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Haslam，Alyson等。 CDK4/6抑制剂作为早期乳腺癌的辅助治疗？不确定的好处，保证危害。在：欧洲罐头杂志
CDK4/6抑制剂是抑制细胞周期调节的关键分子的口服剂。在内分泌受体阳性（ER +）的患者中，人表皮生长因子受体2阴性（HER2-）乳腺癌，内分泌疗法的CDK4/6抑制剂的COMINATION在转移性环境中是一种有效的治疗方法。现在，在辅助环境中进行了两项研究 - 君主（Abemaciclib 2年）和Natalee（Ribociclib 3年） - 报告无侵入性无病生存期。在这里，我们重新评估了这些开创性试验。首先，在两项研究的控制臂的早期，出现了多余的辍学或损失。由于两个试验都是开放标签的，因此担心辍学的患者不会随机，而是基于社会经济因素并改变了本地选择。由于损失的随访而有可能仅仅是有利的吗？基于重新构建的Kaplan-Meier曲线，我们得出结论这些研究的结果仍然脆弱，很容易审查。其次，在这两个试验中，不良事件均明显更高，其中一些人（例如Natalee中的Covid-19相关死亡）引起了严重的关注。第三，给予辅助治疗的CDK4/6抑制作用相关的潜在成本是前所未有的。纳塔莱策略尤其可能影响35％的新诊断为乳腺癌的患者，即全球发病率最高的癌症。没有基于安慰剂对照试验的确认性数据，或者更好地识别将受益于在辅助环境中添加CDK4 /6抑制剂中受益的患者，我们反对他们常规用作ER + /HER2-早期乳腺癌的辅助治疗。
AP40P04Q-AU
The information given in this document describes the independent performance of the product,but similar performance is not guaranteed under other working conditions,and cannot be guaranteed when installed with other products or equipment.To achieve the required performance of the product in actual scenarios,the customer should conduct a complete application test to assess the functionality of the product. Allpower assumes no responsibility for equipment failures result from using products at values that exceed the ratings,operating conditions,or other parameters listed in the product specifications. The product described in this specification is not applicable for aerospace or other applications which requires high reliability.Customers using or selling these products for use in medical,life-saving,or life- sustaining applications do so at their own risk and agree to fully indemnify. Due to product or technical improvements,the information described or contained herein may be changed without prior notice.
EECS 122，讲座29 -Kevin Fall的页面
- - ATM ATM ATM QOS QOS••CBR，VBR，ABR，UBR服务CBR，VBR，ABR，UBR服务••PCR，SCR，SCR，MBS，MCR流量参数PCR，SCR，SCR，MBS，MCR流量参数••CDV（CDV（T），CDV（T），CDV（T），MAXCTD MAXCTD，MAXCTD MAXCTD，CLR，CLR QOS QOS QOS QOS INTER EMENTINT•clr QOS QOS comporty• control, equivalent capacity (not really ATM specific per-se) specific per-se) – – Internet Internet QoS QoS • • IntServ IntServ : TSPECS, controlled load, guaranteed : TSPECS, controlled load, guaranteed • • DiffServ DiffServ : general model, AF and EF : general model, AF and EF PHBs PHBs • • RSVP RSVP
AP120P04D-AU
The information given in this document describes the independent performance of the product,but similar performance is not guaranteed under other working conditions,and cannot be guaranteed when installed with other products or equipment.To achieve the required performance of the product in actual scenarios,the customer should conduct a complete application test to assess the functionality of the product. Allpower assumes no responsibility for equipment failures result from using products at values that exceed the ratings,operating conditions,or other parameters listed in the product specifications. The product described in this specification is not applicable for aerospace or other applications which requires high reliability.Customers using or selling these products for use in medical,life-saving,or life- sustaining applications do so at their own risk and agree to fully indemnify. Due to product or technical improvements,the information described or contained herein may be changed without prior notice.
重型电池电动汽车
1) Based on "overnight" capital cost of grid infrastructure at current price levels – actual utility investment will be higher due to 1) price inflation of labor and equipment, and 2) Utility guaranteed rate of return 2) Distribution grids will serve on-site and on-route charging demand from local fleets – long-haul trucks / highway charging stations will be served by the transmission grid and bulk power system
满足SB1383土壤堆肥的采购要求
❖ Incorporate 1-2” into 6-12” of soil ❖ Apply no pre-plant fertilization ❖ Plant and water Guaranteed Minimum Nutrient Analysis Total Nitrogen………….…..……………..2.00% Water Insoluble Nitrogen………………1.5% Water Soluble Nitrogen………………....0.5% Available Phosphate (P2O5)……….....2.0% Soluble Potash (K2O)…………….…..….0.5% Iron……………………….……………………..3.0% Ingredient List: Composted biosolids (treated sewage sludge), forestry products, yard trimmings and stable bedding
电动工具、设备及配件目录
以下是一个或多个 D E WALT 电动工具和配件的商标：D E WALT®；D E WALT® 徽标；GUARANTEED TOUGH®；VERSA-CLUTCH®；XRP™；XR PACK®；XR2®；XR+™；黄/黑配色方案；紧凑型、XR PACK®、XR2® 和 XR+™ 电池组的接线板/塔式配置的形状；“D”形进气格栅；手柄上的金字塔阵列；工具盒配置；以及工具表面的菱形凸起阵列；MULTI-CUTTER™；TUNE-UP®；RAPID LOAD®；ROCK CARBIDE®；EXTREME DURABILITY™；PILOT POINT®；MAGNETIC DRILL and DRIVE SYSTEM®；SERIES 20®；SERIES 40®；SERIES 60®；圆锯片上的黑色边缘；圆锯片上的黄色边缘；圆锯片上的回旋镖形散热孔；圆锯片上的螺旋形散热孔；圆锯片上的星爆形散热孔；TOUGH CASE™；TOUGH PACK™；GRC™；GRC™ 徽标；GUARANTEED REPAIR COST™；DROP BOX EXPRESS™；D E WALT SERVICE NET™。可能适用其他商标。版权所有© 2004 D E WALT®
电动工具、设备及配件目录
以下是一个或多个 DE WALT 电动工具和配件的商标：DE WALT®；DE WALT® 徽标；GUARANTEED TOUGH®；VERSA-CLUTCH®；XRP™；XR PACK®；XR2®；XR+™；黄/黑配色方案；紧凑型、XR PACK®、XR2® 和 XR+™ 电池组的接线板/塔式配置的形状；“D”形进气格栅；手柄上的金字塔阵列；工具盒配置；以及工具表面的菱形凸起阵列；MULTI-CUTTER™；TUNE-UP®；RAPID LOAD®；ROCK CARBIDE®；EXTREME DURABILITY™；PILOT POINT®；MAGNETIC DRILL and DRIVE SYSTEM®；SERIES 20®；SERIES 40®；SERIES 60®；圆锯片上的黑色边缘；圆锯片上的黄色边缘；圆锯片上的回旋镖形散热孔；圆锯片上的螺旋形散热孔；圆锯片上的星爆形散热孔；TOUGH CASE™；TOUGH PACK™；GRC™；GRC™ 徽标；GUARANTEED REPAIR COST™；DROP BOX EXPRESS™；DE WALT SERVICE NET™。可能适用其他商标。版权所有© 2004 DE WALT®
IAdvisor 529 计划指导信表格
Medallion 签名担保可从美国证券交易委员会定义的任何合格担保机构获得。这些机构包括参与 Medallion 计划的银行、储蓄协会、信用合作社和经纪公司。带有“MEDALLION GUARANTEED”字样的条形码印章必须盖在担保签名附近。担保必须附有担保机构的名称和代表担保机构授权的个人的签名。请注意，公证人印章或印章不予接受。
密码学ENEE/CMSC/MATH 456：作业1
(b) Say encryption scheme E = ( Gen , Enc , Dec ) is perfectly secret for two distinct messages if for all distributions over M × M where the first and second messages are guaranteed to be different (i.e., distributions over pairs of distinct messages), all m 1 , m 2 ∈M , and all c 1 , c 2 ∈C with Pr[ C 1 = c 1 ∧ C 2 = c 2 ] > 0 : Pr[ M 1 = m 1 ∧ M 2 = m 2 | c 1 = c 1∧c 2 = c 2] = pr [m 1 = m1∧m2 = m 2]。显示了一个可证明满足此定义的加密方案。提示：您提出的加密方案不必有效，尽管可以实现效率。