XiaoMi-AI文件搜索系统
World File Search System26R
LOTUS 26R 五缸奥迪标志 - 保时捷汽车历史
C60 青铜渐变绿色 COSC LE 天文台表仅限量 500 件，专为个性主义者打造。在瑞士组装之前，每个表盘都由专业工匠手工做旧，确保每个表盘都完全相同。还有漂亮的 42 毫米青铜表壳。随着时间的推移，它会形成一种铜绿，赋予它独特的“拉丝”外观 - 就像牛仔裤上的褪色一样。因此，无论您是在沉船中潜水 - 防水深度达 600 米 - 还是在城镇中漫步，您都会戴着一款真正独一无二的手表。
1,2,4 ...
摘要：类似木瓜蛋白酶样蛋白酶（PLPRO）是其在SARS-COV-2生命周期中关键作用的有前途的治疗靶标。通过基于SARS-COV-2 PLPRO-GRL0617复杂结构的环形成策略设计和合成了一系列1,2,4-氧化唑衍生物。系统结构 - 活性关系研究表明，向GRL0617引入氧化二唑和芳基羧酸部分可增强酶促抑制活性，亲和力和PLPRO的去泛素化能力。具有PLPRO抑制活性（IC 50 = 1.8和1.0μm）和对SARS-COV-2（EC 50 = 5.4和4.3μm）的1,2,4-氧二唑13F和26R，具有PLPRO抑制活性（IC 50 = 1.8和1.0μm），并且具有良好的代谢稳定性（T 1/2> 93.2 min）和较高的plasma（t 1/2> 93.2 min）和抗病毒（AUC 0）（AUC 0）= 17,3,30-11 17,3.3小鼠中的24,289.76 ng·h/ml）。尤其是，中等口服生物利用度为39.1％和有效抗病毒活性的化合物26R值得在体内进一步研究。我们的发现为发现针对PLPRO的抗病毒剂提供了新的见解。■简介
2025专业/次要博览会
/ MINORS 31R Afroamerican and African Studies 39R American Culture 60P Anthropology - Archaeology 60P Anthropology - Linguistic 60P Anthropology - Sociocultural 9R Applied Statistics 39R Arab and Muslim American Studies 19R Arabic Studies 19R Asian Studies 19R Asian Languages and Culture minor 39R Asian/Pacific Islander American Studies 18R Astronomy and Astrophysics 24R Biochemistry 60P Biological Anthropology 1R Biology 21R Biophysics 54P Bosnian/Croatian/Serbian 64P Business 24R Chemical Measurement Science 24R Chemical Physics 24R Chemistry 46R Classical Archaeology 46R Classical Civilization 22R Complex Systems 8R Computer Science 16R Computing for Expression 16R Computing for Scientific Discovery 58P Creative Writing 44R Crime and Justice 54P Czech 26R Dance 9R Data Science 13R Digital Studies 43R Drama: Text to Performance 55P Dutch and Flemish Studies 3R Earth Sciences 54P East European and Eurasian Studies 1R Ecology, Evolution, & Biodiversity 10R Economics 4R Energy Science and Policy 58P English 65P Entrepreneurship 4R Environment 4R Food 56P French and Francophone Studies 40R Gender and Health 40R Gender, Race, and Nation 36R General Philosophy 3R Geology 55P German 26R Global & Ethnic Performance Studies 47R Global History 42R Global Media Studies 47R History 49R History of Art 47R History of Law and Policy 47R History of Medicine and Health 18R Interdisciplinary Astronomy 51P Intergroup Relations Education 66P International Studies 68P International Studies 67P Islamic Studies 56P Italian 20R Judaic Studies 46R Language, Literature, and Culture of Ancient Greece 46R Language, Literature, and Culture of Ancient罗马67p拉丁美洲和加勒比研究
Deka户外户外草坪花园传单0008
75/86 675DT 650 90 800 — 9-3/4 248 7 178 8-1/8 206 14,16,17,18,22,37,P 34/78 778DT 800 115 985 — 10-3/4 273 6-7/8 175 8 203 14,16,17,18,22,28,P 24 724MF 725 120 890 — 624MF 650 115 800 — 524MF 550 90 675 — 424MF 460 70 565 — 24F 724FMF 725 120 890 — 624FMF 650 115 800 — 524FMF 550 90 675 — 424FMF 460 70 565 — 25 525MF 550 90 675 — 9-3/4 248 6-7/8 175 8-7/8 225 17,22 26 526MF 540 80 665 — 426MF 450 55 555 — 26R 526RMF 540 80 665 — 426RMF 450 55 555 — 27 727MF 840 140 1035 — 12-5/8 321 6-3/4 171 9 229 17,21 627MF 710 120 875 — 12 305 6-3/4 171 9 229 ꟷ 34 734MF 800 115 985 — 634MF 690 110 850 — 534MF 600 90 740 — 35 735MF 640 95 785 — 535MF 550 90 675 — 41 641MF 650 100 800 — 11-9/16 293 6-7/8 175 6-7/8 175 22 45 545MF 485 65 595 — 9-3/8 238 5-1/2 140 9 229 — 49 649MF 900 185 1105 — 13-15/16 354 6-7/8 175 7-1/2 190 17,22 651MF 500 75 615 — 551MF 450 70 555 — 51R 651RMF 500 75 615 — 551RMF 450 70 555 — 55 655MF 540 75 665 — 8-3/4 222 6 152 8-1/2 216 17,18 58 658MF 580 85 715 — 558MF 500 75 615 — 70 570MF 540 80 665 — 8-3/4 222 7 178 7-1/8 181 17,18,22,37，E