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广告通知
广告通知，财政和经济管理部内的瓦努阿图统计局（VBO）正在寻求招募合格的顾问，以“驱动气候变化和自然灾害中的vanuatu数据科学驱动创新”项目。该职位是在15个月内的合同基础上。The purpose of this project is to significantly enhance the capacity of staff to utilise machine learning (ML) models for the analysis of satellite imagery, focusing on monitoring the gradual, slow-moving impacts of climate change including sea level rise, coastal erosion, extreme weather events, temperature and precipitation patterns, vegetation and land use changes, ocean temperature, drought and water resources, mangrove & reef health, and inundation and flooding.所需的基本经验和资格：
国际分子科学杂志
Focusing on deepening our understanding of the molecular complexities that govern the interaction between tumors and immune cells, we invite contributions investigating the role of molecular pathways in tumor immune evasion, characterizing the immune tumor microenvironment, identifying new biomarkers, and highlighting innovative molecular- based immunotherapeutic approaches, such as immune checkpoint inhibitors, CAR-T cell therapy, and cancer 疫苗。本期特刊旨在更多地建立有效的癌症免疫疗法。- 癌症免疫疗法 - 肿瘤免疫微环境 - 肿瘤免疫逃避 - 收养细胞疗法 - 免疫检查点抑制剂 - 基于新抗原的疫苗 - 化学免疫性 - 原发性免疫性 - 适应性免疫性 - 适应性免疫性 - 肿瘤肿瘤 - 肿瘤 - 肿瘤 - 肿瘤 - 含量 - 含量 - 免疫性crosstalk
铅酸电池技术
The goal of the Electrochemical Energy Storage and Conversion book series is to provide comprehensive coverage of the field, with titles focusing on fundamentals, technologies, applications, and the latest developments, including secondary (or rechargeable) batteries, fuel cells, supercapacitors, CO 2 electroreduction to produce low-carbon fuels, electrolysis for hydrogen generation/storage, and photoelectro- chemistry for water splitting to produce氢等。本系列中的每本书都是独立的，是由具有强大学术和工业专业知识的科学家和工程师撰写的，他们处于领域的顶端以及技术的最前沿。凭借各种电化学能源转换和存储设备的各种视图，为大学生，科学家和工程师提供了必不可少的读物，并允许他们轻松地找到有关电化学技术，基础知识和应用的最新信息。
短生物
•用于环境和生物医学应用的功能性P共轭材料和石墨烯复合材料的设计和合成专业知识。•ISOF的高级材料合成小组的负责人•> 110个出版物和9个国际专利家族的作者以及新的商用水过滤器的共同发明家。• Expert member 2022 of the Body of Knowledge of the EIT-Climate KIC- Water scarcity and pollution • Deputy Leader of the spearhead project of the Graphene Flagship ‘Graphil- graphene enhanced filters for water purification', Coordinator of the Flagera project GO-FOR-WATER technical, Manager and PI of the project LIFE-Remembrance, all projects focusing on new sustainable solutions for water purification.•与大型国家和国际工业的合同（ENI，Tetrapak，Culligan，Medica，Hera）
价值链培训计划作者：Kanar Dizyee电子邮件
构建定性和定量SD模型交付方法 - PPT和类练习模块2.1-设置场景（1 - 1.5小时）模块2.2-系统动力学简介（1 HR）模块2.3-动态复杂系统的常见行为（1 - 2 HRS）模块2.4-延迟和非层次和非层次和非层次和非层次模型（1-2 HRENEARITY（1-2 HRE）模型（1 - 2 HR） process-validation-communication-why modelling (1 hr) Module 2.6 - case studies (1 – 2 hrs) Module 2.7 - Introduction to Group Model Building Module 3 – application and use of tools (1 – 2 days) : The purpose of this module is to familiarize participants to application of system dynamics approaches (supply chain management, focusing on livestock modelling using the iThink/Stella software.该模块还旨在向参与者展示如何使用和运行我们的SD值链工具。目标
岛屿生物多样性与保护中心
该中心在吸引其项目的资金方面也非常成功。从2017年到2022年，它从各种赞助商那里获得了2000万美元的赠款。其中包括关键的生态系统合作伙伴基金，以及来自Chateau-De-de-FeuillesHôtel，Ste Anne Beachcomber Resort，Familia Torres Wines，Mauritius商业银行，开发计划署GEF-GOS项目，UNDP-GEF-GOS项目，Macce等公司合作伙伴的额外100,000美元。This level of funding enabled the team to implement a conservation project on Grande Soeur Island, Central Mahé and Ste Anne Island, focusing on the control and eradication of invasive species and associated biosecurity aspects, habitat improvement through producing and replanting native saplings and island transfers to (re)introduce rare and threatened species such as the Seychelles White-Eye and the Aldabra Giant Tortoise.
肠道菌群在自身免疫性疾病中的新兴作用
累积研究表明，肠道菌群通过与宿主进行复杂的相互作用，在自身免疫性疾病的发作中起关键作用。本综述旨在全面概述有关肠道菌群与自身免疫性疾病之间关系的现有文献，从而阐明了肠道微生物群，宿主和免疫系统之间的复杂相互作用。Furthermore, we aim to summarize the impacts and potential mechanisms that underlie the interactions between the gut microbiota and the host in autoimmune diseases, primarily focusing on systemic lupus erythematosus, rheumatoid arthritis, Sjögren ' s syndrome, type 1 diabetes mellitus, ulcerative colitis and psoriasis.本次审查将强调基于肠道微生物群作为自身免疫性疾病的创新辅助疗法的临床意义和潜在的干预措施应用。
全面的生物信息学分析揭示了与库相关的基因UBE2D3在心肌梗死中的作用
Results: Focusing on Ube2d3 for subsequent functional studies, we con fi rmed its high expression in the MI group through qRT-PCR and Western Blot detection after successful construction of a MI mouse model by left anterior descending (LAD) coronary artery ligation, and further clari fi ed the correlation of cuproptosis with MI development by detecting the levels of cuproptosis-related proteins.此外，通过体外实验，ube2d3得到了确认，可以在氧气 - 葡萄糖剥夺（OGD）处理的心肌细胞AC16中高度表达。In order to further clarify the role of Ube2d3, we knocked down Ube2d3 expression in OGD-treated AC16 cells, and con fi rmed Ube2d3 ' s promoting role in the hypoxia damage of AC16 cells by inducing cuproptosis, as evidenced by the detection of MTT, TUNEL, LDH release and cuproptosis-related proteins.
凋亡在糖尿病心肌病中的作用
糖尿病性心肌病（DCM）是糖尿病的常见并发症之一，作为特定的心肌病，在心脏的结构和功能上具有异常。随着糖尿病患病率的增加，DCM在全球范围内具有高发病率和死亡率。最近的研究发现，作为一种程序性细胞死亡，伴有炎症反应，加剧了DCM的生长和起源。这些研究为探索DCM的潜在处理提供了理论基础。Therefore, this review aims to summarise the possible mechanisms by which pyroptosis promotes the development of DCM as well as the relevant studies targeting pyroptosis for the possible treatment of DCM, focusing on the molecular mechanisms of NLRP3 in fl ammasome-mediated pyroptosis, different cellular pyroptosis pathways associated with DCM, the effects of pyroptosis occurring in different cells on DCM和针对NLRP3炎症/热胞菌的相关药物用于治疗DCM。本评论可能为开发DCM的治疗剂提供了新的视角和基础。
使用深度学习技术从ECG图像检测的心血管疾病检测 将数字创新用于社会变革-IJRPR 心脏病发作检测系统-IJRPR
心电图（ECG）是用于识别心血管问题的关键诊断工具，评估心脏的电和肌肉功能。虽然测试本身易于执行，但解释ECG读数需要大量的专业知识。传统上，ECG记录以纸质形式保持，使手动审查劳动密集型。通过数字化这些记录，可以改善自动诊断和分析。this project aims to use machine learning techniques to transform ECG paper records into a onedimensional signal, focusing on the P, QRS, and T waves that reflect heart activity.该过程涉及将ECG报告分割为13个线索，将数据转换为信号，应用平滑并通过阈值生成二进制图像。降低尺寸降低，例如主成分分析，将增强数据理解。机器学习模型，包括KNN，Logistic回归，SVM和集成分类器，将实现。最终模型将诊断诸如心肌梗塞或心律不齐之类的疾病，有助于有效的心脏健康评估。