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参考文献Oseltamivir Zanamivir Peramivir Lanamivir组1 H5N1 V96A 116 RI(11-18)RI(10-63)Ni(4)? e sur(1,2)i97t 117 ri(19)re(12)? ? SUR(3)I117T F 117 Ni(1)Ni(1)Ni(1)Ni(1)Ni(1)SUR(4)I97V 117 Ni(5-9)Ni(5-9)Ni(2-4)? ? rg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zane sur(1,2)i97t 117 ri(19)re(12)? ? SUR(3)I117T F 117 Ni(1)Ni(1)Ni(1)Ni(1)Ni(1)SUR(4)I97V 117 Ni(5-9)Ni(5-9)Ni(2-4)? ? rg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan? SUR(3)I117T F 117 Ni(1)Ni(1)Ni(1)Ni(1)Ni(1)SUR(4)I97V 117 Ni(5-9)Ni(5-9)Ni(2-4)? ? rg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/ZanSUR(3)I117T F 117 Ni(1)Ni(1)Ni(1)Ni(1)Ni(1)SUR(4)I97V 117 Ni(5-9)Ni(5-9)Ni(2-4)? ? rg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan? rg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg; SUR(3,5,6)E99A 119 RI(10-35)HRI(51–1254)Ni(7)? rg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg(5,7)e99d 119 ri(87)HRI(132)HRI(1436)? RG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/ZanRG(7)E99G 119 Ni(3-6)HRI(438–1485)RE/HRI(12-164)? rg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg;体外/ZAN(7,8)Q116L 136 RI(26)HRI(350)? ? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan? in Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanin Vivo/Zan(9)V129a 149 Ni(4)Ni(8)? ? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan? SUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/ZanSUR(10)D179G 198 RE(32)RE(44)Ni(4)? rg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg;体外/ZAN(8)i203m 222 RI(36)Ni(1)Ni(1)? rg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg;体外/ZAN(8)i203v 222 ni(7)ni(1)ni(1)? rg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zanrg;体外/ZAN(8)S227N 246 RI(24)Ni(2)? ? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan? SUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/ZanSUR(1)S247N F 246 Ni(6)Ni(1)Ni(4)Ni(4)Ni(2)SUR(4)H255Y 274 RI/HRI(44–2502)Ni(1-3)ri/hri(23-533)ni(23-533)ni(6)sur;临床/OSE; rg;体外/Zan
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诸如量子计算之类的摘要新技术为满足社会需求提供了新的机会,但是社会参与对于确保公众信任至关重要。量子计算技术在他们从基础研究到部署的旅程中处于关键点,为社会创造了一个时刻,以调查,反映和咨询其含义。负责任的创新(RI)是一种考虑影响,满足社会需求,反映任何关注的方法,并影响了创新的轨迹。本文借鉴了嵌入在网络量子信息技术中心中的RI团队的经验工作。小组调查了研究人员对RI的看法及其对量子技术的社会影响的理解,并试图评估将RI嵌入RI中的挑战,例如英国量子计划等多学科大型企业。这项工作展示了嵌入RI方法以及在创新者和社会之间进行对话的一些困难。最后,作者向政策制定者,研究人员和工业组织提出了建议,以更好地实践负责任的量子计算,并确保与商业动机一起讨论社会考虑。将RI应用于此关键点上的量子计算对其他新兴技术的RI具有影响。
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K412T 432 Ni(9)RE(12)Ni(5)?sur;体外(57)T438i F 439 Ni(1-8)Ri /Hri(17-98)Ni /Ri(6 –23)?RG,SUR(58)T438N F 439 Ni(2)RI(12)Ni(2)Ni(2)Ni(2)SUR(49)I97V+I294V 117+314 RE(16)Ni(1)Ni(1)Ni(1)Ni(1)?SUR(47)E99A+H255Y 119+274 HRI(1530)RE(50)HRI(2686)? RG(5)E99D+H255Y 119+274 HRI(160)RI(65)HRI(1629)? RG(5)E99G+H255Y 119+274 HRI(801)RI(76)HRI(> 7692)? RG(5)i203L+ S27N 222+ 246 RI(14)Ni(1)Ni(5)? sur;体外(57)i203m+H255Y 222+274 HRI(8024)Ni(3)HRI(3340)? rg;体外/ZAN(43)i203v+H255Y 222+274 HRI(1925)Ni(2)HRI(2106)? rg;体外/AN(43)N295S+T438N F 294+439 HRI(51–74)HRI(76–86)HRI(73–90)REI(16–19)REI(16–19)Clin/Sur(49)Clin(49)K130N+I203L+I203L+I203L+S27)150+22+22+22+246 RI+S27+S27+S27+227+227+227+227+227+227)? ? SUR(46)A(H3N2)E119d 119 Ni(2)RI(32)Ni(2)? RG(59)E119I 119 HRI(208)RE(17)Ni(3)? 临床/OSE;体外(60)SUR(47)E99A+H255Y 119+274 HRI(1530)RE(50)HRI(2686)?RG(5)E99D+H255Y 119+274 HRI(160)RI(65)HRI(1629)?RG(5)E99G+H255Y 119+274 HRI(801)RI(76)HRI(> 7692)?RG(5)i203L+ S27N 222+ 246 RI(14)Ni(1)Ni(5)?sur;体外(57)i203m+H255Y 222+274 HRI(8024)Ni(3)HRI(3340)?rg;体外/ZAN(43)i203v+H255Y 222+274 HRI(1925)Ni(2)HRI(2106)?rg;体外/AN(43)N295S+T438N F 294+439 HRI(51–74)HRI(76–86)HRI(73–90)REI(16–19)REI(16–19)Clin/Sur(49)Clin(49)K130N+I203L+I203L+I203L+S27)150+22+22+22+246 RI+S27+S27+S27+227+227+227+227+227+227)??SUR(46)A(H3N2)E119d 119 Ni(2)RI(32)Ni(2)?RG(59)E119I 119 HRI(208)RE(17)Ni(3)? 临床/OSE;体外(60)RG(59)E119I 119 HRI(208)RE(17)Ni(3)?临床/OSE;体外(60)