摘要。端到端图像压缩的最新进展可能会超过传统的编解码器,以超越率延伸性能。但是,当前的方法要么优先考虑人类概念质量,要么仅针对一个或几个预定的下游任务优化,从而忽略了涉及各种不可预见的机器视觉任务的更常见的情况。在本文中,我们提出了一个基于扩散的多任务统一图像压缩框架,旨在通过在开放设定的场景中纳入Hu-Man感知和多个视觉任务来扩展传统图像压缩的边界。我们提出的方法包括多任务协作嵌入模块和基于扩散的不变知识学习模块。以前的模块有助于完成多个任务的协作嵌入,而后一个模块通过将不变知识从可见的视觉任务中提炼出来,从而提高了对不可预见的任务的概括。实验表明,所提出的方法提取了用于Human和Machine Vision协作压缩的紧凑和多功能嵌入,从而带来了出色的性能。Specifically, our method outperforms the state-of-the-art by 52.25%/51.68%/48.87%/48.07%/6.29% BD-rate reduction in terms of mAP/mAP/aAcc/PQ-all/accuracy on the MS-COCO for object de- tection/instance segmentation/semantic segmentation/panoptic segmen- tation and video question answering tasks, 分别。
一种理论模型,该模型试图考虑到革兰氏阴性细菌中的周质 / - 乳糖确定的青霉素抗性水平(22)。The relevant parameters are the kinetic characteristics (Ki,m Vmax, and amount of enzyme produced) of the /)-lactamase, a perme- ability parameter (C) for the diffusion of the antibiotic across the outer membrane, and the concentration of the ,8-lactam antibiotic in the periplasmic space (Sp), specifically the concen- tration, SP, necessary for lethal inhibition内膜中的位点(一个或多个青霉素结合蛋白[17])。使用这种方法Zimmermann和Rosselet(22)成功地解释了TEM,B-乳糖果酶(在这种情况下,由R Plasmid RTEM编码)赋予Escherichia coli K-12的Ampicilin抗性,以及该enzyme diseme concememe conceporance conceporance的无能为力。对于阴茎lin g,该方法失败了。作者考虑了这样的解释,即在微型抑制浓度(MIC)检测过程中,外膜的屏障功能发生了变化(22)。但是,他们对SP的估计也可能是错误的。此处报告的实验为模型提供了不同的测试。通过使用对几种底物的亲和力改变的突变Fi-内酰胺酶,我们避免了估算SP的必要性,而是比较了由突变体直接确定的青霉素耐药性与由野生型酶确定的抗性。
MTAP基因的纯合缺失是癌症中最常见的遗传改变之一,影响了所有人类癌症的10-15%。开发了包括TNG908和TNG462在内的临床MTA合并PRMT5抑制剂,以利用PRMT5抑制和MTAP缺失之间充分表征的合成致死相互作用。的确,第一个披露的MTA合作性PRMT5抑制剂的临床数据证明了TNG908在MTAP删除的肿瘤中有选择性地抑制PRMT5的能力,同时在患者中保留邻近的正常,MTAP-Profofoffic-Profofoffic-MTAP-Profofoffoffient。为了进一步探索MTA骨骼删除细胞中MTA合件性PRMT5抑制剂的作用机理,我们采用了多个基于CRISPR的编辑平台(CRISPRN,CRISPRI和CRISPRA)来进行无偏MTA合件性PRMT5抑制剂锚固筛网,并在In In In In In Intro和Vivo中进行。代表多种组织学的癌症模型揭示了潜在的PRMT5抑制剂敏化和耐药途径,这些途径还包括特定于MTA合并抑制剂的机制。Specifically, the results of these screens identify 1) the effect of MTA/SAM metabolism on MTA-cooperative PRMT5 inhibitors, and 2) identification of potential sub-stratification strategies for patients with MTAP-deleted cancer, and 3) the activity of PRMT5 in anti-apoptotic pathways and synergy between PRMT5 and BCLxL inhibition.
我们旨在评估大型语言模型(LLMS)进行具体的决策。尽管大量的工作一直在利用LLM在体现的环境中进行决策,但我们仍然缺乏对其性能的系统性理解,因为它们通常用于不同的域,用于不同的目的,并基于不同的输入和输出。此外,现有的评估倾向于仅依赖最终的成功率,因此很难确定LLM中缺少什么能力以及问题所在的地方,进而有效地和选择性地利用LLMS的药物。为了解决这些限制,我们提出了一个广义接口(e Mboded a gent i nterface),该界面支持基于LLM的模块的各种任务和输入输出规格的形式化。Specifically, it allows us to unify 1) a broad set of em- bodied decision-making tasks involving both state and temporally extended goals, 2) four commonly-used LLM-based modules for decision making: goal interpre- tation, subgoal decomposition, action sequencing, and transition modeling, and 3) a collection of fine-grained metrics that break down evaluation into error types, such as hallucination errors, affordance errors, and various计划错误的类型。总体而言,我们的基准对LLMS在不同子任务中的性能进行了全面评估,从而指出了LLM驱动的体现体现的AI系统的优势和劣势,并提供了对LLM在体现决策中的有效和选择性使用的见解。
This performance task was intended to assess students' ability to conduct scholarly and responsible research and develop an evidence-based argument that clearly communicates a conclusion or new understanding stemming from a clearly articulated research question or project goal. More specifically, this performance task was intended to assess students' ability to: • Generate a focused research question that is situated within or connected to a larger scholarly context or community; • Explore relationships between and among multiple works representing multiple perspectives within the scholarly literature related to the topic of inquiry; • Articulate what approach, method, or process they have chosen to use to address their research question, why they have chosen that approach to answering their question, and how they employed it; • Develop and present their own argument, conclusion, or new understanding while acknowledging its limitations and discussing its implications to a larger community of practice; • Support their conclusion through the compilation, use, and synthesis of relevant and significant evidence generated by their research; • Use organizational and design elements to effectively convey the paper's message; • Consistently and accurately cite, attribute, and integrate the knowledge and work of others, while distinguishing between the student's voice and that of others; • Generate a paper in which word choice and syntax enhance communication by adhering to established conventions of grammar, usage, and mechanics.
HB 2670试图使非创伤性脑损伤特异性地确定为俄勒冈州学生个性化教育计划(IEP)的资格类别是一个好主意,尽管它比在HB 2670中代表的更为复杂。Current IDEA law does not specifically identify "internally caused" brain injuries (from, for instance, near drowning and other anoxic events, tumor, infection, disease process, and the like) as a type of injury that automatically makes a student eligible for an IEP, and, as a result, many students with "internally caused" brain injuries are required to utilize the "other health impairment" category in order to qualify for an IEP.这应该在俄勒冈州以及想法本身中进行更改。从这个意义上讲,HB 2670的起草者是正确的。需要更改。话虽如此,这是一个比HB 2670中所设想的更大的修复方法,并且需要采用详细且经过深思熟虑的全方位甲板方法,这是来自许多不同利益相关者的投入,包括最重要的是,包括ODE。此外,此修复程序可能会在桨内部的ode规则变更中有效地发生。如果该法案中允许停顿,I和CBIRT的其他人将与起草者和其他重要的利益相关者勤奋合作,以及时进行必要的更改,并希望在本立法会议之后准备好考虑它。
•2021年《美国救援计划法》(P.L.117-2), which, among other things, appropriated $8 billion to the Federal Aviation Administration (FAA) to provide grants to airports for operations costs and debt service, and appropriated $3 billion to the U.S. Economic Development Administration to help state and local governments respond to economic injury as a result of the pandemic, including $750 million reserved for states and local communities specifically affected by job losses in the travel, tourism, or outdoor recreation行业; •《基础设施投资与就业法》(P.L.117-58),除其他外,它还拨款150亿美元用于FAA的机场基础设施项目,用于提高安全性和扩大能力的机场基础设施项目,并要求运输部长更新交通运输部(DOT'S)国家旅行和旅游基础设施基础设施计划,并授权创建一项主要旅行和旅游官员在DOT DOT内部DOT; •《恢复品牌美国法》(《合并拨款法》,2022年[P.L.117-103]),它为公司提供了2.5亿美元的一次性资金,用于旅行促销公司,这是一个公私实体,从事美国品牌的业务;和•《访问美国法》(副标题A,标题VI,第六章,《合并拨款法》的BB,2023年[P.L.117-328]),除其他外,它授权创建新的助理商务部长在商务部内进行旅行和旅游业。关于旅游业的几项政策考虑因素可能引起了国会的关注。这些包括:
抽象tick传播的脑炎(TBE)是一种神经病毒病毒疾病,严重程度从轻度的发热疾病到严重而威胁生命的脑膜脑炎或脑脊髓炎。有越来越多的证据表明,除其他病毒和宿主相关的因素外,除了宿主遗传因素外,对tick传播脑炎病毒(TBEV)诱导的疾病及其严重程度的易感性在很大程度上受到宿主遗传因素的影响。在这项研究中,我们研究了选择的单核苷酸聚合物(SNP)在先天免疫基因中对人类倾向的贡献。More specifically, we investigated a possible association between SNPs rs304478 and rs303212 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 1 ( IFIT1 ), rs7070001 and rs4934470 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 2 ( IFIT2 ), and RIG-I (Retinoic acid-inducible基因I)编码基因DDX58 RS311795343,RS10813831,RS17217280和RS3739674 SNP具有倾向于在捷克共和国人口中的倾向,在捷克共和国的人口中,TBEV是高度绝妙的。在247名非免疫TBE患者中分析了这些SNP的基因型和等位基因频率,并与204名对照组相比。分析表明,IFIT1 RS304478 SNP和DDX58 RS3739674和RS17217280 SNP的关联与捷克人群的倾向,表明临床上的新风险因素,但没有疾病严重性。这些结果还强调了先天免疫基因在发病机理中的作用。
我们很高兴邀请当地法律专家职位的单个申请,以支持在Ecowas Bank投资与发展(EBID)创建和实施采购部门的创建和实施。该邀请将扩展到来自各种公共和私人法律公司的个人和同事,包括律师协会和咨询公司。作为选定的候选人,您将在建立一个与最高标准效率和透明度相符的强大采购单元中发挥关键作用。您的专业知识将在塑造EBID的采购过程的政策和程序方面至关重要。The main tasks shall be the assistance in the implementation and execution of the Procurement for External Actions Legal Framework prepared and approved by EBID, specifically the assistance to the EBID in the preparation and supervision of tender processes for contracts of works, services, consultancy services and acquisition of supplies, the evaluation and award processes, the preparation and elaboration of the subsequent contracts, and the supervision of the payment, the overview of the execution and the review,合同执行后的内部审计和控制。参与将通过框架合同正式化,该合同将涵盖2025年的120个工作日。每天的特定小时数将在合同开始时确定并商定。请注意,提交申请的截止日期是2025年1月22日上午10点。我们鼓励您及时提交申请,以确保考虑。我们期待收到您的申请,并有可能共同努力,以在EBID的采购能力中取得重大进步。有关详细说明,请参阅所附的参考条款(TOR)。最好的问候,如果您有任何疑问或需要更多详细信息,请不要犹豫。
CARRA-Arthritis Foundation Large Grant: Advancing Committee Projects Grant Project Period Length: 2 years Grant Funding Amount: $100,000 Grant Availability: up to 3 awards (at least 1 specifically focusing on JIA) Application Deadline: February 28, 2025 Project period: July 1, 2025-June 30, 2027 CARRA's culture of collaboration focuses on facilitating, accelerating, funding, and performing research driven by academicians,履行其使命的临床医生,患者和家庭:进行协作研究以预防,治疗和治愈小儿风湿病。CARRA的同行审查的壁内赠款计划提供了各种资金机会,以支持各个职业水平的调查人员并提高我们的任务研究。计划描述此机会可用于支持CARRA委员会优先的研究项目,该委员会根据2023 - 2025年战略计划和2023 - 2025年研究议程,包括CARRA委员会,包括旨在修订和更新共识治疗计划(CTPS)的项目。此赠款计划不允许使用CARRA注册表和生物样品使用和收集。f或您可能遇到的任何问题,请通过grants@carragroup.org与Carra Grants Manager联系。将获得最多3赠款。至少一个奖项必须集中于2023 - 2025年CARRA-CARRATHIS炎基金会炎症性关节炎研究议程中发现的少年关节炎和区域。•精密医学
