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Vision 2040至2050
• Retains the same core emphasis on a strong economy, healthy environment, preserving farms and forests, and supporting growth within the urban growth area and centers • Retains the same plan structure as VISION 2040, with a numeric Regional Growth Strategy, multicounty planning policies, and actions • Identifies new regional outcomes and a vision statement for the region • Addresses equity and health in policies and actions throughout the plan • Supports implementation of recent plans and倡议，例如区域运输计划，区域经济战略，区域开放空间保护计划，区域中心框架以及不断增长的过境社区区域合作（以前是一般章节）
牙科骨移植物质设备的动物研究
9 https://www.fda.gov/Regulatory-information/search-fda-guidance-documents/general-considerations-considerations-animal- Animal- animal- structed-tedended-evaluye-Medical-devices 10参见21 CFR 807.87和FDA指导文档指导文档“用于Medical Departing for Medical Depactions 510”（K） https://www.fda.gov/regulatory-information/search-fda-guidance- documents/electronic-submission-template-medical-device-510k-submissions 11 The scope of this guidance includes human demineralized bone matrix (DBM) that is more than minimally manipulated or modified with additives (except for sterilizing, preserving, or storage agents).有关更多信息，请参见2001年1月19日（66 FR 5447）的联邦公报通知和FDA网页，“司法管辖区更新：人类脱矿质骨基质”，可在https://www.fda.gov/combination-products/jurisdipation--jurisditial------------------------------
Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death
The quest for targeted therapies is critical in the battle against cancer. The RAS/ MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that the interaction between ERK and MYD88, an adaptor protein in innate immunity, is crucial for RAS-dependent transforma- tion and cancer cell survival. In this study, we examine the biological con- sequences of disrupting the ERK-MYD88 interaction through the ERK D-recruitment site (DRS), while preserving ERK ' s kinase activity. Our results indicate that EI-52, a small-molecule benzimidazole targeting ERK-MYD88 interaction induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis speci fi c to cancer cells. Additionally, EI-52 exhibits anti-tumor ef fi cacy in patient-derived tumors and induces an anti-tumor T cell response in mice in vivo. These fi ndings suggest that inhibiting the ERK-MYD88 interaction may be a promising therapeutic approach in cancer treatment.
通过靶向分子药物和放射疗法对无法手术的Her2阳性乳腺癌的疾病控制：病例报告
局部控制以前被认为是老年人乳腺癌治疗的主要目标，肿瘤壳或全乳房切除术是日本的主要治疗方法。7然而，80岁妇女的平均预期寿命为12.3岁，而85岁和90岁的非常年老的女性的预期寿命分别为8.8和5.9岁。8因此，我们认为系统治疗对于解决遥远转移的可能性是必要的。然而，接受化疗的老年乳腺癌患者的比例显着低，并且由于单独年龄而省略化疗，这可能导致治疗不足。9 Although comorbidities such as heart diseases can make the use of anthracyclines and taxanes difficult, a randomized controlled trial of trastuzumab with or without chemotherapy in the postoperative adjuvant treatment of elderly HER2-positive early stage breast cancer demonstrated the absence of non-inferiority of trastuzumab alone and the OS difference to be of 1 month at 3 years, reducing side effects and preserving healthy QoL.10我们认为，对于患有合并症的老年乳腺癌患者而言，HER基和每个基于每项疗法可能是可行的选择，表现出身体和认知能力下降。
气候变化缓解（气候授权法的附件1）
附录B避免了建筑工地的影响，以保留水质并避免水压力。男子03：负责任的建筑实践环境管理：一种信用（保存水质）对建筑工地影响的监视 - 公用事业消费：首先监测信用（避免水压力）
策略备忘录24-03
建立了NP，并且其第一世纪的大部分时间发生在假定且相对稳定的环境条件下，预计将在很大程度上反映了历史过去几十年的历史。实现了保存“国家公园系统的自然和文化资源和价值”的NPS任务1因此，1因此，在可行的范围内保存或恢复自然资源的“自然条件”，2，并保留了长期的“自然条件”，从而保留了“自然资源”。 3然而，气候变化的无处不在作用也证明了即使在地球上最偏远地区以及所有类型的资源上也表现出现代人类的影响。由于温度，降水，风暴事件和其他因素的变化
生物多样性政策-JDR电缆
作为我们对生物多样性的承诺的一部分，JDR评估了我们运营对当地生态系统的潜在影响。我们采取积极的步骤来最大程度地减少负面影响，包括保存自然栖息地，恢复退化的地区以及采取措施保护当地的野生动植物。此外，我们还将培养一种环境管理的文化，在那里我们将鼓励我们的员工参加旨在在工作场所和更广泛社区内保护生物多样性的计划。
