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2024; 14(7): 2969-2992. doi: 10.7150/thno.96403 Review Actinium-225 targeted alpha particle therapy for prostate cancer
Targeted alpha particle therapy (TAT) has emerged as a promising strategy for the treatment of prostate cancer (PCa). Actinium-225 ( 225 Ac), a potent alpha-emitting radionuclide, may be incorporated into targeting vectors, causing robust and in some cases sustained antitumor responses. The development of radiolabeling techniques involving EDTA, DOTA, DOTPA, and Macropa chelators has laid the groundwork for advancements in this field. At the forefront of clinical trials with 225 Ac in PCa are PSMA-targeted TAT agents, notably [ 225 Ac]Ac-PSMA-617, [ 225 Ac]Ac-PSMA-I&T and [ 225 Ac]Ac-J591. Ongoing investigations spotlight [ 225 Ac]Ac-hu11B6, [ 225 Ac]Ac-YS5, and [ 225 Ac]Ac-SibuDAB, targeting hK2, CD46, and PSMA, respectively. Despite these efforts, hurdles in 225 Ac production, daughter redistribution, and a lack of suitable imaging techniques hinder the development of TAT. To address these challenges and additional advantages, researchers are exploring alpha-emitting isotopes including 227 Th, 223 Ra, 211 At, 213 Bi, 212 Pb or 149 Tb, providing viable alternatives for TAT.
生物多样性绿色屋顶指南
致谢作者要感谢墨尔本市的公园和城市绿色分公司对该项目的热情和彻底审查。The authors also thank Amy Hahs (University of Melbourne) for developing the process to select target fauna species outlined on page 26, Caragh Threlfall (Macquarie University) for advice on microbats, and Gary Simpson (Infinite Landscape) for his expertise and feedback during the peer review process for the list of plants suitable for biodiversity green roofs in Melbourne (see Urban Nature Planting Guide) which附有此指南文件。本文档中包含的维护指南和样本时间表最初是作为“研究澳大利亚示范绿色屋顶的好处（GC16002）”项目的一部分开发的。这是由霍尔特绿色城市基金会资助的，这是由霍尔特创新制定的霍特边境战略合作伙伴倡议的一部分，由墨尔本大学，墨尔本市，维多利亚州环境，土地，水和规划和澳大利亚政府的贡献。我们感谢他们允许使用材料。
卢顿本地计划审查
•将卢顿2040的交付置于计划决策的核心•确定可持续地点的足够土地以满足需求，并使可持续的遗址能够挺身而出，以鼓励再生和更新，•提供一系列高质量，节能的新房屋，提供一系列可适应性的住房，包括适应性的住房，以满足租用的需求和租用的房屋，待售房屋，专注于房屋，待售房屋• in suitable and sustainable locations • Create sustainable, well-designed, safe, inclusive, mixed communities, with access to services and facilities in order to help address poverty, including child poverty and improve health outcomes • Create an inclusive and accessible urban environment in order to help tackle crime and anti-social behaviour and encourage social interaction and activity • Explore the opportunity to utilise public sector land, assets and delivery mechanisms to help unlock sites, particularly for new负担得起的房屋•分配足够的土地，使可持续地点能够挺身于我们的需求，包括住房和就业
Pite Tech DCC-4801电池充电 /放电仪< / div < / div>
Typical application: Telecom Features • Light weight, portable and convenient to use • Suitable for all standby batteries and power batteries: 2V, 6V and 12V • Multi-function in one unit: it uses 3-phase charging, constant current discharging, cell test, optional online monitor and battery activation • Multi-condition for operation auto-stop: time out, maximum capacity, minimum voltage threshold (for battery or string) • It adapts PTC ceramic resistor which secures your discharging • Lag-out batteries could be automatically sorted, and activation function is used to enhance their performance • Instead of merely a load bank, it has optional wireless communication to monitor each battery voltage in discharging • State-of-the-art technique of soft-off for battery charging • Graphical display, showing test result with curves • Direct USB drive for convenient data transfer to PC • Over voltage protection and under voltage warning function •热保护，在正常温度下自动停止过热和自动启动•功能强大的数据视图软件，用于复杂数据分析和报告打印
应用数学系
Nanoarchaeota(Nanoarchaeum), Crenarchaeota (Sulfolobus, Thermoproteus) and Euryarchaeota [Methanogens (Methanobacterium, Methanocaldococcus), thermophiles (Thermococcus, Pyrococcus, Thermoplasma), and Halophiles (Halobacterium, Halococcus)] Eubacteria: Introduction and以下组的重要性：革兰氏消极：非蛋白杆菌：合适的例子的一般特征alpha protobacteria：一般特征与合适的例子β蛋白杆菌：一般特征与适当的例子示例蛋白杆菌：γ蛋白杆菌：gamma protebacteria：一般特征，具有合适的例子，具有合适的例子，具有合适的例子，具有适当的典范：蛋白质细菌：具有合适例子的一般特征革兰氏正阳性：低g+ c（公司）：一般特征与适当的例子高g+ c（肌动杆菌）：一般特征，有适当的例子cyanobacteria：简介
公共密钥基础架构用户指南
• Cloud-native, AI-Native switches with Wired Assurance and Marvis VNA • Fanless with an extended operating temperature range of -40°C to +75°C for harsh environments • Ruggedized, compact form factor for easy installation in tight spaces • Compliant to IP30 and supports a relative humidity range of 5% to 95%, ensuring non- condensing operation • Meets many industrial certifications, making it suitable for use in需要高公差的广泛应用，以持续振动，冲击和电磁免疫力•干触点警报：两个警报：两个警报和一个警报发出信号外部传感器•双重冗余PSU：两个AC PSU或两个DC PSU或一个DC PSU或一个AC和一个AC和一个DC PSU•一个DC PSU•基于以太网络vpn-vpn-Virtial-Virtial-voliptal-volifter lan（EVPN-VXLAN），•EVPN-VXLAN•EVXLAN） （GBP）•使用媒体访问控制安全性（MACSEC）AES256•IEEE 802.3Bz Multigigabit•IEEE 802.3BT功率（POE ++）（POE ++）•基于流量的遥测•用于监控Anomaly droim droim droim droim droim-droiv droiv-droiv-droiv droiv droiv-firs-forivy droiv•
Primis支持研究人员实现使用初级保健数据的好处。
- supporting the evaluation and implementation of the FAMCAT2 algorithm designed to identify people with familial hypercholesteremia and leading on its implementation across the UK (the University of Nottingham) - developing, refining, and evaluating code lists for the earlier identification of people with MND (MNDA and the University of Sheffield) - implementing algorithms to identify suitable participants for a clinical trial to establish whether deprescribing common drugs较低的血压是安全或有效的（优化2个试验，牛津大学） - 开发和评估决策支持系统，以消除年龄较大的2型糖尿病患者（D-MED研究，Leicester糖尿病中心）的潜在不适当的药物（莱斯特糖尿病中心） - 开发，验证和数字工具的养育过程中的预先预先培训，以有助于医院的预先预先培训，以帮助医院的养育量，以帮助医院的努力。研究，利物浦大学） - 东部米德兰群岛的GP实践收集的数据，以评估Pincer药物安全干预（诺丁汉大学）的规模和传播的有效性 - 领导了Pincer药物安全干预的全国性，向英格兰（University of Nottingham）（Inttingham）
MNVSS Kumar博士
带有Schelkunoff多项式方法的平面天线”，Necicaspc-2k15，13-115年7月14日。技术报告：1。技术报告提交了NSTL（DRDO）咨询项目（NSTL/NA/9162/AUV/CONSULTANCY/2007年11月4日），名为“从AUV AUV auv auv apepar-ii上安装的扇区扫描声纳（SSS）收到的图像中提取障碍方面”，2。在NSTL（DRDO）汽车项目中提交的技术报告（NSTL \ Na \ 9162 \ auv \ auv \ cars \ 2 2010年1月29日），题为“适合编码算法的设计和开发，用于改善ber，以改进水下频道I的ber”。 \ 2010年5月）。3。Technical report submitted on NSTL(DRDO) CARS project (NSTL\NA\9162\AUV\CARS\2 dated 29 th January 2010) entitled “Design and Development of suitable coding algorithm for improving the BER in respect of underwater channel Phase-I”, (Technical Report No: AUCE/ECE/NSTL\NA\9162\AUV\CARS\ II \ 2010年7月）。4。CSIR项目提交的技术报告（CSIR项目制裁文件编号：
高级挤出技术
» Silicone is proven to be inert and bio stable, being the gold standard in terms of biocompatibility » It is non-reactive with other elements » It can be platinum-cured for the highest degree of purity » Durometers can be easily altered » It allows for extended post cure for lowest level extractables » It does not utilize leaching plasticizers » Certain formulations are suitable for long term surgical implant » It is odorless,无味，无毒»它具有有利的身体和触觉属性»它具有良好的拉伸强度»它具有良好的压缩性»可以使具有多种质地»可以通过辐射，ETO，蒸汽，蒸汽-30 psi/2 bar对其进行灭菌，在+123°C/ +253°f in +253°f interively-fertibility interibility interibility interibility interivity-fortive-fertibility interestion +253°的 +-54°cansy-54°c and-54°c and-5 cysists in- +253°c an °F至+400°F;脆点：-73°C/-100°F»可在多种方式上处理，包括成型，过度锻炼，板纸，浸水，浸入和挤出与其他材料和基板结合使用»它可以包含与特定应用程序匹配的不同填充剂»IT»IT具有非凡的渗透性，可提供APIS的APIS这种白皮书的吸收。