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[图片来源：儿童白血病]与儿童患癌症一样困难，很高兴知道大多数患有儿童白血病的孩子和青少年都可以成功治疗。Most childhood leukaemias are ‘acute' meaning that they develop and progress rapidly.Auger, N., Goudie, C., Low, N., Healy-Profitós, J., Lo, E. & Luu, T.M.2019。BACKGROUND: Previous studies provide conflicting evidence of a link between maternal substance use and risk of childhood cancer.METHODS: We analyzed a cohort of 785,438 newborns in Quebec (2006-2016).We identified infants whose mothers had problematic illicit drug, tobacco, or alcohol use before or during pregnancy.The primary outcomes were childhood hematopoietic cancer or solid tumors within 0-5 years of age.使用COX比例危害模型，我们计算了危害比（HR）和95％的置信区间（CI），以针对母体药物使用与儿童期癌症之间的关联，并针对潜在的混杂因素进行了调整。RESULTS: A total of 925 cases of cancer occurred during 3.5 million person-years of follow-up.与未暴露儿童相比，暴露于任何产妇使用的儿童的癌症发病率略有升高（每100,000人年29.4 vs. 26.1）。Maternal illicit drug use was associated with the risk of acute lymphoblastic leukemia (HR 1.63, 95% CI 0.79-3.36) and fibrosarcoma (HR 2.11, 95% CI 0.86-5.16).Maternal tobacco use was associated with acute myeloid leukemia (HR 2.01, 95% CI 0.72-5.60) and fibrosarcoma (HR 2.13, 95% CI 1.05-4.32), but a weak association with neuroblastoma (HR 1.21, 95% CI 0.61-2.40) and renal tumors (HR 1.14, 95% CI 0.42-3.13) also appeared to be present.
儿童期慢性髓样白血病（CML）
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