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1. 以正楷填写全名及地址。应列明所有联名登记持有人的姓名。2. 请填写本代表委任表格所登记的本公司股份数目。如未填写任何数目，本代表委任表格将被视为与所有登记于您名下的股份有关。3. 如希望委任会议主席以外的任何代理人，请删除“会议主席”或并在所提供的空白处填写所需代理人的姓名及地址。对本代表委任表格的任何更改均须由签署人亲自签章。如未填写姓名，会议主席将担任代理人。4. 本决议仅作摘要说明。全文载于本公司会议通知。 5. 重要提示：如果您希望投票赞成某项决议，请在“赞成”方框中打勾。如果您希望投票反对某项决议，请在“反对”方框中打勾。如果未给出指示，您的代理人可以按照其认为合适的方式投票或弃权。您的代理人还有权自行决定对除召集会议通知中提及的决议之外的任何正式提交会议的决议进行投票。6. 本代理表格必须由您或经书面授权的您的律师签署，如果是公司，则必须在其公章下或由经正式授权签署该表格的官员、律师或其他人员签署。7. 有权出席会议并投票的任何公司股东均有权委任另一人作为其代理人，代替其出席会议并投票。持有两股或以上股份的股东可委任多于一名代表出席大会并代表其投票，但如委任多于一名代表，委任书须列明每名代表所代表的股份数目。代表无须为本公司股东，但必须亲自出席大会以代表阁下。8. 本委任表格连同签署本委任表格的授权书或其他授权文件（如有）或该等授权书或授权文件的经核证副本，须于大会或其任何续会指定举行时间前至少 48 小时送达本公司香港股份过户登记分处联合证券登记有限公司，地址为香港北角英皇道 338 号华懋交易广场二期 33 楼 3301-04 室，方为有效。 9. 就股份联名持有人而言，任何一名联名持有人均可亲自或委派代表就该股份投票，犹如他/她独自拥有该股份的投票权，但如果有多于一名联名持有人出席会议，则应接受优先投票人（无论是亲自或委派代表）的投票，而排除其他联名持有人的投票。就此而言，优先次序应按联名持股的公司股东名册上的姓名顺序确定。10. 填妥及交付本代表委任表格并不妨碍任何股东出席股东大会并亲自投票（如该股东愿意），在此情况下，本代表委任表格应被视为撤销。
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A.General .............................................................................................................................................. 5 1.Scope of Bid ..................................................................................................................................................................... 5 2.Source of Funds .............................................................................................................................................................. 5 3.Fraud and Corruption .................................................................................................................................................... 5 4.Eligible Bidders ................................................................................................................................................................ 6 5.Eligible Goods and Related Services ........................................................................................................................... 7 B.Contents of Bidding Document ........................................................................................................ 7 6.Sections of Bidding Document ................................................................................................................................... 7 7.Clarification of Bidding Documents ............................................................................................................................ 8 8.Documents Establishing the Eligibility of the Bidder ............................................................................................ 11 17.Amendment of Bidding Documents ........................................................................................................................... 8 C. Preparation of Bids ............................................................................................................................ 8 9.Cost of Bidding................................................................................................................................................................ 8 10.Language of Bid ............................................................................................................................................................... 8 11.Documents Comprising the Bid ................................................................................................................................... 8 12.Bid Submission Sheet and Price Schedules ................................................................................................................ 9 13.Alternative Bids ............................................................................................................................................................. 10 14.Bid Prices and Discounts ............................................................................................................................................. 10 15.Currencies of Bid .......................................................................................................................................................... 11 16.Documents Establishing the Eligibility of Goods and Related Services............................................................. 11 18.12 19。文件，确定商品及相关服务的合规性。Documents Establishing the Qualifications of the Bidder .................................................................................... 12 20.Period of Validity of Bids ............................................................................................................................................ 12 21.Bid Security .................................................................................................................................................................... 12 22.Format and Signing of Bid .......................................................................................................................................... 13 D. Submission and Opening of Bids .................................................................................................... 13 23.Sealing and Marking of Bids ........................................................................................................................................ 14 24.Deadline for Submission of Bids ................................................................................................................................ 14 25.Late Bids ......................................................................................................................................................................... 14 26.撤回，替代和修改出价...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................Bid Opening ................................................................................................................................................................... 15 E. Evaluation and Comparison of Bids ............................................................................................... 15 28.Confidentiality ................................................................................................................................................................ 15 29.Clarification of Bids ...................................................................................................................................................... 16 30.Responsiveness of Bids ................................................................................................................................................ 16 31.不合格，错误和遗漏............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 16 32。Preliminary Examination of Bids ............................................................................................................................... 17 33.审查条款和条件；技术评估...............................................................................Conversion to Single Currency ................................................................................................................................... 17 35.Margin of Preference .................................................................................................................................................... 17 36.Evaluation of Bids ......................................................................................................................................................... 18 37.Comparison of Bids ...................................................................................................................................................... 19 38.Post-qualification of the Bidder .................................................................................................................................. 19 39.Procuring and Disposal Entity's Right to Accept Any Bid, and to Reject Any or All Bids ............................ 19 F. Award of Contract............................................................................................................................ 19 40.Award Criteria ................................................................................................................................................................ 19 41.Procuring and Disposal Entity's Right to Vary Quantities at Time of Award ................................................... 19 42.Notification of Award .................................................................................................................................................. 19 43.Signing of Contract ....................................................................................................................................................... 20 44.Performance Security.................................................................................................................................................... 20
![[Hiroshima University]防止遗传性顽固性疾病，多囊性肾脏疾病的发作...](/simg/g:\will\search\icon\source\9\98e0a9ee1d2e76f9f014ae06e9b98ce27b5eea93.webp)
加速度诱発性意识消失（Gravity-induced loss of consciousness
摘要 重力引起的意识丧失 (G-LOC) 是战斗机飞行员面临的主要威胁，可能会导致致命事故。高 +Gz（头到脚方向）加速度力会诱发脑出血，导致周边视力丧失、中央视力丧失（昏厥）和 G-LOC。我们尝试建立一个公式，使用脑氧合血红蛋白 (oxyHb) 值、身高、体重和身体质量指数 (BMI) 来预测 G-LOC。我们分析了 2008 年至 2012 年间测量的 249 名人体离心机受训者的脑氧合血红蛋白值。受训者暴露于两种离心机模式。一种是 4G–15s、5G–10s、6G–8s 和 7G–8s，不穿抗荷服（间隔 60 秒，发作率为 1G/s）。另一组为 8G-15s，起始速率为 6G/s，穿着抗荷服。我们使用近红外光谱仪 (NIRS)（NIRO-150G，日本静冈县滨松光子学株式会社，滨松）测量了受训者的脑氧合血红蛋白值。分析了以下参数。A）基线值为 +Gz 暴露前 30 秒的平均值。B）+Gz 暴露期间氧合血红蛋白的最大值。C）+Gz 暴露期间氧合血红蛋白的最小值。D）氧合血红蛋白从最大值到最小值的变化率（变化率）。使用逻辑回归分析进行统计分析，以建立预测 G-LOC 的公式。受训者的年龄为 24.1 ±1.7（S.D.）（范围，22 ～ 30）
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图1多个系统萎缩的治疗方法这种形状说明了针对多系统萎缩（MSA）病理机制的各种治疗策略。MSA的特征是神经元丧失，神经胶质病和α-突触核蛋白夹杂物的积累。抗 - α突触核蛋白疗法包括 - 在诸如ANELE138B，清除剂，例如PD01A，PD03A，LU AF82422，TAK - 341和UB – 312和UB –312和UB –312和抑制方法之类的清除剂中的聚集。细胞疗法涉及修复和再生受损神经组织的间充质干细胞。能量代谢和INSU -LIN信号 - 靶向疗法包括脱齿素 - 4，泛氨醇和NAD +补充。抗炎性和神经保护疗法具有氟西汀，AAV2 - GDNF和KM819的化合物，可减少炎症并提供神经保护作用。细胞调节文本包括显示退化的神经元，α-突触核蛋白夹杂物，活化的星形胶质细胞和小胶质细胞，免疫 - 反应性T细胞，IM成对的线粒体，Pro - 炎性细胞因子，肌蛋白损失和髓质细胞质细胞胞质包含（GCIS）（GCIS）。此视觉代表提供了MSA中治疗策略及其细胞靶标的概述。