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ACALISE African Centre of Excellence in Agro-Ecology and Livelihood Systems ASRH Adolescent Sexual Reproductive Health BoQs Bills of Quantities BRMS Basic Requirements and Minimum Standards BSFL Black Soldier Fly Larvae BTVET Business and Technical Vocational Education Training CBTC Competency Based Training curricula CDC Centre for Disease Control COU Church of Uganda COVID-19 Corona Virus Disease 2019 CPHL Central Public Health Lab CPs Community Polytechnics CUUL Consortium for Uganda University Libraries DBS Diploma in Business Studies DDEG Discretionary Development Equalization Grant DEO District Education Officer DES Directorate of Education Standards DIS District Inspector of Schools DLG District Local Government DLIS Diploma in Library and Information Science DPLM Diploma in Procurement and Logistics Management DRIM Diploma in Records and Information Management DSC District Service Commission DSIM Diploma in Secretarial and Information Management ECCE Early Childhood Care Education ECD Early Childhood Development EGM Early Grade Math EGR Early Grade Reading EMIS Education Management Information System ESA Education Service Agency ESC Education Service Commission ESIA Environmental and Social Impact Assessment ESP Expand Social Protection FCI Faculty of Computing and Informatics FY Financial Year GAVI Global Alliance for Vaccine Initiative GFS Gravity Flow Scheme GOU Government of Uganda HCDP Human Capital Development Project HEIs Higher Education Institutions HESFB Higher Education Students' Financing Board
成纤维细胞生长因子(FGF)受体3(FGFR3)是跨膜受体高度保守的FGFR家族的成员。9-11有四个FGF受体FGFR1-4,每个FGFR1-4由细胞外配体结合结构域,跨膜结构域和一个细胞内酪氨酸激酶结构域组成。10,11受体二聚化在细胞外结构域与FGF配体系列的高亲和力成员结合后,导致细胞内结构域和磷脂酶Cγ,PI3K-AKT,RAS-MAPK-ERK,RAS-MAPK-ERK和STAT PARHWOWEN PATHERACH ENTERATION,在几种过程中扮演重要角色和发展的角色,导致磷酸化。9,11,12 FGFR3畸变作用在肿瘤类型的肿瘤中起作用,已在15%至20%的晚期尿路上皮膀胱癌中被鉴定出来,约15%的子宫癌(子宫癌)在其他固体肿瘤恶性肿瘤中的子宫内膜癌的约5%,较少的频率(<5%)。10,11,13,14激活的FGFR3改变是多种多样的,包括点突变,融合,扩增和过表达。9-12 FGFR3的失调促进了肿瘤生成和肿瘤细胞的增殖,迁移和存活。9-12,15