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emass和weebit nano使用reram
与先前宣布的重组和回报交易（“交易”（“交易”），5e Advanced Materials，Inc。，特拉华州公司（“公司”），签订了一项交换协议（“交换协议”），于2025年1月14日与BEP特殊情况IV LLC（“ BLUESCAPE” CORVENTION，MOR INVENTION INVENTION，MOR INVENTIAN CORVITION，MOR INVENTION INVENTION，MOR INVENTION INVENTION，MOR INVENTIAN CORVITION，MER INVENTIAN CORVITION（” SPC，代表和代表战略SP（与子午线一起，“上升”）。On March 5, 2025 (the “Exchange Effective Date”), the parties consummated the transactions contemplated by the Exchange Agreement, resulting in the termination of the Amended and Restated Note Purchase Agreement, dated as of January 18, 2024 (as amended, the “Note Purchase Agreement”), between the Company, Bluescape and Ascend, and the extinguishment of all indebtedness owed by the Company under the Note Purchase Agreement.
Combination therapies targeting different aspects of tumor ...
Urothelial carcinoma (UC) originates from the urothelial lining renal pelvis, ureter, bladder, and urethra. Based on the report from Global Cancer Statistics 2020, bladder cancer is the 7th and 13th most frequent malignancy among men worldwide and those in Japan, respectively (1,2). Unresectable, metastatic, or advanced UC (aUC) is a progressive, poor prognostic disease with a median overall survival (OS) time of approximately 19–26 months following first-line (1L) platinum-based chemotherapy and subsequent administration of immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies (3-6). A substantial proportion of the population responds poorly to chemotherapy and ICIs, resulting in poor survival outcomes. Novel upfront drug combinations including ICIs, antibody-drug conjugates, and tyrosine kinase inhibitors (TKIs) are currently being tested in an attempt to overcome drug resistance and improve antitumor activity.
Akane Wa
Controlling microstructure in fusion-based metal additive manufacturing (AM) remains a challenge due to numerous parameters directly impacting solidification conditions. Multiprincipal element alloys (MPEAs) offer a vast compositional design space for microstructural engineering due to their chemical complexity and exceptional properties. Here, we establish a novel alloy design paradigm in MPEAs for AM using the FeMnCoCr system. By exploiting the decreasing phase stability with increasing Mn content, we achieve notable grain refinement and breakdown of columnar grain growth. We combine thermodynamic modeling, operando synchrotron X-ray diffraction, multiscale microstructural characterization, and mechanical testing to gain insight into the solidification physics and its ramifications on the resulting microstructure. This work paves way for tailoring grain sizes through targeted manipulation of phase stability, thereby advancing microstructure control in AM.
电信空间的基础设施标准（ISTS）
– Editorial changes resulting from full review by CFM FSS for publication in CFM's TIL – Updated Telecommunications Room (TR), entrance room, and electrical power standards – Added grounding and bonding, transformers, intra- building/inter-building cabling, lighting, and lightning protection system sections, and Request for Variance process instructions – Created VA-modified Data Center Facility Environment Conditioning Standards figure to replace Ashrae不太严格的要求 - 重组的章节顺序，以进行更合乎逻辑的数据中心设计流。请参阅目录和关联的链接，以快速找到任何感兴趣的主题 - 重新定位的数字，表，定义，参考和首字母缩写部分，供领先物质与电信行业协会（TIA）格式保持一致 - 添加的附录 - 包括差异和OIT的请求形式和OIT设计指南设计指南设计包
用...
soriasis（PSO）和特应性皮炎（AD）免疫发病症在典型上由2种不同的T细胞介导的反应驱动。In psoriasis, Th1/Th17 pathways mediated by interleukin (IL)-23/IL-17 cell-mediated signaling, while AD is marked by Th2/Th22 predominant humoral inflammatory response, eliciting IL-4, IL-13, and IL- 22.1 However, certain AD subtypes (eg, intrinsic, pediatric, Asian adults) demonstrate evidence of Th2, Th17, and Th22 co-expression, resulting in a more psoriasiform phenotype.2 Several cases have also been reported of exacerbations following “unilateral” suppression of this spectrum, with cases of paradoxical reactions in which patients with psoriasis develop eczematous eruptions after initiating anti-IL-17/IL-23 biologics and psoriasiform dermatitis after AD biologics.3-5这些示例支持潜在的PSO-AD光谱的想法。
申请表格NYS 2025.01.07
我的签名证明（1）患者已经收到了有序测试的目的，风险和益处的解释； （2）在医学上需要进行有序测试，并将告知患者的治疗计划； （3）除非在这种形式上另外规定，否则患者具有复发，复发，难治性，转移性或晚期阶段III或IV癌； and (4) the patient has provided informed consent that meets the requirements of applicable law for Tempus or its reference lab to: (a) collect and use the patient's samples (including genetic material) and health information and perform the ordered test(s); (b) obtain, receive, and release health information (including test results) as necessary for reimbursement or the processing of insurance claims; （c）根据适用法律保留并使用样本和健康信息在不限期的时间内； and (d) de-identify such samples and information and use and share the resulting de-identified samples and information in accordance with applicable law.
Targeting ERK-MYD88 interaction leads to ERK dysregulation and immunogenic cancer cell death
The quest for targeted therapies is critical in the battle against cancer. The RAS/ MAP kinase pathway is frequently implicated in neoplasia, with ERK playing a crucial role as the most distal kinase in the RAS signaling cascade. Our previous research demonstrated that the interaction between ERK and MYD88, an adaptor protein in innate immunity, is crucial for RAS-dependent transforma- tion and cancer cell survival. In this study, we examine the biological con- sequences of disrupting the ERK-MYD88 interaction through the ERK D-recruitment site (DRS), while preserving ERK ' s kinase activity. Our results indicate that EI-52, a small-molecule benzimidazole targeting ERK-MYD88 interaction induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis speci fi c to cancer cells. Additionally, EI-52 exhibits anti-tumor ef fi cacy in patient-derived tumors and induces an anti-tumor T cell response in mice in vivo. These fi ndings suggest that inhibiting the ERK-MYD88 interaction may be a promising therapeutic approach in cancer treatment.
一项关于小袋锂金属电池外部压力变化长期循环性能的研究
由于高能量密度设备的优势，高能密度的高能密度需求迅速生长。除了锂离子电池，Lith-ium金属电池（LMB）之外，由于理论特异性极高（3860 mAh g –1，2062 mAh cm –3），因此被认为是下一代可充电电池，并且是最低的Redox电势（–3.04 V vs.标准氢电极）[1-3]。However, LMBs has severe problems due to (1) uncontrollable lithium dendrite formation, result in penetration of the separator, causing short circuit, (2) large volumetric and morphological changes during charging process, (3) continuous reactions between lithium metal and electrolyte resulting from the crack of solid electrolyte interphase (SEI) layers on the lith- ium metal surface [4,5].这些问题导致循环寿命和安全风险恶化。已经探索了几种策略，例如改变电解质（锂盐，溶剂（碳酸盐，乙醚）和功能添加剂）以形成稳定的SEI
健康链接 - 癌症治疗后的低人口症
对儿童肿瘤学小组及相关方/协议的一部分不承担赔偿的责任，以赔偿和持有损害儿童肿瘤学小组及相关方：儿童肿瘤学小组或任何关联方或其对损害造成的损害，使用，审查或访问信息的损害不承担任何责任。您同意以下赔偿条款：（i）“赔偿方”包括参考内容的作者和贡献者，所有官员，董事，代表，雇员，代理人以及儿童肿瘤学集团和附属组织的成员； (ii) by using, reviewing, or accessing the Informational Content, you agree, at your own expense, to indemnify, defend and hold harmless Indemnified Parties from any and all losses, liabilities, or damages (including attorneys' fees and costs) resulting from any and all claims, causes of action, suits, proceedings, or demands related to or arising out of use, review or access of the Informational Content.
表格10-Q Northwestern Energy Group，Inc。...
2023年10月2日，西北公司（“ Old NWE”）通过实施控股公司的重组（“合并”），创建了一家新的公共控股公司Northwestern Energy Group，Inc。（“ New NWE”）。合并后，根据经修订的1934年《美国证券交易法》（Securities Exchange Act），根据规则12G-3（a）成为旧NWE的继任发行人（“交换法”）。In the early part of 2024, New NWE and Old NWE intend to complete the second and final phase of the holding company reorganization, when Old NWE proposes to contribute the assets and liabilities of its South Dakota and Nebraska regulated utilities to its direct subsidiary, NorthWestern Energy Public Service Corporation ("NPS"), and then distribute its equity interest in NPS and certain other subsidiaries to New NWE, resulting在旧的NWE拥有和运营蒙大拿州规范的公用事业公司和NPS拥有和运营南达科他州和内布拉斯加州实用程序中，每个实用程序都是New NWE的直接子公司。