Individual has a personal history of a Primary Solid Tumor (excluding basal or squamous cell skin cancer) and at least one of the following: o A pathogenic variant was detected in tumor tissue that has clinical implications if detected in the germline (e.g., BRCA1, BRCA2, BRIP1, MLH1, MSH2, MSH6, MUTYH, PALB2, PMS2, RAD51C, RAD51D, RET, SDHAF2, SDHB, SDHC, SDHD, TMEM127, TSC2, VHL APC, PTEN, RB1, and TP53 ) o Tumor tissue testing demonstrated that the cancer was MSI-high or had immunohistochemical staining showing the absence of one or more mismatch repair (MMR) proteins ( MLH1, MSH2, MSH6, or PMS2 ) o Individual has a Tyrer-Cuzick, BRCAPro, or Penn11 Score of 2.5% or greater for a BRCA1/2 pathogenic variant o Individual has a PREMM 5 , MMRpro, or MMRpredict Score of 2.5% or greater for having a Lynch syndrome gene mutation Individuals With No Personal History of a Primary Solid Tumor Genetic testing with a Multi-Gene hereditary cancer Panel or testing of BRCA1/2 for individuals如果符合以下至少一个标准之一,则没有原发性实体瘤的个人病史(不包括基底或鳞状细胞皮肤癌),并且在医学上是必不可少的:
常染色体隐性遗传:这些疾病会在每个父母继承突变基因的两个副本时就会发生。如果父母双方都是隐性基因突变的载体,他们的孩子有25%的机会继承了疾病,50%的机会成为载体,有25%的机会继承两个正常基因。囊性纤维化,镰状细胞贫血和Tay-Sachs病是常染色体隐性疾病的例子。x连接的遗传:这些疾病是由X染色体上的突变引起的。由于雄性只有一个X染色体,因此该染色体上基因的单个缺陷副本会导致该疾病。在女性中,有两个X染色体,必须存在于两个X染色体上的缺陷基因才能表现出来,尽管如果它们只有一个有缺陷的基因,则可以是载体。血友病和Duchenne肌肉营养不良是X连锁疾病的经典例子[7,8]。
Individual has a personal history of a Primary Solid Tumor cancer (excluding basal or squamous cell skin cancer) and at least one of the following: o A BRCA1/2 pathogenic variant was detected in tumor tissue o Tumor tissue testing demonstrated that the cancer was MSI-high or had immunohistochemical staining showing the absence of one or more mismatch repair proteins ( MLH1, MSH2, MSH6, or PMS2 ) o Individual has a Tyrer-Cuzick, BRCAPro, or Penn11 Score of 2.5% or greater for a BRCA1/2 pathogenic variant o Individual has a PREMM 5 , MMRpro, or MMRpredict Score of 2.5% or greater for having a Lynch syndrome gene mutation Individuals With No Personal History of a Primary Solid Tumor Cancer Genetic testing with a Multi-Gene hereditary cancer Panel or testing of BRCA1/2对于没有原发性实质性癌症病史(不包括基底或鳞状细胞皮肤癌)的个体,如果满足以下至少一个标准,则证明并且在医学上是必不可少的:
申请的呼吁尤其集中在超越科学学科传统界限的项目上,并将从其他领域到工程师高级流程以及可持续生物技术的应用程序纳入了发展。重点是针对生态和社会挑战的生物技术创新,包括用于化学工业和能源的无化石原料的微生物材料转换方法,以及用于碳序列化和利用的生物技术过程。该奖项的范围包括各种创新的方法,包括资源有效的生产过程以及对气候友好的技术和应用。值得注意的是,该奖项特别强调认识到新颖的方法,这些方法为独立于化石燃料的未来提供了实质性贡献。
b'Christopher De Bono 1、Yichi Xu 2,*、Samina Kausar 1,*、\xc2\xa3、Marine Herbane 1、Camille Humbert 1、Sevda Rafatov 1、Chantal Missirian 1,3、Mathias Moreno 1、Weiyang Shi 4、Yorick Gitton 5、Alberto Lombardini 6、Ivo Vanzetta 6、S\xc3\xa9verine Mazaud-Guittot 7、Alain Ch\xc3\xa9dotal 5、Ana\xc3\xafs Baudot 1、St\xc3\xa9phane Zaffran 1 和 Heather C. Etchevers 1,'
如果申请成功,申请人组织将负责与项目相关的所有费用。申请人在2025年11月14日截止日期之前提交详细的最终报告和支出的证据。此外,申请人将需要在2025年8月中旬之前提交临时报告。最终报告必须包括该项目如何实现其既定环境目标的证据,包括对生物多样性或气候缓解工作的任何可衡量影响。
在森林中记录的显着的动物种类包括Mugger鳄鱼,Kanger Valley Rock Gecko,Sacred Grove Bush Frog和各种Avifauna,例如Black Baza,Jerdon's Baza,Malaber Trogon,Malaber Trogon,Common Hill Myna,Common Hill Myna,White Bellied Bellied Woodpecker和Band Cuckoo。森林内的石灰石洞穴是八种蝙蝠的家园,其中两种属于近乎威胁性的类别。
支持执行功能发展 对注意力、计划、组织能力、抑制的影响 理解感官差异 理解情绪反应 帮助孩子识别和管理情绪反应 支持以上所有内容的策略
8.2。社会目标...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................