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重新排列的内生植物副病毒作为基于RNA的免疫的证据
真核基因组学经常揭示出外部入侵核酸（例如病毒元素）的历史自发内源化事件。在植物中，据信据信，内源性植物副病毒（EPRV）的广泛发生，可以赋予宿主额外的内部抑制武器。但是，这种活动的实际恶魔仍然是投机性的。我们分析了Solanum lycopersicum的EPRV成分和随附的沉默效应子，记录了具有倒置重复的内含子/基因间甲状腺病毒整合会为植物的基于RNA的免疫系统提供了具有适当的转录物，并能够引起沉积响应。一组少量的重排解释了大量的副逆转录病毒衍生的内源性小干扰（SI）RNA，富集于22-NT形式，通常与抗病毒后的后文字后基因沉默相关。我们提供了初步证据，表明在solanum属以外的其他物种中可以找到这种遗传和免疫信号。Based on molecular dating, bioinformatics, and empirical explorations, we propose that hom ology-dependent silencing emerging from particular immuno-competent rearranged chromosomal areas that con stitute an adaptive heritable trans -acting record of past infections, with potential impact against the unlocking of plant latent EPRVs and cognate-free pararetroviruses.
基于a-lyapunov的诉讼 - 诉讼 - > ...
Abstract In many real-world reinforcement learning (RL) problems, besides optimizing the main objective function, an agent must concurrently avoid violating a number of constraints.In particular, besides optimizing performance, it is crucial to guar- antee the safety of an agent during training as well as deployment (e.g., a robot should avoid taking actions - exploratory or not - which irrevocably harm its hard- ware).To incorporate safety in RL, we derive algorithms under the framework of constrained Markov decision processes (CMDPs), an extension of the standard Markov decision processes (MDPs) augmented with constraints on expected cu- mulative costs.Our approach hinges on a novel Lyapunov method.We define and present a method for constructing Lyapunov functions, which provide an ef- fective way to guarantee the global safety of a behavior policy during training via a set of local linear constraints.Leveraging these theoretical underpinnings, we show how to use the Lyapunov approach to systematically transform dynamic programming (DP) and RL algorithms into their safe counterparts.To illustrate their effectiveness, we evaluate these algorithms in several CMDP planning and decision-making tasks on a safety benchmark domain.Our results show that our proposed method significantly outperforms existing baselines in balancing con- straint satisfaction and performance.
还原计划
• More localised recruitment to support reduced travel times • Reusable company water bottles • Further use of working from home strategies • Update our supply chain to encourage the use of carbon neutral providers for delivery, uniforms, and technology supplies in particular • Move to green website hosting provider • Encourage travel by green operators • Requiring all suppliers to provide green initiatives they are acting on each year, with the initiative of asking for 5% reduction each year • Work towards a 100％的数字 /无纸办公室环境•捐赠过期或未使用的消耗品和设备向当地学校和家庭宣言等其他组织捐赠，并根据PPN 06/21及其相关的减少碳计划指南和报告标准，并签署了该碳减少计划。的排放已按照已发表的减少碳计划和GHG报告协议公司标准的报告标准进行报告并记录，并使用适当的政府排放转换因子为Greenhouse Gas Company Reportinging 2。范围1和范围2的排放已按照SECR要求报告，并且根据已发表的降低碳价值链和公司价值链（范围3）标准的已发表报告标准报告了所需的范围3排放。该减少碳计划已由董事会（或同等管理机构）审查并签署。日期：01/08/2024代表供应商签署：
负责投资
5自2014年以来，AXA IM管理委员会一直在针对与棕榈油生产有关的投资实施排除政策，重点是最糟糕的商业实践。6根据《可持续发展》的争议研究方法：“高”（争议4类）和“严重”（第5类）。这些标准自2014年以来一直是AXA IM棕榈油政策的一部分。7根据《可持续发展》的ESG风险评级方法：“重要”（争议3类）关于“土地使用与生物多样性”材料ESG问题。8基于“ CDP森林”数据库：森林-CDP 9根据《可持续发展的ESG风险评级》方法：“高”（4类）和“严重”（第5类）（第5类）（第5类）（“土地使用与生物多样性”材料ESG问题。10 These exclusion criteria allow to consider and mitigate the principal adverse impacts (PAIs) of investment decisions on sustainability factors, as defined by the Regulation (EU) 2019/2088 on sustainability-related disclosures in the financial services sector (“SFDR”), in particular those related to the mandatory PAIs n°7 (Activities negatively affecting biodiversity-sensitive areas).更多信息可在AXA IM SFDR实体级别披露中获得，可在AXA IM网站上获得：可持续财务|根据我们的数据提供商ESG，AXA IM公司11。12在可持续棕榈油（RSPO）上圆桌会议：使棕榈油可持续性的全球合作伙伴关系 - 可持续棕榈油（RSPO）13的圆桌会议，以本政策的目的，“分支机构”一词是指任何实体，个人，公司或公司，直接或间接地通过一个或更多的中介机构，由一家或更多的中介公司控制或更多的中介公司。
案例1：23-cv-02536-kmw-eap文件96提交03/28/...
2 Concerted action encompasses a “tacit agreement,” Twombly , 550 U.S. at 553, but not conscious parallelism (sometimes called “tacit collusion”), which refers to a particular type of interdependent action that sometimes occurs in oligopolistic markets, see Brooke Group Ltd. v. Brown & Williamson Tobacco Corp. , 509 U.S. 209, 227 (1993).3另请参见，例如，美国诉Masonite Corp。，316 U.S. 265，274-76（1942）（涉及竞争者和许可人之间的双边和解合同）； Meyer诉Kalanick，174 F. Supp。 3d 817，824-25（S.D.N.Y。 2016）（涉及Uber驾驶员与Uber申请之间的驾驶员条款合同））；玩具“ R” US，Inc。诉FTC，221 F.3d 928，932（7th Cir。 2000）（在制造商中找到非法协议，零售商玩具“ R”美国“从制造商到竞争制造商”的保证，每个人都遵守拟议的抵制）。，美国诉Masonite Corp。，316 U.S. 265，274-76（1942）（涉及竞争者和许可人之间的双边和解合同）； Meyer诉Kalanick，174 F. Supp。3d 817，824-25（S.D.N.Y。2016）（涉及Uber驾驶员与Uber申请之间的驾驶员条款合同））；玩具“ R” US，Inc。诉FTC，221 F.3d 928，932（7th Cir。2000）（在制造商中找到非法协议，零售商玩具“ R”美国“从制造商到竞争制造商”的保证，每个人都遵守拟议的抵制）。
LOCAL NEEDS DUTY & ACCOUNTABILITY AGREEMENT
Yeovil College has a clear mission statement ‘To Create Life-Changing Opportunities'. Our purpose is to proactively engage with our stakeholders to identify the skills needs within our local community, with a particular focus on high value, priority sectors that drive the economy forward. These sectors have currently been identified as Advanced Manufacturing (Aerospace), Health, Science, Construction, Digital (& Design) and Electrical (& Cell) Technology. The College is designing and implementing a curriculum for the local, regional and national skills needs, balancing current and future workforce priorities. The College is focused on creating and growing high quality employer partnerships, which provide opportunities for our learners and deliver the skilled workforce that our business community needs to thrive acknowledging that their prosperity is to the benefit of our whole community and our vision best places us to integrate this locally. The Yeovil College Strategic Plan was last updated and approved in November 2023 and sets the College's direction of travel towards 2028 – in which we will deliver the Government's national and regional skills priorities, while also transforming our campus with three brilliant new buildings made possible with more than £45 million of Department for Education capital investment. Strategic Plan Link: Yeovil College Vision, Mission, Values & Strategic Aims | Yeovil College BEHAVIOURS
导出控制协议
双重使用的关注研究意味着生命科学的研究，基于当前的理解，可以合理地预期提供知识，信息，产品或技术，这些知识，信息，产品或技术可能直接误用，以构成对公共卫生和安全，农作物和其他植物，动物，环境，材料，材料或国家安全的广泛潜在影响，对公共卫生和安全的广泛影响构成重大威胁。Entity of Particular Concern means the designation made by the U.S. Secretary of State of a nonstate actor engaging in particularly severe violations of religious freedom and may include, without limitation, Qa'ida affiliate Al-Shabaab, Boko Haram, Hayat Tahrir al-Sham, the Houthis, ISIS-Sahel (formerly known as ISIS-Greater Sahara), ISIS-West Africa, al Qa'ida affiliate Jamaat Nasr al-Islam Wal穆斯林和塔利班。设备的意思是，不考虑采购的总成本或要求，组合组件，配件，附件，固件或软件，可以一起运行以执行AS，或最终项目或系统的功能。设备可能是基于设备特性的最终项目的子集。符合22CFR§120.40（b）中最终项目定义的设备是最终项目。不符合最终项目定义的设备是组件，附件，附件，固件或软件。出于这些协议的目的，设备并不意味着2CFR§200.1中提供的定义。出口，除非在22 CFR§§§120.54，126.16或126.17中规定，含义：
参数生长过程的随机辅助多孔材料
辅助结构是具有负poisson比率的材料：拉伸时，它们垂直于施加力[26，29]，这是看似违反直觉的特性。辅助材料由于其出色的休克吸收，断裂韧性或振动吸收而发现了多个领域的应用[61，51，25，30，49，45]。大量研究致力于设计辅助机械材料[25,12,58]，这些材料从其小规模几何形状的特定布置中得出了其物理特性。最近的制造技术可以制造复杂的小规模结构，因此可以制造辅助材料。随机材料具有一些显着的优势。In particular, they are more resilient to fabrication-related symmetry-breaking imperfections [ 44 ], can smoothly and seamlessly grade material properties [ 28 ], are well suited to manufacture isotropic structures [ 40 , 21 ], are excellent candidates for energy-absorbing applications [ 10 , 39 , 23 ], and allow to compute the material geometry efficiently [ 34 ].虽然重复的周期性结构定义了大多数辅助材料，但独特的研究线对随机辅助材料感兴趣[36]，因为它们比周期性结构具有某些优势[46，62，27]。辅助聚合物泡沫[29，8]在80年代报道，并广泛用于工业应用中。细胞泡沫的几何形状通常是理想化的，并用Voronoi图[17]进行建模，一些研究辅助泡沫的作品是从建模获得辅助泡沫的最常见过程是压缩一个偶然的透明细胞泡沫，以迫使细胞肋骨扣紧，从而产生一个加热到其软化温度的恢复结构[9，1]。
谷物研究杂志五个十字架的异质能力...
Six generations, namely P 1 , P 2 , F 1 , F 2 , BC 1 and BC 2 of five crosses of bread wheat viz ., AKAW 4842 x Raj 4238, AKAW 4924 x RW 5, DBW 39 x MP 3353, GW 11 x DWAP 1540 and GW 455 x UP 2968 were developed to estimate the extent of heterosis and在面包小麦中，近亲抑郁症和基本遗传原因。对家庭之间的方差分析（十字）表明，由于所有字符，由于十字架引起的均方根都非常重要。每个家族（交叉）中后代（世代）之间方差的分析表明，在所有五个十字架中研究的所有字符的六个基本一代平均值之间存在显着差异。在本研究中，所有十字架都描述了每植物和几乎所有成分性状的谷物产量的显着和正质杂种和杂化。Among which crosses AKAW 4842 x Raj 4238, AKAW 4924 x RW 5, GW 11 x DWAP 1540 and GW 455 x UP 2968 depicted negative inbreeding as well as significant and positive mid parent heterosis and heterobeltiosis for grain yield per plant therefore, intermating in F 2 generation may be advantageous for improving particular character for above mentioned crosses.通常，可以通过谱系选择方法改善受固定添加基因效应的每植物的谷物产量。
决议号149
威尼托地区理事会的观点： - 2010年3月15日法律的第1条（目的）和第2条（定义），n.38“确保获得姑息治疗和疼痛疗法的规定”； - 2017年12月22日，第2条（疼痛疗法，禁止在生命的最后阶段的护理和尊严中不合理的顽固性），n。 219“有关知情同意和早期治疗规定的规则”； - The decree of the President of the Council of Ministers January 12, 2017 "Definition and updating of the essential levels of assistance, referred to in Article 1, paragraph 7, of Legislative Decree 30 December 1992, n. 502" and, in particular, with reference to palliative care and pain therapy in the essential levels of assistance, articles 15 (outpatient specialist assistance), 21 (integrated care paths), 23 (palliative care domicile), 31 （在生命的终端阶段对人们的住宅社会和社会援助）和38（急性的普通住院）； - 2019年3月12日的法令“监测医疗保健的新担保系统”；观察到，最近的报告（2024）根据艺术制定。2019年3月12日的DM 3揭示了“由于姑息治疗网络（D30Z）在2022年记录的肿瘤造成的死者数量的一般改善，近年来该价值的一般改善：然而，只有8个区域在足够的得分之上得到了足够的分数。就Veneto而言，D30Z指标的百分比值（衡量家庭姑息治疗服务的报价）为终端肿瘤患者的负责和协助，为57.03％，涉及该指标的分数等于100；