The United States is locked in a long-term strategic competition with China to shape the rapidly evolving global technological land scape. Innovation in emerging technologies could transform society, create new industries, foster new dependencies, and alter the char acter of warfare. Whichever country secures a lead in key technol ogies—particularly those with first mover advantages—will tip the balance of power in its favor and reap economic benefits far into the 21st century. China under General Secretary of the Chinese Commu nist Party (CCP) Xi Jinping has recognized the potential advantages of seizing the innovation “high ground” in this competition and has aggressively designed, implemented, and funded programs to domi nate technologies of the future. In doing so, Beijing hopes its efforts will underpin national rejuvenation, making the country powerful, self-sufficient, and impervious to perceived technological “contain ment” from the United States and its allies and partners. China has focused on developing emerging technologies such as artificial intelligence (AI), quantum technologies, biotechnology, and battery energy storage systems. The United States has similarly realized the importance of technology competition with China and has sig nificantly altered the policy environment around key technologies, particularly semiconductors, advanced computing, and clean energy. China faces many challenges, including these U.S. policies, a falter ing domestic economy, and inefficiencies inherent in its state-direct ed innovation system. However, if China manages to overcome these challenges, its rapid technological progress threatens U.S. economic and military leadership and may erode deterrence and stability in the Pacific, as well as tip the global balance of power.
Summary of Evidence For asymptomatic individuals who receive prostate cancer screening utilizing prostate serum prostate specific antigen (PSA), the evidence includes 3 very large RCTs, each with at least a decade of median follow-up: the US-based Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, the European Randomized Study of Screening for Prostate Cancer (ERSPC), and the Cluster Randomized Trial PSA测试前列腺癌(CAP)。相关结果是总体生存,特定疾病的生存,临床管理决策变化以及测试准确性和有效性。RCT解决了PSA筛查对癌症检测阶段和疾病特异性生存率的影响,并评估了PSA测试的衍生物类型的相对敏感性和特异性。即使PSA测试被广泛使用,关于基于PSA的筛查是否降低了前列腺癌死亡率的问题仍然存在争议。此外,基于PSA的筛查与过度诊断和过度治疗的风险有关。和治疗并发症(尿失禁和勃起功能障碍)。确定该服务是否适合临床医生,应通过共同决策来考虑基于家族史,种族/民族和合并医疗状况的利益和危害的平衡。证据不足以确定技术可以改善净健康结果。However, even though there is paucity in the scientific evidence regarding prostate cancer screening utilizing PSA testing in preventing morbidity associated with advanced or metastatic prostate cancer this testing is widely considered to be in accordance to generally accepted standards of medical practice in the United States (see Practice Guidelines and Position Statements ), and in certain carefully-selected individuals PSA testing for prostate cancer screening will be considered medically necessary when the criteria below is遇见,请参阅政策。
凯恩戈尔斯国家公园管理局(Cairngorms National Park Authority)支持这一举动,以在评估新计划或项目的潜在影响或影响时,作为欧洲站点提供平等保护的欧洲地点。凯恩戈尔斯国家公园内的拉姆萨尔(Ramsar)站点是SSSI的特殊保护区和特殊保护区,因此不受拟议的变化影响。无论如何,我们都同意,对于整个苏格兰和英国的一致性,应将所有拉姆萨站点视为“栖息地站点”,目的是评估计划或项目的影响,这些计划或项目的影响可能对它们产生不利影响,并为他们提供与欧洲地点相同的重量,以使其与居住法规的目的相同。一种一致的方法将简化过程并更容易实现。这种方法消除了由Ramsar站点支撑的其他指定所产生的任何歧义。为Ramsar站点的自然特征开发特定的保护目标,将提供更大的清晰度,并且对利益相关者和公众都更容易理解。However, as per our previous response to the consultation on the strategic framework for biodiversity, the Park Authority considers designated sites, in their current format, risk being a significant barrier to the National Park being an exemplar of nature restoration and achieving the National Park Partnership Plan outcome for ‘...a biodiversity rich National Park with better functioning, better connected and more resilient ecosystems'.在审查指定系统时,希望看到一种方法,该方法将允许采用更移动和适应性的方法来保护生物多样性,从而可以在景观中进行必要的改变。
strands”在DNA折纸中,接吻环和RNA折纸中的其他连接器图案)。两种方法都已用于设计各种2D形状和3D结构(5,6)。大多数当前的3D折纸设计遵循在彼此顶部包装几层二维螺旋或螺旋束的方法,和/或弯曲的螺旋束如(7,8)中最初建议。3D设计的替代路径是创建一个线框结构,该结构仅包含3D模型的边界边缘和顶点。在这个方向上有几个值得注意的前虫前旅行(9,10),但是随着柔性且坚固的折纸技术的发展,它大多开始获得追随者(6,11)。与螺旋装箱相比,线框设计的一些优势包括使用链的经济,这允许建造较大的结构,并在低盐条件下更好地折叠。一些挑战是结构的刚性较低,尤其是对于大型的单螺旋边缘设计(可以通过使用多螺旋边缘来减轻,以增加链的使用来缓解)和大型复杂设计的产量低。已经存在几种核酸纳米结构设计工具(8、12、13、14、15、16、17、18、19、20、21)。Most of these however address helix-packing designs, with the more recent ones oriented towards wireframe structures including vHelix (14), DAEDALUS (15) and ATHENA (18) for 3D DNA wireframes, Sterna (20) for single-stranded 3D RNA wireframes and PyDAEDALUS (21) for 3D RNA/DNA hybrid wireframes.这些工具主要支持一种特定的设计方法,每个工具也都处于离线状态,需要一个单独的过程来安装工具及其辅助库,有时可能很难找到或在最坏的情况下弃用。
[PDF]南非公立高中系统E Becker-2024的因子关系统计映射本研究为南非公立高中的学习者进步开发了与因素相关的映射,特别关注西开普和豪登省。使用2019年一般家庭调查中的数据是……[PDF]组合数据的计算和学习,张Zhang-2025二十一世纪是一个数据驱动的时代,人类的活动和行为,身体现象,科学发现,技术进步,技术进步以及几乎在世界上发生在大规模发电,收集和chug bat baug bat baug batsigance by sangey becke bection by nagiention b by nakey becke n sharke Ingrogiant by的范围中的一切。 J Lindsey,J Wu… - Arxiv预印式Arxiv…,2025年的机械解释性旨在了解网络能力的计算机制,以实现具体的科学和工程目标。因此,该领域的进展有望提供更大的……[HTML]用于供应链风险预测和干预计划M Wyrembek,G Baryannis的因果机器学习 - Barytrup -barytrup-国际生产研究杂志,2025年,Devel学习模型在供应链管理中的最终目标是使链链管理中的最终目标成为最佳干预措施。我们的结果表明,农田增加了1%会导致…However, most machine learning models identify correlations in data rather than inferring causation, making it difficult … Quantifying the Water Quality Impacts of Cropland Farming in China: A Satellite Data Approach C Tang, Y Guo, L Feng - American Journal of Agricultural Economics, 2025 We compile a unique satellite ‐ derived panel dataset to investigate the impacts of cropland coverage on the outbreak of Harmful Algal Blooms (HABs) in 2003年至2019年之间的中国。
源文档的。 此类源归因042方法使用户可以检查输出的043可靠性(Asai等人。 ,2024)。 044 However, text-based generation with source attri- 045 bution faces several issues: First, citing the source 046 at the document level could impose a heavy cogni- 047 tive burden on users ( Foster , 1979 ; Sweller , 2011 ), 048 where users often struggle to locate the core ev- 049 idence at the section or passage level within the 050 dense and multi-page document. 尽管有051个粒度不匹配可以通过基于052通道引用的生成方法来解决 - 链接 - 053对特定文本块的答案,它需要非054个琐碎的额外工程工作,以匹配文档源中的块055。 此外,源文档中的视觉高-056照明文本块对用户的直观更加直观,但是它仍然具有挑战性,因为它需要控制文档渲染,这是059,它并不总是可以访问,例如PDF方案中。 060受到最新文档屏幕截图EM- 061床上用品检索范式的启发 - 放下文档 - 062 Ment Processing模块,直接使用VLM 063来保留内容完整性和编码Doc-064 UMent ument屏幕截图(Ma等人。 ,2024),065,我们询问源归因是否也可以在066中添加到如此统一的视觉范式中,以es- 067 tablish tablish tablish tablish a Tablish a Tablish a既是视觉,端到端可验证的RAG 068管道,既是用户友好且有效? 069为此,我们提出了通过VI Sual s usce a ttribution(Visa)的检索增加的070代。。此类源归因042方法使用户可以检查输出的043可靠性(Asai等人。,2024)。044 However, text-based generation with source attri- 045 bution faces several issues: First, citing the source 046 at the document level could impose a heavy cogni- 047 tive burden on users ( Foster , 1979 ; Sweller , 2011 ), 048 where users often struggle to locate the core ev- 049 idence at the section or passage level within the 050 dense and multi-page document.尽管有051个粒度不匹配可以通过基于052通道引用的生成方法来解决 - 链接 - 053对特定文本块的答案,它需要非054个琐碎的额外工程工作,以匹配文档源中的块055。此外,源文档中的视觉高-056照明文本块对用户的直观更加直观,但是它仍然具有挑战性,因为它需要控制文档渲染,这是059,它并不总是可以访问,例如PDF方案中。060受到最新文档屏幕截图EM- 061床上用品检索范式的启发 - 放下文档 - 062 Ment Processing模块,直接使用VLM 063来保留内容完整性和编码Doc-064 UMent ument屏幕截图(Ma等人。,2024),065,我们询问源归因是否也可以在066中添加到如此统一的视觉范式中,以es- 067 tablish tablish tablish tablish a Tablish a Tablish a既是视觉,端到端可验证的RAG 068管道,既是用户友好且有效?069为此,我们提出了通过VI Sual s usce a ttribution(Visa)的检索增加的070代。071在我们的方法中,大型视觉模型072(VLM)处理单个或多个检索的文档图像,不仅为074产生了对074用户查询的答案,而且还返回了075框架内的相关区域内的相关区域。076如图1所示,此方法通过视觉上指示文档中的确切078位置来启用di-077 rect归因,从而允许用户在080原始上下文中快速检查生成答案的原始上下文中的支持证据。VLMS 081不受文档格式或渲染的限制,082
先兆子痫是妊娠20周后发生的一种高血压疾病,其特征是血压升高,蛋白尿和水肿。这是怀孕中担心的并发症之一,导致母亲和围产期的发病率和死亡率。However, in Kisumu County and western Kenya in general there is no recent publication on risk factors and prevalence of preeclampsia and its contribution to maternal and perinatal morbidity and mortality The objective of this study was to determine the characteristics and outcomes of women admitted with preeclampsia at Jaramogi Oginga Odinga Teaching and Referral Hospital in Kisumu County in Western Kenya.使用了目的的抽样技术,并包括在研究期内纳入诊断为前启示识别的妇女,而那些没有先兆子痫的妇女则被排除在外。数据收集是通过回顾性审查了80个文件的病历。记录是从医院记录部门的文件中获得的。使用涉及均值,频率和标准偏差计算的描述性统计数据分析了收集的数据。然后在饼图,表格和条形图中介绍了分析的数据,这些数据有助于解释。该研究的道德批准是从Jaramogi Oginga Odinga教学和转诊医院伦理审查委员会(Jootherc)获得的。这一发现表明,大多数女性31.25%的年龄低于24岁。其次,初学和奇偶校验占受试者的55%,而9%的比例超过4和36%,均等2至3。第三,有26%的妇女有慢性高血压史,11%的女性患有糖尿病患者。第四,80%的妇女怀孕了。第五,有77%的妇女在诊断时患有轻度的先兆子痫。第六名,51%的女性没有并发症,而对于那些复杂的患者,有24%的女性患有严重的先兆子痫,16%的人发展为子痫,5%发生急性肾衰竭,3%的肺水肿和1%的肺部肿瘤和1%的人屈服于先兆子痫的并发症。第七,围产期结局为16%,是15%的早产,呼吸窘迫的结果为
Drug discovery is an academical and commercial process of global importance. Accurate identification of drug-target interactions (DTIs) can significantly facilitate the drug discovery process. Compared to the costly, labor-intensive and time-consuming experimental methods, machine learning (ML) plays an ever-increasingly important role in effective, efficient and high-throughput identification of DTIs. However, upstream feature extraction methods require tremendous human resources and expert insights, which limits the application of ML approaches. Inspired by the unsupervised representation learning methods like Word2vec, we here proposed SPVec, a novel way to automatically represent raw data such as SMILES strings and protein sequences into continuous, information-rich and lower-dimensional vectors, so as to avoid the sparseness and bit collisions from the cumbersomely manually extracted features. Visualization of SPVec nicely illustrated that the similar compounds or proteins occupy similar vector space, which indicated that SPVec not only encodes compound substructures or protein sequences efficiently, but also implicitly reveals some important biophysical and biochemical patterns. Compared with manually-designed features like MACCS fingerprints and amino acid composition (AAC), SPVec showed better performance with several state-of-art machine learning classifiers such as Gradient Boosting Decision Tree, Random Forest and Deep Neural Network on BindingDB. The performance and robustness of SPVec were also confirmed on independent test sets obtained from DrugBank database. Also, based on the whole DrugBank dataset, we predicted the possibilities of all unlabeled DTIs, where two of the top five predicted novel DTIs were supported by external evidences. These results indicated that SPVec can provide an effective and efficient way to discover reliable DTIs, which would be beneficial for drug reprofiling.
[PDF]南非公立高中系统E Becker-2024的因子关系统计映射本研究为南非公立高中的学习者进步开发了与因素相关的映射,特别关注西开普和豪登省。使用2019年一般家庭调查中的数据是……[PDF]组合数据的计算和学习,张Zhang-2025二十一世纪是一个数据驱动的时代,人类的活动和行为,身体现象,科学发现,技术进步,技术进步以及几乎在世界上发生在大规模发电,收集和chug bat baug bat baug batsigance by sangey becke bection by nagiention b by nakey becke n sharke Ingrogiant by的范围中的一切。 J Lindsey,J Wu… - Arxiv预印式Arxiv…,2025年的机械解释性旨在了解网络能力的计算机制,以实现具体的科学和工程目标。因此,该领域的进展有望提供更大的……[HTML]用于供应链风险预测和干预计划M Wyrembek,G Baryannis的因果机器学习 - Barytrup -barytrup-国际生产研究杂志,2025年,Devel学习模型在供应链管理中的最终目标是使链链管理中的最终目标成为最佳干预措施。我们的结果表明,农田增加了1%会导致…However, most machine learning models identify correlations in data rather than inferring causation, making it difficult … Quantifying the Water Quality Impacts of Cropland Farming in China: A Satellite Data Approach C Tang, Y Guo, L Feng - American Journal of Agricultural Economics, 2025 We compile a unique satellite ‐ derived panel dataset to investigate the impacts of cropland coverage on the outbreak of Harmful Algal Blooms (HABs) in 2003年至2019年之间的中国。
森林生物多样性对于可持续发展很重要。涉及将森林分为三个区域的三合会森林管理方法:木材生产的密集管理,生物多样性保护以及对混合目标的广泛或多种利用,作为可行的选择,可通过促进可持续森林管理来增强森林生物多样性。尽管已经对三合会对森林生物多样性保护的适用性进行了广泛的测试,但其在发展中国家的应用仍然有限。这项研究从三合会管理的角度探讨了肯尼亚的当前森林生物多样性保护状态,以期推荐增强森林生物多样性保护和管理的策略,并在发展中国家的背景下对三合会管理的理解增加。案例研究设计设计和文档内容分析在这项定性研究中使用。来自十篇经过同行评审的文章和四个政策文件的结果表明,肯尼亚的公共森林是巨大的,并提供许多生态商品和服务。已经开始了几项国家和国际努力,以促进这些森林的可持续发展,包括通过“整个政府”和“整个社会”的方法,将该国的树木覆盖率提高到2032年。然而,由于栖息地破坏,人类野生动物冲突,气候变化,污染和入侵物种造成的威胁,物种种群正在下降。However, from the triad management perspective, even though the current multiple-use forestry approach was yielding some desirable ecological, social, and economic benefits for for- est biodiversity conservation, results show increasing coverage of key biodiversity areas and demarcation of crucial biodiversity hotspots in counties such as Nyandarua, Kilifi, Kwale, and Taita Taveta.解决这些威胁需要在长期可持续性计划中融合生态,社会和经济考虑因素的紧急,有针对性和整体方法,例如国家景观和生态系统修复计划2023 - 2032年,该计划试图恢复肯尼亚的降级景观。