet,Oncoethx,Choress AB,Orion,Pfizer,Pharmamar,Pierre Fabre,Roche,Sannofi,Sannofi,Sannofi,Servier,Servier,Sierra Oncology,Taiho,Taiho,Takeda,Takeda,Takeda,Tesaro,Tesaro,Tesaro,Xencord。 自2017年9月以来的Medimmun的全职员工。 阿斯利康和格里特酮的股份。 B.B.临床试验的主/子注视器(Inst。) for ABBVIE, Aduro, Agios, Amgen, Argan-X, AstraZeneca, Ave Pharmaceuuticals, Bayer, Beigen, Bluepring, BMS, Boeringer Ingelheim, Celgen, Chugai, Clovis, Daichi Sankyo, Deteram, Eisai, EoS, exelixis,格式,gamabs,Genentech,Gotec,GSK,H3 Biomedecine,事件,先天性药物,Jansen,Kura Oncology,Kyowa,Lilly,Lilly,Lylill,Loxy,Lysarc,Lysarc,Lytix Biopharma,Medimmuni,Medimmuni,Medimmuni,Merus,Merus,Merus,Merus,MSD,MSD,MSD,MSD,MSD,网络,网络Therapeutics,Novartis,Octimet,Oncoethx,Choress AB,Orion,Pfizer,Pharmamar,Pierre Fabre,Roche,Sannofi,Sannofi,Sannofi,Servier,Servier,Sierra Oncology,Taiho,Taiho,Takeda,Takeda,Takeda,Tesaro,Tesaro,Tesaro,Xencord。 自2017年9月以来的Medimmun的全职员工。 阿斯利康和格里特酮的股份。 B.B.临床试验的主/子注视器(Inst。)for ABBVIE, Aduro, Agios, Amgen, Argan-X, AstraZeneca, Ave Pharmaceuuticals, Bayer, Beigen, Bluepring, BMS, Boeringer Ingelheim, Celgen, Chugai, Clovis, Daichi Sankyo, Deteram, Eisai, EoS, exelixis,格式,gamabs,Genentech,Gotec,GSK,H3 Biomedecine,事件,先天性药物,Jansen,Kura Oncology,Kyowa,Lilly,Lilly,Lylill,Loxy,Lysarc,Lysarc,Lytix Biopharma,Medimmuni,Medimmuni,Medimmuni,Merus,Merus,Merus,Merus,MSD,MSD,MSD,MSD,MSD,网络,网络Therapeutics,Novartis,Octimet,Oncoethx,Choress AB,Orion,Pfizer,Pharmamar,Pierre Fabre,Roche,Sannofi,Sannofi,Sannofi,Servier,Servier,Sierra Oncology,Taiho,Taiho,Takeda,Takeda,Takeda,Tesaro,Tesaro,Tesaro,Xencord。自2017年9月以来的Medimmun的全职员工。阿斯利康和格里特酮的股份。B.B.B.B.Honararia在过去的5年中,对于以下任何发言人,咨询或咨询角色,来自:Actelon,Agenus,Bayere,Bayer,BMS,BMS,Martipses,Gishk,Gishk,Gsk,Gsk,Haliodx,Incyte,Incyte,IO Biotech,IS io Biotech,是药品GmbH,MSD,Nextarity,Pfizer,Pfizer,polynoma,Regeneron,Sanafi,Sellas,Skylinedx。F. F. A.旅行/住宿/费用,来自阿斯利康,葛兰素史克,诺华和罗氏的费用,他的机构已从阿斯利康,礼来,礼来,诺华,辉瑞,辉瑞和罗氏的研究中获得了研究。C.M:来自Amgen,Asellas,Astra Zeneca,Bayer,Beigen,BMS,Celgen,Celgen,Deleharm,Genentech,Ipsen,Ipsen,Lilly,Lilly,Lilly,Lilly,Medimmuni,MSD,MSD,Novartis,Roche,Roche,Roche,Roche,Sanfi,Oriion,c.m。<最近5年的咨询公司来自阿斯特拉赛,阿斯特克斯,克洛维斯,克洛维斯,gsk,lilly,MSD,Mission Therapeutics,Merus,Pfizer,Pharmamar,Pierre Fabre,Pierre Fabre,Roche/Roche/Geentech,Sanif,Sanif,Sanif,Sance,Serve,Serve,Serve,Serving,Symphogen,Synmphogen和Takeda。<最近5年的咨询公司来自阿斯特拉赛,阿斯特克斯,克洛维斯,克洛维斯,gsk,lilly,MSD,Mission Therapeutics,Merus,Pfizer,Pharmamar,Pierre Fabre,Pierre Fabre,Roche/Roche/Geentech,Sanif,Sanif,Sanif,Sance,Serve,Serve,Serve,Serving,Symphogen,Synmphogen和Takeda。Received institutional grants for clinical and translational research from AstraZeneca, Boehringer-ingelheim, Bristol-Myers Squibb (BMS), Inivata, Lilly, Loxo, OncoMed, Onxeo, Pfizer, Roche-Genentech, Sanofi-Aventis, Servier, and OSE Pharma.