XiaoMi-AI文件搜索系统
World File Search Systemmainly
Gasdermin B过表达调节HER2
抗曲妥珠单抗（TRC1和TRC2）或Lapatinib（LRC1和LRC2）的抗性克隆显示出明显的GSDMB上调（图1E）。这些在体外会导致各种细胞模型（乳腺癌和胃癌细胞系，乳腺PDX原发性培养），以及我们在体内发表的观察结果，与PDXS和HER2乳腺癌患者[12]，确认GSDMB促进了对曲妥珠单抗的抵抗力以及Lapatinib。Since TKIs are mainly utilized in trastuzumab pretreated patients [17] (indeed HCC1954 cells are intrinsically resistant to trastuzumab [14, 28]) and there is a need to understand the molecular mechanisms that underlies the TKI derived resistance, we selected lapatinib as the suitable (second line) anti-HER2 therapy to further decipher the connection between GSDMB and drug 反抗。
OCD14 DIDCOT餐具策略 采购策略2021/22 - 2025/26
There are various schools and ecreational facilities located within the wider residential areas, mainly focused within the north (Ladygrove Park Primary School, Ladygrove Day Nursery, All Saints C of E Primary School) , south-east (Willowcroft Community School, Didcot Sixth Form, St Birinus School) and west (Didcot Girls' School, Manor Primary School, Ladybird Pre-School) suburbs.在这些地区的休闲设施包括南部的Didcot休闲中心和Didcot Wave，北部的Willowbrook休闲中心和西部的Didcot板球俱乐部。在中央走廊三角形内是庄园小学和位于Smallbone休闲公园的Didcot Bowls Club。百老汇西区的另一个设施是马尔伯勒俱乐部大楼，该大楼经常举办社交社区活动和活动。
Q1 2024交易和业务更新
Q1 2024 Trading and Business Update • Second consecutive quarter of bookings above $100m at US$117.9m • Licence and NRE bookings of US$108.9m up 75% over Q1 2023 • Lower silicon orders reflect accelerated transition away from China • Approximately 95% of licence & NRE bookings in advanced nodes, 5nm and below • 9 new design wins, mainly in APAC and North America • Strong 2024财年机会的渠道•管理人员对伦敦的商业前景充满信心，加拿大安大略省，加拿大安大略省，2024年4月23日 - Alphawave IP Group plc（LN：AWE，“公司”或“ Company”或“ Alphawave Semi”），在高速连接中为世界技术基础结构的高速连通性提供了31个月31日的贸易和业务范围。
遗传性视网膜变性的早期和晚期基因治疗干预
《世界肝病学杂志》（WJH，世界J肝素）的主要目的是为来自各个肝病学领域的学者和读者提供一个平台，以发表高质量的基本和临床研究文章，并在线交流他们的研究结果。WJH mainly publishes articles reporting research results and findings obtained in the field of hepatology and covering a wide range of topics including chronic cholestatic liver diseases, cirrhosis and its complications, clinical alcoholic liver disease, drug induced liver disease autoimmune, fatty liver disease, genetic and pediatric liver diseases, hepatocellular carcinoma, hepatic stellate cells和纤维化，肝脏免疫学，肝脏再生，肝手术，肝移植，胆道病理生理学，肝纤维化的非侵入性标记，病毒性肝炎。
Stellantis NV FY 2024新闻稿
________________________________________________________________________________________________________________________________________________________________________________________ (*) Other activities, unallocated items and eliminations (A) Primarily related to workforce reductions, mainly in Enlarged Europe and North America (B) Primarily related to (i) €1,063 million of impairments of certain platform assets in Maserati and Enlarged Europe, net of reversal, driven by projected decreases in margins for certain models and the cancellation of certain projects prior to launch, (ii) €230 million of provisions accrued for supplier obligations, relating to projects in development which were cancelled prior to launch (and for which the related capitalized R&D was impaired under (i) above), and (iii) €514 million of goodwill impairments与玛莎拉蒂市场（c）延长高田安全气囊召回活动（D）的规定（d）在北美出售的终身服务合同有关，然后在2024年（e）中确定合并繁重的其他调整，这些调整是单独的非重要
RSR MYB12作为重新提交的2024-07-03
在成熟激活的番茄E8启动子的控制下以番茄果实表达的ATMYB12转录因子基因会导致苯基丙烷生物合成途径中多个基因表达的增加（Luo等，2008）。有关这些途径中基因表达增加的图形表示，请参见图1。The result is accumulation of flavonol derivatives–primarily rutin and kaempferol rutinoside–and caffeoyl quinic acids–mainly caffeoylquinic acid (also known as chlorogenic acid; already the most prevalent soluble phenolic in Solanaceous species), dicaffeoylquinic acid, and tricaffeoylquinic acid (see Figure 2 for a产生的途径和化合物的图）。果实中的这些升高的酶基因表达水平，以及果实中各种多酚化合物的水平增强，在果实中产生黄色或橙色（见图3）。ATMYB12番茄没有其他表型。
Economic Activity Global economy continued to grow at a ...
The average kina exchange rate depreciated against the US dollar by 112 basis points to US$0.3797 over the month to 27 th February 2015, mainly reflecting high demand for foreign currency. Over the same period, the average kina exchange rate appreciated against the Australian dollar by 251 basis points to AU$0.4870, due to cross-currency movements as the Australian dollar weakened against the US dollar. This follows the 25 basis points cut in the cash rate by the Reserve Bank of Australia on the 4 th of February 2015 and the continued recovery in the US economy. The average Trade Weighted Index (TWI) 1 increased by 0.41 percent to 38.80 over the month to 27 th February 2015, reflecting the appreciation of the kina against the Australian dollar and other major currencies outweighing the depreciation against the US$ (Chart
靶向癌症中天然化合物的自噬
天然产物经过充分的特征，可以具有药理学或生物学活性，可以对癌症治疗具有治疗性有益，这也为发现潜在的新型小分子药物提供了重要的灵感来源。在过去的三十年中，积累的证据表明，天然产物可以调节一系列关键的自噬信号通路，并在不同类型的人类癌症中显示治疗作用。In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53。综上所述，这些鼓舞人心的发现将通过针对未来癌症治疗的自动噬菌学的关键途径来利用更多天然化合物作为候选小分子药物。
急性心肌梗塞的心源性休克的预测因素和结果
方法：这是一项回顾性，比较和分析性的单中心研究，包括在孟加拉国哈比根郡250 Bed District Sadar医院手术部门的319名ACS患者。在入院时出示CS的患者被排除在研究之外。该人群分为两组：冲击组患者最终发展了院内CS和没有冲击组，但我们比较了总体患者特征和结果。Studied characteristics included patient demographics (age, sex), medical history (cardiovascular risk factors and comorbidities), clinical status including the presence of heart failure (HF), electrocardiogram data, laboratory findings such as high-sensitivity troponin and glomerular filtration rate (eGFR), echocardiographic findings mainly left ventricular ejection fraction (LVEF) and left ventricular hypertrophy （LVH）和冠状动脉血管造影期间发现的病变。
海洋总生产的全球估计...
在海洋生态系统中，可以通过通常分类为两种类型的各种方法来估算一级生产：基于孵育的和地球化学（与孵化无关）的方法。The former approach- es mainly include the 14 C-inorganic carbon incorporation methods (Steemann Nielsen, 1952 ), oxygen evo- lution between light-dark bottles (Serret et al., 1999 ), the H 2 18 O-labeling approach (M. Bender et al., 1987 ) and nutrient uptake experiments (Dugdale & Goering, 1967 ).与孵育无关的方法通常基于生产力的地球化学示踪剂，包括溶解氧的三相同位素（Luz＆Barkan，2000），对系泊和滑翔机的氧记录分析（Nicholson 2008，Nicholson 2008，Nicholson 2008，Nicholson等，Nicholson等，2014，2014）和Electon Comptive losive eal eal eal eal ear e ear e ear e et estection ear et estection ear et e ear ear ear et e et estection（KK）。