摘要 结节性筋膜炎通常是一种良性病变,其遗传学特征为泛素特异性蛋白酶 6 (USP6) 重排。我们介绍了一个 10 岁男孩的病例,该男孩右胸壁有无痛肿块,已切除,病史为 1.5 周。观察到组织形态学恶性肿瘤,具有明显的多形性、非典型有丝分裂图和肌样免疫表型。甲基化谱与结节性筋膜炎一致,荧光原位杂交证实了 USP6 重排。随后使用 Archer Fusion Plex(肉瘤面板)和 RNA 测序,鉴定出胶原蛋白 VI 型 alpha 2 (COL6A2) - USP6 基因融合。此外,DNA 聚类分析也显示与结节性筋膜炎相匹配。在 22 个月的随访中,没有出现复发或转移。总之,我们描述了一种临床上良性、组织形态学上恶性的间充质肿瘤,具有肌样免疫表型,遗传和表观遗传特征与结节性筋膜炎一致。在这种情况下,分子分析是一种有用的辅助手段,可以避免不必要的过度治疗。
干细胞通常依靠来自利基市场的信号,在许多组织中,这些信号采用了精确的形态。仍然难以捉摸的是生态位的形成方式以及形态如何影响功能。为了解决这个问题,我们利用了果蝇性促性gonadal壁基,提供遗传性障碍和现场成像。我们先前已经显示了将小众细胞迁移到性腺中适当位置的机制,以及对小众功能的结果。在这里,我们表明,一旦定位,生态位细胞可牢固地极化丝状肌动蛋白(F-肌动蛋白)和非肌肉肌球蛋白II(MyOII),向相邻的生殖细胞。沿利基外围的肌动蛋白张力产生高度可重现的平滑轮廓。没有收缩性,壁ni是错误的,并且在调节生殖线干细胞行为的能力方面表现出缺陷。我们还表明生殖细胞有助于在小众细胞中偏振肌无力,并且外在输入是生态形态发生和功能所必需的。我们的工作揭示了一种反馈机制,其中干细胞塑造了指导其行为的利基市场。关键词果蝇,干细胞,睾丸,利基,反馈,肌动蛋白收缩力,形态发生
图2。MAPBI 3谷物生长。 (a)MAPBI 3成核过程来自半径A的基板表面上的前体,大于临界半径。 晶粒在底物表面生长,生长在损伤后终止。 (b),(c)和(d)MAPBI 3膜在100 O C,130 O C和165 O C退火时的光学显微镜图像(B,C,C,D = 90 µm)。 The dendritic morphology turns spherulitic upon increasing the annealing temperatures, (e) Optical microscope image of MAPbI 3 (scale = 40 μm) crystals spin- coated from 3 M DMSO-based precursors and annealed at 165 o C, (f) SEM Images highlighting the surface morphology of MAPbI 3 crystal film spin-coated over glass from 2M precursor (scale = 100 μm), (g)通过SEM(比例=2μm),(H)Mapbi 3膜的横截面SEM在膜中的三重连接晶界中的变焦,该膜胶片在玻璃上旋转(比例= 1 µm)。MAPBI 3谷物生长。(a)MAPBI 3成核过程来自半径A的基板表面上的前体,大于临界半径。晶粒在底物表面生长,生长在损伤后终止。(b),(c)和(d)MAPBI 3膜在100 O C,130 O C和165 O C退火时的光学显微镜图像(B,C,C,D = 90 µm)。The dendritic morphology turns spherulitic upon increasing the annealing temperatures, (e) Optical microscope image of MAPbI 3 (scale = 40 μm) crystals spin- coated from 3 M DMSO-based precursors and annealed at 165 o C, (f) SEM Images highlighting the surface morphology of MAPbI 3 crystal film spin-coated over glass from 2M precursor (scale = 100 μm), (g)通过SEM(比例=2μm),(H)Mapbi 3膜的横截面SEM在膜中的三重连接晶界中的变焦,该膜胶片在玻璃上旋转(比例= 1 µm)。
摘要:易受攻击的斑块进展和破裂风险的评估和预测对于诊断,管理和治疗心血管疾病以及可能预防急性心血管事件(例如心脏病发作和中风)至关重要。然而,对斑块脆弱性评估的准确评估及其未来变化的预测需要准确的斑块帽厚度,组织成分和结构定量和机械应力/应变计算。多模式性内血管内超声(IVU),光学相干断层扫描(OCT)和血管造影图像数据和随访的血管造影图像数据是从十名患者中获取的,以获得用于模型构建的准确可靠的斑块形态。为228个匹配的IVUS + OCT切片构建了三维薄片薄度有限元模型,以获得斑块应力/应变数据进行分析。定量斑块盖的厚度和应力/应变指数作为替代定量斑块漏洞指数(PVIS),并采用机器学习方法(随机森林)来预测使用实际患者IVUS + OCT随访数据的PVI变化作为金标准。我们的预测结果表明,CAP-PVI(C-PVI),平均CAP应力PVI(emem-PVI)和平均盖CAP菌株PVI(平均值)(平均值)的最佳预测精度为90.3%(AUC = 0.877),85.6%,85.6%(AUC = 0.867)和83.3%(AUC = 0.867)和83.3%(AUC = 0.809)。最佳组合预测因子比最佳单个预测因子的预测准确性提高了6.6%,平均S-PVI为10.0%,平均SN-PVI为8.0%。结合机械和形态学预测因子可能会导致更好的预测准确性。我们的结果证明了使用多模式IVUS + OCT图像的电势准确,有效地预测斑块盖的厚度和应力/应变指数的变化。
• Homogenous starting material, continuous growth (Tiered Cell Bank concept: MCB/WCB) • Supply of a whole product life cycle (from pre-clinical to end of commercial life) • Virus-free cell line generation, only animal-free materials, Sartorius media in the bioreactor • Human Telomerase is not an Oncogene, no oncogenes used for “immortalization” • MSC/TERT display MSC-like morphology and电势
A novel, zero-waste and recycling plastic waste solution is introduced, to scalably produce graphene nanoplatelets/barium titanate (GNP/BaTiO 3 ) polymer nanocomposite fibrils.A comprehensive investigation is performed to evaluate the compatible and non-compatible recycled polypropylene (PP)/polyethyleneterephthalate (PET) blends combined with functional (electrical, piezoelectric,and dielectric) materials for in-situ fibril production.The nanocompositefibrils made from recycled PP, PET and GNPs/BaTiO 3 with high-aspect ratio disparity (400:1) are produced, which exhibit significantly enhanced electrical, thermomechanical, and electromagnetic characteristics.Single-screw extrusion is utilised to fabricate the fibrils with the in-situ fibril morphology of PET and GNPs/BaTiO 3 leading to improved electrical conductivity.It is demonstrated that such fibril morphology restricts the chain mobility of polymer molecules, and ultimately increases viscosity and strain energy.Moreover, the study demonstrates a positive reinforcement effect from the utilisation of PET fibrils and GNPs/BaTiO 3 in a PP matrix, dominated by the high-aspect ratio, stiffness, and thermal stability of GNPs/BaTiO 3 .Furthermore, it is observed that the mechanical properties and tension-bearing capacity of the PP are significantly improved by such incorporation.The study also demonstrates that the protection of the remanufactured nanocomposites against electromagnetic interference is significantly improved with the increasing GNPs/BaTiO 3 content and the morphological transition from spherical to fibril-shaped PET.
Lu, Shunyi, Chen, Wen, Wang, Jiayi, Guo, Zilong, Xiao, Lan , Wei, Lingyu, Yu, Jieqin, Yuan, Ya, Chen, Weisin, Bian, Mengxuan, Huang, Lei, Liu, Yuanyuan, Zhang, Jian, Li, Yu Lin, & Jiang, Li Bo (2023) Polydopamine-Decorated PLCL Conduit to Induce Synergetic Effect of Electrical Stimulation and Topological Morphology for Peripheral Nerve Regeneration.Small Methods , 7 (2), Article number: 2200883.
Principles: -‐ Vascular development follows: -‐ metabolic demand -‐ cerebral morphology -‐ Organiza1on of vascular distribu=ng system evolves as the brain grows -‐ open neural tube: diffusion from amnio=c fluid -‐ prechoroidal stage : neural tube closes, diffusion from meninx primi1va -‐ choroidal stage : invagina = of meninx!脉络丛;外部和室室表面的差异;基本动脉桃子一直存在于以后的阶段 - 实质阶段:脑幔厚:超级血管系统的血管生成
印度理工学院Roorkee部门的名称:人文与社会科学系主题法:HSL-902课程标题:计算语言学L-T-P:3-0-2学分:4主题领域:PRE-PH.D。Course Outlines: Introduction to Linguistics and Language Processing, Fundamentals of Programming and Tools: Introduction to programming languages like Python, Morphology and Syntax: various morphological models, dependency and constituency parsing, Semantics and Meaning Representation: Word Sense Disambiguation techniques, Text Preprocessing, Statistical NLP, Machine Learning for NLP and Machine Translation- concept of statistical, rule-based models.