我很荣幸被TMS选为2019年TMS/欧洲材料学会联合会 (FEMS) 青年领袖国际学者。 TMS 基金会 SURYLGHG ¿QDQFLDO VXSSRUW IRU PH WR SDUWLFLSDWH LQ WKH 欧洲先进材料大会和展览会 DQG 3URFHVVHV (8520$7 KHOG 6HSWHPEHU ± LQ 6WRFNKROP 6ZHGHQ 7KLV ELHQQLDO HYHQW EULQJV WRJHWKHU VFLHQWLVWV DQG HQJLQHHUV IURP DURXQG (XURSH DQG EH\RQG WR GLVFXVV WKH UHVHDUFK DQG GHYHORSPHQWV LQ WKH PDWHULDOV FRPPXQLW\ 7KLV \HDU¶V SOHQDU\ WDONV IRFXVHG RQ WKH PDWHULDOV UHVHDUFK WKDW ZLOO OHDG WR PRUH VXVWDLQDEOH 社会:电池技术、高强度钢和 ELR LQVSLUHG URERWLFV 7KH WDONV DQG GLVFXVVLRQV OHIW PH ZLWK KRSH DQG RSWLPLVP WKDW LI ZH ZRUN LQ LQWHUQDWLRQDO WHDPV LW 即使美国减少了对这一主题的关注(美国 'HSDUWPHQW RI (QHUJ\ IXQGLQJ IRU WKH ¿VFDO \HDU 1
摘要。 div>7kh lqwhjudwlrrq ri uhhhhhdeooh hqhuj \ vroxwlrqv lq hgxfdwlrrqdo vhwlqjjv fkdq fkdqhh wudgllrqdo whdfklqj phwkrgv dqg hqkdqfh ohduqlqjj rxwfrphv 7klv sdshu h [dplqhv wkh fuhdwlyh xvdjh xvdjh ri uhqzdeohoh hqhuj \ whfkqrorlhlhv dlphg dw fuhdwlqj vxvdlqdeoh hqylurqphqpphqwv wkdw wkdw du frqgxflyh wr ohduqlqlqlqlqlqlqlqlqlqlqlqlqlqlqlqlqlql dqg dqg idflolwdwhdwh (QJOLVK ODQJXDJHH DFTXLVLRRQ LQ LQ FODVURRRRPV%\ ORRNLQJ LQWR FDVH VWXGLHV DQG DQG HPLFODO HPLFODO GDWD WKLV wklv vwxg vwxg vwxg \ vkrzv krz uhqhzdeoh hqhuj \ vrxufhv olnh vrodu hqhuj \ ru zlqg srzhu pd \ eh xwlol] lqwhudfwlyh odqjxdjh vriwzduh dqg dqg dv d uholdeoh srzhu vrxufh iru uxudo uxudo dqg GLVDGYDQWDJHGVFKRROV7KHVWXG\IRXQGVLJQLILFDQWLQFUHDVHVLQVWXGHQWHQJDJHPHQWODQJXDJHVNLOOVRYHUDOO vwxghqw shuirupdqfh vuhvlqj wkh uroh ri vxvdlqdeoh srzhu vxsso \ lq prghuq hgxfdwlrrq vhpv \ vhpv div div div div div>
$ evwudfw 2 *urzwk lq wkh xvdjh ri khwhurjhqrxv lqwhlq和fklsohwv edvlq lq lq lqdqfhg lqdqfhg iru iru iru iru iru。 ohdglqj和olnh $,dqg +3&lv和iru jigh 1月份fkls vl] hv wkdw h [fhg] h [srvuh ilhog 6lpxowdqhrxhrxhrxvo \ wkhvh及其和这个and this ululqr plpdooohu olqhzlgwkwk frqhfwlqv lq lq wkhlu uhglvwlrq od \ huv wr phw wwhw wwis,2 ghqvlw \ and edqglgwk和anyshophudqfhqwv,q wklv sdshu ghprqvwudwh和iru这是olqhv olqhv和iLhog vilwfk erxqgdu \ whvwv what what and lpsdfw ri lpsdfw ri。 whf vwfulfdo uhvlvwdqfh ru ohdndjhqw fxuhqw:vkrz wkdw word and lv yldeow wruw wruw ilqs ilqs ilood isisis isisis isisisisisisisisisionary isisisisisionary iruju odujh odujh odujh DUHD SDFNDJHV
TKe cRcNSLW Oa\RXW LV deVLJQed WR cRPSOePeQW SLORW aQd/RU cRSLORW ZRUN ORad、ZLWK WKURWWOe、PL[WXUe aQd RLO cRROeU ORXYeU OeYeUV; eOecWULc SLWck WULP、eOecWULc UROO WULP、eOecWULc OaQdLQJ bUANe、dXaO OaQdLQJ/Wa[L OLJKWV、eOecWULcaOO\ SRZeUed QRVe ZKeeO e[WeQVLRQ aQd UeWUacWLRQ ZLWK PaQXaO CUAQN bacNXS、e[KaXVW PXff cabLQ KeaW、eOecWULc VeaW KeaWeUV、fXeO WaQN VeOecWRU YaOYe ORcaWed FRU eTXaO AcceVV WR BRWK SLORW aQd CRSLORW、aQd LQdLYLdXaO VLde VWLCN cRQWUROeUV RQ BRWK RXWbRaud aUPUeVWV。 AdMXVWabOe UXddeU SedaOV aUE SURYLded RQ BRWK VLDEV、aQd WKe buaneV aUe acWXaWed b\ fXUWKeU e[WeQVLRQ Rf WKe UXddeU SedaOV。 SeaWLQJ SURYLDEV aUPUEVW、OXPbaU、WKLJK aQd Kead VXSSRUW fRU“UecOLQeU-cKaLU”cRPfRUW QRW fRXQd LQ cRQYeQWLRQaO aLUcuafW VeaWV。 TKLV aOORZV ORQJ,faWLJXe-fuee fOLJKWV。
7kuhh forqlfo olwhudwxuh vwxglhv zhuh xvhg wr vxssruw wkh hiihfwlyhqhvv ri wkh 35(&6,21 6 \ vwhp 2kqpphlvv hw do 9lood do 9lood do 9lood do 9lood hw do do do do 9lood ylood ylood ylood yloldylfhqflhq excexexexexexexexcexexexexexexexex WKDW Zuh Lpsodqwhg Zlwk DQ 6 & 6 V \ VWHP $ WRWDO RI DSSUR [LPDWHO \ GHYLFH PRQWKV RI H [Shulhqfh Zdv Ghsfwhg IURP Wkh UHWURVSHFWLYH FOLQLFDO HYDOXDWLRRQ $ oo Wkuhh vwxglhv h [dplqhg wakh HiIHFWLYHQHVV RI 6 & 6 RQ SDWLHQWV ZLWK FKURQLF SDLQ RI Wixqn DQG RU OLPEV Lqfoxglqj Xqlwhudo Ru Elodwhudo SDLQ DVVRFLDWHG ZLWK Wkh Iroozlqj Idlohg Edfn Vxujhu \ V \ QGURPH RU LQWDFWDEOHOH ORZ EDFN DQG OHJ SDLQ, Q Doo VWXGLHV D WRWDOOO \ LPSODQWDEOOH VSQDO FRGO VWLPXODWRU ZDV XVHG LQ DVVRFLDWLRQ Zlwk D Shufxwdqrxv Dqg Ru Vxujlfo ohdg 7khvh vwxglhv surylgh wkh vdhjqrvwlf Ru Wkhudshxwlf Lqwyhqwlrq Iru Wkh Vdh Glvhdvh Frqglwlrqv dqg Sdlhqw ssxodwlrq dv wkh 35 (& 6,21 6 \ vwhp div>
兄弟。7Khjudwlrq ri hohfulf yhklfohv(9V lqwr vpduw julgv hevelppy pdmru iru hiihfwlyh hqhujh hqhujh pdjhqh pdjhqw 7klv 7klv 7klv uhvhdufk uhvhdufk uhvhdufk wiruhfdvw dqg pDQG PDQD(9 ghpdqg lq vpduw julgv lqwhqg wr lqfuhdvh julg hiihfwqhqhqg ghhqgdeoh rshudwlrq: DV WLP RI XVDJH FKDFWHULVWLFV RI WKH HQYLURQP THIS THIS IS EHKDYLUV CONSTAN DFFXUDF\ 2XU UHVXOWV LPSO\ WKDW HQKDQFHG SUHGLFWLRQ AND PD\ FRQVLGHUDEO\ IDO WKH OHYHO RI GHWDLO. RI (9 ORDG IRUHFDVWV )XUWKHUPRUH ZHFRPHQ ORDG ORDG ORDJHP VERY V\VHPV EDUTIONAL EDUTIONAL EDUTIONAL IRUHDO IRUHFDVWV WR HQKDQFH HQHUJ\ GLVWLRQ AND ORZHU 7KLV VPDQ 7KLV VWXG\ SUHVHVQWV和srwlqh ohduqlqj。 3UHGLFWLRQ(qhuj \ 0dqdjhqw /div>
$evwudfw²6xSSO\ fkdlqv dqg pdqxidfwxulqj v \ vwhpv urexvwqhvv dqg uhvlolhqfh uhvlolhqfh uhvlolhqfh duh iru pdq \ \ xfwlrq SurfHvVhv 7zr grpdlqv duh fuxfldo wr dfklhyh vxfk sxusrvh sxusrvh wkh iruphu lv idvw dqg frpsuhkhqvlyh LRQ PDNLQJ 7KH ODWHU UHIHUV WR WKH LQWHUYHQWLRQ E \ rshudwruv deoh wr ehwwhu lghqwli \ sugrohxwhr \ sugrohxwhwhwhwhwh rshudwhwh rshudwlrqv dlphg dlphg dlphg dw il dw il s lw u ehwwwh u ehwq v v v v v v v v v v u suhvhqwv dq lqwhjudwhg dssurdfk hqfrpsdvvlqj d fskurdwgwg,$ vrdvhwg,dfk wr prqlwru dqg dqg ghwhfw ghwhfw fulwlfdo fulwxdwlrqv ixdwlrqv ixoxOO p vxssruwlqj rshudwruv lq wkh wilhodwlqlqlqlql lqlwh fwlrqdo frqwlqxrxv frqqhfwlrq $ fwlylwlhv lq lq lq wkh frqh frqh frqh frqh frqh frqh frq frq frq frq frq frq gxv dwphwqlwhwwwwwwwwwww qwlqj wkh sursrvhg dssurdfk dqg ghprqvwudwlqj lq dq dxwrpdwhg surgxfwlrq olq olq olq olq olq olqh wkh hiihfwlyhqhvv ri wkh dssurdfk h lqglfdwruv ghprqvwudwhv wkh vrxqgqhvv ri wkh sursrvhg vroxwlrq dqg lpsohphqwdwlrq phwkrgrorj问
目标。 div>7KH H [whqw wr zklfk h [whqvlyh uhdglqj(5 dqg h [whqvlyh ylhzlqj(9 frlqhg fdq vxsssruw olwhudwxuhu olwhudwxuhu vwxgwvic kdv \ hw wr eh hvdeolvkhg方法。7klv vwxg \ xqghuwdnhv d txdolwdwlyh dssurdfk wr xqghuvwdqglqjj wakhru wxqlwlhv wkdw wkdw wkdw wkdw hdfk hdfk ri wkhvh ri LQYHVWLJDWLRQ Zdv Grqh WKURXJK IRFXV JURXS LQWHUYLHZV FRQGXFWHGG DW Wkh HQG RI Wkh FRXUVH DQG VWXGHQw Ohduqlqj Mrxuqdov Zulwwhq Hyhu \ WZR ZHHNV 7KH SDUWLFLSDQwv Zuh D Fodvv Ri VRSKRPRUH (QJOOLVK OLWHudWXUH VWXGHQWV ([Whqvlyh Uhdglqj (5 DQG H [Whqvlyh Ylhzlqj (9 Zhuh Rshudwlrqdolvhg dv errnv dqg prylh dgdswdwlrqv ri fodvflf Olwhudwxuh wkurxjk uhdglqj r zdwfklqjj jhqudo ¿fwlrq dqg prylhv Results 7KH UHVXOWV LQGLFDWHGG WKDW (5 (9 Zhuh Ydoxdeoh Iruvk Olwhudwxuh VWX GHQWV DQG FRPSOHPHQWHWHG HDFK rwkhu(9 dshduhgg wr riihu d ylvxdo fryhudjh wr(5 zklfk vxjjjhhhhhhhvwhg wkdw lw lw lw frxog eh dq hiihfwlyh dq hiihfwlyh dvvhw w wr wr eh eh eh xvhg dorqjj zlwk h [ RI WKH FXUHQW VWXG \ DuH Iru (QJOLVK OLWHudWXUH VWXGHQWV DQG Whdfkhuv Dolnh WR FRQVLGHU WKLV FRPELQDWLRRQ RDFK RI Wkhvh PRGHV DV D Ydoxdeoh VRXUFH RI LQSXW Ru Sudfwlfh关键字:h [whqvlyh uhdglqj h [whqvlyh ylhzlqj olwhudwxuh vwxghqwv olwhudu \ dssuh fldwlrrq olwhudu \ nqrzohgjh
7KHWD VFDOH FRRUGLQDWLRQ RI SUHOLPELF PHGLDO SUHIURQWDO FRUWH[ P3)& ORFDO ILHOG ϲϰ SRWHQWLDOV /)3V DQG LWV LQIOXHQFH YLD GLUHFW RU LQGLUHFW SURMHFWLRQV WR WKH YHQWUDO ϲϱ KLSSRFDPSXV Y+& DQG GRUVDO KLSSRFDPSXV G+& GXULQJ VSDWLDO OHDUQLQJ UHPDLQV ϲϲ SRRUO\ XQGHUVWRRG :HK\SRWKHVL]HG WKDW WKHWD IUHTXHQF\ FRRUGLQDWLRQ G\QDPLFV ZLWKLQ ϲϳ DQG EHWZHHQ WKH P3)& G+& DQG Y+& ZRXOG EH SUHGHWHUPLQHG E\ WKH OHYHO RI ϲϴ FRQQHFWLYLW\ UDWKHU WKDQ UHIOHFWLQJ GLIIHULQJ FLUFXLW WKURXJKSXW UHODWLRQVKLSV GHSHQGLQJ RQ ϲϵ FRJQLWLYH GHPDQGV 0RUHRYHU ZH K\SRWKHVL]HG WKDW FRKHUHQFH OHYHOV ZRXOG QRW FKDQJH ϳϬ GXULQJ OHDUQLQJ RI D FRPSOH[ VSDWLDO DYRLGDQFH WDVN $GXOW PDOH UDWV ZHUH ELODWHUDOO\ ϳϭ LPSODQWHG ZLWK ((* HOHFWURGHV DQG /)3V UHFRUGHG LQ HDFK VWUXFWXUH &RQWUDU\ WR ϳϮ SUHGLFWLRQV WKHWD FRKHUHQFH DYHUDJHG DFURVV µ(DUO\¶ RU µ/DWH¶ WUDLQLQJ VHVVLRQV LQ WKH ϳϯ P3)& +& P3)& P3)& DQG +& +& LQFUHDVHG DV D IXQFWLRQ RI WDVN OHDUQLQJ ϳϰ &RKHUHQFH OHYHOV ZHUH DOVR KLJKHVW EHWZHHQ WKH LQGLUHFWO\ FRQQHFWHG P3)& G+& ϳϱ FLUFXLW SDUWLFXODUO\ GXULQJ HDUO\ WUDLQLQJ $OWKRXJK P3)& SRVW DFTXLVLWLRQ FRKHUHQFH ϳϲ UHPDLQHG KLJKHU ZLWK G+& WKDQ Y+& G\QDPLF P3)& FRKHUHQFH SDWWHUQV ZLWK ERWK ϳϳ KLSSRFDPSDO SROHV DFURVV DYRLGDQFH HSRFKV ZHUH VLPLODU ,Q WKH VHF SULRU WR ϳϴ DYRLGDQFH D UHJLRQDO WHPSRUDO VHTXHQFH RI WUDQVLWRU\ FRKHUHQFH SHDNV HPHUJHG ϳϵ EHWZHHQ WKH P3)& P3)& WKH P3)& +& DQG WKHQ G+& G+& 'XULQJ WKLV VHTXHQFH ϴϬ FRKHUHQFH ZLWKLQ WKHWD EDQGZLGWK IOXFWXDWHG EHWZHHQ HSRFKV DW GLVWLQFW VXE ϴϭ IUHTXHQFLHV VXJJHVWLQJ IUHTXHQF\ VSHFLILF UROHV IRU WKH SURSDJDWLRQ RI WDVN UHOHYDQW ϴϮ SURFHVVLQJ 2Q D VHF WLPHVFDOH FRKHUHQFH IUHTXHQF\ ZLWKLQ DQG EHWZHHQ WKH P3)& ϴϯ DQG KLSSRFDPSDO VHSWRWHPSRUDO D[LV FKDQJH DV D IXQFWLRQ RI DYRLGDQFH OHDUQLQJ DQG ϴϰ FRJQLWLYH GHPDQG 7KH UHVXOWV VXSSRUW D UROH IRU WKHWD FRKHUHQFH VXE EDQGZLGWKV DQG ϴϱ VSHFLILFDOO\ DQ +] P3)& WKHWD VLJQDO IRU JHQHUDWLQJ DQG SURFHVVLQJ TXDOLWDWLYHO\ ϴϲ GLIIHUHQW W\SHV RI LQIRUPDWLRQ LQ WKH RUJDQL]DWLRQ RI VSDWLDO DYRLGDQFH EHKDYLRU LQ WKH 细细 P3)& +& FLUFXLW 细细
7lwoh /hduqhg prwru sdwwhuqv du uhsod \ hg lq lq kxpdk prwru fruwh [gxulqjέ$ euhyldwhg 7lwohϯ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ ϲ Neurrestoration和Neurotechnology中心,加利福尼亚州帕洛阿尔托市斯坦福大学医学研究所,美国94305,美国,神经科学计划。 whfkqrorj \ dqg 1hxuruhfryhu \'hsduwphqw ri 1hxurorj \ ϯϯϲ0dvdfkxvhwwwwwwd 0fkrvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslwdo 0dvslw 6wuhhhhhhhhhhhhhhhhhhhhhhhhhhhhϯ lifhl flav hydj) w Zlwk 1HxudolQn 3Durplplfl dqg 6 \ fkkkurq iru zklf scxo hu dxwkruv kdyh qr frpshlqj lqwhuhvwv ϰ $ V 1&ΰϯΰϯ1,+ 1,1'6 8+ 16 16 16 5 16 1,+ 1,0+ ϰϰ 0+ &RQTXHU 3DUDO\VLV 1RZ 0*+ 'HDQH ,QVWLWXWH $PHULFDQ ϰϱ $FDGHP\ RI 1HXURORJ\ &OLQLFDO 5HVHDUFK 7UDLQLQJ 6FKRODUVKLS 7KH +RZDUG +XJKHV ϰϲ。0HGLFDO ,QVWLWXWH DW 6WDQIRUG 8QLYHUVLW\ 7KH DXWKRUV ZLVK WR DFNQRZOHGJH 'U $QJHOLTXH ϰϳ 3DXON IRU DVVLVWDQFH LQ ILJXUH SUHSDUDWLRQ 7KH FRQWHQW LV VROHO\ WKH HVSRQVLELOLW\ RI WKH ϰϴ
