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市政当局将按照宪法规定（MPOFU＆HLATYWAWAYO 2020; ZWENI; ZWENI，YAN＆UYS 2022）公平，透明，竞争和成本效益开发和实施供应链管理（SCM）系统。供应链管理可能被认为是处理产品的整个生产过程，以最大程度地提高客户体验，质量交付和盈利能力（Hugo，Badenhorst-Weiss＆van Biljon 2021）。它促进了产品，资金和信息的平稳流动，从原材料的采购到将最终产品交付给客户或市场（Qrunfleh＆Tarafdar 2014）。However, the public sector SCM system in South Africa is complex because it involves numerous factors such as several relevant pieces of legislation, numerous stakeholders, different SCM standards, its applicability to public sector organisations that perform various roles, e.g., government departments, state-owned enterprises and municipalities and the scarcity of SCM skills in the country, among others (Ambe & Badenhorst-Weiss 2020; Van der Waldt & Fourie 2022）。这种复杂性会阻碍服务交付，从而为满足各种利益相关者的需求和要求做出不利的贡献。
Understanding Consumer Preferences for Movie Trailers from EEG using Machine Learning
Abstract —Neuromarketing aims to understand consumer be- havior using neuroscience. Brain imaging tools such as EEG have been used to better understand consumer behavior that goes beyond self-report measures which can be a more accurate measure to understand how and why consumers prefer choosing one product over another. Previous studies have shown that consumer preferences can be effectively predicted by under- standing changes in evoked responses as captured by EEG. However, understanding ordered preference of choices was not studied earlier. In this study, we try to decipher the evoked responses using EEG while participants were presented with naturalistic stimuli i.e. movie trailers. Using Machine Learning techniques to mine the patterns in EEG signals, we predicted the movie rating with more than above-chance, 72% accuracy. Our research shows that neural correlates can be an effective predictor of consumer choices and can significantly enhance our understanding of consumer behavior. Index Terms —Neuromarketing, EEG, Machine Learning, Dis- crete Wavelet Decomposition
在过渡经济中重新检查外国子公司生存：市场身份重叠和冲突的影响
由于跨国公司的国际扩张（MNC），外国子公司生存的决定因素长期以来一直是国际商业研究中的核心问题。 However, apart from the context of international joint venture (JV) studies ( Mohr et al., 2016 ), little attention has been paid to the potential influence of do mestic firms on foreign subsidiary survival ( Chang & Xu, 2008 ; Li, 2008 ). 有限的先前研究大多从竞争的角度开始对国内企业的影响。 较早的研究人员认为，国内公司的密度越高，外国公司的进入率越低（Li，2008年），其绩效越贫困（Miller＆Eden，2006年），尤其是在发达经济体中。 后来的学者扩展了这一研究，以检查国内企业的异质基因，尤其是其在过渡经济中的所有权类型。 随着经济体系从计划中的市场经济转移到市场经济，主要的国有企业（SOES）和新兴新兴的私有企业（POES）共处（Luo等，2019; Steensma＆Lyles，2000; Xu等人，2014; Yun等，202222222）。 SOES和POES在过渡经济中往往具有不同的资源赋予市场和市场壁ni（Chang＆Xu，2008）。 Chang和Xu（2008）发现，改革的当地po比传统的当地公司（包括国有企业）更有可能挤出外国参赛者由于跨国公司的国际扩张（MNC），外国子公司生存的决定因素长期以来一直是国际商业研究中的核心问题。However, apart from the context of international joint venture (JV) studies ( Mohr et al., 2016 ), little attention has been paid to the potential influence of do mestic firms on foreign subsidiary survival ( Chang & Xu, 2008 ; Li, 2008 ).有限的先前研究大多从竞争的角度开始对国内企业的影响。较早的研究人员认为，国内公司的密度越高，外国公司的进入率越低（Li，2008年），其绩效越贫困（Miller＆Eden，2006年），尤其是在发达经济体中。后来的学者扩展了这一研究，以检查国内企业的异质基因，尤其是其在过渡经济中的所有权类型。随着经济体系从计划中的市场经济转移到市场经济，主要的国有企业（SOES）和新兴新兴的私有企业（POES）共处（Luo等，2019; Steensma＆Lyles，2000; Xu等人，2014; Yun等，202222222）。SOES和POES在过渡经济中往往具有不同的资源赋予市场和市场壁ni（Chang＆Xu，2008）。Chang和Xu（2008）发现，改革的当地po比传统的当地公司（包括国有企业）更有可能挤出外国参赛者
Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023
ycoplasma pneumoniae is a common etiologic agent of community-acquired pneumonia (CAP) among children. Although M. pneumoniae infection often causes a mild and self-limiting dis- ease, pneumonia develops in ≈ 10%–20% of pediatric patients ( 1 ). First-line therapies for M. pneumoniae infection are based on macrolides, a group of anti- microbial drugs widely used in outpatient settings because of their high oral bioavailability. However, overuse and indiscriminate use of macrolides have contributed to the emergence of macrolide-resistant M. pneumoniae (MRMP). Point mutations in the V region of the M. pneumoniae 23S rRNA gene have been associated with macrolide resistance ( 2 ). In recent years, prevalence of MRMP has increased and is very high in Asia (13.6%–100%) ( 2 – 4 ). Dur- ing spring/summer 2023, hundreds of children with CAP were admitted daily to each of the major hospi- tals in Hanoi, Vietnam. M. pneumoniae has emerged as the major pathogen detected in approximately one third of patients with CAP (5). We analyzed the mutations in the 23S rRNA gene of M. pneumoniae isolated from nasopharyngeal samples of pediatric CAP patients during the 2023 outbreak in Vinmec Times City Hospital, Hanoi.
CAR -T细胞在多发性骨髓瘤治疗中
多发性骨髓瘤（MM）是浆细胞的恶性疾病，约占所有血液恶性肿瘤的10％，其特征是骨髓中恶性血浆细胞的克隆增殖。许多治疗策略，包括蛋白酶体抑制剂，免疫调节剂，针对CD38的单克隆抗体和自体干细胞移植，已延长了MM患者的中位存活率。然而，几乎所有MM患者都因耐药性而遭受疾病复发，并最终死于MM或与MM相关的并发症。嵌合抗原受体（CAR）T细胞治疗是MM的一种新型免疫疗法策略，在几项临床试验中表现出令人鼓舞的结果。However, the use of CAR T-cell therapy for the treatment of MM is still associated with several dif fi culties, including antigen escape, poor persistence, an immunosuppressive microenvironment, cytokine release syndrome, immune effector cell- associated neurotoxicity syndrome, CAR T-cell-associated encephalopathy syndrome, cytopenia, and infections.在这篇综述中，我们详细描述了MM中CAR T细胞的靶抗原。我们还全面讨论了CAR T细胞开发的最新创新，以改善临床效率和策略，以克服MM中CAR T细胞治疗的局限性。
思科ISE（身份服务引擎）v3.3
安全策略。2。在加密模块中处理了所有用于会话机构的加密算法。3。所有基础加密算法都支持每个服务的密钥推导功能。根据密码模块验证程序（CMVP）（https://csrc.nist.gov/projects/cryptographic-module-validation-program/validated-模块）提供的指导，生成了这封信。通常，除非对本信中指出的加密模块进行了更改，否则不会为后续软件发行而生成一封信。由于CMVP审查过程的已知延迟，该临时字母将在完成的实验室评估和正式审查最终确定（https://csrc.nist.gov/projects/cryptographic-cryptographic-module-module-validation-validation-program/cmvp-flow）（https://csrc.gov/projects/cmvp-flow）之间。提交在“审查待定”或更高版本的里程碑中，将发布一封临时信件。在正式审核最终确定和证书发布后，该临时信将被标准合规性审查信替换。The ‘Review Pending' and later milestones mean that NIST has received both a complete set of testing documents and a signed recommendation letter for validation from an accredited laboratory, however, CMVP review has not completed ( https://csrc.nist.gov/Projects/cryptographic-module-validation-program/modules-in-process ).
Journal of Cleaner Production - BCU Open Access Repository
The textile and clothing industry is a significant global sector due to its economic and social contributions. However, it is one of the most polluting industries. There has been a significant uptake of research on circular economy implementation to reduce its environmental impacts. Nevertheless, there is a critical gap in reviewing how the research field is evolving and what the core focus and underlying assumptions of the existing research are. This paper utilises bibliometrics, content analysis, and problematisation to comprehensively examine the state of research. Analysing 132 primary documents dating from January 2014 to April 2023, this study reveals that sustainability-oriented innovation and transition challenges are the core focus of existing research. Technology-oriented circularity and its positive impact on sustainability is the in-house assumption that almost all studies are founded on. Besides unpacking the risk of such assumptions, this study provides tangible sug gestions for future research on circular economy disruption, its rebound effect, and sustainability-oriented innovation. Although the time lag and language biases may have impacted the representation of current research trends, findings from this study can facilitate academic research and industry practice in implementing circular economy practices for a more sustainable future.
顺式基因改造和基因组编辑用于葡萄栽培遗传改良：来自 CREA 和 Copagri 的生物技术项目成果
"The history of Biotech began in 2015, when we started talking about new technologies for agriculture, followed in 2016 by a shelving of the Parliament for this project, which started in 2018 and will end at the end of this year. Biodiversity is important, especially for those who work in biotechnology. Biodiversity is important and there are many useful forms, but it is not enough. In the past, biodiversity has been exploited, which gives rise to important mutations, such as the example of the nectarine, without hairs. Sometimes, however, nature is not enough to achieve the objectives we seek, such as resistance to parasites, capable of overcoming the limit of natural biodiversity for example against powdery mildew. A more resistant mutation for durum wheat, in which a gene from the soft variety was implanted, to have a greater yield and resistance. So specific mutations make the difference. This is where Biotech comes into play, latest-generation biotechnologies capable of generating mutations in specific points of the genome or of transferring genes between plants, applying genome editing and cisgenesis.基因组编辑是对特定碱基进行高精度突变，从而改变目标物种的基因。没有“外部”基因，而是编辑已经存在的基因。这意味着事后没有人能够证实生物多样性方面的差异。
病例报告 - ABC心血管图像
有两种不同形式的attr：遗传性，是由致病性突变引起的，这些突变破坏了蛋白质的稳定性，并获得了，也被称为野生型（WTATTR），这是由于WTATTR蛋白的积累而引起的。3关于ATTR的临床表现，在世袭类型的情况下，它们取决于所涉及的遗传变异体，并可能导致心脏和外部受累，包括感觉运动神经病，自主神经病，胃肠道史诗等。在WTATTR的情况下，心脏受累是主要的表现，其特征是心力衰竭，传导障碍和心律不齐。4心脏淀粉样变性诊断的黄金标准是刚果红色组织的极化光显微镜中的苹果绿色双折射的证明。5 However, confirmatory biopsy is no longer necessary for a diagnosis when the following criteria are met: heart failure with an echocardiogram or cardiac magnetic resonance imaging consistent with amyloidosis, a grade 2 or 3 uptake on radionuclide scintigraphy with 99m-Technetium- labeled 3,3- diphosphono - 1 , 2-propanodicarboxylic acid or pyrophosphate （PYP），并且没有可检测到的单克隆性颅脑病。6目前有新的疾病 - 可用于遗传和获得的attr的治疗选择。在可用的药物中有选择性的TTR稳定剂，例如tafamidis和遗传消音器，例如Inotersen或patisiran，它们在疾病早期阶段提供了最重要的好处。7
fyi -105总收入和补偿税 - 概述
简介本出版物包括总收入和补偿税的描述；每项税收可用的豁免，扣除和信用；如何以及何时报告和缴税；税收和税收部（部门）发出的帐户通知；最后，纳税人对常见问题的回答。此信息是总收入和补偿税法的一般说明，并作为对纳税人的服务提供。因为这些说明旨在提供一般指导，并且没有解决所有特定情况，因此它们对部门没有约束力。如果您对自己的情况有任何疑问，请联系该部门的当地地区税务办公室之一，税收呼叫中心或圣达菲总部。本出版物中的法定引用是针对注释的新墨西哥州法规（NMSA 1978）。总收入和补偿税法汇编为7-9-1至7-9-121 NMSA 1978年。2021年7月1日之前，该部门使用了“ CRS”合并报告系统。使用表格CRS-1您可以报告以下一项或多项税。However, going forward these taxes will need to be filed on different forms, see below: TRD-41413 - Gross Receipts Tax (includes municipal and county taxes) TRD-41412 - Compensating Tax (for more information request FYI-230, Compensating Tax from your local district tax office or view it online at https://www.tax.newmexico.gov/forms-publications/预扣税*分为两个不同的计划