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考虑到不同的风险因素，对于小于 2 厘米的头颈部基底细胞癌，3 毫米的手术边缘是否安全？
摘要背景基底细胞癌 (BCC) 是最常见的非黑色素瘤皮肤癌。通常，切除需要 4 毫米的安全边缘。去除肿瘤细胞时，以最小的安全边缘实现完全切除并重建缺损以保留原始外观非常重要。在本研究中，我们使用 3 毫米切除边缘来确认复发和再切除率。方法获取 2015 年 1 月至 2021 年 11 月期间接受 3 毫米手术边缘广泛切除的原发性 BCC 病变直径小于 2 cm 的患者的电子病历和照片数据。我们分析了决定复发和再切除率的因素，例如肿瘤大小、位置、年龄、性别、潜在疾病（包括免疫抑制状态）、种族、亚型、肿瘤边界等。结果本研究纳入 205 名患者。平均年龄和随访期分别为 73.0 11.5 岁和 10.2 8.0 个月。复发率和再切除率分别为 1.95% 和 25.85%。复发率和肿瘤边界之间存在统计学显著相关性（p = 0.013），再切除率与部位（p = 0.022）和免疫抑制患者（p = 0.006）具有统计学相关性。结论我们发现 3 mm 的切除边缘对于小型面部 BCC 提供了足够的安全性，从而易于手术并获得更好的美学效果。然而，手术边缘必须根据具体情况综合考虑患者的各种因素来确定。特别是，对于高风险区域、免疫抑制患者或边界不清晰的 BCC，需要 4 mm 的手术边缘。
使用商业模型帆布分析淡水鱼类营销利润率的效率（关于CV的案例研究
摘要渔业和海洋部门的生长来自捕获渔业的生产和水产养殖。在公平发展的背景下，渔业种植活动可以用作农业行业领域中商品的替代品，而开发时非常有前途。在简历开发淡水鱼业务。Pancuran Mas Pasar Bandar Jaya Lampung Tengah目前表现出极好的进步和进步。这项研究将使用简历上的商业模型画布进行分析。Pancuran Mas Pasar Bandar Jaya Lampung Tengah。业务模型画布作为用于分析的工具。结果显示了一个业务模型，有助于理解，解释和预测应采取哪些活动，以便为公司或组织创造利润。商业模式也是公司赚钱的抽象表示。业务模型Canvas（BMC）在帮助确定由简历运行的业务模型方面有9个重要要素。Pancuran Mas Pasar Bandar Jaya Lampung Tengah，并有助于确定需要改进的要素，以帮助将来有助于业务连续。关键字：效率，营销保证金，淡水鱼，商业模型帆布
可持续的海藻价值链
▪ Seaweed supply chain is fragmented mainly carried out by small holders ▪ Long supply chains with limited connection/linkages with processors, less control on quality ▪ Limited value addition and low margin – driven by volume and price ▪ Income margin is lower for all VCOs (Exporters 5%, Trader 5%, Collector 3% and Farmer 10% ▪ Normal margins for trade in goods is 15 – 20%
Informa plc 2024半年结果
£m £m % % Informa Markets Revenue 838.3 760.8 10.2 12.9 Statutory operating profit / (loss) 176.9 133.8 32.2 Adjusted operating profit 3 274.8 238.1 15.4 24.5 Adjusted operating margin 3 (%) 32.8 31.3 Informa Connect Revenue 328.3 278.7 17.8 6.5 Statutory operating profit / (loss) 24.9 18.1 37.6 Adjusted operating profit 3 67.4 60.7 11.0 6.7 Adjusted operating margin 3 (%) 20.5 21.8 Informa Tech Revenue 227.6 197.6 15.2 15.5 Statutory operating profit / (loss) (10.8) 87.4 n/a Adjusted operating profit 3 30.3 27.6 9.8 15.6 Adjusted operating margin 3 (%) 13.3 14.0 Taylor & Francis Revenue 301.1 283.4 6.2 7.5法定运营利润 /（损失）71.9 59.6 20.6调整后的营业利润3 94.4 87.1 8.4 13.6调整后的操作保证金3（％）31.4 30.7 < / div>
Zalando SE Q4利润超过了期望，新策略...
Zalando SE 2021 2022 2023 2024E 2025E 2026E Sales 10,354 10,345 10,143 10,498 11,233 12,019 Growth Yoy 29.7% -0.1% -1.9% 3.5% 7.0% 7.0% EBITDA 660 376 511 686 815 881 EBIT 425 81 191 315 444 505 Net Profit 235 17 83 185 282 332 Net Debt (Net Cash) -763 -387 -792 -1,012 -1,383 -1,784 Net Debt/Ebitda -1.2x -1.0X -1.5x -1.5x -1.7X -2.0x EPS report 0.91 0.07 0.32 0.71 1.08 1.28 dps 0.00 0.00 0.00 0.00 0.00 Dividing Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% Gross Profit Margin 41.8% 39.2% 38.7% 40.1% 41.0% 41.0% EBITDA Margin 6.4% 3.6% 5.0% 6.5% 7.3% 7.3% EBIT Margin 4.1% 0.8% 1.9% 3.0% 4.0% 4.2% ROCE 10.9% 2.0% 4.3% 6.9% 9.6% 10.7% EV/ebitda 7.8x 14.7x 10.0x 7.1X 5.6x 4.7x EV/EBIT 12.1X 68.2x 26.8x 15.6x 10.2x 8.2X Per 25.0X 349.5x 71.2x 31.9x 21.0x 17.8x FCF Yield 10.5% 7.8% 16.1% 6.2% 9.2% 10.3% Source: Company Data, MWB研究 div>Zalando SE 2021 2022 2023 2024E 2025E 2026E Sales 10,354 10,345 10,143 10,498 11,233 12,019 Growth Yoy 29.7% -0.1% -1.9% 3.5% 7.0% 7.0% EBITDA 660 376 511 686 815 881 EBIT 425 81 191 315 444 505 Net Profit 235 17 83 185 282 332 Net Debt (Net Cash) -763 -387 -792 -1,012 -1,383 -1,784 Net Debt/Ebitda -1.2x -1.0X -1.5x -1.5x -1.7X -2.0x EPS report 0.91 0.07 0.32 0.71 1.08 1.28 dps 0.00 0.00 0.00 0.00 0.00 Dividing Yield 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% Gross Profit Margin 41.8% 39.2% 38.7% 40.1% 41.0% 41.0% EBITDA Margin 6.4% 3.6% 5.0% 6.5% 7.3% 7.3% EBIT Margin 4.1% 0.8% 1.9% 3.0% 4.0% 4.2% ROCE 10.9% 2.0% 4.3% 6.9% 9.6% 10.7% EV/ebitda 7.8x 14.7x 10.0x 7.1X 5.6x 4.7x EV/EBIT 12.1X 68.2x 26.8x 15.6x 10.2x 8.2X Per 25.0X 349.5x 71.2x 31.9x 21.0x 17.8x FCF Yield 10.5% 7.8% 16.1% 6.2% 9.2% 10.3% Source: Company Data, MWB研究 div>
2023财务报告
USD millions, unless otherwise stated 2022 2023 Change in % Group Net income/loss attributable to common shareholders 472 3 214 – Gross premiums written 47 889 49 954 4 Premiums earned and fee income 43 118 45 003 4 Earnings per share in CHF 1.63 9.94 Shareholders' equity 12 699 16 146 27 Return on equity in % 1 2.6 22.3 Return on investments in % 2.0 3.4 Net operating margin in % 2 2.7 10.0 Number of employees 3 14 408 14 719 2 Property & Casualty Reinsurance Net income/loss attributable to common shareholders 312 1 861 – Gross premiums written 23 848 24 367 2 Premiums earned 22 028 22 881 4 Combined ratio in % 4 102.4 94.8 Net operating margin in % 2 3.2 12.5 Life & Health Reinsurance Net income/loss attributable to common shareholders 416 976 – Gross premiums written 15 986 16 909 6 Premiums earned and fee income 14 984 15 648 4 Net operating margin in % 2 4.3 8.6 Corporate Solutions Net income/loss attributable to common shareholders 486 678 40 Gross premiums written 8 198 8 152 –1 Premiums earned 5 482 5 479 –0％4 93.1 91.7净工作保证金为％2 11.0 15.5
机构股票
Per share (Rs) Adj EPS 107.5 85.0 91.8 108.0 121.5 Book value 531.0 614.7 688.1 774.5 871.8 DPS 58.0 22.0 18.4 21.6 24.3 Valuation (x) P/Sales 2.1 2.5 2.3 2.1 2.0 EV/EBITDA 16.9 20.1 17.9 15.9 13.9 P/E 25.2 31.8 29.5 25.1 22.3 P/BV 5.1 4.4 3.9 3.5 3.1 Return ratios (%) RoCE 19.1 13.0 12.5 12.4 12.9 RoCE (pre-tax) 23.7 16.2 15.6 15.6 16.2 RoE 22.0 14.8 14.1 14.8 14.8 RoIC 24.6 16.7 16.0 16.2 16.8 Profitability ratios (%) Gross margin 30.6 32.1 31.0 31.5 30.9 EBITDA margin 12.7 12.2 12.1 12.4 12.9 PAT margin 8.5 7.9 7.8 8.4 8.7 Liquidity ratios (%) Current ratio 2.4 2.8 3.1 3.2 3.4 Quick ratio 1.4 1.9 2.3 2.4 2.6 Solvency ratio (%) Net Debt to Equity ratio 0.0 -0.1 -0.2 -0.3 -0.3周转率固定资产周转率（x）2.9 2.2 2.2 2.2 2.2 2.2债务天数51 58 60 60 55库存天56 58 60 60 48债权人天39 42 45 45 45净营业时间68 74 75 75 75 75 75 62
低温磁铁测试站的低温挑战
4 T dipole with a new Top of 20 K (> 10 K of margin) Frenet-Serret frame used for the conductor (avoid hard way bending) Straight geometry just to start the study (HTS is already difficult enough) Two design options: 2-tapes (980 A) and 4-tapes cable (1990 A) Quench protection is demanded (Cu stabilizer added for this)
通过并购评级
03/30/2019 06/29/2019 09/28/2019 12/31/2019 03/28/2020 06/27/2020 09/26/26/2020 12/31/2021/2021 06/30/30/20212121 6,256 6,759 6,025 7,741 9,361 12,936 cash and cash equivalents 342 521 283 352 335 533 448 581 Priority & other 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5,489 5,517 6,964 7,397 6,823 8,444 10,049 13,480销售391 379 394 427 448 448 448 448 481 518 518 522增长率226 231 236 242 Margin (%) 45 44 43 46 46 46 46 46 46 46 46 46 46 46 EBITDA 110 -25 106 128 123 135 148 148 152 155 Margin (%) 28-6 27 30 30 29 30 net profit 52 40 53 63 72 88 97 98 margin (%) 15 16 16 17 19 19 19 19 19 19 19 0 0.29 0.39 0.45 0.46 0.46 0.46 0.60 0.64 0.64 0.64 0.72 0.72 0.73增长率，YOY -8 -8 -30 19 27 27 22 80 54 45 39操作活动现金-3 231 231 25 120 120 101 101 201 204 -26-23-24-33 -47 -47盈余现金流-52 205-11 106 69 69 69 69 152 21 75周：彭博社调整可能与公司公告或财务报表 /数据不同：彭博，Hana金融投资
Q4 2024季度报告英语
SEK M unless otherwise stated 2024 2023 2024 2023 Net sales 138,413 147,988 526,816 552,252 Adjusted operating income¹ 14,039 18,472 65,718 78,155 Adjusted operating margin, % 10.1 12.4 12.5 14.0 Operating income² 14,039 16,982 66,611 67,301 Operating margin, % 10.1 11.4 12.6 12.1 Income after financial items 14,660 16,884 67,210 66,726 Income for the period 10,817 12,086 50,576 49,932 Earnings per share, SEK 5.28 5.93 24.78 24.50 Operating cash flow in Industrial Operations 24,270 22,655 45,295 45,821 Net financial工业运营中的职位，SEK BN 85.9 83.4工业运营中使用的资本回报率，％35.8 36.7金融服务中的净值回报率，％13.0 13.0 13.0净订单摄入量，卡车数量61,200 49,347 200,895 200,895 204,897 204,897次订购，数量进气口，建筑设备数量15,298 12,907 53,453 48,958交付，建筑设备数量14,629 15,351 56,043 60,064