XiaoMi-AI文件搜索系统
World File Search SystemAlthough
通过靶向分子药物和放射疗法对无法手术的Her2阳性乳腺癌的疾病控制：病例报告
局部控制以前被认为是老年人乳腺癌治疗的主要目标，肿瘤壳或全乳房切除术是日本的主要治疗方法。7然而，80岁妇女的平均预期寿命为12.3岁，而85岁和90岁的非常年老的女性的预期寿命分别为8.8和5.9岁。8因此，我们认为系统治疗对于解决遥远转移的可能性是必要的。然而，接受化疗的老年乳腺癌患者的比例显着低，并且由于单独年龄而省略化疗，这可能导致治疗不足。9 Although comorbidities such as heart diseases can make the use of anthracyclines and taxanes difficult, a randomized controlled trial of trastuzumab with or without chemotherapy in the postoperative adjuvant treatment of elderly HER2-positive early stage breast cancer demonstrated the absence of non-inferiority of trastuzumab alone and the OS difference to be of 1 month at 3 years, reducing side effects and preserving healthy QoL.10我们认为，对于患有合并症的老年乳腺癌患者而言，HER基和每个基于每项疗法可能是可行的选择，表现出身体和认知能力下降。
生成的AI可改善Web可访问性-IJRPR
D-1,2,4-丁二醇（BT）是增塑剂，聚合物，阳离子脂质和药物生产中的重要化学物质。它在1,2,4-丁二醇三硝酸酯（BTTN）生产中也具有重要作用，这是一种适合更换传统硝酸甘油（Abdel-Ghany等，2013; Cao等，2015）的推进剂和爆炸性配方中的能量增塑剂。对冲击，较高的热稳定性和挥发性较小的敏感性比硝酸甘油的优势降低了（Gouranlou，＆Kohsary，2010年）。Chemical reduction of malic acid using NaBH 4 leads to 1,2,4-Butanetriol producedion (Gouranlou & Kohsary, 2010; Bamba et al., 2019), Although this production process generates great amount of borate salts as a disposal by-product, but provide other catalysts such as copper chromite and rubidium for 1,2,4-butanetriol production (Niu et al., 2003年），催化减少需要特定条件，例如高压和高温。此外，副产品的不可避免的产生降低了1,2,4-丁二醇生产率（Niu等，2003； Bamba等，2019）。
Journal of Cleaner Production - BCU Open Access Repository
The textile and clothing industry is a significant global sector due to its economic and social contributions. However, it is one of the most polluting industries. There has been a significant uptake of research on circular economy implementation to reduce its environmental impacts. Nevertheless, there is a critical gap in reviewing how the research field is evolving and what the core focus and underlying assumptions of the existing research are. This paper utilises bibliometrics, content analysis, and problematisation to comprehensively examine the state of research. Analysing 132 primary documents dating from January 2014 to April 2023, this study reveals that sustainability-oriented innovation and transition challenges are the core focus of existing research. Technology-oriented circularity and its positive impact on sustainability is the in-house assumption that almost all studies are founded on. Besides unpacking the risk of such assumptions, this study provides tangible sug gestions for future research on circular economy disruption, its rebound effect, and sustainability-oriented innovation. Although the time lag and language biases may have impacted the representation of current research trends, findings from this study can facilitate academic research and industry practice in implementing circular economy practices for a more sustainable future.
通过HPLC-DAD和UPLC-MS/MS
摘要麻黄是麻黄科家族的属，在温带地区，例如中亚和欧洲。在各种麻黄种中，莫黄（Ephedra Herb）源自Ephedra Sinica Stapf的空中部分，Ephedra Equisetina Bunge和Ephedra Intermedia Schrenk＆C.A.Mey。 Ma Huang contains various ephedra alkaloids, including ( )-ephedrine, (+)-pseudoephedrine, ( )-norephedrine, (+)- norpseudoephedrine, ( )-methylephedrine, and (+)-methylpseudoephedrine, which are found naturally as single enantiomers, although they can be prepared作为种族。 尽管在韩国禁止在食品中使用ma huang，但可以进口含有马黄的产品，因此有必要开发合适的分析技术来检测食品中的ma huang。 在此，我们报告了用于检测包含马黄产品的麻黄碱的分析方法的开发。 通过固相提取样品纯化后，使用超表现液相色谱 - 三极杆质谱法（UPLC-MS/MS）进行定量分析。 此外，使用HPLC-DAD成功分离了对映异构体。 我们成功地分析了各种食物样本，在这些食物样本中，在促定性和定量上确定了麻黄碱，并分离了对映异构体。 预计这些方法可能有助于防止含有Ma Huang的非法产品的分布。 关键字ma huang，ephedra生物碱，uplc-ms/ms，hplc-dad，对映体分离Mey。Ma Huang contains various ephedra alkaloids, including ( )-ephedrine, (+)-pseudoephedrine, ( )-norephedrine, (+)- norpseudoephedrine, ( )-methylephedrine, and (+)-methylpseudoephedrine, which are found naturally as single enantiomers, although they can be prepared作为种族。尽管在韩国禁止在食品中使用ma huang，但可以进口含有马黄的产品，因此有必要开发合适的分析技术来检测食品中的ma huang。在此，我们报告了用于检测包含马黄产品的麻黄碱的分析方法的开发。通过固相提取样品纯化后，使用超表现液相色谱 - 三极杆质谱法（UPLC-MS/MS）进行定量分析。此外，使用HPLC-DAD成功分离了对映异构体。我们成功地分析了各种食物样本，在这些食物样本中，在促定性和定量上确定了麻黄碱，并分离了对映异构体。预计这些方法可能有助于防止含有Ma Huang的非法产品的分布。关键字ma huang，ephedra生物碱，uplc-ms/ms，hplc-dad，对映体分离
jolyon dales
• Person adhering to restricted food intake • BMI <27 kg/m² although diabetes and other specialists may use them in people with lower BMI for potential cardiac or renal benefits • Person at risk of developing high glucose related complications (dehydration, poor compliance to treatment, frequent missed medications) • Person with history of ketoacidosis unless there was a different precipitant for DKA that has been resolved and type 1糖尿病，LADA或胰岛素缺乏症已被排除在外•患有医疗疾病的人急性不适，尽管专家可能希望继续接受SGLT-2抑制剂，即使在老年人或计划的医疗程序中，患有慢性心力衰竭的患者也可能需要饥饿，可能需要饥饿的人•患有过量的酒精消耗或静脉吸毒的人•患有hba1c> 86 mmol/mor> 86 mmol/mol.86 mmol/mor。（这些人的泌尿生殖器感染风险的额外风险）•有脱水风险的脆弱和老年人•认知障碍•1年内迅速发展为诊断后需要胰岛素的人•胰腺疾病•可疑或可能的1型糖尿病或可能的LADA，除非在专业监督
Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023
ycoplasma pneumoniae is a common etiologic agent of community-acquired pneumonia (CAP) among children. Although M. pneumoniae infection often causes a mild and self-limiting dis- ease, pneumonia develops in ≈ 10%–20% of pediatric patients ( 1 ). First-line therapies for M. pneumoniae infection are based on macrolides, a group of anti- microbial drugs widely used in outpatient settings because of their high oral bioavailability. However, overuse and indiscriminate use of macrolides have contributed to the emergence of macrolide-resistant M. pneumoniae (MRMP). Point mutations in the V region of the M. pneumoniae 23S rRNA gene have been associated with macrolide resistance ( 2 ). In recent years, prevalence of MRMP has increased and is very high in Asia (13.6%–100%) ( 2 – 4 ). Dur- ing spring/summer 2023, hundreds of children with CAP were admitted daily to each of the major hospi- tals in Hanoi, Vietnam. M. pneumoniae has emerged as the major pathogen detected in approximately one third of patients with CAP (5). We analyzed the mutations in the 23S rRNA gene of M. pneumoniae isolated from nasopharyngeal samples of pediatric CAP patients during the 2023 outbreak in Vinmec Times City Hospital, Hanoi.
朝着循环经济指标
欧洲环境局（2016年）提议循环经济（CE）是绿色经济模型的核心要素，该模型将废物管理（WM），废物预防和资源效率扩展到人类的福祉和生态系统的复杂性。ce是“一种经济体系，可以通过减少，再利用，回收和回收材料在生产/分配和消费过程中取代'寿命终止'概念”（Kirchherr等人，2017年）。The concept of CE is a crucial theme towards sustainable development (Bockreis and Ragossnig, 2023; D'Adamo et al., 2023a; Zorpas et al., 2021), although the impact of each source of CE value (recycling, renewable energy, repair and reuse) varies across the three dimensions of sustaina- bility (Knäble et al., 2022).可以通过适当的政策（Hartley等，2020）和公司实施的具体项目（Henry et al。，2020）驱动的大规模实施。分析CE上的公司任务陈述，可持续性的主题出现，其次是技术，生产和消费（PC）的主题。然而，在可持续性主题中，社会成分受到较少的关注（Caferra等，2023）。EC的主题与WM密切相关，WM可以从数学模型（Barma et al。，2022; Barma and Modibbo，2022），Local
“一个工作的好地方”
• 71% of colleagues would recommend the Trust as a place to work • 79.5% of colleagues would recommend the Trust to provide care • Appraisal – 90% of our people have an annual appraisal though this has been impacted by the pandemic (76% March 2021) • Training – 90%+ of our people are typically up to date with their statutory and mandatory training, although again this has been impacted by the pandemic （85％2021年3月）•疾病缺席 - 在任何给定时间之间，我们的人有3.9至5％之间的病人•2020年的员工调查告诉我们，自2019年以来，我们的得分有了适度的提高，但仍有更多的工作来达到一致的最高Quartile绩效•响应率•46.3％ - 46.3％ - 46.3％的响应率提高了两种问题•高度相关•竞争者•逃跑•竞争•逃跑•范围•在较高的范围内•••竞争••在较高的问题上•在较高的问题上••在较高的问题上••竞争•在较高的问题上，••在较高的问题上，••范围差异•多样性和包容性•安全环境 - 欺凌和骚扰•我们的评级的56％得到了改善； 24％的人保持不变，而20％的恶化•在十个主题中 - 有7个改善，两个没有改变，一个恶化•同事同意该信托对工作场所健康和健康状况的积极行动有10％的提高
2024年11月15日
Although PLCP intends to document on an ongoing basis that the non-grandfathered corn ethanol it produces at its Steamboat Rock, Iowa facility through the PLCP Steamboat Rock Corn Process meets the appropriate greenhouse gas (GHG) emissions reduction requirements, EPA has performed a threshold lifecycle GHG emissions analysis based on the information in the PLCP petition to determine if it appears that corn ethanol produced at the如果满足某些条件，设施可能会减少所需的温室气体。本文档中解释的结果分析涉及到2010年3月26日发布的最终规则（75 FR 14670）使用的相同方法和建模的直接应用（“ 2010年3月RFS Rule”）。根据原料的数量以及用于生产一定量的玉米乙醇的原料和能量的数量，对2010年3月RFS规则完成的分析之间的差异是评估更有效的燃料生产过程。基于PLCP请愿书中提供的数据，我们的分析发现，如果PLCP满足本文档中指定的所有条件以表明这种乙醇符合至少20％的生命周期性的清洁空中，则通过PLCP Steamboat Rock玉米工艺产生的非祖父玉米乙醇可能能够成为可再生燃料。2
SARS-COV-2感染和H1N1疫苗接种
摘要。– OBJECTIVE: SARS-CoV-2 has been compared with other strains of coronavi- ruses, SARS-CoV and MERS-CoV, and with the flu viruses: all of them manifest themselves with respiratory symptoms and, although their ge- netic patterns are similar, the spread of SARS- CoV-2 infection has quickly reached global di- mensions, demonstrating that SARS-CoV-2 is a virus with greater spreading capacity, albeit less lethal.与流感病毒相比，肺炎病毒的孵育期更长，患有冠状病毒综合征的患者更严重，需要频繁住院和重症监护。目的是探索季节性流感疫苗接种和coro纳维病感染之间的关系，并了解流感疫苗的这种假设作用是否会改变SARS-COV-2感染的结果。患者和方法：在这项反应性的多中心研究中，我们招募了952名被诊断出患有SARS-COV-2感染的患者； 448被我们在费拉拉地区的两家主要医院录取，其余504位在家中被隔离。我们将过去12个月中的流感疫苗接种的患者组与未接种疫苗的患者进行了比较。结果：在接种疫苗和未接种疫苗的患者中，住院需求和30天死亡率都发现了显着差异。我们发现年龄是30天预后较差的唯一独立危险因素，而性别，流感疫苗和年龄本身是住院治疗的独立危险因素。