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2024; 14(7): 2969-2992. doi: 10.7150/thno.96403 Review Actinium-225 targeted alpha particle therapy for prostate cancer
Targeted alpha particle therapy (TAT) has emerged as a promising strategy for the treatment of prostate cancer (PCa). Actinium-225 ( 225 Ac), a potent alpha-emitting radionuclide, may be incorporated into targeting vectors, causing robust and in some cases sustained antitumor responses. The development of radiolabeling techniques involving EDTA, DOTA, DOTPA, and Macropa chelators has laid the groundwork for advancements in this field. At the forefront of clinical trials with 225 Ac in PCa are PSMA-targeted TAT agents, notably [ 225 Ac]Ac-PSMA-617, [ 225 Ac]Ac-PSMA-I&T and [ 225 Ac]Ac-J591. Ongoing investigations spotlight [ 225 Ac]Ac-hu11B6, [ 225 Ac]Ac-YS5, and [ 225 Ac]Ac-SibuDAB, targeting hK2, CD46, and PSMA, respectively. Despite these efforts, hurdles in 225 Ac production, daughter redistribution, and a lack of suitable imaging techniques hinder the development of TAT. To address these challenges and additional advantages, researchers are exploring alpha-emitting isotopes including 227 Th, 223 Ra, 211 At, 213 Bi, 212 Pb or 149 Tb, providing viable alternatives for TAT.
摩尔多瓦共和国的国家诚信管理局
Cristina Prisacari，完整性诚信授权诚信官员的主要诚信检查员，导致艺术规定。7字母。b），艺术。19个字母。c），艺术。26和艺术。法律编号27。 132/2016关于国家诚信管理局（以下简称法律编号。 132/2016），在核实DNA Aurelia Andronache提交的《财富和年度个人利益宣言》之后，Edineț法院法官已准备好此报告。 在18.11.2024上，按照艺术规定。 27 para。 （2）法律编号。 132/2016和Point 1和5的ANI命令。 46 of 09.09.2024，通过电子分销系统，财富和年度个人利益的宣言，在2023财政年度，由DNA Aurelia Andronache提交，以验证，以验证财富和年度个人利益。 根据有效的法律框架，对财富和个人利益的声明的验证在于通过声明的主体验证陈述的提交，验证遵守形式要求的遵守情况以及对法律制度违反法律制度的存在的验证，以宣布资产和个人利益。 根据风险因素，腐败因素，宣言主题的脆弱性以及诚信委员会批准的标准，按照决策号，根据风险因素，腐败因素，脆弱性，每年检查的财富和个人利益的言论随机确定。 9 of 14.08.2024。法律编号27。132/2016关于国家诚信管理局（以下简称法律编号。132/2016），在核实DNA Aurelia Andronache提交的《财富和年度个人利益宣言》之后，Edineț法院法官已准备好此报告。在18.11.2024上，按照艺术规定。27 para。（2）法律编号。132/2016和Point1和5的ANI命令。 46 of 09.09.2024，通过电子分销系统，财富和年度个人利益的宣言，在2023财政年度，由DNA Aurelia Andronache提交，以验证，以验证财富和年度个人利益。 根据有效的法律框架，对财富和个人利益的声明的验证在于通过声明的主体验证陈述的提交，验证遵守形式要求的遵守情况以及对法律制度违反法律制度的存在的验证，以宣布资产和个人利益。 根据风险因素，腐败因素，宣言主题的脆弱性以及诚信委员会批准的标准，按照决策号，根据风险因素，腐败因素，脆弱性，每年检查的财富和个人利益的言论随机确定。 9 of 14.08.2024。1和5的ANI命令。46 of 09.09.2024，通过电子分销系统，财富和年度个人利益的宣言，在2023财政年度，由DNA Aurelia Andronache提交，以验证，以验证财富和年度个人利益。根据有效的法律框架，对财富和个人利益的声明的验证在于通过声明的主体验证陈述的提交，验证遵守形式要求的遵守情况以及对法律制度违反法律制度的存在的验证，以宣布资产和个人利益。根据风险因素，腐败因素，宣言主题的脆弱性以及诚信委员会批准的标准，按照决策号，根据风险因素，腐败因素，脆弱性，每年检查的财富和个人利益的言论随机确定。9 of 14.08.2024。从这个意义上讲，根据艺术。第20号法律。132/2016，诚信检查局通过SIA“ E-Entegrity”，McOnect互操作性平台和州注册者访问了与验证财富和个人利益宣言有关的信息。由于概念概念官员在2023财政年度的年度个人利益和利益宣言中所持有的信息与宣言宣言所指示的数据相反，该声明的声明是在25.03.2024建立的，并于29.03.03.2024建立了个人利益，并于29.03.03.2024建立。Successively, it was established the lack of violation of the legal regime of declaring the assets and personal interests, the lack of appearance of a substantial difference between the obtained income and the expenses, on the one hand, and the wealth acquired, on the other, as well as the lack of appearances to not declare some conflicts,
用于生物医学应用的平板显示技术
Organ-on-Chips (OoCs) have emerged as a human-specific experimental platform for preclinical research and therapeutics testing that will reduce the cost of pre-clinical drug development, provide better physiological relevance and replace animal testing.Yet, the lack of standardization and cost-effective fabrication technologies can hamper wide-spread adoption of OoCs.In this work we validate the use of flat panel display (FPD) tech nology as an enabling and cost-effective technology platform for biomedical applications by demonstrating facile integration of key OoC modules like microfluidics and micro electrode arrays (MEAs) in the standardized 96-well plate format.Individual and integrated modules were tested for their biological applicability in OoCs.For microelectrode arrays we demonstrate 90 – 95% confluency, 3 days after cell seeding and > 70% of the initial mitochondrial cell activity for microfluidic devices.Thus highlighting the biocompatibility of these modules fabricated using FPD technology.Furthermore, we provide two examples of monolithically integrated micro fluidics and microelectronics, i.e.integrated electronic valves and integrated MEAs, that showcase the strength of FPD technology applied to biomedical device fabrication.Finally, the merits and opportunities provided by FPD technology are discussed through examples of advanced structures and functionalities that are unique to this enabling platform.
甘蔗育种：技术和方法驱动的奇妙的过去和有希望的未来
甘蔗是世界上最重要的糖和能源作物。在甘蔗育种期间，技术是需求，方法是手段。我们知道，种子是甘蔗产业发展的基石。Over the past century, with the advancement of technology and the expansion of methods, sugarcane breeding has continued to improve, and sugarcane production has realized a leaping growth, providing a large amount of essential sugar and clean energy for the long-term mankind development, especially in the face of the future threats of world population explosion, reduction of available arable land, and various biotic and abiotic stresses.Moreover, due to narrow genetic foundation, serious varietal degradation, lack of breakthrough varieties, as well as long breeding cycle and low probability of gene polymerization, it is particularly important to realize the leapfrog development of sugarcane breeding by seizing the opportunity for the emerging Breeding 4.0, and making full use of modern biotechnology including but not limited to whole genome selection, transgene, gene editing, and synthetic生物学，结合遥感和深度学习等信息技术。鉴于此，我们从技术和方法的角度专注于甘蔗育种，回顾了主要历史，指出了当前的状态和挑战，并为智能育种前景提供了合理的前景。
2023-12-27-woburn-open-open-and-recreation-plan- ...
自2002年以来，EOEEA一直在执行环境司法政策，以帮助确保所有马萨诸塞州居民在开发，实施和执行环境法律，法规和政策以及公平的环境利益方面都具有平等保护和有意义的参与。这项政策被认为是认识到，英联邦的整个社区，尤其是英联邦较旧的工业区域及其周围人口稠密的城市社区，正面临着与马萨诸塞州工业遗产相关的许多环境挑战。Residents in these predominantly low-income and minority communities – nearly 29% of the Commonwealth's population – lack open space and recreational resources and often live side-by-side numerous existing large and small sources of pollution and old abandoned, contaminated sites, which can pose risks to public health and the environment (Commonwealth of Massachusetts, Executive Office of Energy and Environmental Affairs, Division of Conservation Services, 2008).对于在英联邦推进环境正义（EJ）至关重要的是公园，开放空间和娱乐等环境资产的公平分配。朝着这一目的而言，在适用的情况下，市政当局应在其开放空间和娱乐计划中确定并确定对社区中EJ人群在社会，娱乐和生态上至关重要的开放空间和娱乐计划。
佳能总体策略
本演示文稿包含有关未来结果，绩效和成就的前瞻性陈述，这些陈述受风险和不确定性的影响，并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时，诸如“预期”，“相信”，“估计”，“期望”，“打算”，“五月”，“计划”，“项目”或“应该”和类似表达式（与佳能相关的表达）之类的词，旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素，均在本演讲中引用和未引用。应实现一个或多个风险或不确定性，或者基本假设证明不正确，实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
成像组
本演示文稿包含有关未来结果，绩效和成就的前瞻性陈述，这些陈述受风险和不确定性的影响，并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时，诸如“预期”，“相信”，“估计”，“期望”，“打算”，“五月”，“计划”，“项目”或“应该”和类似表达式（与佳能相关的表达）之类的词，旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素，均在本演讲中引用和未引用。应实现一个或多个风险或不确定性，或者基本假设证明不正确，实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
医学组
本演示文稿包含有关未来结果，绩效和成就的前瞻性陈述，这些陈述受风险和不确定性的影响，并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时，诸如“预期”，“相信”，“估计”，“期望”，“打算”，“五月”，“计划”，“项目”或“应该”和类似表达式（与佳能相关的表达）之类的词，旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素，均在本演讲中引用和未引用。应实现一个或多个风险或不确定性，或者基本假设证明不正确，实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
医学和医疗保健中的生成AI | ama
This report provides information on the fundamentals of generative AI in medicine and health care: terminologies and components of artificial intelligence (AI) and augmented intelligence, definitions, prominent models (Open AI ChatGPT, Google Bard and Med-PaLM, and Microsoft Bing), promises, challenges, and pitfalls, AMA partnerships and resources, and potential ethical and regulatory frameworks.该报告以CLRPD成员对趋势的见解结束。生成的AI模型是商业自然语言处理工具，称为大语言模型（LLMS）。在其核心中，所有AI创新都利用复杂的统计技术来使用越来越强大的计算技术来辨别广泛数据集中的模式。三个组成部分 - BIG数据，高级统计方法和计算资源 - 不仅可以最近销售，而且在以前的技术创新中以前所未有的速度使民主化和访问。While LLMs show promise to make a significant contribution to health care in the future, physicians currently considering using generative AI models in a clinical setting or direct patient care should exercise caution and be aware of the real challenges that remain to ensure reliability: confident responses that are not justified by the model's training data, the “black box” nature of AI, biased and discriminatory tendencies in outputs, lack of knowledge-based reasoning, lack of current ethical and regulatory框架，患者隐私和安全问题以及潜在的责任。生成的AI系统不是有意识的，他们只是使用大量文本来预测一个单词，它们的输出可能会将真相与显然的错误陈述混合在一起。因此，医生将需要学习如何将这些工具整合到临床实践中，从而定义完整，监督和禁止自治之间的明确界限。医生应清楚地了解任何新技术固有的风险，尤其是具有生存含义的技术，同时对改善医疗保健系统效率的未来，更好的患者结果和减少倦怠的未来谨慎乐观。现存的AI辅助程序和快速开发的系统非常复杂，并且由于医生已经开始在社交媒体上展示，因此他们很快就可以可靠地执行测试结果通知，工作信，事先授权等（不仅累积的有价值的时间，而且是实质性的，而且都是物理学的贡献者。将进一步投射到AI增强的未来，想象一下，医生可以要求生成的AI系统来创建患者治疗课程的概要，而不是编写后续护理指示。随着时间的流逝，医生可以远离计算机，面对患者，并解释最突出的随访项目，其中包括与健康素养中最佳实践相兼容的材料。同样，这些计划可能有助于实现《 21世纪治疗法》中《赋予患者（但无法访问）的术语中的术语电子病历》中的令人钦佩的意图。有机会提供有关这些系统开发和部署的临床见解，生成的AI可能会为医生提供减轻行政负担的技术工具，并使他们能够回到为什么他们决定首先从事医学的原因，以改善患者的生活，以改善医生的福祉，改善医生的健康。