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BEXSERO (Meningococcal Group B Vaccine) injectable suspension, for intramuscular use
The NadA component is a fragment of the full-length protein derived from N. meningitidis strain 2996 (peptide 8 variant 2/3) 1 . The NHBA component is a recombinant fusion protein comprised of NHBA (peptide 2) 1 and accessory protein 953 derived from N. meningitidis strains NZ98/254 and 2996, respectively. The fHbp component is a recombinant fusion protein comprised of fHbp (variant 1.1) 1 and the accessory protein 936 derived from N. meningitidis strains MC58 and 2996, respectively. These 3 recombinant proteins are individually produced in Escherichia coli and purified through a series of column chromatography steps. The OMV antigenic component is produced by fermentation of N. meningitidis strain NZ98/254 (expressing outer membrane protein Porin A [PorA] serosubtype P1.4) 2 , followed by inactivation of the bacteria by deoxycholate, which also mediates vesicle formation. The antigens are adsorbed onto aluminum hydroxide.
2023代理语句
本代理声明中的某些陈述可以被视为适用证券法的含义中的“前瞻性”陈述。Forward-looking statements include those preceded by, followed by, or that include the words “will,” “may,” “could,” “would,” “should,” “believes,” “expects,” “forecasts,” “anticipates,” “plans,” “estimates,” “targets,” “projects,” “intends”, or similar expressions.此类前瞻性陈述受风险，不确定性和其他因素的影响，这些因素可能导致实际结果与历史经验有实质性差异，或者与此类前瞻性陈述所表达或暗示的未来结果相差。潜在的风险和不确定性包括但不限于联邦快递公司及其子公司的新闻稿中可以找到的因素，以及对SEC的FedEx提交的文件，包括其关于2023财年10-K表格的年度报告。任何前瞻性陈述仅在制作之日起说话。FedEx不承担或承担任何义务更新或修改任何前瞻性陈述，无论是由于新信息，未来事件还是其他方式。
epcoritamab（duobody®CD3XCD20）-Genmab
• Primary CNS lymphoma or CNS involvement • Known past or current malignancy other than inclusion diagnosis • Autoimmune or other diseases resulting in permanent immunosuppression or immunosuppressive therapy • Seizure disorder requiring therapy (eg, steroids or anti-epileptics) • Any prior therapy with an investigational bispecific antibody targeting CD3 and CD20 • Prior treatment with CAR T therapy within 30 days of first epcoritamab administration • Eligible for curative intensive salvage therapy followed by high-dose chemotherapy with HSCT rescue • Autologous HSCT within 100 days of first epcoritamab administration, or any prior allogeneic HSCT or solid organ transplantation • Active hepatitis B or C infection (evidence of prior hepatitis B virus but PCR-negative is permitted) or known HIV infection
2,5-双（4-吡啶基）-1,3,4-氧二唑作为正常盐酸培养基中碳钢的有效有机腐蚀抑制剂：
摘要：已合成2,5-双（4-吡啶基）-1,3,4- - 奥沙唑（4-Pox），并研究了1M HCl溶液中使用重量范围的1M HCl溶液中的碳钢（CS）作为有机耐受抑制剂的有机耐抑制剂。浓度并随着温度培养基的增加而降低。A mixture of physisorption and chemisorption is proposed for the corrosion inhibition mechanism and the process followed the kinetic/thermodynamic model of Langmuir in the temperature range from 303 to 343 K. The adsorption and kinetic parameters for CS/4-POX/1 M HCl system were calculated from experimental gravimetric data and the interpretation of the results are given.DFT计算，并应用于分析合成抑制剂与CS表面的相互作用。此外，还计算了福克（Fukui）指数，以确定最合理的亲核和亲电攻击位点。
抗生素损害微生物群中的结肠粘液屏障
抗生素使用是炎症性肠病（IBD）发展的危险因素。IBD的特征是受损的粘液层，该粘液层不会将肠上皮与微生物群区分开。 在这里，我们假设抗生素会影响粘液屏障的完整性，从而使细菌渗透性和易于症状炎症。 我们发现抗生素治疗导致结肠粘液屏障和细菌渗透到粘液层中。 Using fecal microbiota transplant, RNA sequencing followed by ma- chine learning, ex vivo mucus secretion measurements, and antibiotic treatment of germ-free mice, we determined that antibiotics induce endoplasmic reticulum stress in the colon that inhibits colonic mucus secretion in a microbiota-independent manner. 这种抗生素诱导的粘液分泌缺陷导致细菌渗透到结肠粘液层中，将微生物抗原转移到循环中，并在IBD小鼠模型中加剧溃疡。 因此，抗生素的使用可能会通过阻碍粘液产生而易于肠道炎症。IBD的特征是受损的粘液层，该粘液层不会将肠上皮与微生物群区分开。在这里，我们假设抗生素会影响粘液屏障的完整性，从而使细菌渗透性和易于症状炎症。我们发现抗生素治疗导致结肠粘液屏障和细菌渗透到粘液层中。Using fecal microbiota transplant, RNA sequencing followed by ma- chine learning, ex vivo mucus secretion measurements, and antibiotic treatment of germ-free mice, we determined that antibiotics induce endoplasmic reticulum stress in the colon that inhibits colonic mucus secretion in a microbiota-independent manner.这种抗生素诱导的粘液分泌缺陷导致细菌渗透到结肠粘液层中，将微生物抗原转移到循环中，并在IBD小鼠模型中加剧溃疡。因此，抗生素的使用可能会通过阻碍粘液产生而易于肠道炎症。
从GW扰动理论
我们介绍了使用GW扰动理论（GW PT）的电子波（E -PH）耦合的实际计算的工作流程。此工作流程结合了BerkeleyGW，ABINIT和EPW软件包，以在GW自我水平上启用精确的E-PH计算，超出了基于密度功能理论（DFT）和密度功能 - 功能扰动理论（DFPT）的标准计算。This workflow begins with DFT and DFPT calculations ( ABINIT ) as starting point, followed by GW and GW PT calculations ( BerkeleyGW ) for the quasiparticle band structures and e -ph matrix elements on coarse electron k - and phonon q -grids, which are then interpolated to finer grids through Wannier interpolation ( EPW ) for computations of various e -ph coupling determined physical诸如各向异性Eliashberg方程的电子自我甲基元或解决方案等数量。开发了一种量规的对称性展开技术，以降低GW PT（以及DFPT）的计算成本，同时满足Wannier插值的规格一致性要求。
Differentiating Small Enterprises in the Innovation Economy:
The recovery which followed in the 2010s was, in many ways, uneven and highly inequitable, with growth not being equitably distributed across sectors, communities or regions. With areas and people feeling ‘left behind' while others benefited from the recovery, this resulted in social, economic and political disruptions. If we wish the recovery of the 2020s to be more inclusive across a diverse set of actors, then we need to adopt an approach that is consciously inclusive and allows us to build back the entrepreneurial foundations of our economies in a different, more equitable way. An effective and inclusive approach to enterprise support requires that we attend to corner stores and ‘main street/high street' SME businesses, not just unicorns and high-tech start-ups. It requires an emphasis on productivity and employment, not simply revenue growth or valuation, and demands that we consider differentiation in support as well as coherence and simplification.
Direct Speech Synthesis from Non-Invasive, Neuromagnetic Signals
Direct speech synthesis from neural activity can enable individuals to communicate without articulatory movement or vocalization. A number of recent speech brain-computer interface (BCI) studies have been conducted using invasive neuroimaging techniques, which require neurosurgery to implant electrodes in the brain. In this study, we investigated the feasibility of direct speech synthesis from non-invasive, magnetoencephalography (MEG) signals acquired while participants performed overt speech production tasks. We used a transformer-based framework (Squeezeformer) to convert neural signals into Mel-spectrograms followed by a neural vocoder to generate speech. Our approach achieved an average correlation coefficient of 0.95 between the target and the generated Mel spectrograms, indicating high fidelity. To the best of our knowledge, this is the first demonstration of synthesizing intelligible speech directly from non-invasive brain signals. Index Terms : speech brain-computer interface, neural speech synthesis, magnetoencephalography, transformer
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结果总共获得了24次扫描，所有扫描都包括在分析中。Among all CT acquisition modes, the highest image quality was obtained for the UHR mode [median score: 4 (interquartile range (IQR): 3.67–4.00)] ( P = 0.0015, with 37.5% rated as “excellent”), followed by the sequential mode [median score: 3.5 (IQR: 2.84–4.00)], P = 0.0326 and the spiral mode [median score: 3.0（IQR：2.53–3.47），p> 0.05]。高点模式的最低图像质量[中位数：2（IQR：1-3），p = 0.028]。同样，评估支架平坦的诊断置信度对于UHR的标准最高，而高点的诊断置信度最低（分别为p <0.001）。Measurement of stent dimensions was accurate for all acquisition modes, with the UHR mode showing highest robustness (FWHM for se quential: 0.926 ± 0.061 vs. high-pitch: 0.990 ± 0.083 vs. spiral: 0.962 ± 0.085 vs. UHR: 0.941 ± 0.036, P = non-significant, respectively).
心血管疾病治疗的时间表
• Cardiovascular disease (CVD) remains the leading cause of death in the United States, accounting for 928,741 deaths in 2020.1 • In 2020, the leading cause of deaths attributable to CVD in the United States was coronary heart disease (CHD) at 41.2%, followed by stroke (17.3%), other CVD (16.8%), high blood pressure (12.9%), heart failure （9.2％）和动脉疾病（2.6％）。1•2018年至2019年美国，美国CVD总CVD的直接和间接成本为4073亿美元（直接成本为2514亿美元，生产率损失/死亡率为1559亿美元）。 1•平均而言，在美国，每36秒的CVD死亡。2•全球，CVD是死亡的主要原因，占2019年全球死亡的32％。1•2018年至2019年美国，美国CVD总CVD的直接和间接成本为4073亿美元（直接成本为2514亿美元，生产率损失/死亡率为1559亿美元）。1•平均而言，在美国，每36秒的CVD死亡。2•全球，CVD是死亡的主要原因，占2019年全球死亡的32％。