外部专家组 Najeeb Al Shorbaji,约旦电子健康发展协会 Arisa Ema,日本东京大学未来倡议研究所 Amel Ghoulia,H3Africa、H3ABioNet,突尼斯 Jennifer Gibson,加拿大多伦多大学达拉拉纳公共卫生学院生物伦理联合中心 Kenneth W. Goodman,美国迈阿密大学米勒医学院生物伦理与卫生政策研究所 Jeroen van den Hoven,荷兰代尔夫特理工大学 Malavika Jayaram,新加坡数字亚洲中心 Daudi Jjingo,乌干达马凯雷雷大学 Tze Yun Leong,新加坡国立大学 Alex John London,美国卡内基梅隆大学 Partha Majumder,印度国家生物医学基因组学研究所 Tshilidzi Marwala,南非约翰内斯堡大学 Roli Mathur,印度医学研究理事会 Timo Minssen,高级生物医学创新法研究 (CeBIL),哥本哈根大学法学院,丹麦 Andrew Morris,英国健康数据研究中心,英国 Daniela Paolotti,ISI 基金会,意大利 Maria Paz Canales,数字权利组织,智利 Jerome Singh,夸祖鲁-纳塔尔大学,南非 Effy Vayena,苏黎世联邦理工学院,瑞士 Robyn Whittaker,奥克兰大学,新西兰 曾毅,中国科学院,中国
Dongwhi Choi, Ψ Younghoon Lee, Ψ Zong-Hong Lin, Ψ Sumin Cho, Miso Kim, Chi Kit Ao, Siowling Soh, Changwan Sohn, Chang Kyu Jeong, Jeongwan Lee, Minbaek Lee, Seungah Lee, Jungho Ryu, Parag Parashar, Yujang Cho, Jaewan Ahn, Il-Doo Kim, Feng Jiang, Pooi See Lee, Gaurav Khandelwal, Sang-Jae Kim, Hyun Soo Kim, Hyun-Cheol Song, Minje Kim, Junghyo Nah, Wook Kim, Habtamu Gebeyehu Menge, Yong Tae Park, Wei Xu, Jianhua Hao, Hyosik Park, Ju-Hyuck Lee, Dong-Min Lee, Sang-Woo Kim, Ji Young Park, Haixia Zhang, Yunlong Zi, Ru Guo, Jia Cheng, Ze Yang, Yannan Xie, Sangmin Lee, Jihoon Chung, Il-Kwon Oh, Ji-Seok Kim, Tinghai Cheng, Qi Gao, Gang Cheng, Guangqin Gu, Minseob Shim, Jeehoon Jung, Changwoo Yun, Chi Zhang, Guoxu Liu, Yufeng Chen, Suhan Kim, Xiangyu Chen, Jun Hu, Xiong Pu, Zi Hao Guo, Xudong Wang, Jun Chen, Xiao Xiao, Xing Xie, Mourin Jarin, Hulin Zhang, Ying-Chih Lai, Tianyiyi He, Hakjeong Kim, Inkyu Park, Junseong Ahn, Nghia Dinh Huynh, Ya Yang, Zhong Lin Wang, * Jeong Min Baik, * and Dukhyun Choi *
Honorary Chair Weihua Gui, China Advisory Chairs Jonathan Chan, Thailand Zeng-Guang Hou, China Nikola Kasabov, New Zealand Derong Liu, China Seiichi Ozawa, Japan Kevin Wong, Australia General Chairs Tingwen Huang, Qatar Chunhua Yang, China Program Chairs Long Cheng, China Chaojie Li, Australia Hongyi Li, China Biao Luo, China Zheng-Guang Wu, China Technical Chairs Xing He, China Keke Huang, China Huaqing Li, China Qi Zhou, China Local Arrangement Chairs Wenfeng Hu, China Bei Sun, China Finance Chairs Fanbiao Li, China Hayaru Shouno, Japan Xiaojun Zhou, China Special Session Chairs Hongjing Liang, China Paul S. Pang, Australia Qiankun Song, China Lin Xiao, China Tutorial Chairs Min Liu, China M. Tanveer, India Guanghui Wen, China Publicity Chairs Sabri Arik, Turkey Sung-Bae Cho, South Korea Maryam Doborjeh, New Zealand El-Sayed M. El-Alfy, Saudi Arabia Ashish Ghosh, India Chuandong Li, China Weng Kin Lai, Malaysia Chu Kiong Loo, Malaysia Qinmin Yang, China Zhigang Zeng, China Publication Chairs Zhiwen Chen, China Andrew Chi-Sing Leung, HK Xin Wang, China Xiaofeng Yuan, China Secretaries Yun Feng, China Bingchuan Wang, China Webmasters Tianmeng Hu, China Xianzhe Liu, China
Jingyun Yang, Wei Wang, Zimin Chen, Shuaiyao Lu, Fanli Yang, Zhenfei Bi, Linlin Bao, Fei Mo, Xue Li, Yong Huang, Weiqi Hong, Yun Yang, Yuan Zhao, Fei Ye, Sheng Lin, Wei Deng, Hua Chen, Hong Lei, Ziqi Zhang, Min Luo, Hong Gao, Yue Zheng, Yanqiu Gong, Xiaohua Jiang, Yanfeng Xu, Qi Lv, Dan Li, Manni Wang, Fengdi Li, Shunyi Wang, Guanpeng Wang, Pin Yu, Yajin Qu, Li Yang, Hongxin Deng, Aiping Tong, Jiong Li, Zhenling Wang, Jinliang Yang, Guobo Shen, Zhiwei Zhao, Yuhua Li, Jingwen Luo, Hongqi Liu, Wenhai Yu, Mengli Yang, Jingwen Xu, Junbin Wang, Haiyan Li, Haixuan Wang, Dexuan Kuang, Panpan Lin, Zhengtao Hu, Wei Guo, Wei Cheng, Yanlin He, Xiangrong Song, Chong Chen, Zhihong Xue, Shaohua Yao, Lu Chen, Xuelei Ma, Siyuan Chen, Maling Gou, Weijin Huang, Youchun Wang, Changfa Fan, Zhixin Tian, Ming Shi, Fu-Sheng Wang, Lunzhi Dai, Min Wu, Gen Li, Guangyu Wang, Yong Peng, Zhiyong Qian, Canhua Huang, Johnson Yiu-Nam Lau, Zhenglin Yang, Yuquan Wei, Xiaobo Cen, Xiaozhong Peng, Chuan Qin, Kang Zhang, Guangwen Lu & Xiawei Wei
建议引用引用引文Negrao,Marcelo V; Araujo,Haniel A; Lamberti,朱塞佩;库珀(Alissa J); Akhave,尼尔S;周,滕;卢克(Delasos),卢克(Luke);希克斯(J Kevin); Mihaela Aldea; Minuti,Gabriele;海因斯,雅各比; Aredo,Jacqueline V;丹尼斯,迈克尔·J; Turja的Chakrabarti;斯科特,苏珊C; Bironzo,Paolo; Scheffler,Matthias; Christopoulos,Petros; Stenzinger,阿尔布雷希特;瑞斯(Ries),乔纳森(Jonathan W);金,所以Yeon; Goldberg,Sarah B; Li,Mingjia;王,气;清,Yun; ni,ying;做,Minh Truong;李,理查德;里奇蒂,生活; Aless,Joao Victor;王,王;尊敬,bley;洛伦扎·兰迪; Tseng,Shu-Chi; Nishino,Mizuki; Digumarthy,Subba R; Rinsurirangkakong,Waree; Rinksurongkaw,Vadeerat; Vaporciyan,Ara Ara; Blumenschein,George R;张,江;欧文,德怀特H; Blakely,Collin M;吉安尼斯山; Shu,Catherine A; Bestvina,Christine M;加拉西斯,玛丽娜·奇亚拉(Marina Chiara); Marrone,克里斯汀·A;格雷,贾纳尔·E;帕特尔(Patel),桑迪普·普拉文(Sandip Pravin);卡明斯,艾米·L; Wakelee,Heather A;狼,尤尔根; Scagliotti,Giorgio Vittorio;费德里科·卡普佐(Cappuzzo); Barlesi,Fabrice;桶,松鼠D; Drussky,Leylah;吉本斯,唐·L; Mericbernsam,Funda; Lee,J Jack; Heymach,John V;洪,大卫S;抢劫,丽贝卡(Rebecca); Awad,Mark M;以及Skoulis,Ferdinandos,“高级NSCLC中的合作和KRASG12C抑制剂疗效”(2023年)。教职员工和学生出版物。1423。https:// distalCommons
创作者的创作者(S)Ana S. A. Cohen,Emily G. Farrow,Ahmed Abdelmoity,Joseph Alaimo,Shivarajan Manickavasavasagam Amudhavalli,John Anderson,Lalit R. Bansal,Lauren E. ,Shreyasee Chakraborty,Warren A. Cheung,Keith A. Coffman,Ashley M. Cooper,Laura A. Cross,Tom Curran,Thuy Tien T. Dang,Mary M. Elfrink,Kendra Engleman,Erin Day Fecske,Erin Day Fecske,Cynthia Fieser,Cynthia Fieser,Keely M. Fitzgerald,Emily Flemgar,Randi N. jenn n. jenn Et Gibson,Jeffrey Goldstein,Elin Grundberg,Kelsee Halpin,Brian S. Harvey,Bryce Heese,Wendy Hein,Suzanne M. Herd,Susan Starling Hughes,Mohammed Ilyas,Jill Jacobson,Janda L. Jenkins,Shao Jiang,Jeffrey J. Johnston,Kathryn Keeler,Jonas Korlach,Jonas Korlach,Jonnifer ,Michael Lypka,Brittany D. McDonald,Neil Miller,Ann Modrcin,Annapoorna Nair,Shelby H. Neal,Christopher M. Oermann,Donna M. Pacicca,Kailash Pawar,Nyshele L. Ol J. Saunders,Caitlin Schwager,Richard M. Schwend,Elizabeth Shaffer,Craig Smail,Sarah E. Soden,Meghan Strenk,Bonnie Sullivan,Brooke Sweeney、Jade B. Tam-Williams、Adam Walter、Holly Welsh、Aaron M. Wenger、Laurel K. Willig、Yun Yan、Scott T. Younger、Dihong Zhou、Tricia N. Zion、Isabelle Thiffault 和 Tomi Pastinen
抽象背景中国土著绵羊是具有独特特征和特征的宝贵资源。它们分布在中国大陆的气候不同的地区;但是,很少有报道根据其基因组分析了绵羊的环境适应性。我们研究了适应于对极端湿度,高度和温度条件的选择的变体和特征,这些绵羊基因组中的41种表型和地理位置代表性的中国土著绵羊繁殖以表征这些种群中的遗传基础环境适应的遗传基础。基于人口结构分析的结果,我们推断中国土著绵羊分为四类:哈萨克(KAZ),蒙古人(MON),藏族(Tib)(Tib)和Yunnan(Yun)。我们还检测了一组与适应极端环境条件相关的罐头基因,例如易于干旱的区域(TBXT,TG,TG和HOXA1),高蓝色区域(DYSF,EPAS1,JAZF1,JAZF1,PDGFD,PDGFD和NF1和NF1和NF1)和温暖的区域(Tshr,tshr,abcD4)和ABCD4和ABCD4和ABCD4,在所有这些候选基因中,八个ABCD4,CNTN4,DOCK10,LOC105608545,LOC121816479,SEM3A,SVIL和TSHR在极端环境条件之间重叠。TSHR基因在温暖组中显示出强烈的签名,并在染色体上置于90,600,001和90,650,001之间的单个核苷酸聚合物(SNP)错义突变,这会导致TSHR蛋白质结构的变化,并影响其稳定性。对选择与环境适应性有关的选择基因和TSHR基因中SNP错义突变的结论分析,该基因影响蛋白质结构和稳定性。它还提供了有关中国土著绵羊种群植物地理结构演变的信息。这些结果为未来的繁殖研究提供了重要的遗传资源,以及有关动物如何适应气候变化的新观点。
Marsha M. Wheeler* 1, Adrienne M. Stilp* 2 , Shuquan Rao* 3 , Bjarni V. Halldórsson 4,5 , Doruk Beyter 4 , Jia Wen 6 , Anna V. Mikhaylova 2 , Caitlin P. McHugh 2 , John Lane 7 , Zhi Gof field , M. Jio 8 . Jun 9 , Fritz J. Sedlazeck 10 , Ginger Metcalf 10 , Yao Yao 3 , Joshua B. Bis 11 , Nathalie Chami 12 , Paul S. de Vries 13 , Pinkal Desai 14 , James S. Floyd 11 , Yan Gao 15 , Kim Kammer 16 , Young-Young Moon 18 , Aakrosh Ratan 19 , Lisa R. Yanek 16 , Laura Almasy 20 , Lewis C. Becker 16 , John Blangero 21 , Michael H. Cho 17 , Joanne E. Curran 21 , Myriam Fornage 22 , Robert C. Kaplan 18 , Jos. Loos 22 , Ruth P. Hua . xton D. Mitchell 23 , Alanna C. Morrison 13 , Michael Preuss 12 , Bruce M. Psaty 11 , Stephen S. Rich 19 , Jerome I. Rotter 24 , Hua Tang 25 , Russell P. Tracy 26 , Eric Boerwinkle 13 , Abeca Smith , Albert V. Smith , 27 . 27 , Andrew D. Johnson 28 , Rasika A. Mathias 16 , Deborah A. Nickerson 1 , Matthew P. Conomos 2 , Yun Li 6 , NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Unnur Þorsteinsdóttir 4,29 , Magnússon , Stefansson , 24 9 , Nathan D. Pankratz* 7 , Daniel E. Bauer* 3 , Paul L. Auer** 30 , Alex P. Reiner** 31
米切尔·布什克(Mitchell Bushuk),位于撒哈拉阿里(Sahara Ali),b david A. Bailey,C Qing Bao,D LaurianeBatté,E Uma S. Bhatt,E Edward Blanchard-Wrigestworth,G Ed Blockley,G Ed Blockley,Hgavin Cawley,Hgavin Cawley,i Junhaw Goulet I. Culllet Richlet I. Cullath,M,M,Kk Francis Dirkis X. diberial Exracu,QMaximilianGöbel,R William Gregory,S Virgini Guemas,T Lawrence Hamilton,U Bean He,D Senifer E. Caya,Uther,Uther,Elliot Kim,M Noriaki Kimura,N Dmitry Condrashov,Y Zachary M. CCED WISED LIN,DD YU’MASSONNET,GG WALTER N. pp Steefen Titsche, qq Michel Tsamadus, rr Keguang Wang, ss Jianwu Wang, b Wonqi Whee Yigo Wang, c Younghua, dad James Williams, bolun Yag, dedd Zhang, n and Youngfei Zhang s
•4:Ashley Bristowe; edited • 6: Alexandra Kovaleva • 7(3): Michael Willis/Alamy • 7(4): Gehl Architects • 8: Leo Novel/Alamy • 9: Jimmytst/Dreamstime • 10: s74/Shutterstock • 12: Glen Bowman - https://flic.kr/p/4DU3FT, CC by-SA 2.0 • 13,14,17:城市重建局(URA);编辑•18(1):Indraneel Biswas-https://flic.kr/p/ cpfm2o,cc by-nc-nc-nd 2.0•18(2):ura•19:nparks•20:nparks•20:hak liang•21:jerry wong•23:jerry wong•23:asia square•asa square•24:yun fuu;编辑•27:Dale East-https://flic.kr/p/bmwwo,cc by-nc-nd 2.0 2.0•28:Marco de Swart•29:David Brossard-https://flic.kr/p/p/nhnflb,cc by-sa 2.0 2.0•31(1):Mario Burger•31(Mario Burger•31(2):2)纽约市的“切尔西之夜”音乐会系列•33:唐人街食品街 - www.chinatownfoodstreet.sg•34:Karo Architekten•35:Olivier Ottevaere和John Lin•36(顶部):Carlos Barrientos:Carlos barrientos -https://https:// https:///flic.kr/pp/9g3cyx•36(Josh)•36(JOSH): jamjarjen.wordpress.com•37(底部):Adam Mork/Schmidt Hammer Lassen Architects•47,48:47:ICLEI•49:Simphiwe nkwali•51:Jewelle Woo(Victoria Junior College),Ura•53(1):JON SIEGEL•53(53) https://flic.kr/p/6luxgx,cc by-nc-sa 2.0•53(3):clc•54,56:fiona li•57:idmanjoe/dreamstime•59(1):www.walkwithcham.com 62:Google地图•63:Steven Severinghaus -https://flic.kr/p/ PE9RGN,CC BY -NC -SA 2.0 2.0•64:纽约州的大都会运输管理局-https:///flic.kr/p/p/ oxnkw1 https://flic.kr/p/dvr6fb,cc by-nd 2.0•66:Kohn Pedersen Fox Associates