与医疗保健相关的感染已成为全球主要的健康问题。致病细菌传播的一种途径是与“高触摸”干燥表面(例如扶手)接触。因此,用消毒化学物质定期清洁表面不足,因此需要使用替代性控制方法。我们预先表明,加热到人皮温度会影响致病细菌在干燥表面上的存活,但在该研究中没有考虑湿度。在这里,我们通过对先前收集的数据的主要成分分析(n = 576,对于CFU计数)进行了影响医院干燥表面上的活细菌数量的投资,并通过实验验证了人类皮肤对人类皮肤温度对病原细菌在干燥表面下的炎症生存的影响。结果表明,与其他人相比,PCA在低温和低湿度(第3组)下将医院的干燥表面分为四组(第1 〜4组)和低温和低湿度(第3组)的干燥表面(第1组和第4组(第1组)(P <0.05)。Experimentally, warming to human-skin temperature (37˚C with 90% humidity) for 18~72h significantly suppressed the survival of pathogenic bacteria on dry surfaces, such as plastic surfaces [ p < 0.05 vs. 15˚C ( Escherichia coli DH5 α , Staphylococcus aureus , Pseudomonas aeruginosa , Acinetobacter baumannii和bla ndm-5 e大肠杆菌)或扶手[p <0.05 vs. 15〜25˚C(e。大肠杆菌DH5α,s。金黄色,p。铜绿,a。bau-mannii)],中等55%的湿度。大肠杆菌DH5α,s。此外,间歇性加热到人皮温度降低了形成孢子的细菌(枯草芽孢杆菌)的存活(p <0.01 vs.连续加热到人类皮肤温度)。nhaa是Na + /H +抗胞剂,可以调节细菌在干燥表面上的存活,而抑制剂2-氨基酰胺氨酸可以增强在人类皮肤温度下变暖对致病细菌存活的影响(e。< /div>金黄色葡萄酒,a。Baumannii)在干燥的表面上。因此,变暖为人类 -
卵巢癌(OC)是最致命的妇科恶性肿瘤(总生存率为5 Y,为46%)。OC。这项研究调查了使用[177 lu] lu-dota-trastuzumab(针对人类表皮生长因子受体2)的[177 lu] lu-dota-trastuzumab(一种抗体),基于gadolinium的纳米颗粒(GD-NP)是否会增加靶向放射性核素治疗的效率。GD-NP在常规外部光束放射疗法中具有放射敏作用,并已在临床II期试验中进行了测试。Methods: First, the optimal activity of [ 177 Lu]Lu-DOTA-trastuzumab (10, 5, or 2.5 MBq) combined or not with 10 mg of Gd-NPs (single injection) was investigated in athymic mice bearing intraperitoneal OC cell (human epidermal growth factor receptor 2 – positive) tumor xenografts.接下来,评估了[177 lu] lu-dota-trastuzumab具有GD-NP(3个给药方案)的5 MBQ的治疗效率和毒性。nacl,曲妥珠单抗加GD-NP和[177 lu] lu-dota-trastuzumab被用作控制。生物分布和剂量法,并对能量沉积进行蒙特卡洛模拟。最后,在3种癌细胞系中研究了GD-NPS的亚细胞定位和摄取以及组合的细胞毒性作用,以获取对所涉及机制的见解。结果:与GD-NP结合使用的最佳[177 lu] lu-dota-trastuzumab活性为5 MBQ。体外实验表明,与溶酶体共定位的GD-NP,其放射性敏感性是由氧化应激介导的,并被铁螯合剂脱脂型抑制。此外,与仅[177 lu] lu-dota-trastuzumab相比,获得最强的治疗性效率(肿瘤质量减少),在注射5 mg的GD-NPS/D(在24和72小时内24 h和72h)注射5 mg的GD-NPS/D(分隔6 h)[177 lu-lu-duudabab] lu-dababab abiabab。GD-NPS暴露于177 LU增加了螺旋钻的产量,但并不能增加吸收剂量。 结论:靶向放射性核素治疗可以与GD-NP结合使用,以增加治疗作用并减少注入活性。 作为GD-NP已在诊所中使用,这种组合可能是一种新的治疗方法,用于卵巢腹膜癌患者。GD-NPS暴露于177 LU增加了螺旋钻的产量,但并不能增加吸收剂量。结论:靶向放射性核素治疗可以与GD-NP结合使用,以增加治疗作用并减少注入活性。作为GD-NP已在诊所中使用,这种组合可能是一种新的治疗方法,用于卵巢腹膜癌患者。
1. 概述 ................................................................................................................................ 1 2. 特点 ................................................................................................................................ 2 3. 焊盘排列 ................................................................................................................................ 3 3.1. 输出焊盘尺寸 ........................................................................................................................ 3 3.2. 焊盘尺寸 ............................................................................................................................. 4 3.3. 对准标记尺寸 ...................................................................................................................... 5 3.4. 焊盘坐标 ............................................................................................................................. 6 4. 框图 ............................................................................................................................. 17 5. 引脚描述 ............................................................................................................................. 18 6. 3 线串行接口 ................................................................................................................ 21 7. 寄存器列表 ........................................................................................................................ 22 7.1. 寄存器汇总 ........................................................................................................................ 22 7.2. 算法 ................................................................................................................................ 25 7.2.1.全局对比度设置 (04h) ...................................................................................................... 25 7.2.2. Sub-R 对比度设置 (05h) ................................................................................................ 26 7.2.3. Sub-B 对比度设置 (06h) ................................................................................................ 27 7.2.4. 全局亮度设置 (07h) ................................................................................................ 28 7.2.5. Sub-R 亮度设置 (08h) ................................................................................................ 29 7.2.6. Sub-B 亮度设置 (09h) ................................................................................................ 30 7.3. OTP 控制设置 ............................................................................................................................. 31 7.3.1. OTP 控制 (10h) ............................................................................................................. 31 7.3.2. OTP 地址 (11h) ................................................................................................................. 32 7.3.3. OTP 写入数据(12h) ...................................................................................................... 33 7.3.4. SPI 读取 OTP 数据(13h) ................................................................................................ 34 7.4. 接口类型和消隐门限控制 ...................................................................................................... 35 7.4.1. 接口类型和极性设置(21h) ............................................................................................. 35 7.4.2. 消隐门限控制 1(22h~26h) ............................................................................................. 36 7.4.3. 消隐门限控制 2(27h~2Bh) ............................................................................................. 37 7.5. 功率微调 ............................................................................................................................. 38 7.5.1. IBAS 调整(30h) ............................................................................................................. 38 7.5.2. IBIAS 和 VCC 调整 (31h) .............................................................................................. 39 7.5.3. LVD 和 VDDS 调整 (32h) .............................................................................................. 40 7.5.4. GVCL 调整 (38h) ...................................................................................................... 41 7.5.5. GVDD 调整 (39h) ...................................................................................................... 42 7.5.6. VGSP 调整 (3Ah) ...................................................................................................... 43 7.6. 栅极设置 ............................................................................................................................. 44 7.6.1. 栅极开关设置 (40h) ................................................................................................ 44 7.6.2. 栅极启动使能设置 (41h) ................................................................................................ 45 7.6.3. 栅极结束使能设置 (43h) ................................................................................................ 46 7.7.源控制设置 ................................................................................................................................ 47 7.7.1. 源负载设置 1 (50h) ................................................................................................ 47 7.7.2. 源负载设置 2 (51h) ................................................................................................ 48 7.7.3. 源负载设置 3 (52h) ................................................................................................ 49 7.7.4. 源负载设置 4 (53h) ................................................................................................ 50 7.7.5. 源负载设置 5 (54h) .................................................................................................................................... 51 7.7.6. 源充电设置 1 (55h) .............................................................................................. 52 7.7.7. 源充电设置 2 (56h) .............................................................................................. 53 7.7.8. 源充电设置 3 (57h) .............................................................................................. 54 7.7.9. 源充电设置 4 (58h) ............................................................................................. 55 7.7.10. 源设置 1 (59h) ...................................................................................................... 56 7.7.11. 源设置 2 (5Ah) ...................................................................................................... 57 7.7.12. 源设置 3 (5Bh) ...................................................................................................... 58 7.7.13. 源设置 4 (5Eh) ...................................................................................................... 59 7.8. 7.9. Gamma P 选择 (60h~72h) .......................................................................................................... 60 7.9. Gamma N 选择 (73h~85h) .......................................................................................................... 61 7.10. 泵控制 ...................................................................................................................................... 62...................................................... 62...................................................... 62
