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疲劳试验控制器的组成部分
Components of Fatigue Test Controller Manjula B K EEE Department BMSIT&M Abstract: This paper describes about the development of computer controlled single channel controller used in servo hydraulic test system for fatigue testing of materials. The closed loop control obtained with load cell and LVDT which provides an electrical signal to the controller proportional to the mechanical position of the actuator or load exerted by it. The electrical signal is passed through signal conditioning circuitry for amplification of the signal which is fed to the servo-controller to generate an error signal. The feedback mode whether in stroke (LVDT) or Load mode is compared with respective set points using a differential amplifier. Add -on boards of digital to analog converter is used to convert the set-points which are in digital form to analog value. The operations of the controller are displayed on the console of the computer. Keywords: Fatigue test, Controller DAC,ADC, Load mode and stroke mode 1. Introduction Fatigue testing is critical requirement of aircraft to determine the life span of the aircraft. A fatigue test helps determine a material's ability to withstand cyclic fatigue loading conditions. By design, a material is selected to meet or exceed service loads that are anticipated in fatigue testing applications. Cyclic fatigue tests produce repeated loading and unloading in tension, compression, bending, torsion or combinations of these stresses. Fatigue tests are commonly loaded in tension – tension, compression – compression and tension into compression and reverse. To perform a fatigue test a sample is loaded into a fatigue tester or fatigue test machine and loaded using the pre- determined test stress, then unloaded to either zero load or an opposite load[1]. This cycle of loading and unloading is then repeated until the end of the test is reached. The test may be run to a pre-determined number of cycles or until the sample has failed depending on the parameters of the test[2]. The purpose of a fatigue test usually is to determine the lifespan that may be expected from a material subjected to cyclic loading, however fatigue strength and crack resistance are commonly sought values as well. The fatigue life of a material is the total number of cycles that a material can be subjected to under a single loading scheme. A fatigue test is also used for the determination of the maximum load that a sample can withstand for a specified number of cycles. All of these characteristics are extremely important in any industry where a material is subject to fluctuating instead of constant forces. Types of fatigue tests: There are several common types of fatigue testing as well as two common forms: load controlled high cycle and strain controlled low cycle fatigue. A high cycle test tends to be associated with loads in the elastic regime and low cycle fatigue tests generally involve plastic deformations. Types of materials for fatigue tests Most of the materials may experience fatigue in one way or another during the lifespan of their application. However, in applications where fatigue is a factor it is common to find components made from metals or composites. These materials have a higher fatigue limit than others because of
Q2 2024季度报告
非IFRS会计标准（非IFR）和其他财务指标公司根据IFRS会计标准报告其财务业绩。However, certain indicators used by the Company to analyze and evaluate its results are non-IFRS or other financial measures and ratios, including: adjusted earnings before interest, taxes, depreciation, and amortization (EBITDA), adjusted net income, adjusted earnings per share (EPS), adjusted return on invested capital (ROIC), net debt to adjusted EBITDA, days sales outstanding (DSO), free cash flow, margin (percentage of净收入），有机增长（收集），收购增长，以恒定的货币为基础描述的措施以及外汇或货币波动的影响，复合年度增长率（CAGR），净债务，总资本管理，营运资金和流动比率以及使用这些非IFR或其他金融指标计算得出的措施和比率。这些措施被归类为非IFRS财务措施和比率，补充财务措施或资本管理措施，并在非IFR和其他财务指标和其他财务指标（定义）以及该MD＆A的流动性和资本资源部分的定义中进行了描述，并在不适用的情况下与非措施相提并论。 2024年财务重点，财务绩效，流动性和资本资源以及定义部分）。
明矾对埃努古州农村和城市地区的井水的微生物负载的影响Aneke Chinwe Jacinta 1*，Iloputaife Emmanuel Jaluchimike 1
摘要：使用1％，5％和10％浓度的明矾分析了十个井水样品，以开发细菌载荷，这些明矾被添加到每个100毫升的井水样品中，以确定明矾对enugu州农村和城市地区微生物水的微生物负荷的影响。对井水样品产生影响后，通过可行的细胞计数分析了上清液和沉积物以开发细菌菌落。It was observed that the effect of alum on bacterial load increases as the percentage concentration of the of alum increases, however, further increase in the concentration of alum has no effect on the bacterial load, and this can be observed in well water from Ufuma Achara layout, Agbani Nkanu, Ugbo Paul Abakpa, Ohofia Uwani and Amodu Awkunanaw.另一方面，从1％到5％的明矾浓度对Amaokwe Achara布局的上清液没有影响，但是随着浓度的增加约10％，它开始对上清液和沉积物的细菌负荷产生影响。关键字：明矾，效果，微生物负载，井水，农村地区，市区，上清液和沉积物。版权所有©2023作者：这是根据Creative Commons Attribution 4.0国际许可（CC BY-NC 4.0）分发的开放访问文章，允许在任何非商业用途的媒介中使用，不受限制地使用，分发和再现，以提供原始作者和源头。i ntroduction
Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release
window of the product, as illustrated by several studies. 2 – 12 In the ADC eld, site-speci c technologies of all types now domi- nate new ADCs entering into clinical trials. However, the recent work of ImmunoGen comparing homogenous and heteroge- nous ADCs that generate the same metabolites, suggests that site-speci c technologies may not always enhance the phar- macokinetics of the drug and may also detrimentally alter its toxicity pro le. 13 – 15 In fact, several criteria such as the nature of the payload, the linker, the conjugation chemistry, the drug- antibody ratio (DAR), the hydrophobicity of the ADC may have an impact on the in vivo properties of the conjugate, which are for the time being di ffi cult to predict. The large number of upcoming clinical studies of site-speci cally prepared ADCs may help clarifying if there is a single conjugation chemistry that will become of widespread use, or whether other methods will also be applicable. Therefore, developing various technol- ogies is of interest for further progress in the eld. Site-speci c conjugation to an antibody is challenging due to the large number of solvent-exposed nucleophilic amino acids, in particular lysines. Despite this di ffi culty, the eld has been very proli c through developing a wide array of technologies that can be summarized as engineered cysteines, disul de
相关的不同靶向疗法的影响
摘要。- 目的：这项研究的目的是系统地评估与辅助化疗相关的不同靶向疗法对三重结束乳腺癌（TNBC）患者临床缓解，生存和安全性的影响。材料和方法：本研究从2010年1月至2022年搜索了TNBC患者的病例对照试验。两个研究者独立提取的数据。Revman 5.3统计软件用于分析。结果：这项研究包括7项临床对照研究，其中包含620个样本。结果表明，与对照组相对，研究组显示客观反应率[OR = 2.44，95％CI（1.69，3.5），p <0.00001]，1年生存率[OR = 3.59，95％CI（2.01，6.39），P <0.0001]，Progressive-Free-Free Survier（PFFIRESS） (1.68, 2.41), p < 0.00001], with statistical significance ( p < 0.05), while there are no significant differ- ences in overall survival [MD = 6.33, 95% CI (-1.65, 14.30), p = 0.12] and incidence of ad- verse events [OR = 0.73, 95% CI (0.52, 1.02), p = 0.006] ( p > 0.05）。结论：与辅助化疗相关的有针对性治疗可以重新提高晚期TNBC患者的预后，延长其无性生存（PFS）和总体存活率（OS）而不会增加不良效果。这项研究的有效性，However，将需要更高质量的研究和更长的随访。
正在进行的试验：一项1/2期研究，用于研究OBX-115工程肿瘤内渗透淋巴细胞（TIL）细胞治疗的安全性和功效
•ICI改善了黑色素瘤患者的治疗结果； however, most patients (~60%) do not achieve long-term survival • Lifileucel, a non-engineered tumor-derived autologous T-cell immunotherapy (tumor-infiltrating lymphocyte [TIL] cell therapy), was recently FDA- approved for anti–PD-1–experienced unresectable or metastatic melanoma 1 and has shown promising activity in this setting (ORR, 31.5%; mDOR NR), but is associated with a treatment-related mortality rate of 7.5% 2 • All non-engineered TIL cell therapies require high-dose interleukin 2 (IL2), which has well-described high-grade toxicity, 2–4 limiting patient eligibility and frequently requiring specialized management • OBX-115 TIL are engineered to express mbIL15 fused to a drug-responsive domain, which allows for a在存在FDA批准的稳定药物（乙酰唑胺[ACZ]）的情况下，功能性MBIL15水平的剂量依赖性增加，避免了对高剂量IL2的需求（图1）•在临床前研究中，在ACZ的存在下，ACZ的持久性替代了ACZ，在临床前研究中，cytotil15 tm tm til（obx-115）均表现出抗虫的持久性，并呈现出较高的持久性，持续效果均具有依赖的持续性，并呈现量。 IL2 5,6（图2）•当前研究（NCT06060613）使用集中制造（图3）
六对腿机构设计与分析
Abstract — Since the wheel was invented back in the Stone Age, it was the primary component used in all forms of mechanical transportation. Even today it is the component of choice for almost any type of moving machine like cars. However, the wheel has always had a major disadvantage with short instant elevation changes like stairs. For most uses, climbing stairs or steep jagged rock piles is not a problem which is why the wheel is still almost always used. For the other applications, people looked at animal and human legs which are already proven to work effectively on this type of terrain. The two most effective leg mechanisms are currently Joe Klann's mechanism which resembles a spider leg and Theo Jansen's mechanism which resembles a human leg. We have chosen Joe Klann mechanism which has more advantage than Jansen mechanism. The main objective of our paper is to replace the function of wheel with an alternative in order to overcome the difficulty of travelling in uneven terrain. This paper is useful in hazardous material handling, clearing minefields or secures an area without putting anyone at risk. Keywords – Joe Klann's Mechanism, Theo Jansen's Mechanism, Steep Jagged Rock piles, Material Handling.
harts：高阈值，适应性的安全和稳健的阈值schnorr签名
schnorr签名方案的阈值变体最近由于其在加密货币上的应用而处于关注的焦点。However, existing constructions for threshold Schnorr signatures among a set of n parties with corruption threshold t c suffer from at least one of the following drawbacks: (i) security only against static (i.e., non-adaptive) adversaries, (ii) cubic or higher communication cost to generate a single signature, (iii) strong synchrony assumptions on the network, or (iv) t c + 1 are sufficient to generate a签名，即该计划的腐败门槛等于其重建阈值。特别是（iv）对于许多异步现实世界应用而言，这是一个严重的限制，在这些应用中，需要t c Ruffing等人提出的最新计划，烤。 （ACM CCS 2022）地址（III）和（IV），但仍未获得亚皮的通信复杂性和自适应安全性。 在这项工作中，我们介绍了Harts，这是结合所有这些Desiderata的第一个阈值Schnorr签名方案。 更具体地：Ruffing等人提出的最新计划，烤。（ACM CCS 2022）地址（III）和（IV），但仍未获得亚皮的通信复杂性和自适应安全性。在这项工作中，我们介绍了Harts，这是结合所有这些Desiderata的第一个阈值Schnorr签名方案。更具体地：
遗传基础和在野生大豆中的甘油蛋白诱导的选择
Glyceollins是一种在豆类物种中引起的植物毒素家族，在环境压力反应（例如防御病原体）和人类健康中起着至关重要的作用。However, little is known about the genetic basis of glyceollin elicitation.在本研究中，我们采用了一种基于代谢物的基因组 - 宽缔合方法（MGWA）方法来鉴定在遗传多样的甘油蛋白诱导的候选基因，并正在研究遭受大豆囊肿线虫的野生大豆。In total, eight SNPs on chromosomes 3, 9, 13, 15, and 20 showed signi fi cant associations with glyceollin elicitation.六个基因分为两个基因簇，它们在苯基丙烷途径中编码糖基转移酶，并在物理上接近染色体9。此外，还发现转录因子（TFS）基因（例如MYB和WRKY）是有前途的候选基因，与染色体上的显着SNP紧密联系。Notably, four signi fi cant SNPs on chromosome 9 show epistasis and a strong signal for selection.The fi ndings describe the genetic foundation of glyceollin biosynthesis in wild soybeans; the identi fi ed genes are predicted to play a signi fi cant role in glyceollin elicitation regulation in wild soybeans.此外，自然种群中的上皮相互作用和选择影响甘油蛋白的变异如何应进一步研究以阐明甘糖苷生物合成的分子机制。
预防性环境的原始研究功效在孕妇中有孕妇中期妊娠损失的史，无痛宫颈扩张：A
背景：最近，已经提出了对宫颈长度的序列超声评估，以作为历史记录的替代管理。通过比较选择了历史指示的cerclage的妇女与选择串行超声评估的女性，研究以前经历过孕妇中期怀孕丧失的女性的预防性环境的疗效。方法：我们检查了2010年至2018年在我们医院分娩的妇女的病历，并提取了孕期中期妊娠损失14至25周的病史。我们比较了有或没有历史记录指示的固定的妇女。对于选择预期管理的妇女，每两周通过经阴道超声检查宫颈长度，并进行超声指示的固定。主要结果是在28或34周之前早产。结果：63名妇女满足了研究标准；其中28名接受了历史识别的环境。两组之间在28和34周时早产的发生率相似。However, among the 30 women who experienced painless cervical dilation at prior pregnancy loss, history-indicated cerclage showed significant low preterm birth rate compared with expectant management: 2/22 (9.1%) vs. 4/8 (50.0%) at < 28 weeks ( p = 0.029) and showed a lower preterm birth rate: 3/22 (13.6%) vs. 4/8 (50.0%) at < 34 weeks ( p = 0.06）。结论：在患有孕妇中期妊娠损失的女性中，可以考虑经历过颈部诊断的颈椎膨胀。