自2002年以来,EOEEA一直在执行环境司法政策,以帮助确保所有马萨诸塞州居民在开发,实施和执行环境法律,法规和政策以及公平的环境利益方面都具有平等保护和有意义的参与。这项政策被认为是认识到,英联邦的整个社区,尤其是英联邦较旧的工业区域及其周围人口稠密的城市社区,正面临着与马萨诸塞州工业遗产相关的许多环境挑战。Residents in these predominantly low-income and minority communities – nearly 29% of the Commonwealth's population – lack open space and recreational resources and often live side-by-side numerous existing large and small sources of pollution and old abandoned, contaminated sites, which can pose risks to public health and the environment (Commonwealth of Massachusetts, Executive Office of Energy and Environmental Affairs, Division of Conservation Services, 2008).对于在英联邦推进环境正义(EJ)至关重要的是公园,开放空间和娱乐等环境资产的公平分配。朝着这一目的而言,在适用的情况下,市政当局应在其开放空间和娱乐计划中确定并确定对社区中EJ人群在社会,娱乐和生态上至关重要的开放空间和娱乐计划。
抽象的目标是确定口服微生物群的特征以及龋齿的关系和牙周与牙周状态的关系,年龄在0至18岁的患者患有非综合裂唇唇唇cle裂(CLP)的患者。材料和方法对文献进行了系统的综述。咨询了五个数据库,包括英语,西班牙语和葡萄牙语的发行。 分别通过纽卡斯尔 - 果酱量表和配偶指南进行了观察研究质量和实验研究的评估。 使用Rev Manager 5.4确定了研究偏见的风险,并对5个出版物进行了荟萃分析。 结果,患有唇裂和pa裂的儿童和青少年的致菌素菌群与没有裂缝的儿童相似,尽管具有较高的链球菌突变和乳酸杆菌的计数。 牙周病生成菌群与存在弯曲杆菌属,螺杆杆菌菌群,核细菌核细菌,prevotella Intermedia/ nigrescens,parvimonas micra和parvimonas micra和卟啉单胞菌,被认为具有高病原体能力的微生物。 Heterogeneity was shown in relation to the microbiota and the type of fissure, presenting numerous microorganisms associ- ated with the pre- and post-surgical condition (cheilorrhaphy and palatorrhaphy) such as Staphylococcus aureus, Streptococ- cus beta hemolyticus, Klebsiella pneumoniae and Klebsiella oxytoca, Moraxella catarrhalis,Candida spp,念珠菌,念珠菌Krusei和Tropicalis。咨询了五个数据库,包括英语,西班牙语和葡萄牙语的发行。分别通过纽卡斯尔 - 果酱量表和配偶指南进行了观察研究质量和实验研究的评估。使用Rev Manager 5.4确定了研究偏见的风险,并对5个出版物进行了荟萃分析。结果,患有唇裂和pa裂的儿童和青少年的致菌素菌群与没有裂缝的儿童相似,尽管具有较高的链球菌突变和乳酸杆菌的计数。牙周病生成菌群与存在弯曲杆菌属,螺杆杆菌菌群,核细菌核细菌,prevotella Intermedia/ nigrescens,parvimonas micra和parvimonas micra和卟啉单胞菌,被认为具有高病原体能力的微生物。Heterogeneity was shown in relation to the microbiota and the type of fissure, presenting numerous microorganisms associ- ated with the pre- and post-surgical condition (cheilorrhaphy and palatorrhaphy) such as Staphylococcus aureus, Streptococ- cus beta hemolyticus, Klebsiella pneumoniae and Klebsiella oxytoca, Moraxella catarrhalis,Candida spp,念珠菌,念珠菌Krusei和Tropicalis。荟萃分析表明,嘴唇和pa裂的患者患有龋齿的可能性是对照组的2.03倍(p <0.005)。在菌群中的结论中,微生物的多样性可能会根据裂缝和手术干预的类型而变化,使患者更有可能的龋齿可能性,重要的是要考虑到用于描述口服微生物群以比较不同研究的技术。研究微生物群的临床相关性以及龋齿和牙科与唇lip裂的牙科状态的关系,可以促进患有这些疾病的患者的全面护理。
Purpose Numerous recent studies and reports [3, 7, 8, 9, 10] have documented the increasing complexity of defense systems. The growth in complexity has increased risk and development time to the point where the time to field new systems and evolve existing systems is not acceptable. In addition, defense systems are operating in a rapidly changing environment, and the ability of systems to respond to those changes requires higher degrees of system adaptability. Traditional systems engineering methods, processes, and tools need significant improvement to meet the challenges posed by the increasing system complexity trend [10] , as do traditional software engineering methods [3]. Additionally, increasing complexity arising from the interdependence of large numbers of component suppliers is posing integration problems that challenge the limits of tradtional approaches [1]. Model Based Engineering (MBE) is an emerging approach to engineering that holds great promise for addressing the increasing complexity of systems, and systems of systems, while reducing the time, cost, and risk to develop, deliver, and evolve these systems. The purpose of this study was to assess the current state of MBE, identify the potential benefits, costs, and risks of MBE within the context of the DOD acquisition life cycle, and provide recommendations that would enable the widespread adoption of MBE practices across the DOD acquisition life cycle. Findings and General Recommendations MBE, as defined by the subcommittee, is an approach to engineering in which models:
缺血性中风是死亡和残疾的最重要临床原因之一,煽动神经元变性,死亡和各种后遗症。尽管标准治疗(例如静脉溶栓和血管内血栓切除术)证明有效,但它们会受到限制。因此,迫切需要开发能够改善神经系统功能结果的神经保护剂。Numerous preclinical studies have demonstrated that lithium can act in multiple molecular pathways, including glycogen synthase kinase 3(GSK-3), the Wnt signaling pathway, the mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling pathway, brain-derived neurotrophic factor (BDNF), mammalian target of雷帕霉素(MTOR)和谷氨酸受体。通过这些途径,锂已被证明会影响炎症,自噬,凋亡,铁凋亡,兴奋性毒性和其他病理过程,从而改善了由缺血性中风引起的中枢神经系统(CNS)损害。尽管有这些有希望的临床前发现,但探索锂功效的临床试验数量仍然有限。必须进行其他试验,以彻底确定锂在临床环境中的有效性和安全性。本综述描述了在缺血性中风的背景下锂神经保护能力的基础的机制。它阐明了这些机制之间的复杂相互作用,并阐明了线粒体功能障碍和炎症标志物在缺血性中风的病理生理学中的参与。此外,该评论还提供了未来研究的指示,从而促进了对锂的潜在治疗效用的理解,并为其临床应用建立了理论基础。
Bio Raj N. Singh博士是摄政教授兼国家工程学院(NAE)的成员。他曾担任材料科学与工程学院的创始局长,威廉姆斯公司杰出主席教授,俄克拉荷马州立大学(OSU)的能源技术主任。他收到了SC.D.马萨诸塞州材料科学与工程技术学院的学位。他在2012年加入OSU之前曾在Argonne国家实验室,GE-R&D中心和辛辛那提大学工作。Dr. Singh has been recognized for his engineering leadership through his scholarly activities (260 journal articles, 95 referred proceeding/reports, and 282 oral/invited presentations), pioneering inventions of MI composite processing technology leading to commercialization (28 granted patents), for graduating 36 students with MS and PhD degrees and through numerous professional awards in recognition of his engineering leadership such as Member of National Academy of Engineering (NAE), National美国陶瓷学会的Rishi Raj创新与商业化奖章,ASM国际Albert Sauveur成就奖,ASM International,Regents教授(OSU),AAAS AAAS,ASM International院士,美国陶瓷学会会员,美国陶瓷学院会员,惠特尼(UC)研究员(UC),惠特尼·盖里(Whitney Gee-cr),ASM国际院士,惠特尼·加里(Geie-Ge-Cr);专利奖GE-CR&D:青铜,银和金申请奖章。他还担任5个国际期刊的编辑委员会成员。
书籍标题:第四版电子材料和设备原理,本教科书提供了与当今工程师相关的电子材料属性的广泛覆盖。它符合固态物理和设备以及基本电子课程的课程要求。这本书通过了新主题,例如微电子学的扩散和互连,其中包括许多工作的例子,家庭作业问题和插图。第四版专为学习电气工程,材料科学和物理学的本科生而设计。它具有改进严格的修订,而不会损害原始方法。这本书包括一个带有颜色高架透明度图的CD-ROM,可以打印。Key Features: - Broad coverage of electronic materials properties - Meets course requirements for solid state physics and devices - Includes new topics such as diffusion and interconnects in microelectronics - Numerous worked examples, homework problems, and illustrations Edition Information: - 4th Edition (2018) - ISBN10: 0078028183 - ISBN13: 9780078028182 This textbook caters to电气工程和工程物理专业的学生,通过关注电子和光电设备,为材料科学提供全面的介绍。该内容旨在适合一个学期和两学期课程,提供了对一般材料科学教科书经常忽略的相关主题的深入探索。更新以反映当前知识,该书的应用程序对电子,材料科学和工程物理学的学生具有特殊的意义。第二版的解决方案手册可在各种平台上获得,包括发布者的网站和作者的网站。这本书是电气工程师和工程物理专业学生的材料科学的合适第一课程。
This report benefitted from the reviews and comments of numerous experts, including: Dennis Volk (Bundesnetzagentur - BNetzA), Marek Harsdorff (International Labour Organization - ILO), Sven Teske (Institute for Sustainable Futures, University of Technology Sydney – UTS), Evelina Trutnevyte (University of Geneva – UNIGE), Fabian Kreuzer (European Commission Directorate-General for Energy – DG ENER), Michael Paunescu (Natural Resources Canada – NRCan), Thiago Barral Ferreira, Giovani Vitória Machado and Gustavo Naciff de Andrade (Energy Research Office, Brazil – EPE), Michele Panella (Energy Services Manager, Italy – GSE), Reshma Francy (Ministry of Energy and Infrastructure, United Arab Emirates – MOEI), Dalius Tarvydas(欧洲委员会联合研究中心),Angela Wilkinson和Anastasia Belostotskaya(世界能源委员会),Kenta Kitamura(日本经济,贸易和工业部,日本 - METI),Alex Santander Guerra和Alex Santander Guerra和Carlos Toro Ortiz(能源,Chile),Kaare Sandholter,Chile Sandholter,CENARE RENERER,CERENER,CERENRED SANDHOLTER,CERENSRABE (荷兰环境评估局 - PBL),尼尔斯·比斯加德·佩德森(Niels Bisgaard Pedersen)(丹麦能源局 - DEA),Tiina Koljonen(Finland Ltd -VTT技术研究中心 - VTT),Abdullah Shehri,Abdullah Shehri(Saudi Arabia -Meim)和VARG VAN Steenberium Seciath(Saudi Arabia)和Federnber Secions(Saudi Arabia)和Federnber Secions and Face and Face and Face and Face and Face Chait,Food Chane,Food Chait,Food Chanch。
在过去的十年中,“智慧城市”一词与以技术为中心的城市环境构想紧密相关。作为这些想象中的期货的一部分,支持者认为,数据构建,算法分析,声誉系统和数字平台可以将城市基础结构转变为个性化服务,增强便利性和效率。口号,例如“城市作为服务”或“城市按需”(Hwang,2008; Klassen and Buske,2018年)是促进这种愿景的修辞手段。在Clues的开创性工作(1997年)之后,我们可以将这些口号视为“生成隐喻。”生成的隐喻不仅是描述性的;它们塑造了围绕其描述并影响其发展的疾病。实际上,生成的隐喻可以主导社会如何感知现象,从而导致与隐喻不符的方面被边缘化或忽略。因此,Wakkary(2021)强调了参与批判性技术实践的进口,该技术实践会消除和解构我们社会中主导的生成隐喻。通过此过程,批评者可以引入替代方案,这些替代方案专注于边缘化问题和关注,并开发新的技术,方法和优先级。In recent years, including within this journal, numerous authors have applied critical technical practice to the dis- courses of the Smart City (e.g., Ashton et al., 2017; Brevini and Pasquale, 2020; Foth et al., 2015; Kitchen, 2014a, 2014b, 2014c; Lake, 2017; Pasquale, 2015; Rijshouwer et al., 2022; Smith, 2020; Zook, 2017)。在这项工作的基础上,我们建议“城市作为许可证”作为该城市作为服务的替代生成隐喻。通过此镜头,我们将智能城市平台不作为消费者服务提供商,而是
5。河巴罗河和诺尔河SAC 002162-该地点由巴罗和诺尔河流集水集的淡水延伸到Slieve Bloom Mountains的上游,它还包括潮汐元素和河口,与沃特福德(Waterford)的Creadun Head一起。它发生在包括基尔代尔在内的八个县。Its designation as an SAC is based on numerous qualifying interests including habitats and species as follows: Estuaries [1130], Mudflats and sandflats not covered by seawater at low tide [1140], Reefs [1170], Salicornia and other annuals colonising mud and sand [1310], Atlantic salt meadows (Glauco-Puccinellietalia maritimae) [1330],地中海盐草甸(Juncetalia maritimi)[1410],水平的水平至山地水平,与ranunculion fluitantis和callitricho-batrachion植被[3260],欧洲干heaths,欧洲干heaths [4030],含水型植物和pet的petrifie selltifie the Mortifie selltifie and Montifie tiut [64330] formation (Cratoneurion) [7220], Old sessile oak woods with Ilex and Blechnum in the British Isles [91A0], Alluvial forests with Alnus glutinosa and Fraxinus excelsior (Alno-Padion, Alnion incanae, Salicion albae) [91E0], Vertigo moulinsiana (Desmoulin's Whorl Snail) [1016],Margaritifera Margaritifera(淡水珍珠贻贝)[1029],Austropotamobius Pallipes(白斑点小龙虾)[1092],Petromyzon Marinus(Sea Lamprey)(Sea Lamprey)[1095] [1095] Alosa Fallax Fallax(Twaite Shad)[1103],Salmo Salar(Salmon)[1106],Lutra Lutra(Otter)[1355] [1355],Trichomanes Speciosum(Killarney Fern)[1421]和Margaritifera Durrovensis(Margaritifera Durrovensis)站点/默认/文件/保护端/概要/sy 002162.pdf)。