strands”在DNA折纸中,接吻环和RNA折纸中的其他连接器图案)。两种方法都已用于设计各种2D形状和3D结构(5,6)。大多数当前的3D折纸设计遵循在彼此顶部包装几层二维螺旋或螺旋束的方法,和/或弯曲的螺旋束如(7,8)中最初建议。3D设计的替代路径是创建一个线框结构,该结构仅包含3D模型的边界边缘和顶点。在这个方向上有几个值得注意的前虫前旅行(9,10),但是随着柔性且坚固的折纸技术的发展,它大多开始获得追随者(6,11)。与螺旋装箱相比,线框设计的一些优势包括使用链的经济,这允许建造较大的结构,并在低盐条件下更好地折叠。一些挑战是结构的刚性较低,尤其是对于大型的单螺旋边缘设计(可以通过使用多螺旋边缘来减轻,以增加链的使用来缓解)和大型复杂设计的产量低。已经存在几种核酸纳米结构设计工具(8、12、13、14、15、16、17、18、19、20、21)。Most of these however address helix-packing designs, with the more recent ones oriented towards wireframe structures including vHelix (14), DAEDALUS (15) and ATHENA (18) for 3D DNA wireframes, Sterna (20) for single-stranded 3D RNA wireframes and PyDAEDALUS (21) for 3D RNA/DNA hybrid wireframes.这些工具主要支持一种特定的设计方法,每个工具也都处于离线状态,需要一个单独的过程来安装工具及其辅助库,有时可能很难找到或在最坏的情况下弃用。
书籍:-Rocamora,G.,Henriette E.,2015年。塞舌尔中的侵入性外星物种。为什么以及如何消除它们?对优先物种的识别和管理。塞舌尔大学的岛屿生物多样性与保护中心。生物管版,Mèze,MuséumNationalD'Histoire Naturelle,巴黎[Inventaires&Bioversitité系列] 384 p。书籍中的章节和案例研究 - Labisko,J.,Maddock,S.,Rocha,S。&Gower,D.,2022。塞舌尔疱疹中的神秘谱系。在A. Monro&S。Mayo中(编辑),隐秘的物种:形态学的停滞,限制和隐藏的多样性;系统协会特别卷系列; pp。242-280。剑桥:剑桥大学出版社。doi:10.1017/9781009070553.010 -Rocamora G.,2021。侵入性植物物种在沿海和岛屿生态系统中的影响。在Lima M.A.A. 白乌鸦:一家沿海植物要知道和保护。 EMC2项目“探索白乌鸦沿岸栖息地”的结果和未来挑战; pp。 30-31。 上议院诺瓦大学。 https://www.researchgate.net/publication/357516954_the_impact_of_invasive_plant_plant_plant_species_in_in_in_co astal_and_isl_island_island_island_ecosystems_ecosystems_30-- 31_IN_IL_LIMA_MAA_WHITE_CROWBERRY_A_COASTAL_PLANT_KOKNOD_AND_AND_END_PROTECT_RESULTS_AND_FUTURE_CHALNENGES_OF_PROJOF_PROJENT_EMC2_'EXPLOIN_EXPLOIN_PEER -REVIEER -REVIERED在科学期刊上的文章 - Nicoll M.A.C.,Nicoll M.A.C.,Jaeger A.提交)。 -Lucas E.A.,Martin G.R.,Rocamora G. J.,葡萄牙S.J. (提交)。 &Rocamora G.(已提交)。在Lima M.A.A.白乌鸦:一家沿海植物要知道和保护。EMC2项目“探索白乌鸦沿岸栖息地”的结果和未来挑战; pp。30-31。上议院诺瓦大学。https://www.researchgate.net/publication/357516954_the_impact_of_invasive_plant_plant_plant_species_in_in_in_co astal_and_isl_island_island_island_ecosystems_ecosystems_30-- 31_IN_IL_LIMA_MAA_WHITE_CROWBERRY_A_COASTAL_PLANT_KOKNOD_AND_AND_END_PROTECT_RESULTS_AND_FUTURE_CHALNENGES_OF_PROJOF_PROJENT_EMC2_'EXPLOIN_EXPLOIN_PEER -REVIEER -REVIERED在科学期刊上的文章 - Nicoll M.A.C.,Nicoll M.A.C.,Jaeger A.提交)。-Lucas E.A.,Martin G.R.,Rocamora G. J.,葡萄牙S.J.(提交)。&Rocamora G.(已提交)。群体内变化在觅食行为和繁殖热带海鸟的AT-SEA分布以及对海洋空间规划的后果。海鸟的眼景:热带海鸟的视野。- Fordham G.,Curd G.,NoguésJ。,Narty C.,FernándezA。,Duhec A.,Jeanne R.,Skerrett A.在Alphonse Group中,黑蓝色Tern(Sterna Sumatrana)的状态,繁殖和保护,塞舌尔,2008-2022。-Apoo J.,Bunbury N.,Letori J.,Hector A.,Gendron A.,Graham N.A.J.,Rocamora G.&Jaquemet S.,2024年(接受)。海鸟的存在和季节性影响环礁栖息地的营养动态。生物体。
利益冲突:K.P。收到了三菱Tanabe Pharma的讲座费。N.V.C. 获得了R-Biopharm,Takeda和UCB的研究赠款和个人费用;以及Alimentiv,Inc。(以前是Robarts Clinical Trials,Inc。)的个人费用,Celltrion和Prometheus。 A.S.C:收到了Abbvie,Janssen,Takeda,Bacainn,Arena Pharmaceuticals,Grifols,Prometheus,Samsung,Bristol Myers Squibb和Pfizer和Pfizer以及Inform诊断的研究支持。 s.v. 获得了Abbvie,J&J,Pfizer和Takeda的赠款;并已收到Abbvie,Arena Pharmaceuticals,Avaxia,Boehringer Ingelheim,Celgene,Celgene,Falk Pharma博士,Falk Pharma,Ferring,Galapagos,Galapagos,Gelentech-Roche,Gilead,Gilead,Hospira,Hospira,Hospira,Hospira,Janssen,Janssen,Janssen,Mundipharma,Msdipharma,Progigest,Promise,Promise,Promise,Promise,promister,promigen,promigen,promigen,promigen,promigen,promigen,基因组,郡,武田,Theravance和Tilots Pharma ag。 N.A. 从辉瑞(Pfizer)获得了赠款,并从辉瑞(Pfizer)和武田(Takeda)获得了詹森(Janssen)的演讲费。 T.K. 报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。 p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.N.V.C.获得了R-Biopharm,Takeda和UCB的研究赠款和个人费用;以及Alimentiv,Inc。(以前是Robarts Clinical Trials,Inc。)的个人费用,Celltrion和Prometheus。A.S.C:收到了Abbvie,Janssen,Takeda,Bacainn,Arena Pharmaceuticals,Grifols,Prometheus,Samsung,Bristol Myers Squibb和Pfizer和Pfizer以及Inform诊断的研究支持。s.v.获得了Abbvie,J&J,Pfizer和Takeda的赠款;并已收到Abbvie,Arena Pharmaceuticals,Avaxia,Boehringer Ingelheim,Celgene,Celgene,Falk Pharma博士,Falk Pharma,Ferring,Galapagos,Galapagos,Gelentech-Roche,Gilead,Gilead,Hospira,Hospira,Hospira,Hospira,Janssen,Janssen,Janssen,Mundipharma,Msdipharma,Progigest,Promise,Promise,Promise,Promise,promister,promigen,promigen,promigen,promigen,promigen,promigen,基因组,郡,武田,Theravance和Tilots Pharma ag。N.A.从辉瑞(Pfizer)获得了赠款,并从辉瑞(Pfizer)和武田(Takeda)获得了詹森(Janssen)的演讲费。T.K. 报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。 p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.T.K.报告了Alfresa Pharma,Covidien,Eli Lilly,Ferring Pharmaceuticals,Janssen,Kyorin Pharmaceutical,Mochida Pharmaceutical,Nippon kyaku,pfizer,Takeda Pharmaceutical,Themo Scientific,Abbvie GK,Abbvie GK,Astrace of Pronmach,Nippare,Nippare,EA,EA KYA,EA KYA,EA KYAAK,NIPPON,EA KYAAK,NIPPON PHARMATICAN,NIPPON PHARMATICATIC三菱Tanabe Pharma,Zeria,Gilead Sciences,Janssen,Jimro,Abbvie GK,EA Pharma,Otsuka Holdings,Zeria,Kyorin Pharmaceutical,Mochida Pharmaceutical,Thermo Fisher,Thermo Fisher Scientific,Alfresa Pharma,Nippon Kyaku。p.m.i. M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.p.m.i.M.F. P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.M.F.P.G.K. N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.P.G.K.N.K. 已从Janssen获得发言人费用。 W.A. A.J.Y.N.K.已从Janssen获得发言人费用。W.A.A.J.Y.A.J.Y.W. J. S. reports: research grants from Abbvie, Abivax, Arena Pharmaceuticals, Boehringer Ingelheim, Celgene, Genentech, Gilead Sciences, Glaxo Smith Kline, Janssen, Lilly, Pfizer, Prometheus Biosciences, Seres Therapeutics, Shire, Takeda, Theravance Biopharma; consulting fees from Abbvie, Abivax, Admirx, Alfasigma, Alimentiv (previously Robarts Clinical Trials, owned by Alimentiv Health Trust), Alivio Therapeutics, Allakos, Amgen, Applied Molecular Transport, Arena Pharmaceuticals, Bausch Health (Salix), Beigene, Bellatrix Pharmaceuticals, Boehringer Ingelheim, Boston药物,Bristol Meyers Squibb,Celgene,细胞训练,细胞,Cosmo Pharmaceuticals,Escalier Biosciences,Equillium,Equillium,Forbion,Genentech/Roche,Gilead Sciences,Glenmark Sciences,Glenmark Pharmaceuticals,Gossamer Bio,Gossamer Bio,Gossamer Bio,Immunic(Immunic Pharmace) Kyverna Therapeutics, Landos Biopharma, Lilly, Oppilan Pharma, Otsuka, Pandion Therapeutics, Pfizer, Progenity, Prometheus Biosciences, Prometheus Laboratories, Protagonists Therapeutics, Provention Bio, Reistone Biopharma, Seres Therapeutics, Shanghai Pharma Biotherapeutics, Shire, Shoreline Biosciences, Sublimity治疗剂,苏格达,武术,Theravance Biopharma,Thetis Pharmaceuticals,Tillotts Pharma,UCB,Vendata Biosciences,Ventyx Biosciences,Vimalan Biosciences,Vimalan Biosciences,Vivelix Pharmaceuticals,Vivreon Biosciences,Vivreon Biosciences,Zealand Pharma;以及来自Allakos,Beigene,Gossamer Bio,Oppilan Pharma,Prometheus Biosciences,Prometheus Laboratories Gropenity,Shoreline Biosciences,Ventyx Biosciences,Vimalan Biosciences,Vimalan Biosciences,Vivreon Biosciences的股票或股票期权。从Abvie,Janssen,Pfizer,Takeda,Ferring,Novartis,Novartis和Takeda和Pfizer的科学赠款中获得了咨询和演讲费。配偶:Iveric Bio-顾问,股票期权;后代 - 股票; Oppilan Pharma-顾问,股票期权; Prometheus Biosciences-员工,股票,股票期权;普罗米修斯实验室 - 股票,股票期权,顾问; Ventyx Biosciences - 股票,股票期权; Vimalan Biosciences - 股票,股票期权。报告了Abbvie,BMS,Celgene,Falk Pharma,Ferring,Gilead,MSD,Janssen,Janssen,Janssen,Pfizer,Takeda,Takeda,Theotts,Sapphire Medical,Sandoz,Shire,Warner Chilcott,Warner Chilcott,MSD,Pfizer,Takeeda和AbbBBBBBBBBBBBBBBB,GILA,GILE,GILE,GILE,GILA,GILE,GILE,sanire,sandoz,sandoz,sandoz,sandoz,sandoz,sandoz,sandoz医学, Janssen,Lilly,MSD,Pfizer,Pharmacosmos,Procise,Prometheus,Roche,Sandoz,Samsung Bioepis,Takeda,Topivert,Topivert,VH2,Vifor Pharma,Warner Chilcott。reports financial support for research from Abbvie, Amgen, Biogen, Janssen, Pfizer, and Takeda, consultancy fees from Abbvie, Boehringer-Ingelheim, Celltrion, Janssen, Lilly, Medtronic, MSD, Pfizer, Sandoz, Takeda and Thermo Fisher and speakers fees from Abbvie, Amgen, Biogen, Boehringer-ingelheim,Falk,Ferring,Janssen,Lamepro,MSD,Mylan,Pfizer,Sandoz,Takeda和Truvion Healthcare。D. D.曾担任MSD,Abbvie,Takeda,Pfizer,Janssen,Amgen,Biogen和Krka的发言人,顾问和顾问委员会成员。J.L received unrestricted grants from AbbVie, Almirall, Celgene, Eli Lilly, Janssen-Cilag, LEO Pharma, Novartis, UCB, speaker fees for AbbVie, Almirall, BMS, Janssen-Cilag, Pfizer, UCB and consultant fees for AbbVie, BMS, Celgene, Eli Lilly, Janssen-Cilag, LEO Pharma,Novartis和UCB。从Abbvie,Amgen,Arena Pharmaceuticals,Dynacare,Janssen,Merck,Novartis,Novartis,Pfizer,Sandoz,Takeda获得了咨询费。S.D.S.D.已从Prometheus Labs,Takeda,Arena Pharmaceuticals和Bristol Myers Squibb获得顾问/顾问委员会费用。曾担任Schering-plow,Abbvie,MSD,UCB Pharma,Ferring,Ferring,Cellerix,Cellerix,Takeda,Nycomed,Pharmacosmos,Actelion,Actelion,Actelion,Actelion,Actelion,Actelerman,Alphawasserman,Genentech,Genentech,Grunenthal,Pfizer,Pfizer,Pfizer and vocm andocm andocm andocm andocm and vocm,约翰逊(Johnson),尼克索(Nikkiso)欧洲Gmbh,Theravance。M.C.D. 从Janssen,Abbvie,Pfizer,Takeda,UCB,Celgene,BMS,Prometheus Biosciences,Arena,Lilly,Lilly和Abbvie,Abbvie,Pfizer,Janssen获得了顾问费。 L.P-B: grant support from AbbVie, MSD, Takeda, consulting fees from AbbVie, Janssen, Genentech, Ferring, Tillots, Pharmacosmos, Celltrion, Takeda, Boerhinger Ingelheim, Pfizer, Index Pharmaceuticals, Sandoz, Celgene, Biogen, Samsung Bioepis, Alma, Sterna, Nestle, Enterome, Allergan,MSD,Roche,Arena,Gilead,Hikma,Amga,Amgr,BMS,Vifor,Norgine; Mylan,Lilly,Fresenius,Oppilan Pharma,Sublimity Therapeutics,应用分子运输,OSE免疫治疗药,Enthera以及CTMA的股票或股票期权。 其余的作者没有什么可披露的。M.C.D.从Janssen,Abbvie,Pfizer,Takeda,UCB,Celgene,BMS,Prometheus Biosciences,Arena,Lilly,Lilly和Abbvie,Abbvie,Pfizer,Janssen获得了顾问费。L.P-B: grant support from AbbVie, MSD, Takeda, consulting fees from AbbVie, Janssen, Genentech, Ferring, Tillots, Pharmacosmos, Celltrion, Takeda, Boerhinger Ingelheim, Pfizer, Index Pharmaceuticals, Sandoz, Celgene, Biogen, Samsung Bioepis, Alma, Sterna, Nestle, Enterome, Allergan,MSD,Roche,Arena,Gilead,Hikma,Amga,Amgr,BMS,Vifor,Norgine; Mylan,Lilly,Fresenius,Oppilan Pharma,Sublimity Therapeutics,应用分子运输,OSE免疫治疗药,Enthera以及CTMA的股票或股票期权。其余的作者没有什么可披露的。