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432自动外部除颤器
A medical heart monitor and defibrillator device that: Has been cleared for market by the federal Food and Drug Administration, Can recognize the presence or absence of ventricular fibrillation or rapid ventricular tachycardia, Can determine, without intervention by an operator, whether defibrillation should be performed, and On determining that defibrillation should be performed, automatically charges and requests delivery of an electrical impulse to an个人的心脏和：（1）需要操作员干预才能提供电脉冲；或（2）随着电脉冲的传递，会自动继续。（马里兰州法规（COMAR）§30.01.01.02）心肺复苏（CPR）：
网络加工 - 老年人网络安全计划
• Cybersecurity 101: The basics of cybersecurity, including the physical threats to cyber safety and the importance of personally identifiable information • Password Management: The importance of password management and creation of strong, unique passwords • Common Internet Threats: Proactive and reactive defense against unwanted software • Internet Scams & Fraud: How to recognize false customer service calls and scam/phishing emails • Social Media Awareness: Understanding personally identifiable information and privacy设置•自助资源：政府和地方资源的直接联系信息
胰腺癌中的孢子
Immunotherapy for Pancreatic Cancer (Principal Investigators: Peter A. Cohen, MD and Sandra J. Gendler, PhD) builds on findings that immunotherapy and chemotherapy can synergize against pancreatic cancer, also building on a newly perfected ability to activate and expand T-cells in culture which recognize cancer- associated MUC1, a novel form of vaccination performed entirely outside the body.I-II期试验，将环磷酰胺化疗与在Folfirinox之后的二线治疗中将环磷酰胺化学疗法与重新输注的T细胞接种疫苗相结合，将有助于优化针对胰腺癌的这种创新策略。
Sean D. MatthewsSean D. Matthews
● Offer key design insights for robotic systems- design sensor suites, identify common pitfalls, estimate effort to achieve your project goals, establish effective software development processes ● Build, mentor & lead teams - recognize skill sets necessary to your projects, provide technical guidance, enable team growth & performance ● Evaluate applicability of incumbent technologies- proof-of-concepts, mitigate project risk through exploratory spike tests ● Algorithm implementation-将论文转换为代码，将现有实现端口转换为您的平台●系统集成 - 将所有零件连接到物理和模拟环境中的功能性整体，测试和调试多学科系统
2020年能源法对联邦可持续发展社区的摘要影响ISWG Update
o Work with key federal agencies, including at least one building from each (Army, Navy, Air Force, DOE, Interior, VA, GSA) o Using FEMP guidelines related to whole-building evaluation and M&V, Secretary shall evaluate costs and benefits of buildings in program (including items such as performance for building occupants and environmental impact) o Awards: Secretary may expand awards made under FEMP and Better Buildings Challenge to recognize specific agency achievements in加速采用智能建筑技术o秘书必须每2年向国会提交有关此倡议的报告，直到提交3项报告
皮奥里亚消防局学徒计划
Review of applicable codes and standards adopted by the City of Peoria P reparation of inspection reports Conduct field inspection of new and existing structures Develop ability to classify construction types Develop ability to determine occupancy types Review of permitting process Participate in legal proceedings relating to code violations Recognize the need and purpose associated with the plan review process Investigate, report, record, resolve and consult regarding common complaints Develop ability to计算占用能力制定制定预火计划的能力获得正确生成正确rafer认证表格的能力获得建筑物或空间中危险火灾增长潜力的能力参与火灾保护系统接受测试
计算机科学与商业系统
了解多样性在工作场所中的重要性确定沟通写作的关键方面在现实生活中应用沟通写作，在沟通写作中使用图表和图表了解情感智力是什么是情感智力认识到个人和职业生活中的情感智力的重要性认识到个人和职业生活中的重要性了解如何在您的工作场所中识别出公共式的习惯。社会责任（CSR）认识到公司社会责任（CSR）的重要性认识到在公司环境中运作和成长所需的属性和成长的属性认识到共享和接收反馈的最佳实践在现实生活中应用情绪智能在现实生活中应用情绪智能采用多个智能的知识来识别互动范围识别基本冲突的范围管理冲突的范围管理冲突的影响•primate crigase管理冲突 认识到业务习惯和公司条款应用业务成语和公司条款认识到压力对生活和工作的影响确定管理压力的最佳实践认识到时间管理的重要性认识到时间管理的重要性确定最佳时间管理实践
站点定向→I RNA编辑为治疗工具
ADAR酶家族的腺苷脱氨酸是一个自然过程，它在通过Messenger RNA时编辑了遗传信息。 腺苷转化为mRNA中的inosine，该基碱在翻译过程中被解释为鸟苷。 意识到这项活动对治疗剂的潜力，许多研究人员开发了将ADAR活动重定向到新目标的系统，该系统通常未进行编辑。 These site-directed RNA editing (SDRE) systems can be broadly classified into two categories: ones that deliver an antisense RNA oligonucleotide to bind opposite a target adenosine, creating an editable structure that endogenously expressed ADARs recognize, and ones that tether the catalytic domain of recombinant ADAR to an antisense RNA oligonucleotide that serves as a targeting mechanism, much like with CRISPR-CAS或RNAi。 迄今为止，SDRE主要用于纠正遗传突变。 在这里，我们认为这些应用不是理想的SDRE，主要是因为RNA编辑是短暂的，遗传突变不是。 相反，我们建议可以使用SDRE来调整细胞生理，以实现治疗上有利的临时结果，尤其是在神经系统中。 这些包括操纵伤害性神经回路中的兴奋性，废除特定的磷酸化事件，以减少与神经变性相关的蛋白质聚集或减少神经性疤痕，从而抑制神经再生或增强G蛋白耦合受体信号的抑制，从而增加象征性障碍性和粘贴性的神经偶联受体信号。ADAR酶家族的腺苷脱氨酸是一个自然过程，它在通过Messenger RNA时编辑了遗传信息。腺苷转化为mRNA中的inosine，该基碱在翻译过程中被解释为鸟苷。意识到这项活动对治疗剂的潜力，许多研究人员开发了将ADAR活动重定向到新目标的系统，该系统通常未进行编辑。These site-directed RNA editing (SDRE) systems can be broadly classified into two categories: ones that deliver an antisense RNA oligonucleotide to bind opposite a target adenosine, creating an editable structure that endogenously expressed ADARs recognize, and ones that tether the catalytic domain of recombinant ADAR to an antisense RNA oligonucleotide that serves as a targeting mechanism, much like with CRISPR-CAS或RNAi。迄今为止，SDRE主要用于纠正遗传突变。在这里，我们认为这些应用不是理想的SDRE，主要是因为RNA编辑是短暂的，遗传突变不是。相反，我们建议可以使用SDRE来调整细胞生理，以实现治疗上有利的临时结果，尤其是在神经系统中。这些包括操纵伤害性神经回路中的兴奋性，废除特定的磷酸化事件，以减少与神经变性相关的蛋白质聚集或减少神经性疤痕，从而抑制神经再生或增强G蛋白耦合受体信号的抑制，从而增加象征性障碍性和粘贴性的神经偶联受体信号。
站点定向→I RNA编辑为治疗工具
ADAR酶家族的腺苷脱氨酸是一个自然过程，它在通过Messenger RNA时编辑了遗传信息。 腺苷转化为mRNA中的inosine，该基碱在翻译过程中被解释为鸟苷。 意识到这项活动对治疗剂的潜力，许多研究人员开发了将ADAR活动重定向到新目标的系统，该系统通常未进行编辑。 These site-directed RNA editing (SDRE) systems can be broadly classified into two categories: ones that deliver an antisense RNA oligonucleotide to bind opposite a target adenosine, creating an editable structure that endogenously expressed ADARs recognize, and ones that tether the catalytic domain of recombinant ADAR to an antisense RNA oligonucleotide that serves as a targeting mechanism, much like with CRISPR-CAS或RNAi。 迄今为止，SDRE主要用于纠正遗传突变。 在这里，我们认为这些应用不是理想的SDRE，主要是因为RNA编辑是短暂的，遗传突变不是。 相反，我们建议可以使用SDRE来调整细胞生理，以实现治疗上有利的临时结果，尤其是在神经系统中。 这些包括操纵伤害性神经回路中的兴奋性，废除特定的磷酸化事件，以减少与神经变性相关的蛋白质聚集或减少神经性疤痕，从而抑制神经再生或增强G蛋白耦合受体信号的抑制，从而增加象征性障碍性和粘贴性的神经偶联受体信号。ADAR酶家族的腺苷脱氨酸是一个自然过程，它在通过Messenger RNA时编辑了遗传信息。腺苷转化为mRNA中的inosine，该基碱在翻译过程中被解释为鸟苷。意识到这项活动对治疗剂的潜力，许多研究人员开发了将ADAR活动重定向到新目标的系统，该系统通常未进行编辑。These site-directed RNA editing (SDRE) systems can be broadly classified into two categories: ones that deliver an antisense RNA oligonucleotide to bind opposite a target adenosine, creating an editable structure that endogenously expressed ADARs recognize, and ones that tether the catalytic domain of recombinant ADAR to an antisense RNA oligonucleotide that serves as a targeting mechanism, much like with CRISPR-CAS或RNAi。迄今为止，SDRE主要用于纠正遗传突变。在这里，我们认为这些应用不是理想的SDRE，主要是因为RNA编辑是短暂的，遗传突变不是。相反，我们建议可以使用SDRE来调整细胞生理，以实现治疗上有利的临时结果，尤其是在神经系统中。这些包括操纵伤害性神经回路中的兴奋性，废除特定的磷酸化事件，以减少与神经变性相关的蛋白质聚集或减少神经性疤痕，从而抑制神经再生或增强G蛋白耦合受体信号的抑制，从而增加象征性障碍性和粘贴性的神经偶联受体信号。
WAPL充当控制神经接线的原钙粘蛋白同工型多样性
简介：建立神经连通性模式需要单个神经元将自我与非自然区分开的能力。In mammals, clustered Protocadherin (Pcdh) genes encode cell surface molecular “ identifiers ” (i.e., barcodes) that allow neural “ self/nonself ” discrimination: Neurites from the same cell carrying identical Pcdh barcodes recognize and repel each other, whereas neu- rites from different cells carrying distinct Pcdh barcodes do not.在小鼠中，两个同源性杂种的基因有116个PCDH基因，有组织的intothreetotheThemellanged簇（a，b和g）。不同的神经类型 - pressDistInctrepertoiresofpcdhgeneStoinstoinstoints Instruct is接线过程。这种行为的最值得注意的例子是血清素能神经元（5-HT）中单个PCDH基因的确定性表达，以及在嗅觉感觉神经元（OSN）中一些PCDH基因的随机表达。PCDH A C2的确定性表达式提供了一个5-HT，并具有单个共享条形码。使用这种机制，来自同一细胞的神经突识别和排斥自我，而且还来自其他5-HT的神经突，从而有利于其整个大脑中其轴突的非重叠瓷砖投影。相比之下，随机