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土地使用技术员（全职）-Weston Consulting
• Staying informed on planning and urban design practices • Policy and regulatory planning research for various sites throughout the Province of Ontario • Collaborating with Planning, Design, Finance, and Administrative Teams • Preparing compelling written documents geared towards business development and project procurement • Providing support to senior-level staff through research, writing, proposal preparation and tracking • Tracking and responding to Request for Proposals (RFPs) • Assisting with maintaining project timelines and milestones • Adhering to internal paradigms in relation to opening and closing files • Developing and keeping an updated projects tracker for all new proposal opportunities • Performing conflict checks using GIS and related software • When required, providing assistance with the preparation of letters, memos, and presentations • Document design and marketing packages, template maintenance, and various tasks related to a variety of interesting and challenging internal projects
推荐引用 推荐引用 Fok, Ernest，挑战国际趋势：美国人工智能发明案例，19 S ANTA C LARA J. I NT'LL. 51 (2021)。网址：https://digitalcommons.law.scu.edu/scujil/vol19/iss1/2
本文认为，通过承认发明人工智能的人为发明人，美国专利制度有望打破全球经济激励与社会成本之间的平衡。本文将探讨美国专利商标局的发明人要求所带来的问题、发明人工智能背后的技术及其创造能力，以及主要国际专利制度中人工智能发明人的现状。随后，本文将讨论尽管全球反对授予计算机此类权利的趋势，但为什么人工智能发明人对美国来说仍然有意义。美国准备推动宪法目标，即推动“科学和实用艺术的进步”，以造福社会。最后，本文将简要讨论承认发明人工智能的人为发明人将带来的一些主要挑战，以及缓解这些问题的潜在解决方案。
2024计划议程 - UCSF牙科学校
Anny Yang（导师：Jean Star博士）“远程医疗后牙科诊所的父母偏爱DRGA之后” Caroline Chen（导师：Dr.杰弗里·布什（Jeffrey Bush）和爱丽丝·古德温（Alice Goodwin））“下颌骨特定的SOX9损失导致下颌畸形学和皮埃尔·罗宾序列鼠标模型中的下颌畸形和left裂。 Zhang) “Investigating the effects of amelogenesis on the junctional epithelial cells” Betty Birbo (Mentor: Dr. Snehlata Oberoi) “Evaluation of maxillary skeletal and dental dimensions in impacted canines” Khushboo Gupta , BDS, MDS Clinical Case “Diagnosing OFG and uncovering Crohn's in a challenging pediatric case” Tiange (Tony) Qu (Mentor: LICIA SELLERI博士）“细胞周期停止'Zimpering'上皮细胞簇介导小鼠和人类的形态发生” 11:30 - 30 - 12:00临床卓越临床卓越的聚光灯Jean M. Star，DDS，DDS，MPH，MPH，Orofacial Sciences，Orofacial Sciences，Orofacial Sciences的助理教授”
Investment Highlights
• First Australian Patient Dosed in Phase 1b Azer-cel Clinical Trial, Targeting Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL): Imugene Limited has announced that the first Australian patient has been dosed in the Phase 1b clinical trial of azer-cel (azercabtagene zapreleucel) at the Royal Prince Alfred Hospital (RPAH) in Sydney. Azer-cel is an allogeneic, off-the-shelf CAR T-cell therapy designed to shorten treatment timelines and expand accessibility for patients who have limited options, particularly those with challenging, aggressive forms of DLBCL. This announcement follows promising data from the Company's U.S. trial sites, where three patients achieved complete responses (CR) despite having failed multiple prior treatments. In Cohort B, which includes lymphodepletion chemotherapy and interleukin-2 (IL-2), responses have extended beyond 90 and 120 days, indicating robust signs of durability. The dosing of the first Australian patient represents an important step in assessing the therapy's broader clinical applicability and potential benefits for patients with advanced lymphoma.
Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release
window of the product, as illustrated by several studies. 2 – 12 In the ADC eld, site-speci c technologies of all types now domi- nate new ADCs entering into clinical trials. However, the recent work of ImmunoGen comparing homogenous and heteroge- nous ADCs that generate the same metabolites, suggests that site-speci c technologies may not always enhance the phar- macokinetics of the drug and may also detrimentally alter its toxicity pro le. 13 – 15 In fact, several criteria such as the nature of the payload, the linker, the conjugation chemistry, the drug- antibody ratio (DAR), the hydrophobicity of the ADC may have an impact on the in vivo properties of the conjugate, which are for the time being di ffi cult to predict. The large number of upcoming clinical studies of site-speci cally prepared ADCs may help clarifying if there is a single conjugation chemistry that will become of widespread use, or whether other methods will also be applicable. Therefore, developing various technol- ogies is of interest for further progress in the eld. Site-speci c conjugation to an antibody is challenging due to the large number of solvent-exposed nucleophilic amino acids, in particular lysines. Despite this di ffi culty, the eld has been very proli c through developing a wide array of technologies that can be summarized as engineered cysteines, disul de
动态吸引的热图回归视频中的人姿势估计
我们提出了一种解决视频中2D人姿势估计的方法。视频中人类姿势估计的问题与估计静态图像中的人类姿势不同，因为视频包含大量相关信息。因此，我们投资了如何通过一系列视频框架来利用人体运动的信息来估算视频中的人类姿势。为此，我们引入了一种新型的热图回归方法，我们称之为运动吸引的热图恢复。我们的方法计算相邻帧的关节关键点中的运动向量。然后，我们签署了一种新的热图样式，我们称之为运动意识到的热图，以反映每个关节点的运动不确定性。与传统的热图不同，我们的运动吸引热图不仅考虑了当前的关节位置，而且还考虑了关节如何随时间移动。此外，我们引入了一个模拟且有效的框架，旨在将运动信息置于热图回归中。我们评估了在Posetrack（2018，21）和Sub-JHMDB数据集上的运动感知热图回归。我们的结果证明，拟议的运动吸引热图可显着提高视频中Human姿势估计的精度，尤其是在Challenging方案中，例如像体育游戏镜头一样具有实质性人类动作的视频。（代码和相关材料可在https://github.com/ songinpyo/mtpose中获得。）
28 THz soliton频率梳子中的连续波泵纤维Fabry-Pérot谐振器
和处理7，范围8，微波光子学9，双弯曲光谱学10和天文学光谱仪校准11。这些孤子作为Lugiato – Lefever方程的局部溶液12,13（LLE）出现，可以在具有高质量因素的谐振器中观察到。CSS的出现依赖于一侧异常的群体色散（GVD）和Kerr非线性之间的双重平衡，以及在另一侧的损耗和能量注入（通常是通过连续波（CW）激光泵）之间的双重平衡。由于它们的高质量因子和紧凑的设计（数百微米的空腔长度），微孔子在过去十年中引起了显着的注意力。De- spite these impressive performances, launching and collect- ing light in these resonators can be challenging, requiring ad- vanced fiber coupling devices such as a prism fiber taper 15 or advanced coupling methods for chip microresonators 16 , and while progresses on packaging are on going, it is still an ob- stacle for fiber applications.在谐振器中产生OFC的另一种方法是，在长度为117米的全纤维环腔中，其有效质量因子可以通过在腔体18中包括一个放大器来达到数百万。使用这些谐振器架构获得的光谱延伸到几个THZ上，几乎就像微孔子一样，但它们具有两个主要缺点。首先，线间距在MHz范围内，该范围限制了应用程序范围（主要在GHz范围14中），其次，它们不是Com-
指责在19号大流行期间未接种疫苗的
抽象的人未接种covid-19（C19）对大流行造成了偏见和责任。由于人们高估了C19的风险，我们检查了这些负面判断是否可以被部分理解为替罪羊的一种形式（即，不公平地指责一个不公平的群体），以及政治意识形态（以前证明是在美国塑造风险感知）是否会调节未诉讼的替代性。我们在C19期间对替罪羊文献和风险感知进行了基础。我们通过2022年初在美国进行的两项基于小插图的研究获得了对我们的猜测的支持。我们改变了Vignette字符的风险概况（年龄，先前感染，合并症）和疫苗接种状态（例如，未接种疫苗，未经近期助推器，未接种，未接种，未接种疫苗接种的疫苗），同时使所有其他信息保持恒定。We observed that people hold the unvaccinated (vs vaccinated) more responsible for negative pandemic outcomes and that political ideology moderated these effects: liberals (vs conservatives) were more likely to scapegoat the unvaccinated (vs vaccinated), even when presented with information challenging the culpability of the unvaccinated known at the time of data collection (eg, natural immunity, availability of vaccines, time自上次疫苗接种以来）。这些发现支持了C19大流行期间出现的特定基于群体的偏见的替罪羊解释。我们鼓励医学伦理学家检查C19大量高估公众的负面后果。公众需要有关健康问题的准确信息。可能涉及打击错误信息，以高估并低估了疾病的风险，以与错误相似的警惕。
社论：哺乳动物大脑中GABA能抑制回路的组装，可塑性和功能的细胞和分子机制
通过GABA能中间神经元（INS）抑制法规在正常大脑中的复杂神经计算中起着至关重要的作用，其畸形和功能错误会导致多种脑部疾病（Del Pino等，2018; Frye等，2016; kepecs and 2016; Kepecs and 2014; kepecs and fishell，2014; theanno; theang; theang; ealig; al ang e e eT; Al。，2016）。在过去的二十年中，在理解GABA能抑制回路的发展，可塑性，功能和病理相关性方面取得了显着进展。尤其是单细胞OMICS，遗传靶向，体内成像，功能操纵和行为分析的最新技术进步，我们在亚型中的知识已经爆炸。文章的研究主题，包括七篇原始研究论文和两项评论，其主题是“哺乳动物大脑中GABA能抑制回路的组装，可塑性和功能的主题”主题，突显了我们要走多远，以及我们需要走的地方。这些报告全面讨论了有关GABA能抑制系统的主题，从细胞类型的规范，突触组件和功能多样性到其在健康和疾病中的作用。总体目标是解开无数的INS将自己编织到功能电路中，这是理解皮质抑制的力量和脆弱性的核心。The challenging but essential tasks for dissecting the inhibitory system is to disentangle intricate inhibitory circuits consisting of diverse GABAergic IN subtypes ( Bandler et al., 2017 ; Hu et al., 2017 ; Lodato and Arlotta, 2015 ; Miyoshi, 2019 ; Pelkey et al., 2017 ).Machold和Rudy回顾了由转录组学和发育起源定义的亚型皮质和海马的新兴观点，并突出了一种用于靶向亚型特定的遗传工具包，以及每种方法固有的技术考虑因素。