假设:随着剂量的增加,米塔唑嗪会导致镇静。文学搜索:PubMed和Scopus搜索文章,其中标题包括“ Mirtazapine”或“ Org-3770”或“ 6-扎米塞林”,以及任何领域中的搜索术语之一:机敏,昏迷,疲倦,疲劳,疲劳,高血压,低音,疲劳,懒惰,懒惰,静态,镇静,厌倦,疲倦,厌倦,疲倦,疲倦。Inclusion Criteria: Human research subjects English Language articles Comments on sedation(or comparable term) with correlation to dose or time Participants must receive mirtazapine during the trial period for more than 1 day Exclusion Criteria: Non-peer reviewed articles Review articles, Meta-analyses, literature reviews, case reports, case series, abstracts, posters, editorials, or animal studies Article Analysis: Each article was assessed by study staff for exclusion 标准。如果通过此审查,医生评估了该研究的包含和排除标准。由于大部分数据的主观性,添加了第二次医师审查,以确认假设适用的结果。