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T细胞反应在早期控制和成功清除SARS-COV-2感染中起着必不可少的作用。However, several important questions remain about the role of cellular immunity in COVID-19, including the shape and composition of disease-speci fi c T cell repertoires across convalescent patients and vaccinated individuals, and how pre-existing T cell responses to other pathogens — in particular, common cold coronaviruses — impact susceptibility to SARS-CoV-2 infection and the subsequent course of disease.本综述着重于T细胞受体（TCR）的曲目如何通过自然感染和随时间疫苗接种来塑造。我们还总结了有关交叉反应性T细胞反应及其保护作用的当前知识，并研究了TCR曲目多样性和交叉反应性的含义，这些疫苗的设计对SARS-COV-2变体提供了更广泛的保护。
SARS-COV-2特异性T细胞库的结构
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