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GAO-21-101SP，武器系统维持：飞机任务能力率通常未达到目标，维持选定武器系统的成本差异很大
国防部 (DOD) 每年花费数百亿美元来维护其武器系统，以确保这些系统能够同时支持当今的军事行动并保持满足未来国防要求的能力。运营和支持 (O&S) 成本历来约占武器系统总生命周期成本的 70%——从初始运营到使用寿命结束运营和维护武器系统的成本——包括维修零件、仓库和现场维护、合同服务、工程支持和人员等成本。1 武器系统的维护成本很高，部分原因是它们通常包含一系列复杂的技术子系统和组件，并且需要昂贵的维修零件和后勤支持才能达到所需的准备水平。飞机是国防部维持的一种武器系统，使其能够执行任务。
quantum-spin-wave-excited-from-a-cr-dy-single-molecule- ...
INTRODUCTION Molecules could become tiny magnets if the spin centers are judiciously chosen and placed in a proper way. 1 Such molecules are widely studied and known as single-molecule magnets (SMMs) and widely perceived as a new generation of nanosized information carriers for highly miniaturized spintronics and quantum computing processors. 2-5 According to the number of the spin centers SMMs can be basically divided into two groups, namely the single-ion magnets 6-12 and the multi-nuclear spin clusters. 13-18 The former is latterly emerged as Ishikawa discovered that the single lanthanide ion could generate strong uniaxial magnetic anisotropy which significantly damps the relaxation of the magnetic moment. 6 The latter actually ignited the starter of the SMM story signaled by the discovery of the magnet-type behavior of a mixed-valent manganese cluster {Mn 12 } in 1993. 13 Due to the multi spin center nature of the latter such class of molecular magnets has developed many interesting branches. Coordination cluster with spin-wave excitations is one of the kinds. 19
datopotamab deruxtecan（dato-dxd）增强了对小鼠中trop2-表达肿瘤pd-1/pd-l1抑制剂的抗肿瘤反应
• Trophoblast cell surface antigen 2 (TROP2) is a 36-kDa single-pass transmembrane protein which is widely expressed in solid tumors, and highly expressed in non-small cell lung cancer (NSCLC), hormone receptor positive breast cancer (HR+BC) and triple negative breast cancer (TNBC) 1 , supporting the therapeutic potential of TROP2- directed therapies in these跨不同治疗线的肿瘤类型
工业热摄像机产品目录
Being a solution provider to public sectors, industries, and commercial markets, we provide a rich portfolio of intelligent photoelectric sensing products, which are widely used in the smart industry, smart robots, gas detection imaging, fire fighting and safety, green energy, carbon neutrality, environmental protection, healthcare, etc.雷德克技术（Raythink Technology）承担着提高智能光电传感技术进步的使命，它集成了光电和智能技术，以不断为客户创造增量价值，并为建立安全，节能和环保的社会做出贡献。
更致命的皇家海军：锐化英国的海军力量
Butanumberofhostilestatesandcompetitorshavegrown strongeratseaoverthepastdecade,countrieswhichhavesoughtto subverttheinternationalorder.Tomeetthischallenge,itiswidely acknowledgedthatBritainneedsalargerandevenmorecapablefleet. ThisReportprovidesanumberofideasastohowastrongernavycould berealised.Morethanthat,itidentifiesareaswhereHisMajesty's(HM) GovernmentandtheRoyalNavycaninducestrategicadvantageby takingspecificmeasurestoenhancethelethalityandsurvivabilityof Britishsubmarines,warshipsandauxiliaries,therebystrengthening theirabilitytodeliverstrategiceffect.Wehopeyoufinditsconclusions andRecondationsInsightfulanduse。
直接和延迟的超敏反应...
Proton pump inhibitors (PPIs) are widely pre scribed for managing acid-related gastrointestinal con ditions such as gastric and duodenal ulcers, dyspepsia, gastroesophageal reflux disease (GERD), Zollinger-El lison syndrome, Helicobacter pylori ( H. pylori ) erad ication, and the prevention and management of与非甾体类抗炎药（NSAIDS）相关的溃疡（1）。这些药物通过不可逆地抑制胃顶细胞中的H⁺/k⁺-ATPase酶来抑制胃酸促进（2）。尽管通常被认为是安全有效的，但PPI与一系列不良反应相关联（1）。其中，超敏反应引起了重大的临床关注，其中包括从轻度皮肤病症状到严重的全身并发症的一系列表现（3）。
ψ-无用模型的无定理
在2010年，Harrigan and Spekkens（HS）提出了一个较大的分类，以对量子状态的性质进行分类，即确定在某个模型中是否对应于量子观察的不动物，在这种情况下，模型称为ψ-接触或某些观察者信息，使其成为ψ-pepistlectic [1]。While their original aim was to clarify Einstein's view of Quan- tum Mechanics (QM), the HS framework has been widely employed in the literature not only to categorize different formulations of QM, but also to argue what types of in- terpretations are admissible ([ 2 – 9 ]; cf.[10，11]进行批判性讨论）。Referring to this, one of the most influential works based on HS classification is due to Pusey, Barrett and Rudolph who published a formal result in Nature Physics —widely known as the PBR theorem—showing that “if the quantum state merely represents informa- tion about the real physical state of a system, then ex- perimental predictions are obtained that contradict those of quantum theory” ([ 12 ], p. 475).另外，PBR认为，在每个模型中，QM的统计数据和预测量子状态ψ必须在构成下而不是代理的知识中代表系统的真实物理特性。模型必须是ψ-接触。因此，量子理论不能是ψ-上的学术。这样的定理具有显着的共鸣[13-25]，今天仍讨论有关其实际含义的问题：一方面，一些作者认为，它排除了QM的解释，其中ψ仅代表了侵入。另一方面，其他学者最近证明了非平凡的认知和QM的实用方法并未被PBR参数驳斥[10，26 - 29]。讨论主要集中于ψ-上皮模型是有问题的还是PBR参数本身是有问题的，但我们问一个不同的问题：基础HS分类本身是什么
December 10, 2024 - Medicine Minute - Lazarte Receives Service Award | Staff Members Take on New Roles | Residents Match into Fellowship Programs
Obesity is a chronic complex disease defined by excessive fat deposits that can impair health. The cardiorenal metabolic syndrome, which includes obesity, diabetes, cardiovascular disease, chronic kidney disease and fatty liver disease, is a target of GLP-1 receptor and/or GIPR incretin-based therapies. These drugs, tirzepatide (sold under the brand names Mounjaro and Zepbound) and semaglutide (sold under the brand names Ozempic, Rybelsus, and Wegovy), are now widely used for weight loss and diabetes, and as such, offer a hopeful avenue to treat obesity and its related diseases. Researchers at UT Southwestern have shown the GIP receptor (GIPR), a protein in fat cells, is a meaningful target for the development of future incretin-based therapeutic interventions for treating obesity and its associated metabolic diseases.
新闻稿，2025年1月21日，韩国授予Diamyd Medical的Precision Medicine in Autommune Diabetes
1st-line benefit in combination with widely approved CDK4/6 inhibitors Positive high-level results from a planned interim analysis of the SERENA-6 Phase III trial showed that AstraZeneca's camizestrant in combination with a cyclin-dependent kinase (CDK) 4/6 inhibitor (palbociclib, ribociclib or abemaciclib) demonstrated a highly statistically significant and clinically meaningful无进展生存期（PFS）的主要终点的改善。该试验评估了切换到芳香酶抑制剂（AI）（ANASTROZOLE或LETROOZOLE）与CDK4/6抑制剂在一线治疗激素受体（HR）患者（HR）蛋白（HR） - 蛋白蛋白酶（Her2）型乳腺较大较大的癌症中的一线治疗中，与CDK4/6抑制剂结合使用了CDK4/6抑制剂，将切换到持续的护理标准治疗。
使用机器学习技术筛选碳钢筛选有机腐蚀抑制剂的数据驱动QSPR模型
Carbon steel is the most widely used metallic material in industry owing to its unique mechanical properties, availability, and low cost.1然而，当暴露于侵袭性环境（例如酸性溶液）时，碳钢的显着性较弱是其耐腐蚀性较差的耐腐蚀性，例如酸性溶液，这些溶液用于各种过程，例如清洁，腌制，淡化，下降和酸化。1,2 To prevent the corrosion of carbon steel, di ff erent methods have been used, including the use of corrosion inhibitors.Organic corrosion inhibitors showed good e ffi ciency and have great potential.3,4 However, their toxicity and envi- ronmental pollution are issues of great concern.The search for less toxic, environmentally friendly, and renewable corrosion inhibitors has become a research focus in this eld.5