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2024 Standard Plan Revision Summary
Standard Plan J-10.25-01 Transformer Cabinet (480V/240V - 240V/120V) : Standardized the design regardless of input and output voltages, removed the secondary main breaker to allow for full use of the 12-position breaker panel, added the option for inclusion of a lighting circuit (including photocell), and added a surge protection device to allow for direct wiring of Variable Message Signs (we will no longer receive a load center in a VMS cabinet, removing the need for a specialized VMS cabinet). Standard Plans J-20.01-01 Light and Signal Standard Index and Identification , J-21.10- 05 Type PS, Type 1, RM & FB Signal Standard Foundation Details, J-21.16-02 Flashing Beacon Type 1 Signal Standard Details, J-22.15-03 Ramp Meter (Type RM) Signal Standard Details, J-22.17-00 Ramp Meter Signal Installation Details (New Plan) - This block of plans has been revised to accomplish two things: 1. Slip-base foundations are being replaced with frangible bolt installations. This allows us to use one base plate, anchor bolt arrangement, and foundation design for both fixed and breakaway poles, with the only difference being the inclusion of breakaway bolt connections (ex: Transpo Pole-Safe), and for any site to be breakaway without significant modifications. Slip base pole drawings will be retained internally to support ordering maintenance spares, but all new construction will be square base plates. 2. Simplify the number of pole types. To reduce the number of pole types, omit duplicate information, and make the types more clear, the short vertical poles have been revised into four basic setups: PS (8 ft, square base), RM (8 ft, triangle base), I (10 ft, square base), and FB (15 ft, square base). To support this, J-22.17 was split out as a separate plan for Type I Ramp Meter Signal installations as it uses different pole types for different base configurations – J-22.15 was reduced to just the Type RM pole itself (no foundation or base details). Standard Plan J-20.05-00 Pedestrian Pushbutton (PPB) Location and Orientation (New Plan) - This is a new plan that shows proper field placement and orientation of accessible pedestrian pushbuttons. This had been in the works for a while, but the pending requirement that all PPBs be accessible (not necessarily APS) pushed this to the top of the list. Along with pending Design Manual revisions (1330 and 1510), this will now be an issue for flashing beacon systems (including RRFBs). Standard Plan J-20.15-04 Accessible Breakaway Pedestrian Pushbutton (PPB) Post - Breakaway PPB Post: Revised to show both a flat and curb based installation. The fixed base version has been deleted and will no longer be allowed for new construction. Standard Plan J-28.30-04 Steel Light Standard Foundation Types A & B - Per discussions with maintenance, we are moving the supplemental ground connection so that it only bonds the pole anchor bolts to the foundation reinforcing steel. This will perform the same function as the previous setup that connected the reinforcing steel to the ground lug in the pole while remaining intact in case of a knockdown (typically the current design is sheared and no longer usable).
细胞专业化| HL IB生物学修订说明2025 细胞专业化| SL IB生物学修订说明2025 级纸2- 2021年11月 AQA GCSE物理修订说明2018 Edexcel IGCSE生物学修订说明2017 22.2光电效应| CIE A级物理修订说明2025 大脑和眼睛 疾病和免疫力 Edexcel GCSE生物学：合并科学 20.1人类影响：生物多样性，污染与保护 人类影响：生物多样性，污染与保护
红色的血细胞很小，可以通过狭窄的毛细血管运动比无效的白色血细胞更大，可以使RER和高尔基体的空间允许蛋白质（抗体）合成精子细胞长期很长，可以使卵细胞运动朝向细胞，它们还具有狭窄的头部来减少卵细胞的抗性，使蛋细胞的耐蛋细胞量均具有大量的含量。神经细胞具有较大的细胞体，可以允许蛋白质合成以维持长轴突的结构，这是在神经系统肌肉细胞周围快速递送脉冲所需的长度比正常细胞大，长度和直径旨在在肌肉收缩期间施加力
细胞专业化| HL IB生物学修订说明2025
红色的血细胞很小，可以通过狭窄的毛细血管运动比无效的白色血细胞更大，可以使RER和高尔基体的空间允许蛋白质（抗体）合成精子细胞长期很长，可以使卵细胞运动朝向细胞，它们还具有狭窄的头部来减少卵细胞的抗性，使蛋细胞的耐蛋细胞量均具有大量的含量。神经细胞具有较大的细胞体，可以允许蛋白质合成以维持长轴突的结构，这是在神经系统肌肉细胞周围快速递送脉冲所需的长度比正常细胞大，长度和直径旨在在肌肉收缩期间施加力
在GISS Modele地球系统模型中对大气棕色碳进行建模
摘要。Brown carbon (BrC) is an absorbing organic aerosol (OA), primarily emitted through biomass burn- ing (BB), which exhibits light absorption unique to both black carbon (BC) and other organic aerosols.Despite many field and laboratory studies seeking to constrain BrC properties, the radiative forcing (RF) of BrC is still highly uncertain.To better understand its climate impact, we introduced BrC to the One-Moment Aerosol (OMA) module of the GISS ModelE Earth system model (ESM).We assessed ModelE sensitivity to primary BrC processed through a novel chemical aging scheme and to secondary BrC formed from biogenic volatile organic compounds (BVOCs).初始结果表明，BRC通常贡献0.04 Wm-2的辐射效应最高的辐射效应。Sensitivity tests indicate that explicitly simulating BrC (separating it from other OAs), including secondary BrC, and simulating chemical bleaching of BrC contribute distinguishable radiative effects and should be accounted for in BrC schemes.This addition of prognostic BrC to ModelE allows greater physical and chemical complexity in OA representation with no apparent trade-off in model performance, as the evaluation of ModelE aerosol optical depth against Aerosol Robotic Network (AERONET) and Moderate Res- olution Imaging Spectroradiometer (MODIS) retrieval data, with and without the BrC scheme, reveals similar skill in both cases.Thus, BrC should be explicitly simulated to allow more physically based chemical compo- sition, which is crucial for more detailed OA studies like comparisons to in situ measurement campaigns.我们在本文结尾的Modele内包含了BRC代表的最佳实践摘要。
服务交付计划
第1节的愿景和愿望（将在即将发布的2021 - 2025年理事会计划发布后进行审查）。注册局在诺丁汉郡议会的精神和2017年至2021年理事会的计划中运作：“您的诺丁汉郡，您的未来”。我们将诺丁汉郡成为以下方面的好地方：•建立您的家人•实现您的野心•享受晚年•开始和发展业务的注册服务的特定愿景是，我们将成为一个成功的创新业务，重点是高水平的客户满意度，收入产生的运营，技术准确性和员工的核心效率，以及员工的效率和员工，并提供了员工，以及员工的效率，以及员工的效率。这是通过以下方式实现的：•客户满意度 - 不断努力通过吸引客户参与我们做出的业务决策，并通过响应客户需求来改善服务。• Income generation – develop the Service to allow it to be self-sustaining and to reinvest in growth and wellbeing • Efficiency of operation – identify and implement efficiencies which reduce costs and improve the service to customers • Technical accuracy - maintenance of technical and statutory standards via induction and training • Staff engagement – give staff the opportunity to contribute to the vision through listening to them, encouraging and acknowledging their contribution and reporting back Commitment to the Code of Practice and National Standards诺丁汉郡县议会（NCC）证实了其对通用注册办公室（GRO）实践守则和相关法定要求的正式承诺。我们致力于满足理事会提供当地注册服务指南中建立的服务交付标准，并将努力开发服务以满足我们社区不断变化的需求。在本计划中详细介绍了实现此雄心的特定目标。
Casgevy™ (exagamglogene autotemcel)
Casgevy (exagamglogene autotemcel) is indicated for the treatment of sickle cell disease (SCD) in patients 12 years and older with recurrent vaso-occlusive crises (VOCs). Casgevy was evaluated in an ongoing single-arm, multicenter, phase 1/2/3 trial with patients who had a history of at least 2 protocol-defined severe VOC events during each of the 2 years prior to screening. Of the 63 patients enrolled in the trial, 44 patients went on to receive Casgevy to form the full analysis set (FAS). Of the 44 patients from the FAS, 31 had adequate follow-up to allow evaluation of the primary efficacy endpoint and formed the primary efficacy set (PES). The primary efficacy outcome was the proportion of VF12 responders, defined as patients who did not experience any protocol-defined severe VOCs for at least 12 consecutive months within the first 24 months after treatment with Casgevy. The VF12 response rate was 29/31 (93.5%, 98% one-sided CI: 77.9%, 100.0%). The proportion of patients who did not require hospitalization due to severe VOCs for at least 12 consecutive months within the 24-month evaluation period (HF12) was also assessed. One patient was not evaluable for HF12 response; the remaining 30 patients achieved the endpoint of HF12 (100% [98% one-sided CI: 87.8%, 100.0%]). The most common grade 3 or 4 adverse reactions with an incidence ≥25% were mucositis, febrile neutropenia, and decreased appetite. The most common grade 3 or 4 laboratory abnormalities (≥ 50%) were neutropenia, thrombocytopenia, leukopenia, anemia, and lymphopenia.
埃格林空军基地的访客需要基地通行证才能进入设施。第 96 安全部队中队为赞助商提供了一个虚拟选项，以便为他们的客人申请通行证，以简化流程并减少等待时间。赞助商需要提供他们的国防部凭证以及访客的姓名、社会安全号码和驾驶执照号码。使用虚拟应用程序的赞助商必须提前至少五天提交申请，以便进行处理。
埃格林空军基地的访客需要基地通行证才能进入设施。第 96 安全部队中队为赞助商提供了一个虚拟选项，以便为他们的客人申请通行证，以简化流程并减少等待时间。赞助商需要提供他们的国防部凭证以及访客的姓名、社会安全号码和驾驶执照号码。使用虚拟应用程序的赞助商必须提前至少五天提交申请，以便进行处理。
通过对现有的
•详尽：应该涵盖上个世纪任何时间，世界任何地方的所有疫苗。•明确：应该足够精确，以允许卫生专业人员确定是否实现了疫苗保护，以及何时以及如何进行疫苗接种计划。•信息性：代码系统应成为嵌入所有必要信息的本体论的一部分，以允许最终用户了解使用了哪种疫苗，可预防疫苗可预防的疾病，并根据哪种诉讼方法。•包括纸条：应允许从基于纸的疫苗接种卡中的书面小径数字化，包括非形式的缩写形式（例如infanrix6，代表Infanrix Hexa）。这样的小径代表了旧记录的主要部分。•包括数字跟踪：无论其编码如何，都应导入任何预先存在的数字记录。•可翻译：应将可转换回其他代码系统，以重新使用所有旧应用程序。
内华达州学生的免疫要求
根据全国州议会会议 (NCSL) 的说法，内华达州的免疫豁免规定与大多数其他州的规定类似。所有 50 个州都允许在医疗需要时免除免疫接种要求，45 个州和哥伦比亚特区允许因宗教原因而免除免疫接种要求。截至 2019 年 6 月，只有 15 个州允许父母或监护人以非宗教哲学为由获得豁免。