摘要目的:研究代谢功能障碍相关的脂肪变性肝病(MASLD)对免疫检查点抑制剂(ICI)基于慢性肝炎B(CHB)相关的肝细胞癌(HCC)患者的影响。方法:共有155例与CHB相关的HCC患者接受了ICI基于ICI的治疗(在2021年4月2021年4月至2023年12月之间,在Tianjin Second Posit's Hospital和Tianjin医学院癌症研究所和医院肝肿瘤学系的肝病学系和肝肿瘤科)进行了评估。患者分为两组:MASLD与CHB [MASLD-CHB](n = 38)和CHB(n = 117)并发。结果:中位无进展生存期(PFS,6.9个月对9.3个月; P = 0.001),进行性疾病(57.89%vs. 37.61%; P = 0.028)和疾病控制率(42.11%vs. 62.39%; P = 0。028)明显比CHB组差得多。未达到中位总生存期。CD4+ PD1+的百分比(17。56%比8.89%;来自MASLD-CHB组的患者样品中P <0.001)和CD8+ PD1+ T细胞(10.50%vs. 7.42%; P = 0.005)明显高于CHB组。并发MASLD [危险比(HR)= 1.921; 95%CI,1.138–3.245;治疗3个月后P = 0.015]和α-五蛋白水平(HR = 2.412; 95%CI,1.360–4.279; P = 0.003)是所有患者的独立危险因素。结论:与单独使用CHB相关的HCC的患者相比,与CHB相关HCC和并发MASLD患者的基于ICI的治疗效果较差,PFS较短。关键词与代谢功能障碍相关的脂肪变性肝病;慢性肝炎B;肝细胞癌;免疫疗法;功效
does not cross-react with the below pathogens: SARS-Cov, MERS-COV, Human Coronaviruses (HCOV-229E, HCOV-OC43, HCOV-NL63, HCOV- HKU1), Adenovirus, Influenza, PARAINFLUENZA 1, ParainFluenza 1, Parainfluenza 2, Parainfluenza 3, Parechovirus, Candida albicans, Legionella non-Pneumophila, Bacillus, Moraxella catarrhalis, Neisseria removed, Neisseria Meningitides, RSV A, RSV B, Rhinovirus, Pseudomonas aeruginosa, Staphylococcus, Streptococcus Leptospirosis, Coxiella burnetii (q- fegetii (q- fegetii(q- fegetii(Q- fegetii(Q-发烧),葡萄球菌表皮,肠病毒,嗜血杆菌,bordetella parapertusis,bordetella parapertusis,bordetella parapertusis,borcoplasmoniae pneumoniae,chamemydia pneumoniae pneumydia pneumydia pneumoniaiaiaiaiae beypeionelly perimopliation sepatis hepatity hepat hepat hepat hepat hepat hepat hepat; Hepatitis Delta, human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, JCV, BKV, Human Papilloma, Parvovirus, herpes simple virus, Mycobacterium tuberculosis, Aspergillus spp., Brucella abortus, Brucella, E.Coli O157, Salmonella spp., Listeria monocytogenes div>does not cross-react with the below pathogens: SARS-Cov, MERS-COV, Human Coronaviruses (HCOV-229E, HCOV-OC43, HCOV-NL63, HCOV- HKU1), Adenovirus, Influenza, PARAINFLUENZA 1, ParainFluenza 1, Parainfluenza 2, Parainfluenza 3, Parechovirus, Candida albicans, Legionella non-Pneumophila, Bacillus, Moraxella catarrhalis, Neisseria removed, Neisseria Meningitides, RSV A, RSV B, Rhinovirus, Pseudomonas aeruginosa, Staphylococcus, Streptococcus Leptospirosis, Coxiella burnetii (q- fegetii (q- fegetii(q- fegetii(Q- fegetii(Q-发烧),葡萄球菌表皮,肠病毒,嗜血杆菌,bordetella parapertusis,bordetella parapertusis,bordetella parapertusis,borcoplasmoniae pneumoniae,chamemydia pneumoniae pneumydia pneumydia pneumoniaiaiaiaiae beypeionelly perimopliation sepatis hepatity hepat hepat hepat hepat hepat hepat hepat; Hepatitis Delta, human immunodeficiency virus, cytomegalovirus, Epstein-Barr virus, JCV, BKV, Human Papilloma, Parvovirus, herpes simple virus, Mycobacterium tuberculosis, Aspergillus spp., Brucella abortus, Brucella, E.Coli O157, Salmonella spp., Listeria monocytogenes div>
与代谢功能障碍相关的脂肪分裂性肝病,在英语代谢功能障碍相关的粘膜肝病(MASLD),以前称为非酒精性脂肪肝肝脏中,是慢性肝病的最常见形式之一,是肥胖和肥胖症和糖尿病的杂物2.25%的人数,这一数字尤其多。您的病理生理学的起源在于肝细胞中的胰腺癌和脂肪积累。有几个临床分数可以使您的筛选具有成本效益,例如FIB-4和NFS。尽管它被认为是金色标准,但可以通过使用肝弹性术最常忽略肝活检。在糖尿病中使用的许多药物具有与代谢功能障碍相关的脂肪变性肝病的治疗潜力,最研究的类是GLP-1受体的激动剂。与元性功能障碍和糖尿病相关的脂肪变性肝病之间的双向病理生理关联将允许该区域的发展与新疗法的出现。
摘要心力衰竭(CI)是各种心脏病的常见并发症,并作为病理生理机制,降低收缩力,增加舒张压以及肺部和全身充血。从这个意义上讲,这是一个严重的公共卫生问题,死亡率很高,对生活质量的影响以及与住院相关的高成本。尽管过去20年的巴西住院下降,但与IC相关的死亡率增加了一倍。鉴于这种情况,该研究试图分析IC与贫血的关系,以解决其病理生理方面,临床影响和预后,旨在更好地了解这些临床实体。为构建本文,对BVS,PubMed和Capes Journal Portal的精选出版物进行了文献综述。研究使用了诸如“贫血”,“心力衰竭”和“病理学”及其英语版本等健康描述符,从DEC中提取。描述符的组合是与布尔操作员“和”一起制成的,也被认为是灰色文献研究。此外,纳入标准是:具有整体访问的研究,在过去20年(2005 - 2024年)和西班牙语,英语或葡萄牙语中发表。排除标准是:未发表的研究,在研究范围之外无法全面访问。从这个意义上讲,铁缺乏症是所研究的贫血的结果是至关重要的,因为在血红蛋白和红细胞合成中必须铁。这种情况的特征是铁代谢的放松管制,包括高水平的炎性细胞因子(例如IL-6和TNF-α)改变了肠道中铁的吸收以及在巨噬细胞和肝细胞中储存的铁的释放。响应贫血的人体的补偿机制包括促红细胞生成素(EPO)和血管舒张产生的增加,试图改善提供
Abstract The World Health Organization (WHO) recognizes that obesity today as a growing global problem, men and women of various age groups suffer from the disease, treat obesity and localized fat you need to reconcile multidisciplinary treatment, with changes in eating habits and physical activity, as there is plenty of side effects when using pharmacological treatment, increased interest in alternative therapies such as alternative therapies such as Phytotherapy are natural products obtained from medicinal plants, the therapeutic properties of herbal medicines are used as a treatment of healing and prevention of some diseases, among the known herbal medicines for decreased localized fat can be highlighted the green tea, Spirulina and Garcinia cambogia, green tea has varied benefits and can be used for both fat burning, Stress, used as thermogenic, has in its composition catechins, caffeine in abundant amount, Spirulina is used for various situations such as打击自由基,骨质疏松症治疗,寻求体重减轻的食欲抑制剂,预防过早衰老,是一种很好的食物补充,在其成分中促进多种维生素的免疫系统,多种砷维生素,藤黄素 - 古木氏菌非常有益于治疗胃口的疾病,疾病的疾病是有益的,疾病的疾病是有效的,疾病的疾病是有效的,疾病的疾病是有效的。比较诸如消费和禁忌症之类的组件的分析,目的是验证脂肪燃烧的最佳草药。Abstract The World Health Organization (WHO) recognizes that obesity today as a growing global problem, men and women of various age groups suffer from the disease, treat obesity and localized fat you need to reconcile multidisciplinary treatment, with changes in eating habits and physical activity, as there is plenty of side effects when using pharmacological treatment, increased interest in alternative therapies such as alternative therapies such as Phytotherapy are natural products obtained from medicinal plants, the therapeutic properties of herbal medicines are used as a treatment of healing and prevention of some diseases, among the known herbal medicines for decreased localized fat can be highlighted the green tea, Spirulina and Garcinia cambogia, green tea has varied benefits and can be used for both fat burning, Stress, used as thermogenic, has in its composition catechins, caffeine in abundant amount, Spirulina is used for various situations such as打击自由基,骨质疏松症治疗,寻求体重减轻的食欲抑制剂,预防过早衰老,是一种很好的食物补充,在其成分中促进多种维生素的免疫系统,多种砷维生素,藤黄素 - 古木氏菌非常有益于治疗胃口的疾病,疾病的疾病是有益的,疾病的疾病是有效的,疾病的疾病是有效的,疾病的疾病是有效的。比较诸如消费和禁忌症之类的组件的分析,目的是验证脂肪燃烧的最佳草药。藤黄,这种干果,可用于汤,即取得茶的成就。这种草药由羟基酸组成,羟基酸在脂肪组织上作用以减少体内脂肪,这是由于脂质氧化增加所致,其每日剂量可能不超过2G,因为在各种文献中,由于多种文献导致肝脏的疾病而导致过多的肝脏的使用,包括garcinia cambogogia and the Comperverse and the danus comporter and the newus and the newus and the newus and newus and the nater效果,并不素效果,并不胃肠道症状。绿茶有助于改善肠道,但必须谨慎使用剂量,因为文献中有报道称,过度摄入的饮食可能是肝毒性的,并且对于对咖啡因的高敏性患者而言是禁忌的,对抗肥胖治疗的一项自然方法的抗肥胖治疗方法提到,对调节型MicroBiota的自然方法具有重要的态度。螺旋藻针对苯酮尿症,自身免疫性,怀孕和哺乳性疾病表示反对,即使罕见病例是头痛,恶心,腹泻和呕吐。由于所有草药都会产生益处,因此在减肥过程中有助于,但是依靠市场螺旋藻的禁忌症和可用性最适合中小型,中等和