EAG: ~35-40% have complement-inhibitor across UK in National PNH Service, most have ravulizumab initially • Eculizumab considered useful particularly in emergency to avoid thrombosis in newly diagnosed people • Renal failure or pregnancy – typically continue eculizumab (limited safety data for ravulizumab/pegcetacoplan) • ~15% remaining anaemic after C5 inhibitor switch to pegcetacoplan(比例正在增加)
This state checklist is a guide for personnel involved in administering ACCESS for ELLs Online, and includes unique steps related to Kindergarten and Alternate ACCESS assessments. The checklist highlights all tasks that need to be completed before , during , and after testing within a school or district and uses color to indicate who typically completes those tasks in your state. This checklist has been customized for your state. The state-specific clarification column contains guidance that your state education agency expects you to follow as you prepare for and administer the test.
For this project, the Bank has agreed with IRC Implementing agencies that the operating costs constitute recurrent costs (excluding purchase of motor vehicles, computers, etc) and typically include equipment rental and maintenance, vehicle operating costs, maintenance and repair, office rental and maintenance, office materials and supplies, utility costs (including electricity, water and gas) communications (including telephone and internet charges) equipment rent, operation and maintenance and cost of banking services (bank费用),每日diem的旅行费用以及与项目准备相关的员工的运输。这些
o High voltage shocks o Direct jet flames o Fires develop in intensity quickly and rapidly reach their maximum intensity (typically within 2-3 minutes) o Toxic gases o Gas explosion (if the released gas accumulates for a while before being ignited) o Long lasting re-ignition risk (can ignite or re-ignite weeks, or maybe months after the provoking incident) o Once established fires are difficult to stop/extinguish o Thermal runaway
• Second leading systemic cancer with CNS metastases – 10-16% • Characteristics of CNS disease • Site is much more likely to be parenchymal than leptomeningeal • Neurological symptoms typically reason for discovery • More likely to be in setting of progressive systemic disease* • Risk is not equal among the breast cancer subtypes • HER-2 positive • Triple negative (ER neg, PR neg, and HER-2 neg) • Mechanism and outcomes are not the same among风险最高的人•HER-2正•三重负面(er neg,pr neg和her-2 neg)
Disadvantages • Low cycle efficiency : Typically around 70-80%, compared to lithium-ion batteries, which are usually 98% or higher • Dendrite formation : Dendrites can form on the zinc anode, which can decrease battery efficiency, cause short circuits, and lead to battery fires • Material corrosion : Materials in ZBFBs can corrode • Short cycle life : ZBFBs have a short cycle life compared to li-离子,nimh等•低功率密度:无法进行高速放电•毒性:溴的存在和在新神经条件下的溴释放是毒性问题
discussion. To prepare for these discussions, you need to read the case beforehand (which I will remind you to do as we go). Cases hinge critically on students having read in advance, so to get a sense of whether students have read the cases, we will typically start with some basic ‘reading check' questions about the case content. I plan for these checks to be informal, but if I get the sense that students are not reading the cases ahead of time, I reserve the right to institute more formal “case quizzes.” HOMEWORK In addition to reading the cases and coming prepared for class discussions, your primary homework in this course will be competing in the MarkStrat simulation (see below). Specifically, you and your teammates will be required to submit seven weekly “decisions” about how to manage a simulated suite of products in a competitive market, competing against your classmates. These decisions will include what products to develop and bring to market, how to advertise them, where to sell them, and what market research to procure for future periods. Decisions will typically be due on Tuesdays and we will discuss the results of them—which impact your grade—weekly in class on Wednesdays. As you will see, the simulation cannot accept late decisions by design. In addition to these seven decisions, you will be asked to complete a short (~5ish) paper assignment as a team to demonstrate your mastery of the simulation at the end of the semester. MARKSTRAT (GROUP WORK) As indicated, the central assignment in this class is a team-based simulation, MarkStrat. You will be assigned by me to teams of 4-5 students and you will need to find time to work together (either
经济RSF:整合联邦机构的资源和专业知识,以帮助SLTT政府和私营部门维持和/或振兴企业和就业机会,并开发新的经济机会,从而导致灾难发生后可持续和经济上有弹性的社区。The Economic RSF typically works on a range of projects that may include the development of community-wide economic recovery or development plans, strategies for adapting to changed market conditions, injections of needed capital (loans and grants), workforce initiatives to build skills for and secure new jobs, business initiatives to employ workers and generate revenue, entrepreneurial programs to re-open and establish new businesses to address recovery needs, and management plans that promote the effective use of recovery resources并整合经济弹性原则。
Duration: Typically 1-2 years (competency based) Start Date: July 1 annually (alternative dates negotiable) Compensation: $90,000 CAD per year with additional eligibility for unique Brain Medicine Research and Catalyst Funds to support academic work Eligibility: Candidates must have completed a residency training program in one of: geriatric medicine, neurology, neurosurgery, physical medicine & rehabilitation, care of the elderly, or psychiatry计划(加拿大和国际医学毕业生欢迎) *代替专业认证,现任国内居民必须提交良好信誉的信,以表明其居民计划预期的毕业日期
Advanced Persisent Threat (APT) An adversary with sophisticated levels of expertise and significant resources, allowing it through the use of multiple different attack vectors (e.g., cyber, physical, and deception), to generate opportunities to achieve its objectives which are typically to establish and extend its presence within the information technology infrastructure of organizations for purposes of continually exfiltrating information and/or to undermine or impede critical aspects of a mission,程序,组织,或将将来做出自己的位置;此外,先进的持久威胁在很长的一段时间内反复追求其目标,适应了辩护人抵制它的努力,并决心保持执行其目标所需的互动水平。