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Factors that predispose patients to ketoacidosis include a low carbohydrate diet, dehydration, acute illness, surgery (see Section Surgery), a previous ketoacidosis, insulin deficiency from any cause (including insulin pump failure, history of pancreatitis, or pancreatic surgery), malnourishment/reduced caloric intake or increased insulin requirements due to infections, and alcohol abuse.jardiamet。减少需要胰岛素的患者的胰岛素剂量时，应谨慎行事（请参阅第4.2节和给药方法）。考虑监测酮症酸中毒，并在已知易感酮症酸中毒的临床情况下暂时停止Jardiamet。在这些情况下，即使贾地尼特治疗被中断，也要考虑监测酮。
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