XiaoMi-AI文件搜索系统
World File Search Systemlikely
通过我们的AI-Immumumanology TM平台解码人类免疫系统以开发癌症和传染病的新型疫苗
本演讲包含经修订的1933年《证券法》第27A条的含义和1934年《证券交易所法》第21E条的含义。The words “target,” “believe,” “expect,” “hope,” “aim,” “intend,” “may,” “might,” “anticipate,” “contemplate,” “continue,” “estimate,” “plan,” “potential,” “predict,” “project,” “will,” “can have,” “likely,” “should,” “would,” “could,” and other words and terms of similar meaning identify forward-looking statements.实际结果可能与通过各种因素所指示的陈述所指示的结果有实质性不同，包括但不限于与以下风险相关的风险：我们的财务状况和需要额外资本的需求；我们的发展工作；我们的产品开发活动以及临床前和临床试验的成本和成功；商业化使用我们的AI平台技术开发的任何批准的制药产品，包括我们产品候选产品的市场接受率和程度；我们对第三方的依赖，包括进行临床测试和产品制造；我们无法建立伙伴关系；政府监管；保护我们的知识产权；员工事务和管理增长；我们的广告和普通股，国际经济，政治，法律，合规性，社会和商业因素的影响，包括通货膨胀，以及其他重大的地缘政治和宏观经济事件对我们业务的影响；以及其他影响我们业务运营和财务状况的不确定性。除法律要求外，我们不承担更新任何前瞻性陈述的义务。有关这些风险的进一步讨论，请参阅我们最近向美国证券交易委员会（SEC）（SEC）提交的年度报告中包含的风险因素，该报告可在www.sec.gov上获得。
生物催化和农业生物技术
进行了为期7个月的玻璃屋研究，以评估生长的生长反应，养分状态和非酶抗氧化剂的特性，其在不育Ultisol上生长的大肠杆菌幼苗的性质，这些卵子在不育Ultisol上生长，这些化学肥料（CF）和商业生物含量（IBG）的化学肥料（CF）和商业生物含量（IBG）的不同组合如下。 BioFertilizer [T3] 50％CF + 50％IBG生物肥料[T4]仅70％CF和[T5]绝对控制。与CF100相比，CF70和IBG30的组合的组合使幼苗的生长增加了15.8％，其新鲜芽和根重量和理想的根与射击比率明显更高。绝对控制幼苗在所有观察到的pa-Rameter中表现出不太理想的表型性状。记录了用CF70 + IBG30处理的幼苗的相对叶绿素水平明显较高，该幼苗与叶绿素A /B比正相关。此外，生物肥料和化学受精允许增加养分的摄取，其中较高的B和P摄取率与增强的FROND产生呈正相关（P <0.05），而较大的根部质量与原发性生长特征相关。The positive impacts of the com- bined IBG biofertilizer and chemical fertilizer application were likely attributed to enhanced ac- cumulation of non-enzymatic antioxidants to counteract the effects of soil infertility, with seedlings in CF70 + IBG30 mostly recorded the highest phenolic, anthocyanin, flavonoid, photo- synthetic pigments, DPPH radical activity and proline levels.
投资者演示
这些前瞻性陈述包括有关Post的潜在绩效和机遇的陈述，包括Post的预期协同作用和通过收购J.M.Smucker Company's (“Smucker”) pet food business (“Pet Food”), Post's Adjusted EBITDA outlook for fiscal year 2023, Post's forecasted Adjusted EBITDA from the Pet Food acquisition, Post's capital expenditure outlook for fiscal year 2023, Post's free cash flow illustrative calculation, Post's illustrative value in future fiscal years, Post's illustrative net debt reduction, Post's expected rates of调整后的EBITDA增长，Post的Pro fora净杠杆，Post的说明性多重，邮政估计的现金利率增加，Post Post餐饮服务业务的预期正常化，预计Post Post冷藏零售业务的数量增长率以及有关Post Holdings Canterning Corporation（“ PHPC”）的报表。These forward-looking statements are sometimes identified from the use of forward-looking words such as “believe,” “should,” “could,” “potential,” “continue,” “expect,” “project,” “estimate,” “predict,” “anticipate,” “aim,” “intend,” “plan,” “forecast,” “target,” “is likely,” “will,” “can,” “may” or “would” or the negative of these terms or similar表达式，包括有关未来绩效，收入预测，事件或发展的所有声明。有许多风险和不确定性可能导致实际结果与此处的前瞻性陈述有重大不同。
靶向与脱靶效应的药物抑制了SARS-COV-2
摘要由严重的急性呼吸综合症冠状病毒-2（SARS-COV-2）引起的冠状病毒疾病19（COVID-19）的当前流行呼吁开发病毒复制抑制剂。在这里，我们对包括伊马替尼梅赛酸酯在内的已发表和声称的SARS-COV-2抗病毒药进行了生物信息学分析，我们发现，我们发现对Vero E6细胞的SARS-COV-2复制抑制了SARS-COV-2复制，并根据有关其他冠状病毒的文献来抑制其他关于其他冠状病毒的文献，这可能会以酪氨酸动物学酶为酪氨酸动物酶抗抑制剂。我们确定了具有溶酶体剂特征的SARS-COV-2抗病毒药簇，这意味着它们是能够渗透到细胞中的亲脂性弱碱基。These agents include cepharentine, chloroquine, chlorpromazine, clemastine, cloperastine, emetine, hydroxychloroquine, haloperidol, ML240, PB28, ponatinib, siramesine, and zotati fi n (eFT226) all of which are likely to inhibit SARS-CoV-2 replication by non-speci fi c（脱靶）的效果，这意味着它们可能不对其“官方”药理学靶标作用，而是通过对包括自噬体，内体和溶酶体在内的嗜酸细胞器的非特征作用来干扰病毒复制。伊马替尼梅赛酸盐并未落入该簇。总而言之，我们根据其理化特征提出了将SARS-COV-2抗病人的初步分类与特异性（靶）与非特殊（非目标）（非目标）药物的特定分类。
Herbicide Strategy to Reduce Exposure of Federally Listed ...
1. Executive Summary When the Environmental Protection Agency (EPA or Agency) takes an action on a pesticide registration ( e.g., registers a pesticide or reevaluates it in registration review) under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), the Agency is responsible under the Endangered Species Act (ESA) to ensure that the action is not likely to jeopardize the continued existence of federally threatened or endangered (referred to as “listed”) species, or result in the destruction or adverse modification of their designated critical habitats. Chemical stressors, such as pesticides, are one of many factors that can contribute to population declines of listed species. Meeting this ESA responsibility is a formidable task, considering the tens of thousands of pesticide products and registration amendments for which EPA is required to review the potential effects for over 1,700 U.S. listed species. Given these challenges, in April 2022, EPA released a workplan (USEPA, 2022a) and an update to the workplan in November 2022 (USEPA, 2022b) that describe how it plans to meet its ESA obligations as part of pesticide registration processes under FIFRA. The update also describes strategies for identifying early mitigation measures to address potential population-level impacts to listed species across groups of chemicals ( e.g ., herbicides, rodenticides, insecticides) or in certain regions of the U.S. These strategies intend to more efficiently determine whether, how much, and where mitigations may be needed to protect listed species from many uses of conventional pesticides. This final Herbicide Strategy is another key step in meeting this goal. This Herbicide Strategy covers only conventional herbicides - an important, widely used tool for growers to prevent or eliminate weeds that compete with crops for light, moisture, and nutrients. EPA focused the strategy on agricultural uses in the lower 48 states because hundreds of millions of pounds of herbicides (and plant growth regulators) are applied each year (USEPA, 2017), which is substantially more than for non-agricultural uses and for other pesticide classes ( e.g. , insecticides, fungicides). In addition, there are hundreds of species listed by the U.S. Fish & Wildlife Service (FWS) 1 in the contiguous U.S. The mitigations identified in the strategy would address potential impacts to listed plants (terrestrial, wetland, and aquatic), which are the types of species likely to be most impacted by herbicides. By identifying mitigations to protect plants, listed animal species that depend on plants would also be protected. This includes animals that depend on plants for food and shelter (habitat). By identifying and defining mitigations for these listed plant and animal species, EPA will consider and apply this final Herbicide Strategy as appropriate in FIFRA actions, which should result in reductions of population-level impacts to over 900 listed species in the lower 48 states. The Herbicide Strategy is intended to create a consistent, reasonable, transparent, and understandable approach to assess potential impacts and identify mitigations to reduce potential population-level impacts to listed species from the use of agricultural herbicides. The strategy does not include ESA effects determinations, but instead is meant to identify proactive mitigations that can be applied in registration and registration review actions to reduce pesticide impacts to listed species. The strategy is intended to provide similar and consistent mitigations for herbicides with similar characteristics ( e.g. ,
数字劳动力澄清 - KPMG LLP
数字化劳动力可能会改变您的后台运营格局，也极有可能改变您的前台职能，但与大多数基于技术的演变一样，它可能会逐步发生。它也可能“在您睡觉时”发生 - 其进展可能会让您感到惊讶。准备好在某个时候说：“我们是怎么走到这一步的，这一切是什么时候发生的？” 接受它、理解它、领先它并成为早期采用者非常重要。
真空型制动液和恢复机的设计和开发
新兴证据表明，除了其在抗病毒RNA沉默中得到良好认可的功能外，dsRNA还引发了触发免疫力（PTI），还可能导致植物抵抗病毒感染。然而，与细菌和真菌诱导剂介导的PTI相比，DSRNA诱导的防御的行动方式和信号传导途径的性质仍然很差。Here, using multicolor in vivo imaging, analysis of GFP mobility, callose staining, and plasmodesmal marker lines in Arabidopsis thaliana and Nicotiana benthamiana , we show that dsRNA-induced PTI restricts the progression of virus infection by triggering callose deposition at plasmodesmata, thereby likely limiting the macromolecular transport through these单元格通信通道。The plasma membrane-resident SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE 1, the BOTRYTIS INDUCED KINASE1/AVRPPHB SUSCEPTIBLE1-LIKE KINASE1 kinase module, PLASMODESMATA-LOCATED PROTEINs 1/2/3, as well as CALMODULIN-LIKE 41 and Ca 2+ signals are involved in the dsRNA-induced signaling leading to callose deposition at浆膜和抗病毒防御。与经典的细菌诱发剂鞭毛蛋白不同，dsRNA不会触发可检测到的活性氧（ROS）爆发，从而证实了不同的微生物模式触发具有不同特征的部分共享免疫信号传导框架的观念。可能是一种反策略，来自不同病毒的病毒运动蛋白抑制了DSRNA诱导的宿主反应，从而导致callose沉积以实现感染。因此，我们的数据支持一个模型，在该模型中，植物免疫信号传导通过诱导浆果膜上的callo糖沉积来限制病毒运动，并重新使用病毒抵消这种免疫力。
指责在19号大流行期间未接种疫苗的
抽象的人未接种covid-19（C19）对大流行造成了偏见和责任。由于人们高估了C19的风险，我们检查了这些负面判断是否可以被部分理解为替罪羊的一种形式（即，不公平地指责一个不公平的群体），以及政治意识形态（以前证明是在美国塑造风险感知）是否会调节未诉讼的替代性。我们在C19期间对替罪羊文献和风险感知进行了基础。我们通过2022年初在美国进行的两项基于小插图的研究获得了对我们的猜测的支持。我们改变了Vignette字符的风险概况（年龄，先前感染，合并症）和疫苗接种状态（例如，未接种疫苗，未经近期助推器，未接种，未接种，未接种疫苗接种的疫苗），同时使所有其他信息保持恒定。We observed that people hold the unvaccinated (vs vaccinated) more responsible for negative pandemic outcomes and that political ideology moderated these effects: liberals (vs conservatives) were more likely to scapegoat the unvaccinated (vs vaccinated), even when presented with information challenging the culpability of the unvaccinated known at the time of data collection (eg, natural immunity, availability of vaccines, time自上次疫苗接种以来）。这些发现支持了C19大流行期间出现的特定基于群体的偏见的替罪羊解释。我们鼓励医学伦理学家检查C19大量高估公众的负面后果。公众需要有关健康问题的准确信息。可能涉及打击错误信息，以高估并低估了疾病的风险，以与错误相似的警惕。
获取盎格鲁美国镍巴西
本演示文稿包含某些“前瞻性语句”和预测，这些陈述基于本介绍之日向MMG组提供的信息。Forward looking statements can generally be identified by the use of forward looking words such as, ‘expect', ‘anticipate', ‘likely', ‘intend', ‘should', ‘could', ‘may', ‘predict', ‘plan', ‘propose', ‘will', ‘believe', ‘forecast', ‘estimate', ‘target' ‘outlook', ‘guidance' and other similar expressions.对未来收入或财务状况或绩效的指示，指导或前景也是前瞻性陈述。本演示文稿中包含的前瞻性陈述和预测是使用本文所述的假设进行的说明性练习，而不是保证或预测未来绩效。此类陈述和信息涉及已知和未知的风险，不确定性和其他因素，其中许多因素超出了MMG组的控制，并且可能涉及对未来事件的主观判断和假设的重大要素，即可能是正确的事件。许多重要因素可能会导致实际结果或绩效与前瞻性陈述有重大不同，包括（不限于）任何采矿业务，未来的业务决策，MMG集团及其实施的业务策略的成功或其他业务策略的成功或其他因素和市场上的变化以及MMG Group和Brazil nickel nickel nickel nickel nickel nickel nickel nickel nickel nickel and convertation convertation of MMG集团所采用的业务策略的成功或其他业务策略所固有的固有的不确定性，资本成本以及金融市场和一般经济状况的变化。因此，无法保证实际结果与这些前瞻性陈述和预测不会实质性差异。投资者应考虑到这些披露，而不是不依赖它们的前瞻性陈述和预测。