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高Q锂尼堡微腔及其应用
Since the discovery of optical nonlinearities in the 1960s, lithium niobate (LiNbO 3 , or LN) has been the most widely used second-order ( χ (2) ) material, with applications ranging from nonlinear wavelength conversion for classical and quantum light source [1], optical modulators for data communications [2], as well as surface acoustic wave (SAW) based electronic components for mobile phone industry [3]。与其他常见的光子材料相比，LN在非线性和线性光学方面具有许多有利的特性。LN中最大的χ（2）张量分量是对角线对齐的（χ（2）ZZZ），对于非线性波长转换（称为D 33）和电仪调制（r 33），对于非线性波长转换（称为D 33）。作为线性光学材料，LN具有相对较高的普通和非凡的折射率（N O = 2.21，N E = 2.14，在1550 nm处），并且高度
智能功率模块（IPMS）的扭曲建模和表征
Intelligent power modules (IPMs) are widely used in the electric vehicle (and hybrid electric vehicle industry nowadays due to their high power densityandabilitytointegratemultiplecomponentswithinasinglepackage.However,thereliabilityofIPMsisseverelydegradedbythesubstrate warpage effect produced during the packaging process.因此，本研究开发了一个计算模型，以分析包装过程的各个阶段IPM组装的经线。通过比较直接镀铜底物的经线的数值结果与实验观察结果来确认模拟模型的有效性。Taguchi experiments are then performed to examine the effects of eight control factors on the IPM package warpage following the post-mold cure (PMC) process, namely (1) the dam bar layout, (2) the epoxy molding compound (EMC) thickness, (3) the lead frame thickness, (4) the ceramic thickness, (5) the bottom layer Cu foil thickness, (6) the top layer Cu foil thickness, （7）陶瓷材料类型和（8）EMC材料类型。最后，Taguchi分析结果用于确定最大程度地减少POST-PMC软件包的经线的最佳包装设计。
EDA的应用
摘要：为了提高3D过渡金属复合物中M @ L键的理解，可以通过能量分解分析分析化学价模型（EDA-NOCV）的天然轨道，因为它提供了对M @ L Incractions的完整，定量和化学直觉的缩写描述。在这项研究中，由于过渡温度（T 1/2）对M @ l键的微妙变化而言，通过使用八面体自旋（SCO）配合物来建立并验证了通常适用的碎片和计算方案。Specifically, EDA-NOCV analysis of Fe @ N bonds in five [Fe II ( L azine ) 2 (NCBH 3 ) 2 ], in both low-spin (LS) and paramagnetic high-spin (HS) states led to: 1) development of a general, widely applicable, corrected M + L 6 fragmenta- tion, tested against a family of five LS [Fe II ( L azine ) 3 ](BF 4 ) 2复合物；这证实了三个L苯二氮更强
基于肽的基因疗法的纳米材料-RSC Publishing
能够稳定地与带负电荷的核酸结合，从而提高了基于肽的纳米材料的载荷能力，靶向能力和转染的效率，并使材料能够实时成像。近几十年来，已经广泛研究了传统的use液分子，但是由于聚集引起的淬火（ACQ）效应，它们的排放可能会在高浓度下弱化。95,96在2001年，Tang和他的同事提出了聚集诱导的发射（AIE）的概念，以说明一系列在高度聚合状态下发出强效的效应分子。97 Di ff erent from the case of uorescent molecules a ff ected by the ACQ e ff ect, for AIE lumi- nogens (AIEgens) there is no need to control their concentration during use and they can emit uorescence in the aggregated state, and some AIEgens have photosensitivity, so they are widely used in bioimaging, 98 – 101 biosensing 102,103和生物疗法的ELD。104 - 109我们的小组审查了一些基于AIE的材料的应用。110 - 112
这些男人爱上了采矿公司和皮卡车：
2所有这些术语都是英语的事实，它使“goiás版”贴纸，尤其是2022年在米纳松流行，甚至更具启示性。所有这些都带给我们这个巨大的问题，如果没有充分解决空间或能力，我只会在这里提及：北美西部征服的“影响”对巴西人的“ backlands”殖民化所构成的世界的社会和历史形态的“影响”（例如，我在此处讨论的中央区域）。Beyond the imaginary surrounding the figures of the ‘cowboy' (Pimentel 1996; Machado 2022) or the ‘pioneer' (Heredia, Palmeira & Leite 2010; Marques 2012; Cordeiro 2018), let us remember how this influence materialized in public policies that were decisive for the contemporary structuring of these areas (Minaçu included): for example, in the already mentioned March to the West of the first getúliovargas政府。A recurring theme in Brazilian historiography and social thought, this influence (or the comparison between the Brazilian and North American cases) was a topic widely discussed in the ethnographies that, in the 1970s, focused on ‘Central Brazil' (Esterci 1972; Velho 1979; Ribeiro 1980) - but which, later, seemed to disappear from Brazilian anthropological production.
Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023
ycoplasma pneumoniae is a common etiologic agent of community-acquired pneumonia (CAP) among children. Although M. pneumoniae infection often causes a mild and self-limiting dis- ease, pneumonia develops in ≈ 10%–20% of pediatric patients ( 1 ). First-line therapies for M. pneumoniae infection are based on macrolides, a group of anti- microbial drugs widely used in outpatient settings because of their high oral bioavailability. However, overuse and indiscriminate use of macrolides have contributed to the emergence of macrolide-resistant M. pneumoniae (MRMP). Point mutations in the V region of the M. pneumoniae 23S rRNA gene have been associated with macrolide resistance ( 2 ). In recent years, prevalence of MRMP has increased and is very high in Asia (13.6%–100%) ( 2 – 4 ). Dur- ing spring/summer 2023, hundreds of children with CAP were admitted daily to each of the major hospi- tals in Hanoi, Vietnam. M. pneumoniae has emerged as the major pathogen detected in approximately one third of patients with CAP (5). We analyzed the mutations in the 23S rRNA gene of M. pneumoniae isolated from nasopharyngeal samples of pediatric CAP patients during the 2023 outbreak in Vinmec Times City Hospital, Hanoi.
细胞外囊泡在发育，微环境，抗癌耐药性以及头颈鳞状细胞癌的治疗中的作用
头部和颈部鳞状细胞癌（HNSCC）是影响人类健康的主要恶性肿瘤之一，主要是由于诊断延迟和侵入性高。Extracellular vehicles (EVs) are membranous vesicles released by cells into the extracellular matrix that carry important signalling molecules and stably and widely exist in various body fluids, such as plasma, saliva, cerebrospinal fluid, breast milk, urine, semen, lymphatic fluid, synovial fluid, amniotic fluid, and sputum.evs传输几乎所有类型的生物活性分子（DNA，mRNA，microRNA（miRNA），蛋白质，代谢物，甚至药理化合物）。这些“货物”可以对受体细胞作用，重塑周围的微环境并改变遥远的靶标，最终影响其生物学行为。对电动汽车的广泛探索加深了我们对HNSCC生物学的全面理解。在这篇综述中，我们不仅总结了HNSCC衍生的EV对肿瘤微环境的影响，而且还描述了微环境衍生的EV在HNSCC中的作用，并讨论了肿瘤和微环境之间的“相互对话”如何介导生长，转移性，远离抗药性，免疫，抗药性，抗药性，抗药性，抗药性，抗药性，抗药性。最后，评估了电动汽车在HNSCC中的临床应用。
Spilanthes acmella纳米颗粒的生物合成
引言纳米技术代表了一个快速增长的领域，在催化，太阳能，废物管理和传感技术中采用了不同的应用。在医疗领域，纳米材料用于药物输送，疾病诊断，心血管疾病的治疗，伤口愈合和抗菌剂的发育。纳米颗粒，尤其是使用贵金属合成的纳米颗粒，表现出在单个分子或散装金属中未发现的独特物理化学特性。Silver nanoparticles, in particular, are widely used due to their versatile applications.然而，纳米颗粒合成的常规方法是昂贵且对环境毒性的，因此需要探索替代性，环保合成方法。使用植物材料对银纳米颗粒的绿色合成提供了一种具有成本效益，快速和环境良性的方法。富含植物成分的植物提取物是银离子的还原剂，促进纳米颗粒合成。诸如温度，pH，植物提取物浓度和硝酸银浓度等因素会影响合成过程。Premna Integiria L.长期以来一直在传统医学中用于其抗菌和抗氧化特性。这项研究旨在使用综合假单胞菌的水叶提取物合成银纳米颗粒，并评估其物理化学特征和生物学活性。
分析未来的气候变化 - 蓝色 - 尼尔 -
摘要。气候变化已成为当今世界上最具威胁性的问题之一，其全球背景及其对环境和社会经济驱动力的反应。然而，不同的一般循环模型（GCM）和粗空间分辨率之间的巨大不确定性使得直接使用GCM的输出很难，尤其是在区域规模上可持续水管理的尤其是对降低降压技术的需求。This study aims (i) to evalu- ate the comparative performance of two widely used sta- tistical downscaling techniques, namely the Long Ashton Research Station Weather Generator (LARS-WG) and the Statistical Downscaling Model (SDSM), and (ii) to down- scale future climate scenarios of precipitation, maximum temperature ( T max ) and minimum temperature ( T min ) of the Upper Blue Nile River basin at finer空间和时间尺度适合进一步的水文影响研究。卡尔和验证结果表明，降尺度技术（LARS-WG和SDSM）均显示出可构成的综合和良好的模拟能力，可以模拟当前的局部气候变量。仅通过同样加权和变化的统计指数的权重进行进一步的定量和定性比较性能评估。评估结果表明，使用CANESM2 CMIP5 GCM的SDSM能够再现更准确的长期平均每月降水量，但Lars-WG在捕获整个数据范围内每天的极端事件和每日预启动的分布方面表现最佳。六个选定的多模型CMIP3 GCM，即HADCM3，GFDL-CM2.1，ECHAM5-OM，CCSM3，MRI-CGCM2.3.2和CSIRO-MK3 GCMS，用于降低缩放的气候
过渡金属二分法的光电氧相位工程
晶体学相工程在精确控制材料的物理和电子特性中起着重要的作用。In two-dimensional transition metal dichalcogenides (2D TMDs), phase engineering using chemical lithiation with the organometallization agent n -butyllithium ( n -BuLi), to convert the semiconducting 2H (trigonal) to the metallic 1T (octahedral) phase, has been widely explored for applications in areas such as transistors, catalysis and batteries 1–15 .尽管可以在环境温度和压力下进行这种化学期工程，但对基本机制的理解很少，并且N -Buli的使用引起了显着的安全问题。在这里，我们将单型相位从2H到1T相的典型相跃迁到1T和双层2D TMD中，发现该反应可以通过455 nm处的低功率照明来加速六个数量级。我们确定上述差距照明通过光电氧化过程改善了限制速率的电荷转移动力学。我们使用这种方法来实现TMD的快速和高质量的相位工程，并证明可以利用该方法将任意相模式用衍射限制的边缘分辨率刻在几层TMD中。最后，我们用更安全的多环芳族芳族细胞岩剂代替了热情的n -buli，并表明它们的性能超过了n -buli作为相变剂的性能。我们的工作为探索电化学过程的原位表征开辟了机会，并为通过Photoredox阶段工程提供可持续扩展的材料和设备铺平了道路。