XiaoMi-AI文件搜索系统
World File Search Systemhowever
On the Feasibility of CubeSats Application Sandboxing for Space Missions
Satellites, now numbering over 10,000 as of 2024 [43], have transitioned from extraordinary space achievements to common orbital fixtures, especially with the surge in small satellites like CubeSats and nanosatellites. This accessibil- ity has allowed diverse entities, including universities and startups, to engage in space projects. However, the ease of developing these smaller satellites often comes at the cost of security, making them prone to cyberattacks. Teams be- hind these projects may lack comprehensive cybersecurity knowledge, leading to significant vulnerabilities. Furthermore, the evolving nature of cybersecurity means satellite software can quickly become outdated, with updates in orbit posing a challenge, as noted in research like Willbold et al. [47]. Concurrently, there has been a significant evolution in satellite on-board computing, particularly in processing power. This advancement enables small satellites to run full operating systems like Linux, a shift from the basic systems in earlier models. This technological progress enhances satellite func- tionalities but also adds complexity and vulnerability, neces- sitating stronger security measures. As systems become more sophisticated, they are more susceptible to threats, requiring a layered defense approach. Sandboxing is one of the effective methods to isolate software vulnerabilities and protect these advanced systems. In this paper, we discuss the process of selecting a sandbox- ing mechanism for a satellite project currently under develop- ment, named RACCOON [41]. The project's goal is to design
NHS英格兰健康不平等信息责任
概述•减少健康不平等是我们作为ICB目的的核心。Intrinsic to this is having good quality data available by demographics to be able to assess, act on and monitor how inequalities are being reduced over time, and this duty provides a helpful framework to guide us in this.• We recognise, however, that this is the first year of this new duty and, as such, see this as the beginning of an approach that we would like to refine and build on in terms of how we detect and monitor health inequalities in NCL, and how we might report on these in future annual reports - through the exercise of reporting this data in 2023/24 there has been learning about how we might analyse and present the data in future, in addition to learning from the insights shown.•我们在这里发布了一份摘要报告，从我们对每个指标进行的分析中强调了关键发现。Behind the summary report sits a longer, more detailed data analysis which will used internally to inform how we use this data to drive action within NCL.•除了NHSE要求的数据外，ICB还收集，分析和使用一系列其他数据来解决健康不平等。This includes qualitative data from local communities, which is a vital part of understanding and addressing the needs of under-served populations.本摘要中报告的数据是我们健康不平等分析的一部分。
Cisco Meraki MR平台，具有软件版本30.6
安全策略。2。在加密模块中处理了所有用于会话机构的加密算法。3。所有基础加密算法都支持每个服务的密钥推导功能。根据密码模块验证程序（CMVP）（https://csrc.nist.gov/projects/cryptographic-module-validation-program/validated-模块）提供的指导，生成了这封信。通常，除非对本信中指出的加密模块进行了更改，否则不会为后续软件发行而生成一封信。由于CMVP审查过程的已知延迟，该临时字母将在完成的实验室评估和正式审查最终确定（https://csrc.nist.gov/projects/cryptographic-cryptographic-module-module-validation-validation-program/cmvp-flow）（https://csrc.gov/projects/cmvp-flow）之间。提交在“审查待定”或更高版本的里程碑中，将发布一封临时信件。在正式审核最终确定和证书发布后，该临时信将被标准合规性审查信替换。The ‘Review Pending' and later milestones mean that NIST has received both a complete set of testing documents and a signed recommendation letter for validation from an accredited laboratory, however, CMVP review has not completed ( https://csrc.nist.gov/Projects/cryptographic-module-validation-program/modules-in-process ).预计该POA＆M将用于促进该模块的正式列表以及随后更新授权软件包的内容。这封信还旨在充当授权包人工制品，可以增强行动计划和里程碑计划（POA＆M），类似于Fedramp计划管理办公室（PMO）提供的指导（https://wwwww.fedramp.gov/blog/202222-22-22-22-22-crypto-modules-historical-nistor-sistors-sistasuss/）。CMVP尚未独立审查此分析，测试或结果。
lineZolid负载的纳米颗粒用于局部糖尿病脚治疗：配方，体外和离体表征
这项研究的目的是制定含纳米颗粒的局部凝胶，用于糖尿病足溃疡（DFU）。在这方面，使用自发乳化技术制备纳米颗粒制剂。lineZolid（LZD）负载的纳米颗粒配方表现出较低的平均颗粒尺寸（PS）为195.27±5.42 nm，低散射指数（PI）为0.214±0.019，高Zeta势率（ZP）高Zeta电位（ZP），为20.57±0.35 mV和高毒药效率（99.09）。为了提高局部停留时间，使用甲基TM K4M（HPMC）和Carbopol®974P NF将LZD负载的纳米颗粒分散在凝胶配方中。配制的凝胶表现出有利的特性，包括适当的pH值，适当的机械性能以及理想的粘度和局部应用的可传播性。所有配方均显示了指定频率值的假塑性流和典型的凝胶型机械光谱。Moreover, the developed formulation achieved sustained drug release as intended for these systems.During ex vivo drug diffusion studies, 0.007±0.004% of LZD was found in receptor phase, indicating a local effect.The optimum formulation was stable for six months.最初的发现表明，配制的含有LZD的纳米颗粒的局部凝胶具有有效的DFU管理药物输送系统。However, further comprehensive investigations are required to substantiate this hypothesis.
Oscillator without equilibrium and linear terms - IRIS
tors, vice versa, conservative chaotic oscillators do not loss energy over time. Their orbits appear on the surface exhibiting constant en- ergy in phase space. Despite their chaotic nature, the orbits of these oscillators remain within conserved boundaries. Recently, there are peculiar chaotic oscillators that do not precisely fit within conserva- tive or dissipative categories. This kind of high complicated oscillators can interact with both. It operates according to principles of conser- vation and dissipation of energy, or defies traditional classification. Their behavior is particularly fascinating and provides insight into the diversity of chaos in different environments. Conservative and dissi- pative chaotic oscillators are structurally stable. However, the initial conditions fall within the chaotic basin or not, the orbits of such os- cillators whether chaotic or not are bounded. On the other hand, the behavior of a peculiar chaotic may change suddenly. Depending on its conditions, it can respond with either bounded or unbounded oscilla- tion. Therefore, designing and studying such peculiar oscillators is a very hard task. For example, having a positive, zero and negative Lya- punov exponents of three dimensional autonomous chaotic oscillator with unstable equilibrium points, the boundedness of its orbits under all possible initial conditions does not necessarily guarantee. Consequently, the basin of attraction is an essential tool that should be used to recog- nize the chaotic and other dynamics, particularly, for peculiar chaotic dynamics.
car damage detection using machine learning
Siruganur ,Trichy Abstract – Modern car insurance industries waste a lot of resources due to claim leakages, which determines the amount they pay. Currently,visual Inspections and Validations are done manually,which can delay the claim processes.Previous study have shown that classifying images is possible with a small data set,by transferring and re purposing knowledge from models trained for a different task. Our goal is to build a Car Damage classifier using a deep learning model that is able to detect the different damage types and give an accurate depiction given a car image. However, due to the limiting set of data, it can be result in being a determining factor.Training a Convolutional Network from scratch (with random initialization) is difficult because it is relatively rare to have a large enough dataset.In this project we explore the problem of classifying images containing damaged cars to try and assess the monetary value of the damage. Because of the nature of this problem,classifying this data may prove to be a difficult task since no standardized dataset exists and some of the clases utilized might not be discriminative enough. Utilizing a pretrained YOLOv8 model,we trained a classifier in order to categorize the dataset,testing 3 different cases: damaged or not (damage vs whole),damage location (front vs rear vs side),damage level (minor vs moderate vs severe). Index Terms - YOLO model,CNN
Genetics and beyond
Abstract: Advances in molecular tumor diagnostics have transformed cancer care. However, it remains unclear whether precision oncology has the same impact and transformative nature across all malignancies. We conducted a retrospective analysis of patients with human papillomavirus (HPV)-related gynecologic malignancies who underwent comprehensive molecular profiling and subsequent discussion at the interdisciplinary Molecular Tumor Board (MTB) of the University Hospital, LMU Munich, between 11/2017 and 06/2022. We identified a total cohort of 31 patients diagnosed with cervical (CC), vaginal or vulvar cancer. Twenty-two patients (fraction: 0.71) harbored at least one mutation. Fifteen patients (0.48) had an actionable mutation and fourteen (0.45) received a recommendation for a targeted treatment within the MTB. One CC patient received a biomarker- guided treatment recommended by the MTB and achieved stable disease on the mTOR inhibitor temsirolimus for eight months. Factors leading to non-adherence to MTB recommendations in other patient cases included informed patient refusal, rapid deterioration, stable disease, or use of alternative targeted but biomarker-agnostic treatments such as antibody–drug conjugates or checkpoint inhibitors. Despite a remarkable rate of actionable mutations in HPV-related gynecologic malignancies at our institution, immediate implementation of biomarker-guided targeted treatment recommendations remained low, and access to targeted treatment options after MTB discussion remained a major challenge.
egfr- ...
在过去的15年中，随着突变的发现以及新的靶向疗法和免疫检查点抑制剂的发展，非小细胞肺癌（NSCLC）治疗发生了变化。表皮生长因子受体（EGFR）是NSCLC中的第一个突变，该突变在2013年获得了FDA批准的药物。osimertinib是第三代酪氨酸激酶抑制剂，被批准为晚期NSCLC的第一线治疗，并在切除的IB-IIIA阶段的辅助设置中被批准。However, resistance to osimertinib is inevitably an issue, and thus patterns of resistance to EGFR -mutated NSCLC have been studied, including MET ampli fi cation, EGFR C797X-acquired mutation, human epidermal growth factor 2 (HER2) ampli fi cation, and transformation to small cell and squamous cell lung cancer.EGFR TKI进展后，EGFR渗透的NSCLC的当前管理目前受到化学疗法和放射疗法的限制，有时与Osimertinib的持续结合在一起。抗体 - 药物缀合物（ADC）由与细胞毒性药物相关的单克隆抗体组成，并且是NSCLC中越来越流行的药物类别。Trastuzumab Deruxtecan在HER2-Mutated NSCLC中获得了加速FDA的批准。ADC提供了一种可能的解决方案，以找到可以绕过细胞内电阻机制的新处理。在这篇评论文章中，我们总结了ADC和ADC的机制和EGFR被渗透的NSCLC的机制，其中包括满足放大的目标，HER3，Trop2和EGFR，以及其他ADC目标，以及其他在NSCLC中进行调查的ADC目标，并讨论了未来与ADC的方向。
靶向缺氧的设计，合成和评估...
在软骨肉瘤（CHS）中的肿瘤微环境，化学抗性和耐药性癌症为开发软骨肉瘤的靶向药物递送系统提供了独特的标志。可以使用第四纪铵功能（QA）作为Aggrecan的配体，CHS的细胞外基质的主要高负电荷蛋白聚糖和2-硝基胺作为触发，可以实现肿瘤的靶向。在先前的工作中，ICF05016被确定为在小鼠中人类外部骨骼外肌瘤软骨模型中的有效蛋白聚糖靶向缺氧的前药，并且对QA功能的结构活性关系和烷基接头的长度进行了首次研究。在这里，我们报告了研究的第二部分，即硝化芳香族触发的修饰以及蛋白聚糖靶向配体在芳香环上的位置以及烷基化芥末的性质。合成方法，以用终末三级烷基胺在N -1和C -4位置在2-硝基咪唑环中官能化，并通过使用氨基硼烷复合物进行磷酸化步骤，从而导致磷酸酰胺和异磷酸酰胺酰胺芥末和磷酸固定型磷酸盐均必须磷酸盐。在使用还原化学激活的初步研究中，除4-硝基苯基外，QA偶联物被证明随着相应芥末的释放而进行有效的裂解。However N,N,N -trimethylpropylamimium tethered to the N -1 or C -4 positions of the imidazole seemed to hamper the enzymatic reduction of the prodrugs and all tested compounds featured moderate selectivity toward hypoxic cells, likely not sufficient for application as hypoxia-activated prodrugs.
布朗尼水合水中的解密密度波动
水对于地球上的所有生命都是必不可少的，是最常见的液体。However, its behaviour is unique exhibiting a range of anomalous properties, including increased density upon melting, a density maximum at 277 K (4 °C), reduced viscosity under pressure at below 306 K (33 °C), high surface tension, and decreased isothermal compressibility and heat capacity with the temperature at ambient conditions, with minimum values at 319 K (46 °C) and 308 K (35 °C), 分别。[1]已经提出了在热平衡上竞争的两个竞争氢键组织的假设来解释这种行为。[2]这两个组织表现为两个阶段，即高加密液体（LDL）和高密度液体（HDL），在超冷方案中。[3]然而，尽管在水中出现了最近可能的伪相图，但在环境条件下，这两个不同的结构组织的存在及其含义仍然难以捉摸和有争议。[2]在这里，我们展示了NAYF 4：YB/ER上转换纳米粒子（UCNPS）的实验测量如何通过在水平条件下通过上转化的液化液体测量法分散在水中的某些假设。该方法可以使用不同尺寸的UCNP评估液体水中LDL基序的尺寸分布，从而通过简单地改变水性悬浮液的pH来模仿压力对氢键网络的影响，从而在环境条件下工作的好处。[4]这种实验方法提供了一种新的方法来研究水的两态模型，并通过检查环境条件对UCNP的运动的影响，例如不同的pH值和溶剂，从而更深入地了解液态水中氢键的组织。