本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
本演示文稿包含有关未来结果,绩效和成就的前瞻性陈述,这些陈述受风险和不确定性的影响,并反映了由可用信息形成的管理层的观点和假设。历史事实陈述以外的所有陈述都是可以认为是前瞻性陈述的陈述。在此文档中使用时,诸如“预期”,“相信”,“估计”,“期望”,“打算”,“五月”,“计划”,“项目”或“应该”和类似表达式(与佳能相关的表达)之类的词,旨在识别前瞻性陈述。Many factors could cause the actual results, performance or achievements of Canon to be materially different from any future results, performance or achievements that may be expressed or implied by such forward-looking statements, including, among others, changes in general economic and business conditions, changes in currency exchange rates and interest rates, introduction of competing products by other companies, lack of acceptance of new products or services by Canon's targeted customers, inability to meet efficiency and cost reduction objectives, changes in business strategy and various其他因素,均在本演讲中引用和未引用。应实现一个或多个风险或不确定性,或者基本假设证明不正确,实际结果可能与本文所述的结果有很大不同。佳能不打算或承担更新这些前瞻性语句的任何义务。
开发针对利什曼原虫的保护性疫苗取决于抗原配方和诱导特异性免疫和持久免疫反应的佐剂。我们之前证明,鼻腔内接种编码 p36/LACK 利什曼原虫抗原 (LACK-DNA) 的质粒 DNA 的 BALB/c 小鼠在接种疫苗后可产生长达 3 个月的保护性免疫,这与疫苗 mRNA 在外周器官中的全身表达有关。在本研究中,LACK-DNA 疫苗与交联甘油醛 (CMC) 的生物相容性壳聚糖微粒相结合,以增强对晚期利什曼原虫攻击的持久免疫力。与未接种疫苗的对照组相比,接种疫苗后 7 天、3 或 6 个月感染导致寄生虫负荷显著降低。此外,接种 LACK-DNA-壳聚糖疫苗的小鼠在晚期时间点攻击后表现出长期保护作用。所获得的保护与脾细胞对寄生虫抗原的增强反应相关,其特点是增殖和 IFN-g 增加以及 IL-10 产生减少。此外,我们发现 TNF-a 的系统水平降低,这与 LACK-DNA/CMC 疫苗接种感染小鼠中观察到的较好健康状况相一致。总之,我们的数据表明壳聚糖微粒作为递送系统工具来延长 LACK-DNA 疫苗赋予的保护性免疫的可行性,这可以在针对利什曼原虫感染的疫苗制剂中进行探索。
的优势,劣势,机遇和威胁在行政上的优势:市政当局拥有经验丰富的专业员工,具有强大的职业道德,专注于变革管理和最佳管理实践。环境:位于安大略湖沿岸,可以轻松地通过公园和小径,优质的水,温带气候和众多自然资源进入生态丰富的环境。在经济上:我们的位置与三个县接壤,为经济发展,营销和旅游业重叠的区域支持提供了重叠的优势。在社交上:布莱顿拥有强大而积极的志愿者基础,渴望与参加我们当地学校的一群才华横溢的青年分享他们的专业知识和时间。基础设施:市政当局拥有维护良好的市政资产基础。_____________________________________________________________ Weaknesses Administratively: Proactive growth of our administrative infrastructure (systems, policies and staffing) addressing the lack of change readiness.社会上:布莱顿缺乏可靠的互联网连接,社会基础设施,包括医疗服务,过境和经济适用房,公共绿色空间。人们担心铁路轨道以南的可及性标准和紧急响应的不一致。环境:由于高水位桌子,社区的地区越来越容易受到洪水的影响。目前,没有可持续性或气候行动计划。布莱顿的水污染控制厂需要扩大和遵守氨水排水标准。缺乏资本资产的标识,映射和营销。在经济上:有必要通过工业,商业和机构部门的增长来评估多元化。
治疗和管理•患有HIVºRIF的患者不应用于接受大多数抗HIV蛋白酶抑制剂(PIS)和非核苷逆转录酶抑制剂(NNRTIS)的患者。RFB;可能需要调整RFB剂量以同时给予某些抗HIV PI和NNRTIS。RIF可与核苷逆转录酶抑制剂(NRTIS)一起使用。请咨询专家。• RIPE treatment regimen º Doses should not be divided º Use EMB with caution in children whose vision cannot be monitored º Discontinue EMB when susceptibility to INH and RIF is demonstrated with good clinical response º Discontinue PZA after the Initial Phase - 8 weeks ( see treatment table for number of doses ) - unless there is resistance to either INH or RIF or lack of clinical response • Drug resistance º Mono-drug resistant disease可能需要改变治疗方案。寻求专家咨询。º多药抗性疾病(对INH和RIF的抗性)需要个性化的治疗方案并延长治疗。寻求专家咨询。•对肺结核患者的痰监测º进行至少每月进行痰液监测,直到连续2种持续的痰培养物变为阴性。ºEDOH建议与结核病专家咨询,以便在初始阶段结束时仍然是痰培养阳性的任何人。 •正在进行的评估ºEDOH建议与结核病专家咨询,以便在初始阶段结束时仍然是痰培养阳性的任何人。•正在进行的评估
Satellites, now numbering over 10,000 as of 2024 [43], have transitioned from extraordinary space achievements to common orbital fixtures, especially with the surge in small satellites like CubeSats and nanosatellites. This accessibil- ity has allowed diverse entities, including universities and startups, to engage in space projects. However, the ease of developing these smaller satellites often comes at the cost of security, making them prone to cyberattacks. Teams be- hind these projects may lack comprehensive cybersecurity knowledge, leading to significant vulnerabilities. Furthermore, the evolving nature of cybersecurity means satellite software can quickly become outdated, with updates in orbit posing a challenge, as noted in research like Willbold et al. [47]. Concurrently, there has been a significant evolution in satellite on-board computing, particularly in processing power. This advancement enables small satellites to run full operating systems like Linux, a shift from the basic systems in earlier models. This technological progress enhances satellite func- tionalities but also adds complexity and vulnerability, neces- sitating stronger security measures. As systems become more sophisticated, they are more susceptible to threats, requiring a layered defense approach. Sandboxing is one of the effective methods to isolate software vulnerabilities and protect these advanced systems. In this paper, we discuss the process of selecting a sandbox- ing mechanism for a satellite project currently under develop- ment, named RACCOON [41]. The project's goal is to design
听众反应:• 缺乏政治意愿 • 过于雄心勃勃 • 缺乏对计划的认识 • 没有“坚持”来激励实施 • 只是“空谈” • 期限太长 • 缺乏支持 • 没有合适的利益相关者参与 • 目标模糊,不可衡量 • 缺乏问责制
“不可抗力事件”是指在交换控制或相关成员或非会员的赞助本金之外发生的情况,如适用,阻止,阻碍或延迟绩效的全部或部分义务在其符合此处的任何义务中(不包括付款的义务)(并且仅在此类债务中,其债务均在此类义务中,该义务是由成员或不在债务中的义务,而这些义务是由成员造成的,这些义务是一定成员的义务。 an occurrence which would prevent, hinder or delay the performance in whole or in part of any of its obligations thereunder were the occurrence or effects of the occurrence to continue until the date of performance of the relevant obligation), including, but not limited to, fire, flood, storm, earthquake, explosion, war, hostilities, accidents howsoever caused, strike, labour dispute, lockout, work to rule or other industrial dispute, lack of energy supply, disruption or停电气体或电力传输系统,刑事诉讼,恐怖行动,内乱,禁运,上帝的行为,公共敌人的行为,不可用或损害计算机或数据处理设施,第三人的行动或不作为(包括,不受限制,回购设施,交付机构,政府在境内定义),交换机构,交换机构,交换系统,交换系统,清理系统,清理,清除,清理,清理,清除,清理,清理,;和违法;或者,根据任何合同的交付,任何事件是不可抗力的事件(或类似事件,无论何时定义),根据ICE期货阿布扎比合同条款和程序;
缺乏活力并不代表缺乏创意或缺乏雄心。欧洲充满了才华横溢的研究人员和企业家。这是因为创新往往缺乏协同效应,而且我们未能将创意转化为商业成功。缺乏单一市场和一体化资本市场,创新公司想要在欧洲扩大规模的每个阶段都会受到阻碍,从而阻碍创新的循环。