XiaoMi-AI文件搜索系统
World File Search SystemCharacterized
探索杂物体的化学空间
Figure 1: Depicts a) A conceptual figure showing different chemical subspaces, including unknown chemical space (gray), exposome chemical space (yellow), measurable chemical space (blue), measured chemical space (magenta), and identified/characterized chemical space (green) whereas b) shows the chemicals in US-EPA CompTox with 800 k unique structures.主成分图是使用六个元素质量缺陷和US-EPA Comptox中化学物质的单异位素质量产生的（这些计算的详细信息可在其他地方提供33,34）。应注意的是，子空间的大小仅用于可视化目的，并且不代表这些空间的真实大小。
Sorafenib sensitizes melanoma cells to vemurafenib through ferroptosis
Ferroptosis is a recently recognized form of regulated cell death driven by small molecules or conditions that induce lipid-based reactive oxygen species (ROS) accumulation, and this iron-dependent form of cell death is morphologically and genetically distinct from apoptosis, necroptosis, and autophagy (8,9). Ferroptosis is characterized by cell volume shrinkage and increased mitochondrial membranes and is mediated by iron-dependent lipid peroxide accumulation (10). The ferroptosis-inducing compounds, such as erastin and Ras selective lethal 3 (RSL3) could inactivate cellular glutathione (GSH)-dependent antioxidant defenses, leading to the accumulation of toxic lipid ROS (11,12). Glutathione peroxidase 4 (GPX4) is a key antioxidant enzyme that is responsible for removing lipid hydroperoxides within biological membranes (8). Once GPX4 inactivation, GSH will loses ability in removing the local peroxidase reaction, which eventually lead to a lipid ROS accumulation and ferroptosis.
糖尿病性酮症酸中毒（DKA） - 范式压力机
糖尿病性酮症酸中毒（DKA）是威胁生命的医疗紧急情况，需要立即评估和治疗。它仍然是糖尿病的重要并发症，在全球范围内正在增加。这是一种内分泌并发症，涉及高血糖，阴离子间隙代谢性酸中毒和酮症。It is characterized by hyperglycaemia with glucose is greater than 11 mmol/l (200 mg/dl), capillary/venous pH is less than 7.3, bicarbonate (HCO 3 –) is less than 15 mEq/l, serum anion gap is greater than 16 mmol/l, moderate to severe dehydration is seen and creatinine ratio is increased, and ketones (ketonemia and存在酮尿≥3mmol/L）。它发生在1型糖尿病（T1D）和2型糖尿病（T2D）的患者中；以及早期诊断，监测和治疗对于患者的福利是必需的。DKA的治疗涉及体积膨胀，胰岛素置换和预防低钾血症。DKA可以通过早期识别和开始胰岛素治疗来预防。在这里试图详细讨论DKA的各个方面。
基于铂纳米结构和多吡咯层的组合的无试剂葡萄糖生物传感器
摘要：开发了基于石墨杆（GR）电极的两种类型的低成本试剂电化学生物传感器。用电化学合成的铂纳米结构（PTNS），1,10-苯磺氨酸-5,6-二酮（PD），葡萄糖氧化酶（GOX），没有息肉（PPY）层 - （PPY）层 - （I）GR/PTNS/PD/PD/PT/PT/PT/PT，分别准备和测试。Glucose biosensors based on GR/PtNS/PD/GOx and GR/PtNS/PD/GOx/Ppy electrodes were characterized by the sensitivity of 10.1 and 5.31 µ A/(mM cm 2 ), linear range (LR) up to 16.5 and 39.0 mM, limit of detection (LOD) of 0.198 and 0.561 mM, good reproducibility, and storage 稳定。基于GR/PTN/PD/GOX/PPY电极的开发的葡萄糖生物传感器对干扰化合物的耐药性具有非凡的耐药性，并证明对测定血清中葡萄糖水平的测定非常有效。
摘要
在IVL和旋转动脉粥样硬化之前，大多数患者在血管造影引导组的5.75％中均在成像引导中为7.4％。在两组中使用IVL的使用相似，IVL气球的中位数为1，直径中位数为3.00mm，并且传递的脉冲中位数为60（所有比较，P> 0.05）。Nota- bly, the imaging-guided cohort was characterized by the deployment of stents with larger dimensions (median 3.5mm [IQR 3-3.5] versus 3.0mm [IQR 3-3.5] in the angiography cohort; p<0.001) and post-dilatation balloon sizes (median 4.0 [IQR 3.5-3.5] versus 3.5 [IQR 3.25-4.0]在Angiogra-Phy队列中；在成像引导组中记录了孤独的院内死亡率。结论这种单中心分析暗示，冠状动脉内成像引导的IVL在治疗钙化冠状病变中与使用支架的使用和较大能力的脱丝后气球相关，可能表明对病变制剂的更积极的方法进行了更为积极的方法。尽管有这些程序性分歧，但与血管造影引导的IVL相比，院内死亡率并没有显着影响。安全
在功能化石墨烯片上的聚氧盐，作为有效合成苯甲酰唑
在这项工作中，合成了氧化石墨烯（GO）纳米颗粒并随后使用3-氨基丙基三甲氧基硅烷（APTMS）进行了修饰。Anderson型多氧碱[（C 4 H 9）4 N] 2 [CRMO 6 O 18（OH）6]，然后将其固定在改良的石墨烯氧化石墨烯纳米颗粒的表面上。The obtained catalyst was characterized using Fourier-transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDS), inductively coupled plasma (ICP), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Raman spectroscopy, and X-ray diffraction (XRD).在基于溶剂的条件下，评估了该可回收混合催化剂的催化性能在75°C下合成了苯咪唑衍生物。混合催化剂表现出易于分离，并且可以成功重复使用至少六次，而所需产品的产量仅略有降低。浸出和恢复测试以及FT-IR分析证实了催化活性物种的高稳定性和催化剂的异质性。
梅赛德斯 - 奔驰卡车庆祝电池电力长途卡车EACTROS 600
• Heavy-duty electric truck is planned to define the new standard in terms of technology, sustainability, design and profitability • E-truck to replace majority of diesel trucks in the segment over the long term • Range of 500 kilometers 1 without intermediate charging • Significantly more than 1,000 kilometers per day with intermediate charging during the legally prescribed driver breaks possible • Gross combination weight of up to 44 tons • Payload of around 22 tons with standard trailer • Start of sales this year - start of series production planned for end of 2024 • New design language of the driver's cab characterized by efficient aerodynamics • More than 80 percent CO2 savings 2 compared to diesel-truck over entire life cycle possible • Karin Rådström, CEO Mercedes-Benz Trucks: “The eActros 600 stands for the transformation of road freight transport towards CO2-neutrality like no other卡车带有三角星。它的特征是高度创新的驱动技术，可以为我们的客户提供特别高的能源效率，从而盈利。这使得进入电子操作员对车队运营商的吸引力更具吸引力。”
印尼医学化学与生物信息学杂志
摘要：甲状腺杆菌是一种棒状细菌，革兰氏阳性（紫色），生长需要氧气存在或可以与氧气或没有氧气，非氧气，非乳状，非囊膜，非孢子，非孢子孢子，催化酶阳性。Most species ferment carbohydrates such as fructose, galactose, glucose, maltose, and mannose and produce an exotoxin called diphtheria toxin (DT) which can cause diphtheria, a respiratory infection characterized by sore throat and the production of a thick layer / gray pseudo-membrane and generally affects children aged 15 years and under and is very vulnerable in people who are not immunized and在低免疫系统中。白喉是一种危险且威胁生命的疾病，如果未及早发现，因此必须立即进行临床诊断。因此，必须通过实验室检查来支持临床诊断方法以检测细菌。可以为诊断Corynebacterium的细菌诊断的检查包括在生长培养基，毒性测试/毒素鉴定，血清学测试，组织学检查和成像测试，生物标志物测试和PCR（聚合酶链链链反应）测试的培养检查。
脑血清素2a受体结合预测psilocybin对健康人的主观时间和神秘作用
psilocybin是一种血清素能的迷幻药物（Nichols，2016），最近被探索为一种与其他迷幻物质一起的新型胸膜疾病治疗方法（Dos Santos和Hallak，2020; Johnson et el。来自一系列临床试验的结果，这些证据表明可以在治疗上使用psilocybin，例如重度抑郁症（Carhart-Harris等，2016，2016，2018），强迫性强迫症（Moreno等，2006）（2006年），焦虑和抑郁症，与生命繁重的癌症相关（Griffiths et and and and and and and。 Al。，2015年； Johnson等人，2014年）。中等剂量（即> 0.2 mg/kg), psilocybin induces an acute psychedelic experience, characterized by three experiential phases: (a) the onset of psy- choactive effects followed by (b) a peak plateau and (c) a gradual return to normal waking consciousness (i.e.研究参与者将其视为其典型的清醒意识状态，没有任何精神活性药物）（Madsen等，2019； Preller和Vollenweider，2018）。In contrast to normal waking consciousness, perceptual alterations and changes in sense of self, affect, meaning and cognition are typically experi- enced during the psilocybin psychoactive phases within a spec- trum of what users of psychedelic drugs and researchers have termed ‘peak' (Maslow, 1959), ‘mysticomimetic' (Nielson et al.,
免疫原性细胞死亡诱导剂在癌症免疫治疗中的临床应用：让冷肿瘤变热
Immunotherapy has emerged as a promising cancer treatment option in recent years. In immune “ hot ” tumors, characterized by abundant immune cell in fi ltration, immunotherapy can improve patients ' prognosis by activating the function of immune cells. By contrast, immune “ cold ” tumors are often less sensitive to immunotherapy owing to low immunogenicity of tumor cells, an immune inhibitory tumor microenvironment, and a series of immune-escape mechanisms. Immunogenic cell death (ICD) is a promising cellular process to facilitate the transformation of immune “ cold ” tumors to immune “ hot ” tumors by eliciting innate and adaptive immune responses through the release of (or exposure to) damage-related molecular patterns. Accumulating evidence suggests that various traditional therapies can induce ICD, including chemotherapy, targeted therapy, radiotherapy, and photodynamic therapy. In this review, we summarize the biological mechanisms and hallmarks of ICD and introduce some newly discovered and technologically innovative inducers that activate the immune system at the molecular level. Furthermore, we also discuss the clinical applications of combing ICD inducers with cancer immunotherapy. This review will provide valuable insights into the future development of ICD- related combination therapeutics and potential management for “ cold ” tumors.